zinc protoporphyrin (BioDeep_00000005124)
代谢物信息卡片
zinc-protoporphyrin IX
化学式: C34H32N4O4Zn (624.1715)
中文名称: 锌原卟啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C(=C3CCC(=O)O)C)CCC(=O)O.[Zn+2]
InChI: /q
描述信息
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:28783
- KEGG: C03184
- PubChem: 3802528
- PubChem: 439935
- Metlin: METLIN65926
- DrugBank: DB03934
- CAS: 15442-64-5
- CAS: 15442-64-5 137090-60
- PubChem: 6063
- CAS: 137090-60-9
- PDB-CCD: ZNH
- KNApSAcK: 28783
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kendell R German, Bryan A Comstock, Pratik Parikh, Dale Whittington, Dennis E Mayock, Patrick J Heagerty, Timothy M Bahr, Sandra E Juul. Do Extremely Low Gestational Age Neonates Regulate Iron Absorption via Hepcidin?.
The Journal of pediatrics.
2022 02; 241(?):62-67.e1. doi:
10.1016/j.jpeds.2021.09.059. [PMID: 34626672] - Hui Yang, Li Zhang, Jie Chen, Xiaoqian Zhang, Zhongfu Zhao, Longfeng Zhao. Heme Oxygenase-1 Inhibits the Proliferation of Hepatic Stellate Cells by Activating PPARγ and Suppressing NF-κB.
Computational and mathematical methods in medicine.
2022; 2022(?):8920861. doi:
10.1155/2022/8920861. [PMID: 35047060] - Meltem Kilercik, Yasemin Ucal, Muhittin Serdar, Mustafa Serteser, Aysel Ozpinar, Florian J Schweigert. Zinc protoporphyrin levels in COVID-19 are indicative of iron deficiency and potential predictor of disease severity.
PloS one.
2022; 17(2):e0262487. doi:
10.1371/journal.pone.0262487. [PMID: 35113876] - Yusmaris Cariaco, Marcos Paulo Oliveira Almeida, Ester Cristina Borges Araujo, Marisol Patricia Pallete Briceño, Andrea Tatiana Durán-Rodriguez, Rodrigo Rodrigues Franco, Foued Salmen Espindola, Neide Maria Silva. Inhibition of Heme Oxygenase-1 by Zinc Protoporphyrin IX Improves Adverse Pregnancy Outcomes in Malaria During Early Gestation.
Frontiers in immunology.
2022; 13(?):879158. doi:
10.3389/fimmu.2022.879158. [PMID: 35619717] - Cheol Park, Hee-Jae Cha, Hyesook Lee, Gi-Young Kim, Yung Hyun Choi. The regulation of the TLR4/NF-κB and Nrf2/HO-1 signaling pathways is involved in the inhibition of lipopolysaccharide-induced inflammation and oxidative reactions by morroniside in RAW 264.7 macrophages.
Archives of biochemistry and biophysics.
2021 07; 706(?):108926. doi:
10.1016/j.abb.2021.108926. [PMID: 34029560] - Navendu Paul, Rudra Sarkar, Sabyasachi Sarkar. Zinc protoporphyrin-trimethylamine-N-oxide complex involves cholesterol oxidation causing atherosclerosis.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2021 05; 26(2-3):367-374. doi:
10.1007/s00775-021-01861-z. [PMID: 33713182] - Jun Pei, Shuyu Cai, Shang Song, Yuangao Xu, Mei Feng, Guangheng Luo, Yuanlin Wang, Fa Sun, Hua Shi, Shuxiong Xu. Normobaric hyperoxia plays a protective role against renal ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway.
Biochemical and biophysical research communications.
2020 10; 532(1):151-158. doi:
10.1016/j.bbrc.2020.07.004. [PMID: 32838965] - Zhaoyuan Zhang, Weili Wang, Dan Ma, Jie Xiong, Xingyi Kuang, Siyu Zhang, Qin Fang, Jishi Wang. Heme oxygenase-1 inhibition mediates Gas6 to enhance bortezomib-sensitivity in multiple myeloma via ERK/STAT3 axis.
Aging.
2020 04; 12(8):6611-6629. doi:
10.18632/aging.102996. [PMID: 32298237] - Dan Chen, Ya-Xian Wu, Yu-Bao Qiu, Bin-Bin Wan, Gang Liu, Jun-Liang Chen, Mu-Dan Lu, Qing-Feng Pang. Hyperoside suppresses hypoxia-induced A549 survival and proliferation through ferrous accumulation via AMPK/HO-1 axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Feb; 67(?):153138. doi:
10.1016/j.phymed.2019.153138. [PMID: 31881478] - Dan Chen, Chen Wu, Yu-Bao Qiu, Qing Chu, Xue-Qian Sun, Xue Wang, Jun-Liang Chen, Mu-Dan Lu, Dao-Zhen Chen, Qing-Feng Pang. Curcumin ameliorates hepatic chronic inflammation induced by bile duct obstruction in mice through the activation of heme oxygenase-1.
