5-Aminoimidazole ribonucleotide (BioDeep_00000005191)

 

Secondary id: BioDeep_00001869063

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


{[(2R,3S,4R,5R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C8H14N3O7P (295.0569)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 10.97%

分子结构信息

SMILES: C1=C(N(C=N1)C2C(C(C(O2)COP(=O)(O)O)O)O)N
InChI: InChI=1S/C8H14N3O7P/c9-5-1-10-3-11(5)8-7(13)6(12)4(18-8)2-17-19(14,15)16/h1,3-4,6-8,12-13H,2,9H2,(H2,14,15,16)/t4-,6-,7+,8+/m1/s1

描述信息

5-aminoimidazole ribonucleotide (AIR), is an intermediate of purine nucleotide biosynthesis. It is also the precursor to 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP), the first product of pyrimidine biosynthesis. This reaction is mediated by the enzyme HMP-P kinase (ThiD). HMP is a precursor of thiamine phosphate (TMP), and subsequently to thiamine pyrophosphate (TPP). TPP is an essential cofactor in all living systems that plays a central role in metabolism. (PMID: 15326535). 5-Aminoimidazole ribonucleotide is a substrate for a number of proteins including: Scaffold attachment factor B2, Multifunctional protein ADE2, Pulmonary surfactant-associated protein B, Tumor necrosis factor receptor superfamily member 25, Pulmonary surfactant-associated protein C, Serine/threonine-protein kinase Chk1, Vinexin, Trifunctional purine biosynthetic protein adenosine-3, Antileukoproteinase 1 and Scaffold attachment factor B.
5-aminoimidazole ribonucleotide (AIR), is an intermediate of purine nucleotide biosynthesis. It is also the precursor to 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP), the first product of pyrimidine biosynthesis. This reaction is mediated by the enzyme HMP-P kinase (ThiD). HMP is a precursor of thiamine phosphate (TMP), and subsequently to thiamine pyrophosphate (TPP). TPP is an essential cofactor in all living systems that plays a central role in metabolism. (PMID: 15326535)
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

27 个代谢物同义名

{[(2R,3S,4R,5R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid; 5-Amino-1-beta-D-ribofuranosyl-5-(dihydrogen phosphoric acid)-imidazole; 5-Amino-1-β-D-ribofuranosyl-5-(dihydrogen phosphoric acid)-imidazole; 5-Amino-1-b-D-ribofuranosyl-5-(dihydrogen phosphoric acid)-imidazole; 5-Amino-1-beta-D-ribofuranosyl-5-(dihydrogen phosphate)-imidazole; 5-Amino-1-β-D-ribofuranosyl-5-(dihydrogen phosphate)-imidazole; 5-Amino-1-b-D-ribofuranosyl-5-(dihydrogen phosphate)-imidazole; Aminoimidazole ribotide, (alpha-D-ribofuranosyl)-isomer; Aminoimidazole ribotide, (beta-D-ribofuranosyl)-isomer; Aminoimidazole ribotide, phosphonoribofuranosyl-isomer; 5-Amino-1-ribofuranosylimidazole 5-phosphoric acid; 5-Amino-1-(5-phospho-beta-D-ribosyl)imidazole; 5-Amino-1-ribofuranosylimidazole 5-phosphate; 5-Amino-1-(5-phospho-b-D-ribosyl)imidazole; 5-Amino-1-(5-phospho-β-D-ribosyl)imidazole; 1-(5-Phospho-D-ribosyl)-5-aminoimidazole; 5-Amino-1-(5-phospho-D-ribosyl)imidazole; 1-(5-Phosphoribosyl)-5-aminoimidazole; 5-Phosphoribosyl-5-aminoimidazole; 5-Aminoimidazole ribonucleotide; Aminoimidazole ribonucleotide; Phosphoribosylaminoimidazole; 5-Aminoimidazole ribotide; Aminoimidazole ribotide; AIR (nucleotide); AIR; Aminoimidazole ribotide



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

63 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(7)

