Sakuranetin (BioDeep_00000000483)

 

Secondary id: BioDeep_00000270710

natural product human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (2S)-

化学式: C16H14O5 (286.0841194)
中文名称: 樱花精, 樱花素, 樱花亭, 樱花亭
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 0.12%

分子结构信息

SMILES: c1(cc(c2c(c1)O[C@@H](CC2=O)c1ccc(cc1)O)O)OC
InChI: InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3

描述信息

Sakuranetin is a flavonoid phytoalexin that is (S)-naringenin in which the hydroxy group at position 7 is replaced by a methoxy group. It has a role as an antimycobacterial drug and a plant metabolite. It is a dihydroxyflavanone, a monomethoxyflavanone, a flavonoid phytoalexin, a member of 4-hydroxyflavanones and a (2S)-flavan-4-one. It is functionally related to a (S)-naringenin.
Sakuranetin is a natural product found in Ageratina altissima, Chromolaena odorata, and other organisms with data available.
Sakuranetin is found in black walnut. Sakuranetin is a flavanone, a type of flavonoid. It can be found in Polymnia fruticosa and rice, where it acts as a phytoalexin against spore germination of Pyricularia oryzae
Sakuranetin is a flavanone, a type of flavonoid. It can be found in Polymnia fruticosa and rice, where it acts as a phytoalexin against spore germination of Pyricularia oryzae.
A flavonoid phytoalexin that is (S)-naringenin in which the hydroxy group at position 7 is replaced by a methoxy group.
Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity[1]. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury[2].
Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity[1]. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury[2].

同义名列表

29 个代谢物同义名

4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (S)-; (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-3,4-dihydro-2H-1-benzopyran-4-one; (S)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one; (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one; (2S)--5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one; (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chroman-4-one; (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one; (S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one; 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chroman-4-one; Flavanone, 4,5-dihydroxy-7-methoxy-, (S)-(-)-; (S)-(-)-4,5-dihydroxy-7-methoxyflavanone; (2S)-5,4-dihydroxy-7-methoxyflavan-4-one; (2S)-4,5-dihydroxy-7-methoxyflavanone; 5,4-Dihydroxy-7-methoxyflavanone; 4,5-Dihydroxy-7-methoxyflavanone; Sakuranetin, analytical standard; 5,4-dihydroxy-7-methoxyflavanone; Naringenin 7-O-methyl ether; naringenin 7-methyl ether; 7-O-Methylnaringenin; (2S)-sakuranetin; SAKURANETIN [MI]; UNII-3O38P61299; Sakuranetin; 3O38P61299; 3d04; 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one; 4,5-Dihydroxy-7-methoxyflavone



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

16 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(15)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