International immunopharmacology.
2020 01; 78(?):106054. doi:
10.1016/j.intimp.2019.106054. [PMID: 31812069] - Zbigniew Szlacheta, Marta Wąsik, Anna Machoń-Grecka, Aleksandra Kasperczyk, Michał Dobrakowski, Francesco Bellanti, Patryk Szlacheta, Sławomir Kasperczyk. Potential Antioxidant Activity of Calcium and Selected Oxidative Stress Markers in Lead- and Cadmium-Exposed Workers.
Oxidative medicine and cellular longevity.
2020; 2020(?):8035631. doi:
10.1155/2020/8035631. [PMID: 33082913] - Ruihua Li, Jing Zhang, Yongfeng Zhou, Qi Gao, Rui Wang, Yurong Fu, Lianwen Zheng, Hao Yu. Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells.
Oxidative medicine and cellular longevity.
2020; 2020(?):3469840. doi:
10.1155/2020/3469840. [PMID: 33294119] - Hai-Bo Li, Xi-Zhe Zhang, Yi Sun, Qi Zhou, Jian-Nan Song, Zhan-Fei Hu, Yun Li, Jian-Nan Wu, Ying Guo, Yuan Zhang, Jia Shi, Jian-Bo Yu. HO-1/PINK1 Regulated Mitochondrial Fusion/Fission to Inhibit Pyroptosis and Attenuate Septic Acute Kidney Injury.
BioMed research international.
2020; 2020(?):2148706. doi:
10.1155/2020/2148706. [PMID: 33145342] - Xin Hu, Yuanyuan Liang, Bo Zhao, Yongyi Wang. Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt/HO-1 pathway.
Journal of pharmacological sciences.
2019 Mar; 139(3):166-173. doi:
10.1016/j.jphs.2019.01.003. [PMID: 30709701] - Christian Homann, Georg Hennig, Felicitas Maier, Herbert Stepp, Lesca M Holdt, Michael Vogeser, Ronald Sroka, Berthold Koletzko. Non-invasive measurement of erythrocyte zinc protoporphyrin in children.
Pediatric research.
2019 02; 85(3):349-354. doi:
10.1038/s41390-018-0247-x. [PMID: 30655607] - Adriane Ribeiro Duarte, Aline Lukasievicz Chenet, Fhelipe Jolner Souza de Almeida, Cláudia Marlise Balbinotti Andrade, Marcos Roberto de Oliveira. The inhibition of heme oxigenase-1 (HO-1) abolishes the mitochondrial protection induced by sesamol in LPS-treated RAW 264.7 cells.
Chemico-biological interactions.
2018 Dec; 296(?):171-178. doi:
10.1016/j.cbi.2018.09.012. [PMID: 30261164] - Vafa Baradaran Rahimi, Vahid Reza Askari, Seyed Hadi Mousavi. Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):1712-1724. doi:
10.1016/j.biopha.2018.10.024. [PMID: 30372874] - Samah A Ata, Kamal I Abu-Dari, Maha F Tutunji, Mohammad S Mubarak. Reversing the adverse biochemical effects in lead-intoxicated rats by N,N`- bis[(1,2-didehydro-1-hydroxy-2-thioxopyrid-4-yl)-carbonyl]- L-lysine.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2018 Dec; 50(?):93-99. doi:
10.1016/j.jtemb.2018.06.008. [PMID: 30262322] - Jie Ma, K N Yu, Cheng Cheng, Guohua Ni, Jie Shen, Wei Han. Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells.
Archives of biochemistry and biophysics.
2018 11; 658(?):54-65. doi:
10.1016/j.abb.2018.09.015. [PMID: 30248308] - James H Campbell, John J Heikkila. Effect of hemin, baicalein and heme oxygenase-1 (HO-1) enzyme activity inhibitors on Cd-induced accumulation of HO-1, HSPs and aggresome-like structures in Xenopus kidney epithelial cells.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2018 Aug; 210(?):1-17. doi:
10.1016/j.cbpc.2018.04.003. [PMID: 29698685] - Zhen Zhou, Shuang Ma, Jie Liu, Qiao-Rong Ji, Cheng-Zhu Cao, Xiao-Na Li, Feng Tang, Wei Zhang. [Protective effects of endogenous carbon monoxide against myocardial ischemia-reperfusion injury in rats].
Sheng li xue bao : [Acta physiologica Sinica].
2018 Apr; 70(2):115-122. doi:
. [PMID: 29691575] - Marwa A M Ali, Gehan H Heeba, Azza A K El-Sheikh. Modulation of heme oxygenase-1 expression and activity affects streptozotocin-induced diabetic nephropathy in rats.
Fundamental & clinical pharmacology.
