gamma-Carotene (BioDeep_00000004100)

 

Secondary id: BioDeep_00000412500

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E,19E)-3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaen-1-yl]-1,3,3-trimethylcyclohex-1-ene

化学式: C40H56 (536.4382)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 25.86%

分子结构信息

SMILES: CC(C)=CCC/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
InChI: InChI=1S/C40H56/c1-32(2)18-13-21-35(5)24-15-26-36(6)25-14-22-33(3)19-11-12-20-34(4)23-16-27-37(7)29-30-39-38(8)28-17-31-40(39,9)10/h11-12,14-16,18-20,22-27,29-30H,13,17,21,28,31H2,1-10H3/b12-11+,22-14+,23-16+,26-15+,30-29+,33-19+,34-20+,35-24+,36-25+,37-27+

描述信息

gamma-Carotene is a cyclic carotene obtained by the cyclization of lycopene. It is found in human serum and breast milk (PMID: 9164160). Carotenoids are isoprenoid molecules that are widespread in nature and are typically seen as pigments in fruits, flowers, birds, and crustacea. Animals are unable to synthesize carotenoids de novo and rely upon the diet as a source of these compounds. Over recent years there has been considerable interest in dietary carotenoids with respect to their potential in alleviating age-related diseases in humans. This attention has been mirrored by significant advances in cloning most of the carotenoid genes and in the genetic manipulation of crop plants with the intention of increasing levels in the diet. Studies have shown an inverse relationship between the consumption of certain fruits and vegetables and the risk of epithelial cancer. Since carotenoids are among the micronutrients found in cancer-preventive foods, detailed qualitative and quantitative determination of these compounds, particularly in fruits and vegetables and in human plasma, have recently become increasingly important (PMID: 1416048, 15003396).
Gamma-carotene, also known as γ-carotene, is a member of the class of compounds known as carotenes. Carotenes are a type of unsaturated hydrocarbons containing eight consecutive isoprene units. They are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Gamma-carotene can be found in a number of food items such as corn, yellow bell pepper, fig, and papaya, which makes gamma-carotene a potential biomarker for the consumption of these food products.

同义名列表

8 个代谢物同义名

2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E,19E)-3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaen-1-yl]-1,3,3-trimethylcyclohex-1-ene; all-trans-gamma-Carotene; all-trans-γ-Carotene; γ-Carotene; gamma-Carotene; γ-Carotene; g-Carotene; gamma-Carotene



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(7)

PlantCyc(4)

代谢反应

485 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(11)

WikiPathways(0)

Plant Reactome(228)

INOH(0)

PlantCyc(245)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

182 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CAD, NQO1, PARVA, PGP
Peripheral membrane protein 1 PLOD2
Endoplasmic reticulum membrane 2 PLOD1, PLOD2
Nucleus 3 CAD, NQO1, PARVA
cytosol 3 CAD, NQO1, PARVA
dendrite 1 NQO1
phagocytic vesicle 1 STX8
trans-Golgi network 1 STX8
nucleoplasm 1 CAD
Cell membrane 2 KIR2DP1, SLC6A8
lamellipodium 1 PARVA
Multi-pass membrane protein 1 SLC6A8
Synapse 1 NQO1
neuronal cell body 2 CAD, NQO1
Cytoplasm, cytosol 1 NQO1
endosome 1 STX8
plasma membrane 5 CAD, KIR2DP1, PARVA, SLC6A8, STX8
terminal bouton 1 CAD
Membrane 5 CAD, KIR2DP1, NQO1, SLC6A8, STX8
apical plasma membrane 1 SLC6A8
extracellular exosome 3 CAD, PLOD1, PLOD2
Lumenal side 1 PLOD2
endoplasmic reticulum 3 PLOD1, PLOD2, STX8
extracellular space 1 CRP
perinuclear region of cytoplasm 1 STX8
protein-containing complex 1 CAD
Single-pass type I membrane protein 1 KIR2DP1
Secreted 1 CRP
extracellular region 1 CRP
Single-pass membrane protein 1 STX8
actin cytoskeleton 2 CAD, PARVA
Z disc 1 PARVA
nucleolus 1 CAD
Early endosome 1 STX8
recycling endosome 1 STX8
vesicle 1 STX8
Apical cell membrane 1 SLC6A8
Cell junction, focal adhesion 1 PARVA
Cytoplasm, cytoskeleton 2 CAD, PARVA
focal adhesion 1 PARVA
myofibril 1 CAD
Late endosome 1 STX8
chromatin 1 CAD
cell projection 1 CAD
cytoskeleton 1 CAD
Endomembrane system 1 STX8
Cytoplasm, myofibril 1 CAD
Cytoplasm, myofibril, sarcomere, Z line 1 PARVA
stress fiber 1 CAD
SNARE complex 1 STX8
nuclear matrix 1 CAD
actin cap 1 CAD
rough endoplasmic reticulum membrane 2 PLOD1, PLOD2
Single-pass type IV membrane protein 1 STX8
Cytoplasm, cytoskeleton, stress fiber 1 CAD
Rough endoplasmic reticulum 1 PLOD2
catalytic complex 1 PLOD1


