Sanguinarine (BioDeep_00000000499)

 

Secondary id: BioDeep_00000397985, BioDeep_00001867514

human metabolite PANOMIX_OTCML-2023 Endogenous Toxin natural product


代谢物信息卡片


24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21),23-nonaen-24-ium

化学式: [C20H14NO4]+ (332.0923)
中文名称: 血根碱, 假白屈菜季铵碱
谱图信息: 最多检出来源 Homo sapiens(plant) 9.45%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Sanguinarine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/sanguinarine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000499). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C[n+1](c1)c(c54)c(ccc(cc(O6)c(OC6)c5)4)c(c2)c(cc(O3)c(OC3)2)1
InChI: InChI=1S/C20H14NO4/c1-21-8-12-5-17-18(24-10-23-17)6-14(12)13-3-2-11-4-16-19(25-9-22-16)7-15(11)20(13)21/h2-8H,9-10H2,1H3/q+1

描述信息

Sanguinarine is a benzophenanthridine alkaloid, an alkaloid antibiotic and a botanical anti-fungal agent.
Sanguinarine is a natural product found in Fumaria capreolata, Fumaria kralikii, and other organisms with data available.
Sanguinarine is found in opium poppy. Consumption of Sanguinarine, present in poppy seeds and in the oil of Argemone mexicana which has been used as an adulterant for mustard oil in India, has been linked to development of glaucoma. Sanguinarine is banned by FDA. Sanguinarine is a quaternary ammonium salt from the group of benzylisoquinoline alkaloids. It is extracted from some plants, including bloodroot (Sanguinaria canadensis), Mexican prickly poppy Argemone mexicana, Chelidonium majus and Macleaya cordata. It is also found in the root, stem and leaves of the opium poppy but not in the capsule. Sanguinarine is a toxin that kills animal cells through its action on the Na+-K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine. Sanguinarine has been shown to exhibit antibiotic, anti-apoptotic, anti-fungal, anti-inflammatory and anti-angiogenic functions Sanguinarine belongs to the family of Benzoquinolines. These are organic compounds containing a benzene fused to a quinoline ring system. (A3208, A3209, A3208, A3208, A3208).
See also: Sanguinaria canadensis root (part of); Chelidonium majus flowering top (part of).
Sanguinarine is found in opium poppy. Consumption of Sanguinarine, present in poppy seeds and in the oil of Argemone mexicana which has been used as an adulterant for mustard oil in India, has been linked to development of glaucoma. Sanguinarine is banned by FDA. Sanguinarine is a quaternary ammonium salt from the group of benzylisoquinoline alkaloids. It is extracted from some plants, including bloodroot (Sanguinaria canadensis), Mexican prickly poppy Argemone mexicana, Chelidonium majus and Macleaya cordata. It is also found in the root, stem and leaves of the opium poppy but not in the capsule.[citation needed]; Sanguinarine is a toxin that kills animal cells through its action on the Na+-K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine

Sanguinarine (13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium) is derived from the root of Sanguinaria canadensis and other poppy-fumaria species (for references, see Ref. 1). This benzophenanthridine alkaloid is a structural homologue of chelerythrine, which is a potent inhibitor of protein kinase C (2). Sanguinarine has been shown to display antitumor (3) and anti-inflammatory properties in animals (4) and to inhibit neutrophil function, including degranulation and phagocytosis in vitro(5). It is also a potent inhibitor of Na-K-dependent ATPase (6, 7, 8) and cholinesterase (9).

