clofibrate (BioDeep_00000409844)
Main id: BioDeep_00000001936
代谢物信息卡片
clofibrate
化学式: C12H15ClO3 (242.070967)
中文名称: 氯贝特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(OC1=CC=C(Cl)C=C1)C(OCC)=O
InChI: InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AB - Fibrates
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D009676 - Noxae > D000963 - Antimetabolites
CONFIDENCE standard compound; INTERNAL_ID 2719
Clofibrate is an agonist of PPAR, with EC50s of 50 μM, ～500 μM for murine PPARα and PPARγ, and 55 μM, ～500 μM for human PPARα and PPARγ, respectively.
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Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Haitao Liu, Panpan Zhang, Xiaoxiao Ge, Qiong Wu, Chuchu Han, Linyang Zhang, Yuxin Hua, Yuxuan Zhang, Jiping Liu, Yongheng Shi, Bin Wang, Xiaoping Wang, Wei Wang, Yi Jiang, Huawei Zhang, Chong Deng, Yundong Xie, Ying Liu, Shipeng He. Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect.
Bioorganic & medicinal chemistry letters.
2022 09; 72(?):128844. doi:
10.1016/j.bmcl.2022.128844. [PMID: 35697180] - Emily Marques, Marisa Pfohl, Wei Wei, Giuseppe Tarantola, Lucie Ford, Ogochukwu Amaeze, Jessica Alesio, Sangwoo Ryu, Xuelian Jia, Hao Zhu, Geoffrey D Bothun, Angela Slitt. Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes.
Toxicology and applied pharmacology.
2022 05; 442(?):115991. doi:
10.1016/j.taap.2022.115991. [PMID: 35337807] - Yundong Xie, Jiping Liu, Yongheng Shi, Bin Wang, Xiaoping Wang, Wei Wang, Meng Sun, Xinya Xu, Haihui Jiang, Min Guo, Yiyi He, Cuicui Ren, Lifei Cheng. The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity.
Bioorganic & medicinal chemistry letters.
2021 07; 44(?):128121. doi:
10.1016/j.bmcl.2021.128121. [PMID: 34015506] - Tianfeng Wan, Zilin Chen. Covalent organic nanospheres modified magnetic nanoparticles for extraction of blood lipid regulators in water samples.
Journal of separation science.
2021 Jun; 44(11):2301-2309. doi:
10.1002/jssc.202001283. [PMID: 33783965] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment.
European journal of medicinal chemistry.
2020 Jul; 197(?):112311. doi:
10.1016/j.ejmech.2020.112311. [PMID: 32339855] - Florencia Heinecke, María Belén Mazzucco, Daiana Fornes, Sabrina Roberti, Alicia Jawerbaum, Verónica White. The offspring from rats fed a fatty diet display impairments in the activation of liver peroxisome proliferator activated receptor alpha and features of fatty liver disease.
Molecular and cellular endocrinology.
2020 07; 511(?):110818. doi:
10.1016/j.mce.2020.110818. [PMID: 32298755] - Yih-Ting Chen, Chang-Chyi Jenq, Cheng-Kai Hsu, Yi-Ching Yu, Chih-Hsiang Chang, Pei-Chun Fan, Heng-Chih Pan, I-Wen Wu, Wen-Jin Cherng, Yung-Chang Chen. Acute kidney disease and acute kidney injury biomarkers in coronary care unit patients.
BMC nephrology.
2020 06; 21(1):207. doi:
10.1186/s12882-020-01872-z. [PMID: 32487168] - Xi Lin, Brandon Pike, Jinan Zhao, Yu Fan, Yongwen Zhu, Yong Zhang, Feng Wang, Jack Odle. Effects of Dietary Anaplerotic and Ketogenic Energy Sources on Renal Fatty Acid Oxidation Induced by Clofibrate in Suckling Neonatal Pigs.
International journal of molecular sciences.
2020 Jan; 21(3):. doi:
10.3390/ijms21030726. [PMID: 31979102] - Yumiko Mizukawa, Yoko Amagase, Tetsuro Urushidani. Extraction of peroxisome proliferator-activated receptor α agonist-induced lipid metabolism-related and unrelated genes in rat liver and analysis of their genomic location.