2017 Oct; 31(5):546-557. doi:
10.1111/fcp.12296. [PMID: 28543864] - Sheila Moreira Alves, Susana Capistrano Abreu, Jonas Cavalcante Lemos, Francisco Isaac Fernandes Gomes, Shirley Moreira Alves, Danielle Rocha do Val, Raul Sousa Freitas, Karuza Maria Alves Pereira, Vicente de Paulo Teixeira Pinto, Gerly Anne de Castro Brito, Mirna Marques Bezerra, Gerardo Cristino-Filho, Hellíada Vasconcelos Chaves. Anti-inflammatory and anti-nociceptive effects of strontium ranelate on the zymosan-induced temporomandibular joint inflammatory hypernociception in rats depend on TNF-α inhibition.
Pharmacological reports : PR.
2017 Aug; 69(4):764-772. doi:
10.1016/j.pharep.2017.03.007. [PMID: 28587937] - Michał Dobrakowski, Marta Boroń, Sławomir Kasperczyk, Agnieszka Kozłowska, Aleksandra Kasperczyk, Anna Płachetka, Natalia Pawlas. The analysis of blood lead levels changeability over the 5-year observation in workers occupationally exposed to lead.
Toxicology and industrial health.
2017 Jun; 33(6):469-477. doi:
10.1177/0748233716674380. [PMID: 27807287] - Christine Cruz-Oliveira, Andreza F Almeida, João M Freire, Marjolly B Caruso, Maria A Morando, Vivian N S Ferreira, Iranaia Assunção-Miranda, Andre M O Gomes, Miguel A R B Castanho, Andrea T Da Poian. Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX.
Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.00053-17. [PMID: 28348154] - Marjolijn D Akkermans, Mirjam Vreugdenhil, Daniëlle M Hendriks, Anemone van den Berg, Joachim J Schweizer, Johannes B van Goudoever, Frank Brus. Iron Deficiency in Inflammatory Bowel Disease: The Use of Zincprotoporphyrin and Red Blood Cell Distribution Width.
Journal of pediatric gastroenterology and nutrition.
2017 06; 64(6):949-954. doi:
10.1097/mpg.0000000000001406. [PMID: 27622900] - I Thuret. [Biological diagnosis of iron deficiency in children].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2017 May; 24(5S):5S6-5S13. doi:
10.1016/s0929-693x(17)24003-2. [PMID: 28622783] - Seth Adu-Afarwuah, Anna Lartey, Harriet Okronipa, Per Ashorn, Mamane Zeilani, Lacey M Baldiviez, Brietta M Oaks, Stephen Vosti, Kathryn G Dewey. Impact of small-quantity lipid-based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women.
Maternal & child nutrition.
2017 04; 13(2):. doi:
10.1111/mcn.12262. [PMID: 26924599] - Kyoji Morita, Naoyoshi Nishibori, Reina Kishibuchi, Mari Itoh, Yukiko Horie, Hideyuki Nemoto. Fermented Brown Rice Extract Stimulates BDNF Gene Transcription in C6 Glioma Cells: Possible Connection with HO-1 Expression.
Journal of dietary supplements.
2017 Mar; 14(2):214-228. doi:
10.1080/19390211.2016.1207743. [PMID: 27560964] - Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang. Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects.
International journal of molecular medicine.
2017 Jan; 39(1):113-125. doi:
10.3892/ijmm.2016.2809. [PMID: 27878246] - Marta Jurdziak, Paweł Gać, Rafał Poręba, Marzena Gonerska, Anna Jonkisz, Małgorzata Gromek, Małgorzata Poręba, Anna Szymańska-Chabowska, Grzegorz Mazur, Małgorzata Sobieszczańska. Genetic variability in the system of natriuretic B peptide and principal toxicological parameters in workers exposed to lead.
Environmental toxicology and pharmacology.
2017 Jan; 49(?):74-80. doi:
10.1016/j.etap.2016.11.012. [PMID: 27918957] - R Abo El Gheit, M N Emam. Targeting heme oxygenase-1 in early diabetic nephropathy in streptozotocin-induced diabetic rats.
Physiology international.
2016 Dec; 103(4):413-427. doi:
10.1556/2060.103.2016.4.001. [PMID: 28229631] - Jianbo Yu, Ying Wang, Zhen Li, Shuan Dong, Dan Wang, Lirong Gong, Jia Shi, Yuan Zhang, Daquan Liu, Rui Mu. Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats.
Scientific reports.
2016 11; 6(?):36530. doi:
10.1038/srep36530. [PMID: 27830717] - Raul Sousa Freitas, Danielle Rocha do Val, Maria Ester Frota Fernandes, Francisco Isaac Fernandes Gomes, José Thalles Jocelino Gomes de Lacerda, Tatiane SantiGadelha, Carlos Alberto de Almeida Gadelha, Vicente de Paulo Teixeira Pinto, Gerardo Cristino-Filho, Karuza Maria Alves Pereira, Gerly Anne de Castro Brito, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves. Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-α and il-1β suppression.