同义名列表

65 个代谢物同义名

24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21),23-nonaen-24-ium; 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14,16,21,23-nonaen-24-ium; 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.0^{2,10.0^{4,8.0^{14,22.0^{17,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene; 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0²,¹⁰.0⁴,⁸.0¹⁴,²².0¹⁷,²¹]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaen-24-ium; 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene; 13-methyl-2H,10H-(1,3)dioxolo(4,5-i)(1,3)dioxolo(4,5:4,5)benzo(1,2-c)phenanthridinium; 13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4,5:4,5]benzo[1,2-c]phenanthridinium; 13-Methyl-[1,3]dioxolo[4,5:4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium; 13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium(1+), 9CI; 13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium nitrate; (1,3)-Benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-; 13-Methyl[1,3]benzodioxolo[5,6-C][1,3]dioxolo[4,5-I]phenanthridin-13-Ium; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-; (1,3)BENZODIOXOLO(5,6-C)-1,3-DIOXOLO(4,5-I)PHENANTHRIDINIUM, 13-METHYL-; 13-methyl(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium; 13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium; 5-Methyl-2,3:7,8-bis(methylenedioxy)benzo[c]phenanthridinium(1+); Dimethylenedioxy benzphenanthridine; Pseudochelerythrine;Sanguinarin; Benzophenanthridine alkaloid; INVGWHRKADIJHF-UHFFFAOYSA-N; compound 1 [PMID: 28621943]; sanguinarine sulfate (2:1); sanguinarine sulfate (1:1); sanguinarine hydroxide; sanguinarium-chloride; SANGUINARINE [WHO-DD]; sanguinarine chloride; sanguinarine nitrate; pseudo-chelerythrine; pseudochelerythrine; Prestwick1_000987; Prestwick3_000987; Prestwick0_000987; Prestwick2_000987; SANGUINARINE [MI]; Spectrum2_000724; Spectrum3_001148; Spectrum4_001838; Spectrum5_000635; |x-Chelerythrine; y-Chelerythrine; UNII-AV9VK043SS; Tox21_110268_1; BPBio1_001159; Lopac0_001108; DivK1c_000495; sanguinarine; Sanguinarium; KBio2_005875; Tox21_110268; sanguiritrin; KBio1_000495; KBio2_003307; KBio2_000739; KBio3_002175; sanguinarin; IDI1_000495; sangvinarin; AV9VK043SS; Sangrovit; Viadent; Veadent; UI5; Sanguinarine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

27 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(25)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