The Journal of toxicological sciences.
2020; 45(8):449-473. doi:
10.2131/jts.45.449. [PMID: 32741897] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Bioorganic & medicinal chemistry.
2019 08; 27(15):3307-3318. doi:
10.1016/j.bmc.2019.06.012. [PMID: 31204228] - Yun-Dong Xie, Zi-Zhang Chen, Li-Hua Shao, Qiu-Tang Wang, Na Li, Wen-Fang Lu, Yan-Hong Xu, Yu-Qiong Gao, Li-Ying Guo, Hao-Le Liu, Yi-Ping Li, Guang-De Yang, Xiao-Li Bian. A new multifunctional hydroxytyrosol-clofibrate with hypolipidemic, antioxidant, and hepatoprotective effects.
Bioorganic & medicinal chemistry letters.
2018 10; 28(18):3119-3122. doi:
10.1016/j.bmcl.2018.06.010. [PMID: 30119959] - Tânia Vieira Madureira, Fernanda Malhão, Tiago Simões, Ivone Pinheiro, Célia Lopes, José F Gonçalves, Ralph Urbatzka, L Filipe C Castro, Marco F L Lemos, Eduardo Rocha. Sex-steroids and hypolipidemic chemicals impacts on brown trout lipid and peroxisome signaling - Molecular, biochemical and morphological insights.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2018 Oct; 212(?):1-17. doi:
10.1016/j.cbpc.2018.06.001. [PMID: 29885532] - Masoud Delashoub, Mojtaba Ziaee, Arash Khorrami, Seyed Mahdi Banan-Khojasteh. Comparison of the Effects of Clofibrate and Silafibrate on Sperm Parameters Quality and Sex Hormones in Male Rats.
Urology journal.
2018 03; 15(2):38-43. doi:
10.22037/uj.v0i0.3954. [PMID: 29299890] - Sandra Chuppa, Mingyu Liang, Pengyuan Liu, Yong Liu, Marc C Casati, Allen W Cowley, Leah Patullo, Alison J Kriegel. MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4.
Kidney international.
2018 02; 93(2):375-389. doi:
10.1016/j.kint.2017.05.014. [PMID: 28760335] - Youcai Zhang, Andrew J Lickteig, Iván L Csanaky, Curtis D Klaassen. Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.
Toxicology and applied pharmacology.
2018 01; 338(?):112-123. doi:
10.1016/j.taap.2017.11.014. [PMID: 29175453] - Yonghui He, Imad Khan, Xiumei Bai, Jack Odle, Lin Xi. Activation of PPARα by Oral Clofibrate Increases Renal Fatty Acid Oxidation in Developing Pigs.
International journal of molecular sciences.
2017 Dec; 18(12):. doi:
10.3390/ijms18122663. [PMID: 29292738] - Prasad Kumar, B Adhisivam, B Vishnu Bhat. Clofibrate as an Adjunct to Phototherapy for Unconjugated Hyperbilirubinemia in Term Neonates.
Indian journal of pediatrics.
2017 Oct; 84(10):763-767. doi:
10.1007/s12098-017-2360-y. [PMID: 28512725] - Ananda B Venkatachalam, Manoj B Parmar, Jonathan M Wright. Evolution of the duplicated intracellular lipid-binding protein genes of teleost fishes.
Molecular genetics and genomics : MGG.
2017 Aug; 292(4):699-727. doi:
10.1007/s00438-017-1313-5. [PMID: 28389698] - Zhiying Ji, Matthew J LeBaron. Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.
Environmental and molecular mutagenesis.
2017 08; 58(7):485-493. doi:
10.1002/em.22109. [PMID: 28714084] - Pierre Maliver, Matthias Festag, Moritz Bennecke, Francois Christen, Balázs Bánfai, Barbara Lenz, Michael Winter. Assessment of Preclinical Liver and Skeletal Muscle Biomarkers Following Clofibrate Administration in Wistar Rats.
Toxicologic pathology.