International immunopharmacology.
2016 Sep; 38(?):313-23. doi:
10.1016/j.intimp.2016.06.012. [PMID: 27344040] - Sarah E Cusick, Robert O Opoka, Steven A Abrams, Chandy C John, Michael K Georgieff, Ezekiel Mupere. Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial.
The Journal of nutrition.
2016 09; 146(9):1769-74. doi:
10.3945/jn.116.233239. [PMID: 27358418] - Tianxin Hu, Guo Wei, Miaomiao Xi, Jiajia Yan, Xiaoxiao Wu, Yanhua Wang, Yanrong Zhu, Chao Wang, Aidong Wen. Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway.
International journal of molecular medicine.
2016 Jul; 38(1):83-94. doi:
10.3892/ijmm.2016.2584. [PMID: 27176815] - Ajibola I Abioye, Said Aboud, Zulfiqar Premji, Analee J Etheredge, Nilupa S Gunaratna, Christopher R Sudfeld, Robert Mongi, Laura Meloney, Anne Marie Darling, Ramadhani A Noor, Donna Spiegelman, Christopher Duggan, Wafaie Fawzi. Iron Supplementation Affects Hematologic Biomarker Concentrations and Pregnancy Outcomes among Iron-Deficient Tanzanian Women.
The Journal of nutrition.
2016 06; 146(6):1162-71. doi:
10.3945/jn.115.225482. [PMID: 27121530] - Sheng-Hua Wu, Xiao-Qing Chen, Jing Lü, Ming-Jie Wang. BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1.
Inflammation.
2016 Apr; 39(2):611-24. doi:
10.1007/s10753-015-0286-y. [PMID: 26597893] - V Kürten, N J Neumann, J Frank. [Diagnosis of the porphyrias : From A (as in aminolevulinic acid) to Z (as in zinc protoporphyrin)].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.
2016 Mar; 67(3):201-6. doi:
10.1007/s00105-015-3741-7. [PMID: 26743052] - Kazumichi Fujioka, Flora Kalish, Ronald J Wong, David K Stevenson. Inhibition of heme oxygenase activity using a microparticle formulation of zinc protoporphyrin in an acute hemolytic newborn mouse model.
Pediatric research.
2016 Feb; 79(2):251-7. doi:
10.1038/pr.2015.207. [PMID: 26488552] - Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A Jose, Xi Lu, Chunyu Zeng. Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
PloS one.
2016; 11(2):e0149032. doi:
10.1371/journal.pone.0149032. [PMID: 26866373] - Eric W Gou, Manisha Balwani, D Montgomery Bissell, Joseph R Bloomer, Herbert L Bonkovsky, Robert J Desnick, Hetanshi Naik, John D Phillips, Ashwani K Singal, Bruce Wang, Sioban Keel, Karl E Anderson. Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias.
Clinical chemistry.
2015 Dec; 61(12):1453-6. doi:
10.1373/clinchem.2015.245456. [PMID: 26482161] - Fengji Geng, Xiaoqin Mai, Jianying Zhan, Lin Xu, Zhengyan Zhao, Michael Georgieff, Jie Shao, Betsy Lozoff. Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age.
The Journal of pediatrics.
2015 Dec; 167(6):1226-32. doi:
10.1016/j.jpeds.2015.08.035. [PMID: 26382625] - Sławomir Kasperczyk, Ludmiła Słowińska-Łożyńska, Aleksandra Kasperczyk, Tomasz Wielkoszyński, Ewa Birkner. The effect of occupational lead exposure on lipid peroxidation, protein carbonylation, and plasma viscosity.
Toxicology and industrial health.
2015 Dec; 31(12):1165-71. doi:
10.1177/0748233713491804. [PMID: 23709227] - Aleksandra Kasperczyk, Michal Dobrakowski, Alina Ostałowska, Jolanta Zalejska-Fiolka, Ewa Birkner. The metabolism of carbohydrates and lipid peroxidation in lead-exposed workers.
Toxicology and industrial health.
2015 Dec; 31(12):1318-24. doi:
10.1177/0748233713483204. [PMID: 23833244] - Lu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao. Inflammation and Edema in the Lung and Kidney of Hemorrhagic Shock Rats Are Alleviated by Biliary Tract External Drainage via the Heme Oxygenase-1 Pathway.
Inflammation.
2015 Dec; 38(6):2242-51. doi:
10.1007/s10753-015-0208-z. [PMID: 26253294] - Ryo Kinoshita, Yu Ishima, Mayumi Ikeda, Ulrich Kragh-Hansen, Jun Fang, Hideaki Nakamura, Victor T G Chuang, Ryota Tanaka, Hitoshi Maeda, Azusa Kodama, Hiroshi Watanabe, Hiroshi Maeda, Masaki Otagiri, Toru Maruyama. S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes.
Journal of controlled release : official journal of the Controlled Release Society.