WikiPathways(0)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(53)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 APOE, DHFR, PAICS, PFAS, PKM, PNP, PTK2, PURA, SNCA
Peripheral membrane protein 1 PTK2
Nucleus 8 APOE, NCOR2, PKM, PTK2, PURA, PURG, SNCA, VGLL3
cytosol 11 ADSL, DHFR, GART, GPT, PAICS, PFAS, PKM, PNP, PPAT, PTK2, SNCA
dendrite 2 APOE, PURA
nuclear body 1 NCOR2
trans-Golgi network 1 BACE2
centrosome 1 PTK2
nucleoplasm 1 NCOR2
Cell membrane 2 BACE2, PTK2
Cytoplasmic side 1 PTK2
Cell projection, axon 1 SNCA
Synapse 2 PURG, SNCA
cell cortex 2 PTK2, SNCA
glutamatergic synapse 2 APOE, PURA
Golgi apparatus 2 APOE, BACE2
growth cone 1 SNCA
neuronal cell body 3 APOE, PURA, SNCA
postsynapse 2 PURA, SNCA
Lysosome 1 SNCA
endosome 1 BACE2
plasma membrane 4 APOE, BACE2, PTK2, SNCA
synaptic vesicle membrane 1 SNCA
Membrane 5 APOE, BACE2, NCOR2, PAICS, SNCA
axon 1 SNCA
extracellular exosome 7 APOE, GART, GPT, PAICS, PFAS, PKM, PNP
endoplasmic reticulum 2 APOE, BACE2
extracellular space 3 APOE, PNP, SNCA
perinuclear region of cytoplasm 2 PTK2, SNCA
mitochondrion 3 DHFR, PKM, SNCA
protein-containing complex 2 ADSL, SNCA
intracellular membrane-bounded organelle 1 PTK2
Single-pass type I membrane protein 1 BACE2
Secreted 3 APOE, PNP, SNCA
extracellular region 4 APOE, PKM, PNP, SNCA
anchoring junction 1 PTK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
Endosome, multivesicular body 1 APOE
Extracellular vesicle 2 APOE, PKM
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
actin cytoskeleton 1 SNCA
dendritic spine 1 PTK2
Melanosome membrane 1 BACE2
Early endosome 1 APOE
vesicle 1 PKM
Cytoplasm, perinuclear region 1 PTK2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 1 PTK2
focal adhesion 1 PTK2
extracellular matrix 1 APOE
collagen-containing extracellular matrix 2 APOE, PKM
ciliary basal body 1 PTK2
cilium 1 PKM
chromatin 1 NCOR2
cell projection 1 PTK2
supramolecular fiber 1 SNCA
cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
Secreted, extracellular space 1 APOE
chromosome, telomeric region 1 PURA
Cytoplasm, cell cortex 1 PTK2
blood microparticle 1 APOE
Melanosome 2 APOE, BACE2
stress fiber 1 PTK2
ficolin-1-rich granule lumen 2 PKM, PNP
secretory granule lumen 2 PKM, PNP
endoplasmic reticulum lumen 1 APOE
nuclear matrix 1 NCOR2
transcription repressor complex 1 NCOR2
axon terminus 1 SNCA
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 1 APOE
Rough endoplasmic reticulum 1 PKM
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
inclusion body 1 SNCA
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM


文献列表

  • Angad P Mehta, Sameh H Abdelwahed, Michael K Fenwick, Amrita B Hazra, Michiko E Taga, Yang Zhang, Steven E Ealick, Tadhg P Begley. Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B₁₂ Biosynthesis. Journal of the American Chemical Society. 2015 Aug; 137(33):10444-7. doi: 10.1021/jacs.5b03576. [PMID: 26237670]
  • M O Farber, J J Szwed, A R Dowell, R A Strawbridge. The acute effects of respiratory and metabolic acidosis on renal function in the dog. Clinical science and molecular medicine. 1976 Mar; 50(3):165-9. doi: 10.1042/cs0500165. [PMID: 3305]