Sanguinarine (BioDeep_00000000499)

 

Secondary id: BioDeep_00000397985, BioDeep_00001867514

human metabolite PANOMIX_OTCML-2023 Endogenous Toxin Volatile Flavor Compounds natural product


代谢物信息卡片


24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21),23-nonaen-24-ium

化学式: [C20H14NO4]+ (332.09227840000005)
中文名称: 血根碱, 假白屈菜季铵碱
谱图信息: 最多检出来源 Viridiplantae(plant) 0.46%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Sanguinarine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/sanguinarine (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000000499). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C[n+1](c1)c(c54)c(ccc(cc(O6)c(OC6)c5)4)c(c2)c(cc(O3)c(OC3)2)1
InChI: InChI=1S/C20H14NO4/c1-21-8-12-5-17-18(24-10-23-17)6-14(12)13-3-2-11-4-16-19(25-9-22-16)7-15(11)20(13)21/h2-8H,9-10H2,1H3/q+1

描述信息

Sanguinarine is a benzophenanthridine alkaloid, an alkaloid antibiotic and a botanical anti-fungal agent.
Sanguinarine is a natural product found in Fumaria capreolata, Fumaria kralikii, and other organisms with data available.
Sanguinarine is found in opium poppy. Consumption of Sanguinarine, present in poppy seeds and in the oil of Argemone mexicana which has been used as an adulterant for mustard oil in India, has been linked to development of glaucoma. Sanguinarine is banned by FDA. Sanguinarine is a quaternary ammonium salt from the group of benzylisoquinoline alkaloids. It is extracted from some plants, including bloodroot (Sanguinaria canadensis), Mexican prickly poppy Argemone mexicana, Chelidonium majus and Macleaya cordata. It is also found in the root, stem and leaves of the opium poppy but not in the capsule. Sanguinarine is a toxin that kills animal cells through its action on the Na+-K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine. Sanguinarine has been shown to exhibit antibiotic, anti-apoptotic, anti-fungal, anti-inflammatory and anti-angiogenic functions Sanguinarine belongs to the family of Benzoquinolines. These are organic compounds containing a benzene fused to a quinoline ring system. (A3208, A3209, A3208, A3208, A3208).
See also: Sanguinaria canadensis root (part of); Chelidonium majus flowering top (part of).
Sanguinarine is found in opium poppy. Consumption of Sanguinarine, present in poppy seeds and in the oil of Argemone mexicana which has been used as an adulterant for mustard oil in India, has been linked to development of glaucoma. Sanguinarine is banned by FDA. Sanguinarine is a quaternary ammonium salt from the group of benzylisoquinoline alkaloids. It is extracted from some plants, including bloodroot (Sanguinaria canadensis), Mexican prickly poppy Argemone mexicana, Chelidonium majus and Macleaya cordata. It is also found in the root, stem and leaves of the opium poppy but not in the capsule.[citation needed]; Sanguinarine is a toxin that kills animal cells through its action on the Na+-K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine

Sanguinarine (13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium) is derived from the root of Sanguinaria canadensis and other poppy-fumaria species (for references, see Ref. 1). This benzophenanthridine alkaloid is a structural homologue of chelerythrine, which is a potent inhibitor of protein kinase C (2). Sanguinarine has been shown to display antitumor (3) and anti-inflammatory properties in animals (4) and to inhibit neutrophil function, including degranulation and phagocytosis in vitro(5). It is also a potent inhibitor of Na-K-dependent ATPase (6, 7, 8) and cholinesterase (9).