2015 Nov; 217(?):1-9. doi:
10.1016/j.jconrel.2015.08.036. [PMID: 26302904] - Min-Young Kwon, Eunhee Park, Seon-Jin Lee, Su Wol Chung. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.
Oncotarget.
2015 Sep; 6(27):24393-403. doi:
10.18632/oncotarget.5162. [PMID: 26405158] - Anna Szymańska-Chabowska, Łukasz Łaczmański, Iwona Jędrychowska, Mariusz Chabowski, Paweł Gać, Agnieszka Janus, Katarzyna Gosławska, Beata Smyk, Urszula Solska, Grzegorz Mazur, Rafał Poręba. The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead.
Toxicology.
2015 Aug; 334(?):12-21. doi:
10.1016/j.tox.2015.05.002. [PMID: 25963508] - Genhuan Yang, Yanchuan Li, Wei Wu, Bao Liu, Leng Ni, Zhanqi Wang, Shiying Miao, Linfang Wang, Changwei Liu. Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury.
Molecular medicine reports.
2015 Aug; 12(2):2481-6. doi:
10.3892/mmr.2015.3722. [PMID: 25955183] - Yuan Li, Keliang Xie, Hongguang Chen, Guolin Wang, Yonghao Yu. Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1.
The Journal of surgical research.
2015 Jun; 196(1):136-48. doi:
10.1016/j.jss.2015.02.042. [PMID: 25818978] - Hong Yang, Hengdong Zhang, Qianqian Zhou, Wei Gong, Baoli Zhu, Wenchao Li, Yang Zhou. [Study on relationships between biomarkers in workers with low-level occupational lead exposure].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2015 Jun; 33(6):403-8. doi:
. [PMID: 26653370] - Hayley Mylroie, Odile Dumont, Andrea Bauer, Clare C Thornton, John Mackey, Damien Calay, Shahir S Hamdulay, Joan R Choo, Joseph J Boyle, Allen M Samarel, Anna M Randi, Paul C Evans, Justin C Mason. PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis.
Cardiovascular research.
2015 Jun; 106(3):509-19. doi:
10.1093/cvr/cvv131. [PMID: 25883219] - Jun-ichi Wakamatsu, Naoko Murakami, Takanori Nishimura. A comparative study of zinc protoporphyrin IX-forming properties of animal by-products as sources for improving the color of meat products.
Animal science journal = Nihon chikusan Gakkaiho.
2015 May; 86(5):547-52. doi:
10.1111/asj.12326. [PMID: 25441257] - Han-Fei Huang, Zhong Zeng, Kun-Hua Wang, Hai-Yan Zhang, Shuai Wang, Wen-Xiang Zhou, Zhan-Bo Wang, Wang-Gang Xu, Jian Duan. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways.
World journal of gastroenterology.
2015 Mar; 21(10):2937-48. doi:
10.3748/wjg.v21.i10.2937. [PMID: 25780291] - Jiale Li, Dan Zhu, Ren Wang, Wenbiao Shen, Yingying Guo, Yong Ren, Wei Shen, Liqin Huang. β-Cyclodextrin-hemin complex-induced lateral root formation in tomato: involvement of nitric oxide and heme oxygenase 1.
Plant cell reports.
2015 Mar; 34(3):381-93. doi:
10.1007/s00299-014-1716-2. [PMID: 25433859] - Weiti Cui, Fang Qi, Yihua Zhang, Hong Cao, Jing Zhang, Ren Wang, Wenbiao Shen. Methane-rich water induces cucumber adventitious rooting through heme oxygenase1/carbon monoxide and Ca(2+) pathways.
Plant cell reports.
2015 Mar; 34(3):435-45. doi:
10.1007/s00299-014-1723-3. [PMID: 25503851] - Huifang Cao, Ying Feng, Yunye Ning, Zinan Zhang, Weihao Li, Qiang Li. Edaravone protects rats and human pulmonary alveolar epithelial cells against hyperoxia injury: heme oxygenase-1 and PI3K/Akt pathway may be involved.
Experimental lung research.
2015; 41(7):404-14. doi:
10.3109/01902148.2015.1054053. [PMID: 26151294] - Li-juan Wang, Yan Zhang, Chun-yang Zhang. A target-triggered exponential amplification-based DNAzyme biosensor for ultrasensitive detection of folate receptors.
Chemical communications (Cambridge, England).
2014 Dec; 50(97):15393-6. doi:
10.1039/c4cc07230h. [PMID: 25350483] - Martin N Mwangi, Sumi Maskey, Pauline E A Andang o, Noel K Shinali, Johanna M Roth, Laura Trijsburg, Alice M Mwangi, Han Zuilhof, Barend van Lagen, Huub Fj Savelkoul, Ayşe Y Demir, Hans Verhoef. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women.
BMC medicine.