2017 06; 45(4):506-525. doi:
10.1177/0192623317707271. [PMID: 28485676] - Vijay R More, Christopher R Campos, Rebecca A Evans, Keith D Oliver, Gary Ny Chan, David S Miller, Ronald E Cannon. PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2017 Apr; 37(4):1199-1212. doi:
10.1177/0271678x16650216. [PMID: 27193034] - Matthew Kochem, Paul A S Breslin. Clofibrate inhibits the umami-savory taste of glutamate.
PloS one.
2017; 12(3):e0172534. doi:
10.1371/journal.pone.0172534. [PMID: 28248971] - Yufei Chen, Wei Li, Guqi Wang, Frank J Burczynski. Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2017; 20(0):239-251. doi:
10.18433/j3ts70. [PMID: 28810950] - Matthew Kochem, Paul A S Breslin. Lipid-Lowering Pharmaceutical Clofibrate Inhibits Human Sweet Taste.
Chemical senses.
2017 01; 42(1):79-83. doi:
10.1093/chemse/bjw104. [PMID: 27742692] - Yoshikazu Muroya, Osamu Ito. Effect of clofibrate on fatty acid metabolism in the kidney of puromycin-induced nephrotic rats.
Clinical and experimental nephrology.
2016 Dec; 20(6):862-870. doi:
10.1007/s10157-016-1253-0. [PMID: 26949064] - Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, Elizabeth Soria-Castro, Juan C Torres-Narváez, Francisca Pérez-Severiano, María Sánchez-Aguilar, Margarita Ramírez-Ortega, Luz G Cervantes-Pérez, Gustavo S Pastelín-Hernández, Víctor H Oidor-Chan, Gabriela Zarco-Olvera, Alicia Sánchez-Mendoza. Peroxisome proliferator-activated receptor-α stimulation by clofibrate favors an antioxidant and vasodilator environment in a stressed left ventricle.
Pharmacological reports : PR.
2016 Aug; 68(4):692-702. doi:
10.1016/j.pharep.2016.03.002. [PMID: 27110876] - Laia Tolosa, M José Gómez-Lechón, Nuria Jiménez, David Hervás, Ramiro Jover, M Teresa Donato. Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.
Toxicology and applied pharmacology.
2016 07; 302(?):1-9. doi:
10.1016/j.taap.2016.04.007. [PMID: 27089845] - Elzbieta Sucajtys-Szulc, Marek Szolkiewicz, Julian Swierczynski, Boleslaw Rutkowski. Up-regulation of Hnf1α gene expression in the liver of rats with experimentally induced chronic renal failure - A possible link between circulating PCSK9 and triacylglycerol concentrations.
Atherosclerosis.
2016 May; 248(?):17-26. doi:
10.1016/j.atherosclerosis.2016.02.027. [PMID: 26978583] - Karen Bodié, Wayne R Buck, Julia Pieh, Michael J Liguori, Andreas Popp. Biomarker evaluation of skeletal muscle toxicity following clofibrate administration in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2016 May; 68(5):289-99. doi:
10.1016/j.etp.2016.03.001. [PMID: 27020044] - Yoshiji Asaoka, Yuko Togashi, Mayu Mutsuga, Naoko Imura, Tomoya Miyoshi, Yohei Miyamoto. Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2016 Apr; 68(4):233-9. doi:
10.1016/j.etp.2015.12.005. [PMID: 26776450] - Karthic Chandran, Sudeshna Goswami, Neelam Sharma-Walia. Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer.
Oncotarget.
2016 Mar; 7(13):15577-99. doi:
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The Journal of toxicological sciences.
2015 Dec; 40(6):895-900. doi:
10.2131/jts.40.895. [PMID: 26558470] - Karen R Sando, Michelle Knight. Nonstatin therapies for management of dyslipidemia: a review.
Clinical therapeutics.
2015 Oct; 37(10):2153-79. doi:
10.1016/j.clinthera.2015.09.001. [PMID: 26412799] - Xiaoze Guo, Xu-Fang Liang, Liu Fang, Xiaochen Yuan, Yi Zhou, Shan He, Dan Shen. Effects of lipid-lowering pharmaceutical clofibrate on lipid and lipoprotein metabolism of grass carp (Ctenopharyngodon idellal Val.) fed with the high non-protein energy diets.
Fish physiology and biochemistry.