同义名列表

65 个代谢物同义名

24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21),23-nonaen-24-ium; 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14,16,21,23-nonaen-24-ium; 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.0^{2,10.0^{4,8.0^{14,22.0^{17,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene; 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0²,¹⁰.0⁴,⁸.0¹⁴,²².0¹⁷,²¹]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaen-24-ium; 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene; 13-methyl-2H,10H-(1,3)dioxolo(4,5-i)(1,3)dioxolo(4,5:4,5)benzo(1,2-c)phenanthridinium; 13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4,5:4,5]benzo[1,2-c]phenanthridinium; 13-Methyl-[1,3]dioxolo[4,5:4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium; 13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium(1+), 9CI; 13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium nitrate; (1,3)-Benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-; 13-Methyl[1,3]benzodioxolo[5,6-C][1,3]dioxolo[4,5-I]phenanthridin-13-Ium; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-; (1,3)BENZODIOXOLO(5,6-C)-1,3-DIOXOLO(4,5-I)PHENANTHRIDINIUM, 13-METHYL-; 13-methyl(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium; 13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium; 5-Methyl-2,3:7,8-bis(methylenedioxy)benzo[c]phenanthridinium(1+); Dimethylenedioxy benzphenanthridine; Pseudochelerythrine;Sanguinarin; Benzophenanthridine alkaloid; INVGWHRKADIJHF-UHFFFAOYSA-N; compound 1 [PMID: 28621943]; sanguinarine sulfate (2:1); sanguinarine sulfate (1:1); sanguinarine hydroxide; sanguinarium-chloride; SANGUINARINE [WHO-DD]; sanguinarine chloride; sanguinarine nitrate; pseudo-chelerythrine; pseudochelerythrine; Prestwick1_000987; Prestwick3_000987; Prestwick0_000987; Prestwick2_000987; SANGUINARINE [MI]; Spectrum2_000724; Spectrum3_001148; Spectrum4_001838; Spectrum5_000635; |x-Chelerythrine; y-Chelerythrine; UNII-AV9VK043SS; Tox21_110268_1; BPBio1_001159; Lopac0_001108; DivK1c_000495; sanguinarine; Sanguinarium; KBio2_005875; Tox21_110268; sanguiritrin; KBio1_000495; KBio2_003307; KBio2_000739; KBio3_002175; sanguinarin; IDI1_000495; sangvinarin; AV9VK043SS; Sangrovit; Viadent; Veadent; UI5; Sanguinarine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

27 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(25)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