83 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lihui Jiang, Xiaoyan Zhang, Yiting Zhao, Haiyan Zhu, Qijing Fu, Xinqi Lu, Wuying Huang, Xinyue Yang, Xuan Zhou, Lixia Wu, Ao Yang, Xie He, Man Dong, Ziai Peng, Jing Yang, Liwei Guo, Jiancheng Wen, Huichuan Huang, Yong Xie, Shusheng Zhu, Chengyun Li, Xiahong He, Youyong Zhu, Jiří Friml, Yunlong Du. Phytoalexin sakuranetin attenuates endocytosis and enhances resistance to rice blast. Nature communications. 2024 Apr; 15(1):3437. doi: 10.1038/s41467-024-47746-y. [PMID: 38653755]
  • Yao Zhao, Xueying Zhang, Zhuoliang Lang, Chi Zhang, Linying Li, Yuqing He, Na Liu, Ying Zhu, Gaojie Hong. Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin. Journal of agricultural and food chemistry. 2024 Mar; 72(11):6053-6063. doi: 10.1021/acs.jafc.3c08968. [PMID: 38452150]
  • Matheus Lima de Souza, André Campos Machado, Henrique Barbosa, João Henrique Ghilardi Lago, Luciano Caseli. Interaction of sakuranetin with unsaturated lipids forming Langmuir monolayers at the air-water interface: A biomembrane model. Colloids and surfaces. B, Biointerfaces. 2024 Jan; 234(?):113747. doi: 10.1016/j.colsurfb.2024.113747. [PMID: 38219639]
  • Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J Villar, Felipe Lombó. Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin. Microbial cell factories. 2023 Nov; 22(1):234. doi: 10.1186/s12934-023-02247-3. [PMID: 37964284]
  • Anish Kundu. Antimicrobial to anti-herbivore: Sakuranetin in rice efficiently inhibits brown planthopper by targeting their beneficial endosymbionts. Physiologia plantarum. 2023 Nov; 175(6):e14110. doi: 10.1111/ppl.14110. [PMID: 38148222]
  • Sarfaraz Ahmed, Mohammad K Parvez, Mohammed S Al-Dosari, Mazin A S Abdelwahid, Tawfeq A Alhowiriny, Adnan J Al-Rehaily. Novel anti‑hepatitis B virus flavonoids sakuranetin and velutin from Rhus retinorrhoea. Molecular medicine reports. 2023 Sep; 28(3):. doi: 10.3892/mmr.2023.13063. [PMID: 37539729]
  • Mengyu Liu, Gaojie Hong, Huijing Li, Xiaoli Bing, Yumeng Chen, Xiangfeng Jing, Jonathan Gershenzon, Yonggen Lou, Ian T Baldwin, Ran Li. Sakuranetin protects rice from brown planthopper attack by depleting its beneficial endosymbionts. Proceedings of the National Academy of Sciences of the United States of America. 2023 Jun; 120(23):e2305007120. doi: 10.1073/pnas.2305007120. [PMID: 37256931]
  • Shuai Tu, Feng Xiao, Chengyu Mei, Shuang Li, Pei Qiao, Ziyan Huang, Yan He, Zhixing Gong, Weihong Zhong. De novo biosynthesis of sakuranetin from glucose by engineered Saccharomyces cerevisiae. Applied microbiology and biotechnology. 2023 May; ?(?):. doi: 10.1007/s00253-023-12564-7. [PMID: 37148336]
  • Guilherme Henrique da Cruz Ramos Pires, Vitor Torres Freire, Rafael Guimarães Pereira, Leonardo José Amaral de Siqueira, Eric Umehara, João Henrique Ghilardi Lago, Luciano Caseli. Sakuranetin interacting with cell membranes models: Surface chemistry combined with molecular simulation. Colloids and surfaces. B, Biointerfaces. 2022 Aug; 216(?):112546. doi: 10.1016/j.colsurfb.2022.112546. [PMID: 35588685]
  • Zhongyan Yang, Nana Li, Takashige Kitano, Ping Li, Jennifer E Spindel, Lishuo Wang, Genxiang Bai, Yiying Xiao, Susan R McCouch, Atsushi Ishihara, Jili Zhang, Xin Yang, Zepeng Chen, Jianyu Wei, Honghua Ge, Georg Jander, Jian Yan. Genetic mapping identifies a rice naringenin O-glucosyltransferase that influences insect resistance. The Plant journal : for cell and molecular biology. 2021 06; 106(5):1401-1413. doi: 10.1111/tpj.15244. [PMID: 33745166]