2015 Apr; 41(2):331-43. doi:
10.1007/s10695-014-9986-8. [PMID: 25213789] - Xiumei Bai, Xi Lin, Josephine Drayton, Yulan Liu, Cheng Ji, Jack Odle. Clofibrate increases long-chain fatty acid oxidation by neonatal pigs.
The Journal of nutrition.
2014 Nov; 144(11):1688-93. doi:
10.3945/jn.114.193169. [PMID: 25332467] - I Sovadinová, A Liedtke, K Schirmer. Effects of clofibric acid alone and in combination with 17β-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout.
Toxicology in vitro : an international journal published in association with BIBRA.
2014 Sep; 28(6):1106-16. doi:
10.1016/j.tiv.2014.05.002. [PMID: 24880017] - Daniel Plano, Shantu Amin, Arun K Sharma. Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors.
Journal of medicinal chemistry.
2014 Jul; 57(13):5509-24. doi:
10.1021/jm4011687. [PMID: 24471412] - Sara Nafisi, Reza Heidari, Mohammad Ghaffarzadeh, Mojtaba Ziaee, Hossein Hamzeiy, Alireza Garjani, Mohammad Ali Eghbal. Cytoprotective effects of silafibrate, a newly-synthesised siliconated derivative of clofibrate, against acetaminophen-induced toxicity in isolated rat hepatocytes.
Arhiv za higijenu rada i toksikologiju.
2014 Jun; 65(2):169-78. doi:
10.2478/10004-1254-65-2014-2434. [PMID: 24706421] - Zivar Yousefipour, Mohammad Newaz. PPARα ligand clofibrate ameliorates blood pressure and vascular reactivity in spontaneously hypertensive rats.
Acta pharmacologica Sinica.
2014 Apr; 35(4):476-82. doi:
10.1038/aps.2013.193. [PMID: 24562305] - Mototsugu Fukaya, Hajime Kimata. Topical clofibrate improves symptoms in patients with atopic dermatitis and reduces serum TARC levels: a randomized, double-blind, placebo-controlled pilot study.
Journal of drugs in dermatology : JDD.
2014 Mar; 13(3):259-63. doi:
NULL. [PMID: 24595568] - Daniel Patschan, Katrin Schwarze, Elvira Henze, Susann Patschan, Roman Scheidemann, Gerhard Anton Müller. Fibrate treatment of eEOCs in murine AKI.
Journal of nephrology.
2014 Feb; 27(1):37-44. doi:
10.1007/s40620-013-0027-y. [PMID: 24430761] - S Kim, N Kiyosawa, L D Burgoon, C C Chang, T R Zacharewski. PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.
The Journal of steroid biochemistry and molecular biology.
2013 Nov; 138(?):236-47. doi:
10.1016/j.jsbmb.2013.06.004. [PMID: 23811191] - Gabriel Navarrete-Vázquez, Alfredo Alaniz-Palacios, Sergio Hidalgo-Figueroa, Cristina González-Acevedo, Gabriela Ávila-Villarreal, Samuel Estrada-Soto, Scott P Webster, José L Medina-Franco, Fabian López-Vallejo, Jorge Guerrero-Álvarez, Hugo Tlahuext. Discovery, synthesis and in combo studies of a tetrazole analogue of clofibric acid as a potent hypoglycemic agent.
Bioorganic & medicinal chemistry letters.
2013 Jun; 23(11):3244-7. doi:
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Cellular signalling.
2013 May; 25(5):1252-63. doi:
10.1016/j.cellsig.2013.01.021. [PMID: 23385087] - Hisao Nemoto, Masaki Kamiya, Aki Nakamoto, Tsuyoshi Matsushita, Kosuke Matsumura, Hatsuhiko Hattori, Tomoyuki Kawamura, Chiaki Taoka, Shinji Abe, Keisuke Ishizawa, Licht Miyamoto, Koichiro Tsuchiya. Synthesis of highly water-soluble fibrate derivatives via BGLation.
Bioorganic & medicinal chemistry letters.