2014 Nov; 12(?):229. doi:
10.1186/s12916-014-0229-8. [PMID: 25428714] - Bing Zhao, Jian Fei, Ying Chen, Yi-Lin Ying, Li Ma, Xiao-Qin Song, Jie Huang, Er-Zhen Chen, En-Qiang Mao. Vitamin C treatment attenuates hemorrhagic shock related multi-organ injuries through the induction of heme oxygenase-1.
BMC complementary and alternative medicine.
2014 Nov; 14(?):442. doi:
10.1186/1472-6882-14-442. [PMID: 25387896] - D R do Val, M M Bezerra, A A R Silva, K M A Pereira, L C Rios, J C Lemos, N C Arriaga, J N Vasconcelos, N M B Benevides, V P T Pinto, G Cristino-Filho, G A C Brito, F R L Silva, G M P Santiago, A M C Arriaga, H V Chaves. Tephrosia toxicaria Pers. reduces temporomandibular joint inflammatory hypernociception: the involvement of the HO-1 pathway.
European journal of pain (London, England).
2014 Oct; 18(9):1280-9. doi:
10.1002/j.1532-2149.2014.488.x. [PMID: 24715714] - Fredric M Pieracci, Robert T Stovall, Brant Jaouen, Maria Rodil, Anthony Cappa, Clay Cothren Burlew, Daniel N Holena, Ronald Maier, Stepheny Berry, Jerry Jurkovich, Ernest E Moore. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness*.
Critical care medicine.
2014 Sep; 42(9):2048-57. doi:
10.1097/ccm.0000000000000408. [PMID: 24797376] - A K Phillips, S C Roy, R Lundberg, T W Guilbert, A P Auger, S E Blohowiak, C L Coe, P J Kling. Neonatal iron status is impaired by maternal obesity and excessive weight gain during pregnancy.
Journal of perinatology : official journal of the California Perinatal Association.
2014 Jul; 34(7):513-8. doi:
10.1038/jp.2014.42. [PMID: 24651737] - Shiliu Tian, Xinfa Ge, Ke Wu, Huabing Yang, Yu Liu. Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation.
The Journal of pharmacology and experimental therapeutics.
2014 Jul; 350(1):5-13. doi:
10.1124/jpet.114.212928. [PMID: 24741076] - Dan Ma, Qin Fang, Yan Li, Jishi Wang, Jia Sun, Yaming Zhang, Xiuying Hu, Ping Wang, Shengshu Zhou. Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid.
Anti-cancer drugs.
2014 Apr; 25(4):406-14. doi:
10.1097/cad.0000000000000068. [PMID: 24413389] - H Wan, J Wu, P Sun, Yuelin Yang. Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China.
Acta physiologica Hungarica.
2014 Mar; 101(1):59-66. doi:
10.1556/aphysiol.101.2014.1.7. [PMID: 24631795] - Jia Xu, Kexin Meng, Rui Zhang, He Yang, Chang Liao, Wenliang Zhu, Jundong Jiao. The use of functional chemical-protein associations to identify multi-pathway renoprotectants.
PloS one.
2014; 9(5):e97906. doi:
10.1371/journal.pone.0097906. [PMID: 24830678] - M Petracca, F Scafa, R Boeri, Daniela Flachi, S M Candura. Imported occupational lead poisoning: report of four cases.
La Medicina del lavoro.
2013 Nov; 104(6):428-33. doi:
. [PMID: 24640829] - Yan-feng Wang, Yan-ting Gu, Guang-hua Qin, Lei Zhong, Ying-nan Meng. Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells.
Journal of molecular neuroscience : MN.
2013 Oct; 51(2):344-51. doi:
10.1007/s12031-013-9989-4. [PMID: 23494637] - Kazuma Takahashi, Takashi Kondo, Yasunaga Yoshikawa, Kiyotaka Watanabe, Koichi Orino. The presence of heat-labile factors interfering with binding analysis of fibrinogen with ferritin in horse plasma.
Acta veterinaria Scandinavica.
2013 Sep; 55(?):70. doi:
10.1186/1751-0147-55-70. [PMID: 24053588] - S M Miller. Iron supplementation in premature infants using the zinc protoporphyrin to heme ratio: short- and long-term outcomes.
Journal of perinatology : official journal of the California Perinatal Association.
2013 Sep; 33(9):712-6. doi:
10.1038/jp.2013.40. [PMID: 23599120] - Yun Yen Hsu, Yun-Yang Chao, Ching Huei Kao. Cobalt chloride-induced lateral root formation in rice: the role of heme oxygenase.
Journal of plant physiology.
2013 Aug; 170(12):1075-81. doi:
10.1016/j.jplph.2013.03.004. [PMID: 23566873] - Liting Tian, Guang Zheng, Johan Nilsson Sommar, Yihuai Liang, Tomas Lundh, Karin Broberg, Lijian Lei, Weijun Guo, Yulan Li, Mingguang Tan, Staffan Skerfving, Taiyi Jin, Ingvar A Bergdahl. Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by δ-aminolevulinic acid dehydratase gene polymorphism.
