Hydrogen selenide (BioDeep_00000004704)

 

Secondary id: BioDeep_00001889496

human metabolite Endogenous


代谢物信息卡片


Hydrogen selenide, 75Se-labeled

化学式: H2Se (81.9322)
中文名称: 硒化氢
谱图信息: 最多检出来源 Viridiplantae(plant) 11.93%

分子结构信息

SMILES: [SeH2]
InChI: InChI=1S/H2Se/h1H2

描述信息

Hydrogen selenide is a metabolite of selenium which could have potential antiangiogenic effect in the chemoprevention of cancer. The hydrogen selenide is a key intermediate in the selenium methylation metabolism of inorganic and organic selenium compounds. Accumulation of the hydrogen selenide resulting from inhibition of the selenium methylation metabolism, detoxification metabolic pathway of selenium, is found in animals following repeated administration of a toxic dose of selenocystine. The excess of the hydrogen selenide produced by inhibition of the selenium methylation metabolism contributes to the hepatotoxicity caused by selenocystine. (PMID: 9414580, 11799926) [HMDB]
Hydrogen selenide is a metabolite of selenium which could have potential antiangiogenic effect in the chemoprevention of cancer. The hydrogen selenide is a key intermediate in the selenium methylation metabolism of inorganic and organic selenium compounds. Accumulation of the hydrogen selenide resulting from inhibition of the selenium methylation metabolism, detoxification metabolic pathway of selenium, is found in animals following repeated administration of a toxic dose of selenocystine. The excess of the hydrogen selenide produced by inhibition of the selenium methylation metabolism contributes to the hepatotoxicity caused by selenocystine. (PMID: 9414580, 11799926).

同义名列表

15 个代谢物同义名

Hydrogen selenide, 75Se-labeled; Dihydrogen monoselenide; Selenium hydride (seh2); Dihydrogen selenide; Selenium dihydride; Hydroselenic acid; HYDROGEN SELENIDE; Selenium hydride; Hydroselenate; 7783-07-5; selenide; [SeH2]; Selane; H2Se; Hydrogen selenide



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(3)

PlantCyc(0)

代谢反应

205 个相关的代谢反应过程信息。

Reactome(67)

BioCyc(12)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(118)

COVID-19 Disease Map(0)

PathBank(8)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANG, AXIN2, CASP3, CAT, CDKN1B, HINT1, HMGB1, LBH, MAPK14, MTOR, TXN, VEGFA
Peripheral membrane protein 3 HMGB1, HSD17B6, MTOR
Endoplasmic reticulum membrane 1 MTOR
Nucleus 11 ANG, AXIN2, CASP3, CDKN1B, HINT1, HMGB1, LBH, MAPK14, MTOR, TXN, VEGFA
cytosol 11 ANG, AXIN2, CASP3, CAT, CDKN1B, GSR, HINT1, MAPK14, MTOR, SCLY, TXN
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 AXIN2
nucleoplasm 9 ATP2B1, CASP3, CD2, CDKN1B, HINT1, HMGB1, MAPK14, MTOR, TXN
Cell membrane 3 ATP2B1, CD2, HMGB1
Cytoplasmic side 1 MTOR
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 ATP2B1
Golgi apparatus membrane 1 MTOR
Synapse 1 ATP2B1
cell surface 3 CD2, HMGB1, VEGFA
glutamatergic synapse 3 ATP2B1, CASP3, MAPK14
Golgi apparatus 4 ATRN, CD2, SCLY, VEGFA
Golgi membrane 1 MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 2 ANG, CASP3
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 SCLY
Lysosome 1 MTOR
endosome 2 CDKN1B, HMGB1
plasma membrane 6 ATP2B1, ATRN, AXIN2, CD2, HINT1, HMGB1
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ATP2B1, CAT, LBH, MTOR, SELENOP, VEGFA
basolateral plasma membrane 1 ATP2B1
extracellular exosome 7 ATP2B1, ATRN, CAT, GSR, HINT1, SELENOP, TXN
Lysosome membrane 1 MTOR
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 HMGB1, HSD17B6, VEGFA
extracellular space 5 ANG, ATRN, HMGB1, TST, VEGFA
adherens junction 1 VEGFA
mitochondrion 4 CAT, GSR, MAPK14, TST
protein-containing complex 4 CAT, CD2, CDKN1B, LBH
intracellular membrane-bounded organelle 4 ATP2B1, CAT, CDKN1B, HSD17B6
Microsome membrane 2 HSD17B6, MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ATRN, CD2
Secreted 5 ANG, HMGB1, SELENOP, TXN, VEGFA
extracellular region 8 ANG, CAT, CD2, HMGB1, MAPK14, SELENOP, TXN, VEGFA
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 LBH
mitochondrial outer membrane 1 MTOR
[Isoform 2]: Secreted 1 ATRN
Mitochondrion matrix 1 TST
mitochondrial matrix 3 CAT, GSR, TST
Extracellular side 1 HMGB1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 CD2, GSR
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
beta-catenin destruction complex 1 AXIN2
nucleolus 1 ANG
cell-cell junction 1 CD2
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 1 VEGFA
lateral plasma membrane 1 ATP2B1
nuclear speck 1 MAPK14
cell projection 1 ATP2B1
Chromosome 2 ANG, HMGB1
cytoskeleton 1 HINT1
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
Basolateral cell membrane 1 ATP2B1
[Isoform 3]: Secreted 1 ATRN
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Presynaptic cell membrane 1 ATP2B1
ficolin-1-rich granule lumen 3 CAT, HMGB1, MAPK14
secretory granule lumen 3 CAT, HMGB1, MAPK14
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 1 VEGFA
histone deacetylase complex 1 HINT1
endocytic vesicle 1 ANG
immunological synapse 1 ATP2B1
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ATRN
condensed chromosome 1 HMGB1
Cytoplasmic vesicle, phagosome 1 MTOR
platelet dense granule lumen 1 SELENOP
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
catalytic complex 1 SCLY
photoreceptor ribbon synapse 1 ATP2B1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
Cul4A-RING E3 ubiquitin ligase complex 1 CDKN1B


文献列表

  • D H Cox, A E Bibb. Hydrogen selenide evolution-electrothermal atomic absorption method for determining nanogram levels of total selenium. Journal - Association of Official Analytical Chemists. 1981 Mar; 64(2):265-9. doi: . [PMID: 7228821]
  • . . . . doi: . [PMID: 17988700]