2012 Oct; 22(20):6425-8. doi:
10.1016/j.bmcl.2012.08.057. [PMID: 22975299] - Luz Ibarra-Lara, Enrique Hong, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Francisca Pérez-Severiano, Leonardo Del Valle-Mondragón, Luz Graciela Cervantes-Pérez, Margarita Ramírez-Ortega, Gustavo S Pastelín-Hernández, Alicia Sánchez-Mendoza. Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia.
Journal of cardiovascular pharmacology.
2012 Oct; 60(4):323-34. doi:
10.1097/fjc.0b013e31826216ed. [PMID: 22691880] - Raimondo Lazzara, Denise Fernandes, Melissa Faria, Jordi F López, Romà Tauler, Cinta Porte. Changes in lipid content and fatty acid composition along the reproductive cycle of the freshwater mussel Dreissena polymorpha: its modulation by clofibrate exposure.
The Science of the total environment.
2012 Aug; 432(?):195-201. doi:
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BMC evolutionary biology.
2012 Jul; 12(?):112. doi:
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European journal of pharmacology.
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Journal of advanced pharmaceutical technology & research.
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
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European journal of pharmacology.
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Antimicrobial agents and chemotherapy.
2012 Jun; 56(6):2814-8. doi:
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JPEN. Journal of parenteral and enteral nutrition.
2012 May; 36(3):337-43. doi:
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The Tohoku journal of experimental medicine.
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Journal of neuroinflammation.
2012 Apr; 9(?):81. doi:
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Bioorganic & medicinal chemistry letters.
2012 Apr; 22(8):2954-8. doi:
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Molecular pharmacology.
2012 Apr; 81(4):598-609. doi:
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Environmental technology.
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BMC veterinary research.
2012 Mar; 8(?):28. doi:
10.1186/1746-6148-8-28. [PMID: 22417075] - Shan He, Xu-Fang Liang, Chun-Mei Qu, Wei Huang, Dan Shen, Wen-Bing Zhang, Kang-Sen Mai. Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2012 Mar; 155(2):381-8. doi:
10.1016/j.cbpc.2011.10.008. [PMID: 22079418] - Biswas Gopa, Jagatkumar Bhatt, Kovur G Hemavathi. A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin.
Indian journal of pharmacology.
2012 Mar; 44(2):238-42. doi:
10.4103/0253-7613.93857. [PMID: 22529483] - Kan Nakagawa, Naoki Tanaka, Miwa Morita, Atsushi Sugioka, Shin-ichi Miyagawa, Frank J Gonzalez, Toshifumi Aoyama. PPARα is down-regulated following liver transplantation in mice.
Journal of hepatology.
2012 Mar; 56(3):586-94. doi:
10.1016/j.jhep.2011.08.021. [PMID: 22037025] - Razieh Fallah, Zia Islami, Saeid Reza Lotfi. Single dose of 50 mg/kg clofibrate in jaundice of healthy term neonates: randomised clinical trial of efficacy and safety.
Indian journal of pediatrics.
2012 Feb; 79(2):194-7. doi:
10.1007/s12098-011-0531-9. [PMID: 21785863] - Takefumi Kimura, Takero Nakajima, Yuji Kamijo, Naoki Tanaka, Lixuan Wang, Atsushi Hara, Eiko Sugiyama, Eiji Tanaka, Frank J Gonzalez, Toshifumi Aoyama. Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice.
PPAR research.
2012; 2012(?):174932. doi:
10.1155/2012/174932. [PMID: 22645601] - Rodrigo d'Eça Neves, Marcello Alberton Herdt, Felipe Barbieri Wohlgemuth, Jorge Bins Ely, Zulmar Antonio Accioli de Vasconcellos, José Caldeira Ferreira Bastos, Armando José d'Acampora. Possible migration and histopathological analysis of injections of polymethylmethacrylate in wistar rats.
ISRN dermatology.
2012; 2012(?):609158. doi:
10.5402/2012/609158. [PMID: 22701181] - Jorge A López-Velázquez, Luis D Carrillo-Córdova, Norberto C Chávez-Tapia, Misael Uribe, Nahum Méndez-Sánchez. Nuclear receptors in nonalcoholic Fatty liver disease.
Journal of lipids.