Toxicology letters.
2013 Aug; 221(2):102-9. doi:
10.1016/j.toxlet.2013.06.214. [PMID: 23792432] - J I Manzano, R García-Hernández, S Castanys, F Gamarro. A new ABC half-transporter in Leishmania major is involved in resistance to antimony.
Antimicrobial agents and chemotherapy.
2013 Aug; 57(8):3719-30. doi:
10.1128/aac.00211-13. [PMID: 23716044] - Kai Kang, Chuanchuan Nan, Dongsheng Fei, Xianglin Meng, Wen Liu, Weiwei Zhang, Lei Jiang, Mingran Zhao, Shangha Pan, Mingyan Zhao. Heme oxygenase 1 modulates thrombomodulin and endothelial protein C receptor levels to attenuate septic kidney injury.
Shock (Augusta, Ga.).
2013 Aug; 40(2):136-43. doi:
10.1097/shk.0b013e31829d23f5. [PMID: 23807243] - I Pérez-de-Puig, A Martín, R Gorina, X de la Rosa, E Martinez, A M Planas. Induction of hemeoxygenase-1 expression after inhibition of hemeoxygenase activity promotes inflammation and worsens ischemic brain damage in mice.
Neuroscience.
2013 Jul; 243(?):22-32. doi:
10.1016/j.neuroscience.2013.03.046. [PMID: 23562577] - Ashraf Taye, Badr Mostafa Ibrahim. Activation of renal haeme oxygenase-1 alleviates gentamicin-induced acute nephrotoxicity in rats.
The Journal of pharmacy and pharmacology.
2013 Jul; 65(7):995-1004. doi:
10.1111/jphp.12067. [PMID: 23738727] - Qiu-Ming Wang, Jian-Ling Du, Zhi-Jun Duan, Shi-Bin Guo, Xiao-Yu Sun, Zhen Liu. Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation.
World journal of gastroenterology.
2013 May; 19(19):2921-34. doi:
10.3748/wjg.v19.i19.2921. [PMID: 23704825] - Juhyun Park, Jung-Woo Kang, Sun-Mee Lee. Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia/reperfusion injury via heme oxygenase-1 induction.
European journal of pharmacology.
2013 May; 707(1-3):61-70. doi:
10.1016/j.ejphar.2013.03.026. [PMID: 23535606] - Alex Brito, Eva Hertrampf, Manuel Olivares. Iron status biomarkers and C-reactive protein in children aged 19 to 72 months in Chile.
Food and nutrition bulletin.
2013 Mar; 34(1):14-20. doi:
10.1177/156482651303400103. [PMID: 23767277] - Hideaki Nakamura, Long Liao, Yuki Hitaka, Kenji Tsukigawa, Vladimir Subr, Jun Fang, Karel Ulbrich, Hiroshi Maeda. Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo.
Journal of controlled release : official journal of the Controlled Release Society.
2013 Feb; 165(3):191-8. doi:
10.1016/j.jconrel.2012.11.017. [PMID: 23220104] - Mingzhu Wu, Fangquan Wang, Chen Zhang, Yanjie Xie, Bin Han, Jingjing Huang, Wenbiao Shen. Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.
Plant molecular biology.
2013 Jan; 81(1-2):27-40. doi:
10.1007/s11103-012-9979-x. [PMID: 23090695] - J Baumgartner, C M Smuts, I Aeberli, L Malan, H Tjalsma, M B Zimmermann. Overweight impairs efficacy of iron supplementation in iron-deficient South African children: a randomized controlled intervention.
International journal of obesity (2005).
2013 Jan; 37(1):24-30. doi:
10.1038/ijo.2012.145. [PMID: 22945607] - Yun Yen Hsu, Yun-Yang Chao, Ching Huei Kao. Methyl jasmonate-induced lateral root formation in rice: the role of heme oxygenase and calcium.
Journal of plant physiology.
2013 Jan; 170(1):63-9. doi:
10.1016/j.jplph.2012.08.015. [PMID: 22989945] - Sumithra Muthayya, Prashanth Thankachan, Siddhivinayak Hirve, Vani Amalrajan, Tinku Thomas, Himangi Lubree, Dhiraj Agarwal, Krishnamachari Srinivasan, Richard F Hurrell, Chittaranjan S Yajnik, Anura V Kurpad. Iron fortification of whole wheat flour reduces iron deficiency and iron deficiency anemia and increases body iron stores in Indian school-aged children.
The Journal of nutrition.
2012 Nov; 142(11):1997-2003. doi:
10.3945/jn.111.155135. [PMID: 23014487] - Cassiane Dezoti Fonseca, Mirian Watanabe, Maria de Fátima Fernandes Vattimo. Role of heme oxygenase-1 in polymyxin B-induced nephrotoxicity in rats.