221 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ANXA5, BCL2, CASP3, CASP8, CASP9, CAT, CTNNB1, CYP1A1, MTOR, PIK3CA, PTGS2, STAT3, TP53
Peripheral membrane protein 6 ANXA5, CYP1A1, CYP1B1, GORASP1, MTOR, PTGS2
Endoplasmic reticulum membrane 6 BCL2, CYP1A1, CYP1A2, CYP1B1, MTOR, PTGS2
Nucleus 10 BCL2, CASP3, CASP8, CASP9, CTNNB1, GABPA, MTOR, PARP1, STAT3, TP53
cytosol 13 ANXA5, BCL2, CASP3, CASP8, CASP9, CAT, CTNNB1, GPT, MTOR, PARP1, PIK3CA, STAT3, TP53
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 2 CTNNB1, TP53
nucleoplasm 8 CASP3, CASP8, CTNNB1, GABPA, MTOR, PARP1, STAT3, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 2 CTNNB1, TNF
Cytoplasmic side 2 GORASP1, MTOR
lamellipodium 3 CASP8, CTNNB1, PIK3CA
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 1 TNF
glutamatergic synapse 2 CASP3, CTNNB1
Golgi apparatus 1 GORASP1
Golgi membrane 2 GORASP1, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 CTNNB1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 PARP1
Lysosome 1 MTOR
plasma membrane 4 CTNNB1, PIK3CA, STAT3, TNF
Membrane 8 ANXA5, BCL2, CAT, CTNNB1, CYP1B1, MTOR, PARP1, TP53
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CAT, CTNNB1, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, PTGS2, TP53
extracellular space 1 TNF
perinuclear region of cytoplasm 2 CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 8 BCL2, CASP8, CASP9, CAT, CYP1A1, CYP1B1, PARP1, TP53
protein-containing complex 8 BCL2, CASP8, CASP9, CAT, CTNNB1, PARP1, PTGS2, TP53
intracellular membrane-bounded organelle 4 CAT, CYP1A1, CYP1A2, CYP1B1
Microsome membrane 5 CYP1A1, CYP1A2, CYP1B1, MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
extracellular region 3 ANXA5, CAT, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, CASP8, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 4 CTNNB1, PARP1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 2 PARP1, TP53
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
Cell projection, lamellipodium 1 CASP8
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 3 ANXA5, CAT, CTNNB1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
collagen-containing extracellular matrix 1 ANXA5
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 4 GABPA, PARP1, STAT3, TP53
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Chromosome 1 PARP1
cytoskeleton 1 CASP8
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 PARP1
spindle pole 1 CTNNB1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 2 PARP1, TP53
nuclear envelope 2 MTOR, PARP1
Endomembrane system 2 CTNNB1, MTOR
euchromatin 1 CTNNB1
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
apoptosome 1 CASP9
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 CTNNB1, PARP1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Weixiao Lei, Hui Zhu, Man Cao, Feng Zhang, Qing Lai, Shengming Lu, Wenpan Dong, Jiahui Sun, Dafu Ru. From genomics to metabolomics: Deciphering sanguinarine biosynthesis in Dicranostigma leptopodum. International journal of biological macromolecules. 2024 Feb; 257(Pt 2):128727. doi: 10.1016/j.ijbiomac.2023.128727. [PMID: 38092109]
  • Jian-Sheng Dai, Jian Xu, Hao-Jie Shen, Ni-Pi Chen, Bing-Qi Zhu, Zheng-Jie Xue, Hao-Han Chen, Zhi-Shan Ding, Rui Ding, Chao-Dong Qian. The induced and intrinsic resistance of Escherichia coli to sanguinarine is mediated by AcrB efflux pump. Microbiology spectrum. 2024 Jan; 12(1):e0323723. doi: 10.1128/spectrum.03237-23. [PMID: 38038452]
  • Jing-Ying Fan, Jie Liu, Wen-Qing Zhang, Ting Lin, Xi-Ran Hu, Fang-Liang Zhou, Le Tang, Ying-Chun He, Hong-Jian Shi. Anti-Nasopharyngeal carcinoma mechanism of sanguinarine based on network pharmacology and molecular docking. Medicine. 2023 Dec; 102(48):e36477. doi: 10.1097/md.0000000000036477. [PMID: 38050231]
  • Mengting Liu, Zhiqin Liu, Zhuang Dong, Xianglin Zou, Jianguo Zeng, Zihui Yang. Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS. Molecules (Basel, Switzerland). 2023 Nov; 28(22):. doi: 10.3390/molecules28227641. [PMID: 38005364]
  • Xue Li, Li Zhang, Zilin Zhong, Sujie Sun, Jie Wu, Fasheng Liu, Zigang Cao, Huiqiang Lu, Xinjun Liao, Bing Zhou, Jianjun Chen. Sanguinarine exposure induces immunotoxicity and abnormal locomotor behavior in zebrafish. Fish & shellfish immunology. 2023 Jun; 139(?):108898. doi: 10.1016/j.fsi.2023.108898. [PMID: 37301310]
  • Zhijie Zheng, Yonghui Zheng, Xiaoben Liang, Guanhong Xue, Haichong Wu. Sanguinarine Enhances the Integrity of the Blood-Milk Barrier and Inhibits Oxidative Stress in Lipopolysaccharide-Stimulated Mastitis. Cells. 2022 11; 11(22):. doi: 10.3390/cells11223658. [PMID: 36429086]