2012; 2012(?):139875. doi:
10.1155/2012/139875. [PMID: 22187655] - Malin Almgren, Richard Atkinson, Jia He, Agneta Hilding, Emilia Hagman, Alicja Wolk, Anders Thorell, Claude Marcus, Erik Näslund, Claes-Göran Östenson, Martin Schalling, Catharina Lavebratt. Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA.
PloS one.
2012; 7(7):e41652. doi:
10.1371/journal.pone.0041652. [PMID: 22848557] - Morteza Habibi, Abolfazl Mahyar, Parviz Ayazi, Farzad Ahmadabadi, Amir Javadi. The effect of clofibrate on hyperbilirubinemia of term neonates.
Acta medica Iranica.
2012; 50(1):21-5. doi:
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PloS one.
2012; 7(4):e35356. doi:
10.1371/journal.pone.0035356. [PMID: 22530008] - Patricia Illoldi-Rangel, Michael Ciarleglio, Leia Sheinvar, Miguel Linaje, Victor Sánchez-Cordero, Sahotra Sarkar. Opuntia in México: identifying priority areas for conserving biodiversity in a multi-use landscape.
PloS one.
2012; 7(5):e36650. doi:
10.1371/journal.pone.0036650. [PMID: 22606279] - Koji Hashimoto, Yuji Kamijo, Takero Nakajima, Makoto Harada, Makoto Higuchi, Takashi Ehara, Hidekazu Shigematsu, Toshifumi Aoyama. PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling.
PPAR research.
2012; 2012(?):976089. doi:
10.1155/2012/976089. [PMID: 22675338] - Nithi Asavapanumas, Suticha Kittayaruksakul, Paranee Meetam, Chatchai Muanprasat, Varanuj Chatsudthipong, Sunhapas Soodvilai. Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways.
Drug metabolism and pharmacokinetics.
2012; 27(5):513-9. doi:
10.2133/dmpk.dmpk-11-rg-123. [PMID: 22473497] - Antonio Belda, Victoriano Peiró, Eduardo Seva. The Relationship between Plants Used to Sustain Finches (Fringillidae) and Uses for Human Medicine in Southeast Spain.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):360913. doi:
10.1155/2012/360913. [PMID: 22611428] - Fernanda M Cerqueira, Laura I Brandizzi, Fernanda M Cunha, Francisco R M Laurindo, Alicia J Kowaltowski. Serum from calorie-restricted rats activates vascular cell eNOS through enhanced insulin signaling mediated by adiponectin.
PloS one.
2012; 7(2):e31155. doi:
10.1371/journal.pone.0031155. [PMID: 22319612] - András Szarka, Bálint Tomasskovics, Gábor Bánhegyi. The ascorbate-glutathione-α-tocopherol triad in abiotic stress response.
International journal of molecular sciences.
2012; 13(4):4458-4483. doi:
10.3390/ijms13044458. [PMID: 22605990] - M C Thomas, K A Jandeleit-Dahm, C Tikellis. The renoprotective actions of peroxisome proliferator-activated receptors agonists in diabetes.
PPAR research.
2012; 2012(?):456529. doi:
10.1155/2012/456529. [PMID: 22448165] - Tao Xiong, Dapeng Chen, Zhoujin Duan, Yi Qu, Dezhi Mu. Clofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review.
Indian pediatrics.
2012 Jan; 49(1):35-41. doi:
10.1007/s13312-012-0012-x. [PMID: 22318100] - M Khazaei, E Salehi, B Rashidi. Pan-PPAR Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats.
International journal of peptides.
2012; 2012(?):637212. doi:
10.1155/2012/637212. [PMID: 22701496] - David A Rudnick, Nicholas O Davidson. Functional Relationships between Lipid Metabolism and Liver Regeneration.
International journal of hepatology.
2012; 2012(?):549241. doi:
10.1155/2012/549241. [PMID: 22319652] - Gyeong-Min Do, Eun-Young Kwon, Tae-Youl Ha, Yong Bok Park, Hye-Jin Kim, Seon-Min Jeon, Mi-Kyung Lee, Myung-Sook Choi. Tannic acid is more effective than clofibrate for the elevation of hepatic β-oxidation and the inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and aortic lesion formation in apo E-deficient mice.