Antimicrobial agents and chemotherapy.
2012 Oct; 56(10):5082-7. doi:
10.1128/aac.00925-12. [PMID: 22802257] - Rafał Poręba, Paweł Gać, Małgorzata Poręba, Ryszard Andrzejak. Assessment of cardiovascular risk in workers occupationally exposed to lead without clinical presentation of cardiac involvement.
Environmental toxicology and pharmacology.
2012 Sep; 34(2):351-357. doi:
10.1016/j.etap.2012.05.008. [PMID: 22717663] - Ibrahim Ibrahim, Salah El-Sayed, Selim Abdel-Hakim, Magdy Hassan, Neven Aziz. Inhibition of endogenous CO by ZnPP protects against stress-induced gastric lesion in adult male albino rats.
Journal of physiology and biochemistry.
2012 Sep; 68(3):319-28. doi:
10.1007/s13105-011-0143-x. [PMID: 22247033] - Weiti Cui, Le Li, Zhaozhou Gao, Honghong Wu, Yanjie Xie, Wenbiao Shen. Haem oxygenase-1 is involved in salicylic acid-induced alleviation of oxidative stress due to cadmium stress in Medicago sativa.
Journal of experimental botany.
2012 Sep; 63(15):5521-34. doi:
10.1093/jxb/ers201. [PMID: 22915740] - Yuting Lin, Meiyue Li, Liqin Huang, Wenbiao Shen, Yong Ren. Involvement of heme oxygenase-1 in β-cyclodextrin-hemin complex-induced cucumber adventitious rooting process.
Plant cell reports.
2012 Sep; 31(9):1563-72. doi:
10.1007/s00299-012-1270-8. [PMID: 22532008] - Bruce S Gillis, Zarema Arbieva, Igor M Gavin. Analysis of lead toxicity in human cells.
BMC genomics.
2012 Jul; 13(?):344. doi:
10.1186/1471-2164-13-344. [PMID: 22839698] - Yun Yen Hsu, Yun-Yang Chao, Ching Huei Kao. Biliverdin-promoted lateral root formation is mediated through heme oxygenase in rice.
Plant signaling & behavior.
2012 Jul; 7(7):885-7. doi:
10.4161/psb.20458. [PMID: 22751314] - Yi-Hsuan Chen, Yun-Yang Chao, Yun Yen Hsu, Chwan-Yang Hong, Ching Huei Kao. Heme oxygenase is involved in nitric oxide- and auxin-induced lateral root formation in rice.
Plant cell reports.
2012 Jun; 31(6):1085-91. doi:
10.1007/s00299-012-1228-x. [PMID: 22262313] - Dongsheng Fei, Xianglin Meng, Kai Kang, Chuanchuan Nan, Mingran Zhao, Shangha Pan, Meizhuo Gao, Songlin Yang, Mingyan Zhao. Heme oxygenase-1 modulates thrombomodulin and activated protein C levels to attenuate lung injury in cecal ligation and puncture-induced acute lung injury mice.
Experimental lung research.
2012 May; 38(4):173-82. doi:
10.3109/01902148.2012.660559. [PMID: 22417130] - H-J Park, B T Jeon, H C Kim, G S Roh, J-H Shin, N-J Sung, J Han, D Kang. Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through haeme oxygenase-1 induction.
Acta physiologica (Oxford, England).
2012 May; 205(1):61-70. doi:
10.1111/j.1748-1716.2012.02425.x. [PMID: 22353229] - Hui Yang, Long-Feng Zhao, Zhong-Fu Zhao, Yan Wang, Jing-Jing Zhao, Li Zhang. Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPARγ and NF-κB.
World journal of gastroenterology.
2012 Apr; 18(14):1680-8. doi:
10.3748/wjg.v18.i14.1680. [PMID: 22529699] - Bin Han, Sheng Xu, Yan-Jie Xie, Jing-Jing Huang, Li-Juan Wang, Zheng Yang, Chang-He Zhang, Ya Sun, Wen-Biao Shen, Gui-Shui Xie. ZmHO-1, a maize haem oxygenase-1 gene, plays a role in determining lateral root development.
Plant science : an international journal of experimental plant biology.
2012 Mar; 184(?):63-74. doi:
10.1016/j.plantsci.2011.12.012. [PMID: 22284711] - Dongsheng Fei, Xianglin Meng, Mingran Zhao, Kai Kang, Gang Tan, Shangha Pan, Yunpeng Luo, Wen Liu, Chuanchuan Nan, Hongchi Jiang, Geoffrey W Krissansen, Mingyan Zhao, Xueying Sun. Enhanced induction of heme oxygenase-1 suppresses thrombus formation and affects the protein C system in sepsis.
Translational research : the journal of laboratory and clinical medicine.
2012 Feb; 159(2):99-109. doi:
10.1016/j.trsl.2011.10.009. [PMID: 22243794]
