octopamine (BioDeep_00000411061)

   

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


octopamine

化学式: C8H11NO2 (153.079)
中文名称: 奥克巴胺, 章鱼胺
谱图信息: 最多检出来源 Viridiplantae(plant) 74.8%

分子结构信息

SMILES: C1=CC(=CC=C1C(CN)O)O
InChI: InChI=1S/C8H11NO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,8,10-11H,5,9H2

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
Octopamine, also known as beta,4-dihydroxyphenethylamine, is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems. Octopamine is found in lemon, sweet orange, and pepper (c. frutescens).

同义名列表

3 个代谢物同义名

octopamine; Octopamine; US10112926, Example 104.14



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

32 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AANAT, AOC3, DBH, DDC, ITPR3, SLC6A3, TH
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 4 DRD1, ITPR3, PNMT, TAAR1
Mitochondrion membrane 1 PNMT
Nucleus 4 ACHE, DRD1, PLCZ1, TH
cytosol 6 AANAT, DDC, PLCZ1, PNMT, PRKCQ, TH
dendrite 1 TH
mitochondrial membrane 1 PNMT
nucleoplasm 2 ITPR3, PLCZ1
Cell membrane 7 ACHE, ADRB3, AOC3, DRD1, GPRC5A, SLC6A3, TAAR1
Cell projection, axon 2 SLC6A3, TH
Multi-pass membrane protein 7 ADRB3, DRD1, GPRC5A, ITPR3, PNMT, SLC6A3, TAAR1
Synapse 4 ACHE, DBH, NPS, TAC1
cell surface 3 ACHE, AOC3, SLC6A3
glutamatergic synapse 1 DRD1
Golgi apparatus 3 ACHE, AOC3, ATRN
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 3 ITPR3, SLC6A3, TAC1
presynaptic membrane 2 DRD1, SLC6A3
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
plasma membrane 10 ACHE, ADRB3, AOC3, ATRN, DRD1, GPRC5A, ITPR3, PRKCQ, SLC6A3, TAAR1
terminal bouton 1 TH
Membrane 5 ACHE, AOC3, DBH, ITPR3, SLC6A3
axon 3 SLC6A3, TAC1, TH
brush border 1 ITPR3
extracellular exosome 4 ATRN, DDC, GPRC5A, LYZ
endoplasmic reticulum 4 AOC3, DBH, ITPR3, PNMT
extracellular space 6 ACHE, ATRN, DBH, INS, LYZ, TAC1
perinuclear region of cytoplasm 4 AANAT, ACHE, PLCZ1, TH
mitochondrion 2 PNMT, TH
intracellular membrane-bounded organelle 3 DBH, GPRC5A, PNMT
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 ATRN
Secreted 3 ACHE, DBH, INS
extracellular region 6 ACHE, DBH, INS, LYZ, NPS, TAC1
cytoplasmic side of plasma membrane 1 TH
neuronal cell body membrane 1 SLC6A3
[Isoform 2]: Secreted 1 ATRN
Extracellular side 1 ACHE
centriolar satellite 2 DBH, PRKCQ
ciliary membrane 1 DRD1
dendritic spine 1 DRD1
perikaryon 1 TH
cytoplasmic vesicle 1 TH
nucleolus 3 GPRC5A, ITPR3, PLCZ1
Melanosome membrane 1 TH
Early endosome 1 AOC3
apical part of cell 1 ITPR3
Single-pass type II membrane protein 2 AOC3, DBH
vesicle 1 GPRC5A
postsynaptic membrane 2 DRD1, SLC6A3
Cytoplasm, perinuclear region 2 PLCZ1, TH
Membrane raft 1 SLC6A3
GABA-ergic synapse 1 DRD1
flotillin complex 1 SLC6A3
basement membrane 1 ACHE
sarcoplasmic reticulum 1 ITPR3
Cell projection, dendritic spine 1 DRD1
nuclear outer membrane 1 ITPR3
receptor complex 3 ADRB3, GPRC5A, ITPR3
Cell projection, neuron projection 1 SLC6A3
neuron projection 2 SLC6A3, TH
cilium 1 DRD1
non-motile cilium 1 DRD1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
Endomembrane system 1 TAAR1
endosome lumen 1 INS
microvillus 1 AOC3
[Isoform 1]: Endoplasmic reticulum membrane 1 PNMT
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 1 DRD1
side of membrane 1 ACHE
secretory granule lumen 2 DBH, INS
secretory granule membrane 2 DBH, ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
axon terminus 1 SLC6A3
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
platelet dense tubular network membrane 1 ITPR3
synaptic cleft 1 ACHE
[Isoform 1]: Cell membrane 1 ATRN
dopaminergic synapse 1 SLC6A3
Cytoplasmic vesicle, secretory vesicle membrane 2 DBH, ITPR3
[Isoform 2]: Endoplasmic reticulum membrane 1 PNMT
Cell projection, cilium membrane 1 DRD1
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
transport vesicle membrane 2 DBH, ITPR3
sperm head 1 PLCZ1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