  • InWha Park, Hee Sun Byun, Gang Min Hur, MinKyun Na. Tulipiferamide A, an Alkamide from Liriodendron tulipifera, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation. Journal of natural products. 2021 05; 84(5):1598-1606. doi: 10.1021/acs.jnatprod.1c00146. [PMID: 33939429]
  • Xiaonan Wang, Zhenghong Li, Lizelle Policarpio, Mattheos A G Koffas, Haoran Zhang. De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering. Applied microbiology and biotechnology. 2020 Jun; 104(11):4849-4861. doi: 10.1007/s00253-020-10576-1. [PMID: 32285175]
  • Hye Lin Park, Youngchul Yoo, Seong Hee Bhoo, Tae-Hoon Lee, Sang-Won Lee, Man-Ho Cho. Two Chalcone Synthase Isozymes Participate Redundantly in UV-Induced Sakuranetin Synthesis in Rice. International journal of molecular sciences. 2020 May; 21(11):. doi: 10.3390/ijms21113777. [PMID: 32471084]
  • Ramiro Quintanilla-Licea, Javier Vargas-Villarreal, María Julia Verde-Star, Verónica Mayela Rivas-Galindo, Ángel David Torres-Hernández. Antiprotozoal Activity against Entamoeba histolytica of Flavonoids Isolated from Lippia graveolens Kunth. Molecules (Basel, Switzerland). 2020 May; 25(11):. doi: 10.3390/molecules25112464. [PMID: 32466359]
  • Koichi Murata, Takashige Kitano, Riko Yoshimoto, Ryo Takata, Naoki Ube, Kotomi Ueno, Makoto Ueno, Yukinori Yabuta, Masayoshi Teraishi, Cynthia K Holland, Georg Jander, Yutaka Okumoto, Naoki Mori, Atsushi Ishihara. Natural variation in the expression and catalytic activity of a naringenin 7-O-methyltransferase influences antifungal defenses in diverse rice cultivars. The Plant journal : for cell and molecular biology. 2020 03; 101(5):1103-1117. doi: 10.1111/tpj.14577. [PMID: 31630460]
  • Chen Li, Chunting Hu, Ruili Wang, Hui Wang, Qiaoya Ma, Songsheng Chen, Ya He. Protective effect of sakuranetin in brain cells of dementia model rats. Cellular and molecular biology (Noisy-le-Grand, France). 2019 Jun; 65(5):54-58. doi: . [PMID: 31304907]
  • Yuko Yamauchi, Tetsuya Okuyama, Toshinari Ishii, Tadayoshi Okumura, Yukinobu Ikeya, Mikio Nishizawa. Sakuranetin downregulates inducible nitric oxide synthase expression by affecting interleukin-1 receptor and CCAAT/enhancer-binding protein β. Journal of natural medicines. 2019 Mar; 73(2):353-368. doi: 10.1007/s11418-018-1267-x. [PMID: 30467676]
  • Fernanda P R Santana, Rafael C da Silva, Simone Dos S Grecco, Aruanã J M C R Pinheiro, Luciana C Caperuto, Fernanda M Arantes-Costa, Samuel R Claudio, Kelly Yoshizaki, Mariângela Macchione, Daniel A Ribeiro, Iolanda F L C Tibério, Lídio G Lima-Neto, João H G Lago, Carla M Prado. Inhibition of MAPK and STAT3-SOCS3 by Sakuranetin Attenuated Chronic Allergic Airway Inflammation in Mice. Mediators of inflammation. 2019; 2019(?):1356356. doi: 10.1155/2019/1356356. [PMID: 31565031]
  • Dur-Han Kwon, Jeong-Hun Ji, Soon-Ho Yim, Byoung-Soo Kim, Hwa-Jung Choi. Suppression of influenza B virus replication by sakuranetin and mode of its action. Phytotherapy research : PTR. 2018 Dec; 32(12):2475-2479. doi: 10.1002/ptr.6186. [PMID: 30187587]
  • Hyesoo Jeong, Jimin Lee, Soolin Kim, Yoo Yeon Yeo, Hyunyoung So, Honghua Wu, Yun Seon Song, Chang-Young Jang, Hee-Doo Kim, Min Jung Kim, Minsun Chang. Hepatic Metabolism of Sakuranetin and Its Modulating Effects on Cytochrome P450s and UDP-Glucuronosyltransferases. Molecules (Basel, Switzerland). 2018 Jun; 23(7):. doi: 10.3390/molecules23071542. [PMID: 29949932]