文献列表

  • M Varzakakou, T Roukas. Identification of carotenoids produced from cheese whey by Blakeslea trispora in submerged fermentation. Preparative biochemistry & biotechnology. 2010; 40(1):76-82. doi: 10.1080/10826060903400666. [PMID: 20024797]
  • Luciana Y Tomita, Lana C Almeida, Cecília Roteli-Martins, Vania D'Almeida, Marly A Cardoso. Dietary predictors of serum total carotene in low-income women living in São Paulo, south-east Brazil. Public health nutrition. 2009 Nov; 12(11):2133-42. doi: 10.1017/s1368980009005321. [PMID: 19335942]
  • Marja-Leena Silaste, Georg Alfthan, Antti Aro, Y Antero Kesäniemi, Sohvi Hörkkö. Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation. The British journal of nutrition. 2007 Dec; 98(6):1251-8. doi: 10.1017/s0007114507787445. [PMID: 17617941]
  • David Ruiz, José Egea, Francisco A Tomás-Barberán, María I Gil. Carotenoids from new apricot (Prunus armeniaca L.) varieties and their relationship with flesh and skin color. Journal of agricultural and food chemistry. 2005 Aug; 53(16):6368-74. doi: 10.1021/jf0480703. [PMID: 16076120]
  • L Tao, S Picataggio, P E Rouvière, Q Cheng. Asymmetrically acting lycopene beta-cyclases (CrtLm) from non-photosynthetic bacteria. Molecular genetics and genomics : MGG. 2004 Mar; 271(2):180-8. doi: 10.1007/s00438-003-0969-1. [PMID: 14740205]
  • I Bergheim, A Parlesak, C Dierks, J C Bode, C Bode. Nutritional deficiencies in German middle-class male alcohol consumers: relation to dietary intake and severity of liver disease. European journal of clinical nutrition. 2003 Mar; 57(3):431-8. doi: 10.1038/sj.ejcn.1601557. [PMID: 12627180]
  • Frederick Khachik, Lorena Carvalho, Paul S Bernstein, Garth J Muir, Da-You Zhao, Nikita B Katz. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Experimental biology and medicine (Maywood, N.J.). 2002 Nov; 227(10):845-51. doi: 10.1177/153537020222701002. [PMID: 12424324]
  • Paolo Davoli, Roland W S Weber. Identification and quantification of carotenoid pigments in aeciospores of the daisy rust fungus, Puccinia distincta. Phytochemistry. 2002 Jun; 60(3):309-13. doi: 10.1016/s0031-9422(02)00120-6. [PMID: 12031451]
  • Mahmoud Raeini-Sarjaz, Fady Y Ntanios, Catherine A Vanstone, Peter J H Jones. No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet. Metabolism: clinical and experimental. 2002 May; 51(5):652-6. doi: 10.1053/meta.2002.32021. [PMID: 11979401]
  • Dalal Asker, Tarek Awad, Yoshiyuki Ohta. Lipids of Haloferax alexandrinus strain TM(T): an extremely halophilic canthaxanthin-producing archaeon. Journal of bioscience and bioengineering. 2002; 93(1):37-43. doi: . [PMID: 16233162]
  • S Takaichi, T Maoka, M Yamada, K Matsuura, Y Haikawa, S Hanada. Absence of carotenes and presence of a tertiary methoxy group in a carotenoid from a thermophilic filamentous photosynthetic bacterium Roseiflexus castenholzii. Plant & cell physiology. 2001 Dec; 42(12):1355-62. doi: 10.1093/pcp/pce172. [PMID: 11773528]