  • Xueliang Yang, Lei Li, Yuxin Shi, Xue Wang, Yun Zhang, Meng Jin, Xiqiang Chen, Rongchun Wang, Kechun Liu. Neurotoxicity of sanguinarine via inhibiting mitophagy and activating apoptosis in zebrafish and PC12 cells. Pesticide biochemistry and physiology. 2022 Nov; 188(?):105259. doi: 10.1016/j.pestbp.2022.105259. [PMID: 36464364]
  • Yang Mengzhe, Zhang Beibei, Liang Zhenqiang, Cheng Nannan, Lü Anqiao, Yang Jianyu, Guo Xingzhe, Bai Xianyu, Huang Yuanjiao, Jiao Aijun, X U Ning. Sanguinarine suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma inhibiting mTOR signaling. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 10; 42(5):687-692. doi: 10.19852/j.cnki.jtcm.20220426.001. [PMID: 36083474]
  • Qiang Lu, Zhenshan Zhang, Yifei Xu, Yujia Chen, Cailan Li. Sanguinarine, a major alkaloid from Zanthoxylum nitidum (Roxb.) DC., inhibits urease of Helicobacter pylori and jack bean: Susceptibility and mechanism. Journal of ethnopharmacology. 2022 Sep; 295(?):115388. doi: 10.1016/j.jep.2022.115388. [PMID: 35577159]
  • Bei Li, Yingbin Luo, Yixi Zhou, Jianchun Wu, Zhihong Fang, Yan Li. Role of sanguinarine in regulating immunosuppression in a Lewis lung cancer mouse model. International immunopharmacology. 2022 Sep; 110(?):108964. doi: 10.1016/j.intimp.2022.108964. [PMID: 35728305]
  • Asmat Ullah, Najeeb Ullah, Touseef Nawaz, Tariq Aziz. Molecular mechanisms of Sanguinarine in cancer prevention and treatment. Anti-cancer agents in medicinal chemistry. 2022 Aug; ?(?):. doi: 10.2174/1871520622666220831124321. [PMID: 36045531]
  • Yong Shi, Lei Zhong, Kaijian Chen, Yuding Fan, Kai Xie, Junzhi Zhang, Jihong Dai, Yi Hu. Sanguinarine attenuates hydrogen peroxide-induced toxicity in liver of Monopterus albus: Role of oxidative stress, inflammation and apoptosis. Fish & shellfish immunology. 2022 Jun; 125(?):190-199. doi: 10.1016/j.fsi.2022.05.013. [PMID: 35569777]
  • Tengfei Liu, Yuanwei Gou, Bei Zhang, Rui Gao, Chang Dong, Mingming Qi, Lihong Jiang, Xuanwei Ding, Chun Li, Jiazhang Lian. Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast. Biotechnology and bioengineering. 2022 05; 119(5):1314-1326. doi: 10.1002/bit.28040. [PMID: 35060115]
  • Shasank S Swain, Sanghamitra Pati, Tahziba Hussain. Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation. European journal of medicinal chemistry. 2022 Mar; 232(?):114173. doi: 10.1016/j.ejmech.2022.114173. [PMID: 35168150]
  • José Ignacio Laines-Hidalgo, José Armando Muñoz-Sánchez, Lloyd Loza-Müller, Felipe Vázquez-Flota. An Update of the Sanguinarine and Benzophenanthridine Alkaloids' Biosynthesis and Their Applications. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041378. [PMID: 35209167]
  • Xue Wang, Xueliang Yang, Jiazhen Wang, Lei Li, Yun Zhang, Meng Jin, Xiqiang Chen, Chen Sun, Rongchun Wang, Kechun Liu. Cardiotoxicity of sanguinarine via regulating apoptosis and MAPK pathways in zebrafish and HL1 cardiomyocytes. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Feb; 252(?):109228. doi: 10.1016/j.cbpc.2021.109228. [PMID: 34744004]
  • Rongzhong Xu, Jianchun Wu, Yingbin Luo, Yuli Wang, Jianhui Tian, Wenjing Teng, Bo Zhang, Zhihong Fang, Yan Li. Sanguinarine Represses the Growth and Metastasis of Non-small Cell Lung Cancer by Facilitating Ferroptosis. Current pharmaceutical design. 2022; 28(9):760-768. doi: 10.2174/1381612828666220217124542. [PMID: 35176976]
  • Guanhua Lou, Jin Wang, Ju Hu, Qingxia Gan, Chengyi Peng, Haijun Xiong, Qinwan Huang. Sanguinarine: A Double-Edged Sword of Anticancer and Carcinogenesis and Its Future Application Prospect. Anti-cancer agents in medicinal chemistry. 2021 10; 21(16):2100-2110. doi: 10.2174/1871520621666210126091512. [PMID: 33573577]
  • Xueliang Yang, Xue Wang, Daili Gao, Yun Zhang, Xiqiang Chen, Qing Xia, Meng Jin, Chen Sun, Qiuxia He, Rongchun Wang, Kechun Liu. Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways. Toxicology letters. 2021 Oct; 350(?):71-80. doi: 10.1016/j.toxlet.2021.07.001. [PMID: 34252508]
  • Siyu Tian, Rui Wang, Shuming Chen, Jialing He, Weili Zheng, Yong Li. Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26196012. [PMID: 34641558]
  • Wilfred Mabeche Anjago, Wenlong Zeng, Yixiao Chen, Yupeng Wang, Jules Biregeya, Yunxi Li, Tian Zhang, Minghui Peng, Yan Cai, Mingyue Shi, Baohua Wang, Dongmei Zhang, Zonghua Wang, Meilian Chen. The molecular mechanism underlying pathogenicity inhibition by sanguinarine in Magnaporthe oryzae. Pest management science. 2021 Oct; 77(10):4669-4679. doi: 10.1002/ps.6508. [PMID: 34116584]
  • Mohammad A Alfhili, Jawaher Alsughayyir, Ahmed B Basudan. Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes. Toxicon : official journal of the International Society on Toxinology. 2021 Aug; 199(?):41-48. doi: 10.1016/j.toxicon.2021.05.013. [PMID: 34081931]
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