  • Perwez Alam, Mohammad Khalid Parvez, Ahmed Hassan Arbab, Nasir Ali Siddiqui, Mohammed Salem Al-Dosary, Adnan Jathlan Al-Rehaily, Sarfaraz Ahmed, Mohd Abul Kalam, Mohammad Shamim Ahmad. Inter-species comparative antioxidant assay and HPTLC analysis of sakuranetin in the chloroform and ethanol extracts of aerial parts of Rhus retinorrhoea and Rhus tripartita. Pharmaceutical biology. 2017 Dec; 55(1):1450-1457. doi: 10.1080/13880209.2017.1304428. [PMID: 28345446]
  • Shun Katsumata, Kazuho Hamana, Kiyotaka Horie, Hiroaki Toshima, Morifumi Hasegawa. Identification of Sternbin and Naringenin as Detoxified Metabolites from the Rice Flavanone Phytoalexin Sakuranetin by Pyricularia oryzae. Chemistry & biodiversity. 2017 Feb; 14(2):. doi: 10.1002/cbdv.201600240. [PMID: 27647729]
  • Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):420-426. doi: 10.1016/j.bmcl.2016.12.051. [PMID: 28049590]
  • Satoshi Ogawa, Koji Miyamoto, Keiichirou Nemoto, Tatsuya Sawasaki, Hisakazu Yamane, Hideaki Nojiri, Kazunori Okada. OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability. Scientific reports. 2017 01; 7(?):40175. doi: 10.1038/srep40175. [PMID: 28067270]
  • Alfredo Aires, Carla Dias, Rosa Carvalho, Maria José Saavedra. Analysis of glycosylated flavonoids extracted from sweet-cherry stems, as antibacterial agents against pathogenic Escherichia coli isolates. Acta biochimica Polonica. 2017; 64(2):265-271. doi: 10.18388/abp.2016_1374. [PMID: 28411365]
  • Riadh Drira, Kazuichi Sakamoto. Sakuranetin Induces Melanogenesis in B16BL6 Melanoma Cells through Inhibition of ERK and PI3K/AKT Signaling Pathways. Phytotherapy research : PTR. 2016 Jun; 30(6):997-1002. doi: 10.1002/ptr.5606. [PMID: 27000529]
  • Sileshi G Wubshet, Yousof Tahtah, Allison M Heskes, Kenneth T Kongstad, Irini Pateraki, Björn Hamberger, Birger L Møller, Dan Staerk. Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR. Journal of natural products. 2016 Apr; 79(4):1063-72. doi: 10.1021/acs.jnatprod.5b01128. [PMID: 26960032]
  • Ilenia Siciliano, Greice Amaral Carneiro, Davide Spadaro, Angelo Garibaldi, Maria Lodovica Gullino. Jasmonic Acid, Abscisic Acid, and Salicylic Acid Are Involved in the Phytoalexin Responses of Rice to Fusarium fujikuroi, a High Gibberellin Producer Pathogen. Journal of agricultural and food chemistry. 2015 Sep; 63(37):8134-42. doi: 10.1021/acs.jafc.5b03018. [PMID: 26323788]
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  • Morifumi Hasegawa, Ichiro Mitsuhara, Shigemi Seo, Kazunori Okada, Hisakazu Yamane, Takayoshi Iwai, Yuko Ohashi. Analysis on blast fungus-responsive characters of a flavonoid phytoalexin sakuranetin; accumulation in infected rice leaves, antifungal activity and detoxification by fungus. Molecules (Basel, Switzerland). 2014 Aug; 19(8):11404-18. doi: 10.3390/molecules190811404. [PMID: 25093982]
  • Hye Lin Park, Sang-Won Lee, Ki-Hong Jung, Tae-Ryong Hahn, Man-Ho Cho. Transcriptomic analysis of UV-treated rice leaves reveals UV-induced phytoalexin biosynthetic pathways and their regulatory networks in rice. Phytochemistry. 2013 Dec; 96(?):57-71. doi: 10.1016/j.phytochem.2013.08.012. [PMID: 24035516]
  • Hisakazu Yamane. Biosynthesis of phytoalexins and regulatory mechanisms of it in rice. Bioscience, biotechnology, and biochemistry. 2013; 77(6):1141-8. doi: 10.1271/bbb.130109. [PMID: 23748776]
  • Takafumi Shimizu, Fengqiu Lin, Morifumi Hasegawa, Hideaki Nojiri, Hisakazu Yamane, Kazunori Okada. The potential bioproduction of the pharmaceutical agent sakuranetin, a flavonoid phytoalexin in rice. Bioengineered. 2012 Nov; 3(6):352-7. doi: 10.4161/bioe.21546. [PMID: 22895058]
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