221 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Weixiao Lei, Hui Zhu, Man Cao, Feng Zhang, Qing Lai, Shengming Lu, Wenpan Dong, Jiahui Sun, Dafu Ru. From genomics to metabolomics: Deciphering sanguinarine biosynthesis in Dicranostigma leptopodum. International journal of biological macromolecules. 2024 Feb; 257(Pt 2):128727. doi: 10.1016/j.ijbiomac.2023.128727. [PMID: 38092109]
  • Jian-Sheng Dai, Jian Xu, Hao-Jie Shen, Ni-Pi Chen, Bing-Qi Zhu, Zheng-Jie Xue, Hao-Han Chen, Zhi-Shan Ding, Rui Ding, Chao-Dong Qian. The induced and intrinsic resistance of Escherichia coli to sanguinarine is mediated by AcrB efflux pump. Microbiology spectrum. 2024 Jan; 12(1):e0323723. doi: 10.1128/spectrum.03237-23. [PMID: 38038452]
  • Jing-Ying Fan, Jie Liu, Wen-Qing Zhang, Ting Lin, Xi-Ran Hu, Fang-Liang Zhou, Le Tang, Ying-Chun He, Hong-Jian Shi. Anti-Nasopharyngeal carcinoma mechanism of sanguinarine based on network pharmacology and molecular docking. Medicine. 2023 Dec; 102(48):e36477. doi: 10.1097/md.0000000000036477. [PMID: 38050231]
  • Mengting Liu, Zhiqin Liu, Zhuang Dong, Xianglin Zou, Jianguo Zeng, Zihui Yang. Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS. Molecules (Basel, Switzerland). 2023 Nov; 28(22):. doi: 10.3390/molecules28227641. [PMID: 38005364]
  • Xue Li, Li Zhang, Zilin Zhong, Sujie Sun, Jie Wu, Fasheng Liu, Zigang Cao, Huiqiang Lu, Xinjun Liao, Bing Zhou, Jianjun Chen. Sanguinarine exposure induces immunotoxicity and abnormal locomotor behavior in zebrafish. Fish & shellfish immunology. 2023 Jun; 139(?):108898. doi: 10.1016/j.fsi.2023.108898. [PMID: 37301310]
  • Zhijie Zheng, Yonghui Zheng, Xiaoben Liang, Guanhong Xue, Haichong Wu. Sanguinarine Enhances the Integrity of the Blood-Milk Barrier and Inhibits Oxidative Stress in Lipopolysaccharide-Stimulated Mastitis. Cells. 2022 11; 11(22):. doi: 10.3390/cells11223658. [PMID: 36429086]
  • Xueliang Yang, Lei Li, Yuxin Shi, Xue Wang, Yun Zhang, Meng Jin, Xiqiang Chen, Rongchun Wang, Kechun Liu. Neurotoxicity of sanguinarine via inhibiting mitophagy and activating apoptosis in zebrafish and PC12 cells. Pesticide biochemistry and physiology. 2022 Nov; 188(?):105259. doi: 10.1016/j.pestbp.2022.105259. [PMID: 36464364]
  • Yang Mengzhe, Zhang Beibei, Liang Zhenqiang, Cheng Nannan, Lü Anqiao, Yang Jianyu, Guo Xingzhe, Bai Xianyu, Huang Yuanjiao, Jiao Aijun, X U Ning. Sanguinarine suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma inhibiting mTOR signaling. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 10; 42(5):687-692. doi: 10.19852/j.cnki.jtcm.20220426.001. [PMID: 36083474]
  • Qiang Lu, Zhenshan Zhang, Yifei Xu, Yujia Chen, Cailan Li. Sanguinarine, a major alkaloid from Zanthoxylum nitidum (Roxb.) DC., inhibits urease of Helicobacter pylori and jack bean: Susceptibility and mechanism. Journal of ethnopharmacology. 2022 Sep; 295(?):115388. doi: 10.1016/j.jep.2022.115388. [PMID: 35577159]
  • Bei Li, Yingbin Luo, Yixi Zhou, Jianchun Wu, Zhihong Fang, Yan Li. Role of sanguinarine in regulating immunosuppression in a Lewis lung cancer mouse model. International immunopharmacology. 2022 Sep; 110(?):108964. doi: 10.1016/j.intimp.2022.108964. [PMID: 35728305]
  • Asmat Ullah, Najeeb Ullah, Touseef Nawaz, Tariq Aziz. Molecular mechanisms of Sanguinarine in cancer prevention and treatment. Anti-cancer agents in medicinal chemistry. 2022 Aug; ?(?):. doi: 10.2174/1871520622666220831124321. [PMID: 36045531]
  • Yong Shi, Lei Zhong, Kaijian Chen, Yuding Fan, Kai Xie, Junzhi Zhang, Jihong Dai, Yi Hu. Sanguinarine attenuates hydrogen peroxide-induced toxicity in liver of Monopterus albus: Role of oxidative stress, inflammation and apoptosis. Fish & shellfish immunology. 2022 Jun; 125(?):190-199. doi: 10.1016/j.fsi.2022.05.013. [PMID: 35569777]
  • Tengfei Liu, Yuanwei Gou, Bei Zhang, Rui Gao, Chang Dong, Mingming Qi, Lihong Jiang, Xuanwei Ding, Chun Li, Jiazhang Lian. Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast. Biotechnology and bioengineering. 2022 05; 119(5):1314-1326. doi: 10.1002/bit.28040. [PMID: 35060115]