G protein-coupled receptor complex 1 DRD1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Shuhao Wang, Yang Li, Xin Lin, Xiangjin Fu, Haiyan Zhong, Kangzi Ren, Cheng Liu, Wen Yao. Rapid Screening of Phenolic Compounds with Anti-Enteritis Activity from Camellia oleifera Oil Using a Smurf Drosophila Model and Molecular Docking Methods. Molecules (Basel, Switzerland). 2023 Dec; 29(1):. doi: 10.3390/molecules29010076. [PMID: 38202658]
  • Ping Cai, Yuanyuan Zhang, Mu Yang, Chenghao Zhang, Mingxia Li, Wei Xiao, Zhifeng Xu, Yongqiang Zhang. Target identification and acaricidal activity difference of amitraz and its metabolite DPMF in Tetranychus cinnabarinus (Boisduval). Pest management science. 2023 Apr; ?(?):. doi: 10.1002/ps.7500. [PMID: 37036086]
  • Gang Xu, Yuan-Yuan Zhang, Gui-Xiang Gu, Guo-Qing Yang, Gong-Yin Ye. Molecular and Pharmacological Characterization of β-Adrenergic-like Octopamine Receptors in the Endoparasitoid Cotesia chilonis (Hymenoptera: Braconidae). International journal of molecular sciences. 2022 Nov; 23(23):. doi: 10.3390/ijms232314513. [PMID: 36498840]
  • Yue Yang, Xingyu Ma, Long Zhang, Wenli Zhao, Xiaoguang Liu, Xiang Li, Mengfang Du, Shiheng An. Octopamine terminates sex pheromone biosynthesis by suppressing PBAN signal in moths. Insect molecular biology. 2022 10; 31(5):647-658. doi: 10.1111/imb.12793. [PMID: 35652818]
  • Dandan Liu, Xinxin Zhang, Fang Chiqin, Innocent Nyamwasa, Yazhong Cao, Jiao Yin, Shuai Zhang, Honglin Feng, Kebin Li. Octopamine modulates insect mating and Oviposition. Journal of chemical ecology. 2022 Aug; 48(7-8):628-640. doi: 10.1007/s10886-022-01366-2. [PMID: 35687218]
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  • Dahae Lee, Ji Hwan Lee, Byoung Ha Kim, Sanghyun Lee, Dong-Wook Kim, Ki Sung Kang. Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet. Nutrients. 2022 May; 14(10):. doi: 10.3390/nu14102164. [PMID: 35631305]
  • Sheraz Ahmad, Yu Chen, Jieyu Zhang, David Stanley, Qisheng Song, Linquan Ge. Octopamine signaling is involved in the female postmating state in Nilaparvata lugens Stål (Hemiptera: Delphacidae). Archives of insect biochemistry and physiology. 2021 Aug; 107(4):e21825. doi: 10.1002/arch.21825. [PMID: 34164848]
  • Li-Sha Zheng, Xiao-Qiang Liu, Ge-Ge Liu, Qian-Qiao Huang, Jin-Jun Wang, Hong-Bo Jiang. Knockdown of a β-Adrenergic-Like Octopamine Receptor Affects Locomotion and Reproduction of Tribolium castaneum. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147252. [PMID: 34298876]
  • Yicong Jia, Shan Jin, Kunkun Hu, Lei Geng, Caihong Han, Ruxue Kang, Yuxin Pang, Erjun Ling, Eng King Tan, Yufeng Pan, Wei Liu. Gut microbiome modulates Drosophila aggression through octopamine signaling. Nature communications. 2021 05; 12(1):2698. doi: 10.1038/s41467-021-23041-y. [PMID: 33976215]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Li Xu, Hong-Bo Jiang, Xiao-Feng Chen, Ying Xiong, Xue-Ping Lu, Yu-Xia Pei, Guy Smagghe, Jin-Jun Wang. How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles. International journal of molecular sciences. 2018 Mar; 19(3):. doi: 10.3390/ijms19030846. [PMID: 29538302]
  • Hailong Kong, Chuanlei Dong, Zhen Tian, Nian Mao, Cheng Wang, Yunxia Cheng, Lei Zhang, Xingfu Jiang, Lizhi Luo. Altered immunity in crowded Mythimna separata is mediated by octopamine and dopamine. Scientific reports. 2018 02; 8(1):3215. doi: 10.1038/s41598-018-20711-8. [PMID: 29453438]
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  • Shun-Fan Wu, Xiao-Min Jv, Jian Li, Guang-Jian Xu, Xiao-Yi Cai, Cong-Fen Gao. Pharmacological characterisation and functional roles for egg-laying of a β-adrenergic-like octopamine receptor in the brown planthopper Nilaparvata lugens. Insect biochemistry and molecular biology. 2017 08; 87(?):55-64. doi: 10.1016/j.ibmb.2017.06.008. [PMID: 28629966]
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