5-Aminoimidazole ribonucleotide (BioDeep_00000005191)

 

Secondary id: BioDeep_00001869063

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


{[(2R,3S,4R,5R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C8H14N3O7P (295.0569344)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.03%

分子结构信息

SMILES: C1=C(N(C=N1)C2C(C(C(O2)COP(=O)(O)O)O)O)N
InChI: InChI=1S/C8H14N3O7P/c9-5-1-10-3-11(5)8-7(13)6(12)4(18-8)2-17-19(14,15)16/h1,3-4,6-8,12-13H,2,9H2,(H2,14,15,16)/t4-,6-,7+,8+/m1/s1

描述信息

5-aminoimidazole ribonucleotide (AIR), is an intermediate of purine nucleotide biosynthesis. It is also the precursor to 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP), the first product of pyrimidine biosynthesis. This reaction is mediated by the enzyme HMP-P kinase (ThiD). HMP is a precursor of thiamine phosphate (TMP), and subsequently to thiamine pyrophosphate (TPP). TPP is an essential cofactor in all living systems that plays a central role in metabolism. (PMID: 15326535). 5-Aminoimidazole ribonucleotide is a substrate for a number of proteins including: Scaffold attachment factor B2, Multifunctional protein ADE2, Pulmonary surfactant-associated protein B, Tumor necrosis factor receptor superfamily member 25, Pulmonary surfactant-associated protein C, Serine/threonine-protein kinase Chk1, Vinexin, Trifunctional purine biosynthetic protein adenosine-3, Antileukoproteinase 1 and Scaffold attachment factor B.
5-aminoimidazole ribonucleotide (AIR), is an intermediate of purine nucleotide biosynthesis. It is also the precursor to 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP), the first product of pyrimidine biosynthesis. This reaction is mediated by the enzyme HMP-P kinase (ThiD). HMP is a precursor of thiamine phosphate (TMP), and subsequently to thiamine pyrophosphate (TPP). TPP is an essential cofactor in all living systems that plays a central role in metabolism. (PMID: 15326535)
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同义名列表

26 个代谢物同义名

{[(2R,3S,4R,5R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid; 5-Amino-1-beta-D-ribofuranosyl-5-(dihydrogen phosphoric acid)-imidazole; 5-Amino-1-β-D-ribofuranosyl-5-(dihydrogen phosphoric acid)-imidazole; 5-Amino-1-b-D-ribofuranosyl-5-(dihydrogen phosphoric acid)-imidazole; 5-Amino-1-beta-D-ribofuranosyl-5-(dihydrogen phosphate)-imidazole; 5-Amino-1-β-D-ribofuranosyl-5-(dihydrogen phosphate)-imidazole; 5-Amino-1-b-D-ribofuranosyl-5-(dihydrogen phosphate)-imidazole; Aminoimidazole ribotide, (alpha-D-ribofuranosyl)-isomer; Aminoimidazole ribotide, (beta-D-ribofuranosyl)-isomer; Aminoimidazole ribotide, phosphonoribofuranosyl-isomer; 5-Amino-1-ribofuranosylimidazole 5-phosphoric acid; 5-Amino-1-(5-phospho-beta-D-ribosyl)imidazole; 5-Amino-1-ribofuranosylimidazole 5-phosphate; 5-Amino-1-(5-phospho-b-D-ribosyl)imidazole; 5-Amino-1-(5-phospho-β-D-ribosyl)imidazole; 1-(5-Phospho-D-ribosyl)-5-aminoimidazole; 5-Amino-1-(5-phospho-D-ribosyl)imidazole; 1-(5-Phosphoribosyl)-5-aminoimidazole; 5-Phosphoribosyl-5-aminoimidazole; 5-Aminoimidazole ribonucleotide; Aminoimidazole ribonucleotide; Phosphoribosylaminoimidazole; 5-Aminoimidazole ribotide; Aminoimidazole ribotide; AIR (nucleotide); AIR



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

63 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(7)

WikiPathways(0)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(53)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Angad P Mehta, Sameh H Abdelwahed, Michael K Fenwick, Amrita B Hazra, Michiko E Taga, Yang Zhang, Steven E Ealick, Tadhg P Begley. Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B₁₂ Biosynthesis. Journal of the American Chemical Society. 2015 Aug; 137(33):10444-7. doi: 10.1021/jacs.5b03576. [PMID: 26237670]
  • M O Farber, J J Szwed, A R Dowell, R A Strawbridge. The acute effects of respiratory and metabolic acidosis on renal function in the dog. Clinical science and molecular medicine. 1976 Mar; 50(3):165-9. doi: 10.1042/cs0500165. [PMID: 3305]