  • Shasank S Swain, Sanghamitra Pati, Tahziba Hussain. Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation. European journal of medicinal chemistry. 2022 Mar; 232(?):114173. doi: 10.1016/j.ejmech.2022.114173. [PMID: 35168150]
  • José Ignacio Laines-Hidalgo, José Armando Muñoz-Sánchez, Lloyd Loza-Müller, Felipe Vázquez-Flota. An Update of the Sanguinarine and Benzophenanthridine Alkaloids' Biosynthesis and Their Applications. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041378. [PMID: 35209167]
  • Xue Wang, Xueliang Yang, Jiazhen Wang, Lei Li, Yun Zhang, Meng Jin, Xiqiang Chen, Chen Sun, Rongchun Wang, Kechun Liu. Cardiotoxicity of sanguinarine via regulating apoptosis and MAPK pathways in zebrafish and HL1 cardiomyocytes. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Feb; 252(?):109228. doi: 10.1016/j.cbpc.2021.109228. [PMID: 34744004]
  • Rongzhong Xu, Jianchun Wu, Yingbin Luo, Yuli Wang, Jianhui Tian, Wenjing Teng, Bo Zhang, Zhihong Fang, Yan Li. Sanguinarine Represses the Growth and Metastasis of Non-small Cell Lung Cancer by Facilitating Ferroptosis. Current pharmaceutical design. 2022; 28(9):760-768. doi: 10.2174/1381612828666220217124542. [PMID: 35176976]
  • Guanhua Lou, Jin Wang, Ju Hu, Qingxia Gan, Chengyi Peng, Haijun Xiong, Qinwan Huang. Sanguinarine: A Double-Edged Sword of Anticancer and Carcinogenesis and Its Future Application Prospect. Anti-cancer agents in medicinal chemistry. 2021 10; 21(16):2100-2110. doi: 10.2174/1871520621666210126091512. [PMID: 33573577]
  • Xueliang Yang, Xue Wang, Daili Gao, Yun Zhang, Xiqiang Chen, Qing Xia, Meng Jin, Chen Sun, Qiuxia He, Rongchun Wang, Kechun Liu. Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways. Toxicology letters. 2021 Oct; 350(?):71-80. doi: 10.1016/j.toxlet.2021.07.001. [PMID: 34252508]
  • Siyu Tian, Rui Wang, Shuming Chen, Jialing He, Weili Zheng, Yong Li. Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26196012. [PMID: 34641558]
  • Wilfred Mabeche Anjago, Wenlong Zeng, Yixiao Chen, Yupeng Wang, Jules Biregeya, Yunxi Li, Tian Zhang, Minghui Peng, Yan Cai, Mingyue Shi, Baohua Wang, Dongmei Zhang, Zonghua Wang, Meilian Chen. The molecular mechanism underlying pathogenicity inhibition by sanguinarine in Magnaporthe oryzae. Pest management science. 2021 Oct; 77(10):4669-4679. doi: 10.1002/ps.6508. [PMID: 34116584]
  • Mohammad A Alfhili, Jawaher Alsughayyir, Ahmed B Basudan. Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes. Toxicon : official journal of the International Society on Toxinology. 2021 Aug; 199(?):41-48. doi: 10.1016/j.toxicon.2021.05.013. [PMID: 34081931]
  • Masoumeh Bavarsadi, Amir Hossein Mahdavi, Saeed Ansari-Mahyari, Elaheh Jahanian. Sanguinarine improved nutrient digestibility, hepatic health indices and productive performance in laying hens fed low crude protein diets. Veterinary medicine and science. 2021 05; 7(3):800-811. doi: 10.1002/vms3.436. [PMID: 33570254]
  • Siu Wah Wong-Deyrup, Xun Song, Tsz-Wai Ng, Xiu-Bin Liu, Jian-Guo Zeng, Zhi-Xing Qing, Stephen T Deyrup, Zhen-Dan He, Hong-Jie Zhang. Plant-derived isoquinoline alkaloids that target ergosterol biosynthesis discovered by using a novel antifungal screening tool. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111348. doi: 10.1016/j.biopha.2021.111348. [PMID: 33578237]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mohsin Ahmad Ghauri, Qi Su, Asmat Ullah, Jingjing Wang, Ammar Sarwar, Qing Wu, Dongdong Zhang, Yanmin Zhang. Sanguinarine impedes metastasis and causes inversion of epithelial to mesenchymal transition in breast cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Apr; 84(?):153500. doi: 10.1016/j.phymed.2021.153500. [PMID: 33626427]
  • Yuting Fu, Wanting Liu, Miao Liu, Jianing Zhang, Min Yang, Ting Wang, Weidong Qian. In vitro anti-biofilm efficacy of sanguinarine against carbapenem-resistant Serratia marcescens. Biofouling. 2021 03; 37(3):341-351. doi: 10.1080/08927014.2021.1919649. [PMID: 33947279]
  • Daniela Marasco, Caterina Vicidomini, Pawel Krupa, Federica Cioffi, Pham Dinh Quoc Huy, Mai Suan Li, Daniele Florio, Kerensa Broersen, Maria Francesca De Pandis, Giovanni N Roviello. Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation. Chemico-biological interactions. 2021 Jan; 334(?):109300. doi: 10.1016/j.cbi.2020.109300. [PMID: 33098838]
  • Peng Huang, Liqiong Xia, Li Zhou, Wei Liu, Peng Wang, Zhixing Qing, Jianguo Zeng. Influence of different elicitors on BIA production in Macleaya cordata. Scientific reports. 2021 01; 11(1):619. doi: 10.1038/s41598-020-79802-0. [PMID: 33436669]
  • Ping Li, Yan-Xiu Wang, Guang Yang, Zun-Cheng Zheng, Chao Yu. Sanguinarine Attenuates Neuropathic Pain in a Rat Model of Chronic Constriction Injury. BioMed research international. 2021; 2021(?):3689829. doi: 10.1155/2021/3689829. [PMID: 34409102]
  • Chun Qing, Huiling Zhang, Anwei Chen, Yiqing Lin, Jihai Shao. Effects and possible mechanisms of sanguinarine on the competition between Raphidiopsis raciborskii (Cyanophyta) and Scenedesmus obliquus (Chlorophyta): A comparative toxicological study. Ecotoxicology and environmental safety. 2020 Dec; 206(?):111192. doi: 10.1016/j.ecoenv.2020.111192. [PMID: 32858326]
  • Duy Thanh Nguyen, Jamila Iqbal, Jianying Han, Gregory K Pierens, Stephen A Wood, George D Mellick, Yunjiang Feng. Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line. Bioorganic & medicinal chemistry. 2020 11; 28(21):115732. doi: 10.1016/j.bmc.2020.115732. [PMID: 33065438]
  • Andrea Balažová, Júlia Urdová, Vladimír Forman, Pavel Mučaji. Enhancement of Macarpine Production in Eschscholzia Californica Suspension Cultures under Salicylic Acid Elicitation and Precursor Supplementation. Molecules (Basel, Switzerland). 2020 Mar; 25(6):. doi: 10.3390/molecules25061261. [PMID: 32168770]
  • Yi Li, Thilo Winzer, Zhesi He, Ian A Graham. Over 100 Million Years of Enzyme Evolution Underpinning the Production of Morphine in the Papaveraceae Family of Flowering Plants. Plant communications. 2020 03; 1(2):100029. doi: 10.1016/j.xplc.2020.100029. [PMID: 32685922]
  • Yong Wu, Na-Jiao Zhao, Yan Cao, Zhuo Sun, Qin Wang, Zhao-Ying Liu, Zhi-Liang Sun. Sanguinarine metabolism and pharmacokinetics study in vitro and in vivo. Journal of veterinary pharmacology and therapeutics. 2020 Mar; 43(2):208-214. doi: 10.1111/jvp.12835. [PMID: 31943246]
  • Roya Sarkhosh-Inanlou, Morteza Molaparast, Adel Mohammadzadeh, Vahid Shafiei-Irannejad. Sanguinarine enhances cisplatin sensitivity via glutathione depletion in cisplatin-resistant ovarian cancer (A2780) cells. Chemical biology & drug design. 2020 02; 95(2):215-223. doi: 10.1111/cbdd.13621. [PMID: 31512406]
  • Chao Yu, Ping Li, Yan-Xiu Wang, Kai-Gang Zhang, Zun-Cheng Zheng, Li-Shuang Liang. Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model. Drug design, development and therapy. 2020; 14(?):4725-4733. doi: 10.2147/dddt.s276424. [PMID: 33177809]
  • Zhu-Ying Liu, Xiao-Long Wang, Shu-Qi Ou, De-Xing Hou, Jian-Hua He. Sanguinarine modulate gut microbiome and intestinal morphology to enhance growth performance in broilers. PloS one. 2020; 15(6):e0234920. doi: 10.1371/journal.pone.0234920. [PMID: 32559224]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Lan Gao, Hans-Joachim Schmitz, Karl-Heinz Merz, Dieter Schrenk. Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes. Toxicology letters. 2019 Sep; 311(?):91-97. doi: 10.1016/j.toxlet.2019.04.031. [PMID: 31054355]
  • Zhong-Min Zhao, Xiao-Fei Shang, Raymond Kobla Lawoe, Ying-Qian Liu, Rui Zhou, Yu Sun, Yin-Fang Yan, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine. Pesticide biochemistry and physiology. 2019 Sep; 159(?):51-58. doi: 10.1016/j.pestbp.2019.05.015. [PMID: 31400784]
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