The British journal of nutrition.
2011 Dec; 106(12):1855-63. doi:
10.1017/s000711451100256x. [PMID: 21736774] - Kuniyasu Soda. The mechanisms by which polyamines accelerate tumor spread.
Journal of experimental & clinical cancer research : CR.
2011 Oct; 30(?):95. doi:
10.1186/1756-9966-30-95. [PMID: 21988863] - Alaa A-M Abdel-Aziz, Adel S El-Azab, Sabry M Attia, Abdulrahman M Al-Obaid, Mohamed A Al-Omar, Hussein I El-Subbagh. Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents.
European journal of medicinal chemistry.
2011 Sep; 46(9):4324-9. doi:
10.1016/j.ejmech.2011.07.002. [PMID: 21783284] - Giselle Guerra, Gaetano Ciancio, Jeffrey J Gaynor, Alberto Zarak, Randolph Brown, Lois Hanson, Junichiro Sageshima, David Roth, Linda Chen, Warren Kupin, Lissett Tueros, Phillip Ruiz, Alan S Livingstone, George W Burke. Randomized trial of immunosuppressive regimens in renal transplantation.
Journal of the American Society of Nephrology : JASN.
2011 Sep; 22(9):1758-68. doi:
10.1681/asn.2011010006. [PMID: 21807891] - Silvia Savastano, Carolina Di Somma, Genoveffa Pizza, Annalba De Rosa, Valeria Nedi, Annalisa Rossi, Francesco Orio, Gaetano Lombardi, Annamaria Colao, Giovanni Tarantino. Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females.
Journal of translational medicine.
2011 Aug; 9(?):136. doi:
10.1186/1479-5876-9-136. [PMID: 21846339] - Sungjin Chung, Cheol Whee Park. Role of Peroxisome Proliferator-Activated Receptor α in Diabetic Nephropathy.
Diabetes & metabolism journal.
2011 Aug; 35(4):327-36. doi:
10.4093/dmj.2011.35.4.327. [PMID: 21977451] - Tamas Varga, Zsolt Czimmerer, Laszlo Nagy. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
Biochimica et biophysica acta.
2011 Aug; 1812(8):1007-22. doi:
10.1016/j.bbadis.2011.02.014. [PMID: 21382489] - Nora Martínez, Melisa Kurtz, Evangelina Capobianco, Romina Higa, Verónica White, Alicia Jawerbaum. PPARα agonists regulate lipid metabolism and nitric oxide production and prevent placental overgrowth in term placentas from diabetic rats.
Journal of molecular endocrinology.
2011 Aug; 47(1):1-12. doi:
10.1530/jme-10-0173. [PMID: 21502283] - Masaki Kobayashi, Keisuke Gouda, Ikumi Chisaki, Manami Ochiai, Shirou Itagaki, Ken Iseki. Regulation mechanism of ABCA1 expression by statins in hepatocytes.
European journal of pharmacology.
2011 Jul; 662(1-3):9-14. doi:
10.1016/j.ejphar.2011.04.043. [PMID: 21554872] - Guojing Liu, Weichao Wang, Hui Xie, Yongzhe Che, Jun Xue, Youzhen Wu, Qingwen Zhou, Deling Kong. Improved neuronal survival of focal ischemia after delipid extracorporeal lipoprotein treatment in hyperlipidemic rabbits.
Artificial organs.
2011 Jul; 35(7):E145-54. doi:
10.1111/j.1525-1594.2011.01249.x. [PMID: 21749409] - Minoo M-Shirazi, Mohammad Farhadi, Maryam Jalessi, Seyyed-Kamran Kamrava, Ashkan Heshmatzade Behzadi, Behin Arami. Prevalence of dyslipidemia among Iranian patients with idiopathic tinnitus.
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.
2011 Jul; 16(7):890-6. doi:
NULL. [PMID: 22279456] - M John Chapman, Henry N Ginsberg, Pierre Amarenco, Felicita Andreotti, Jan Borén, Alberico L Catapano, Olivier S Descamps, Edward Fisher, Petri T Kovanen, Jan Albert Kuivenhoven, Philippe Lesnik, Luis Masana, Børge G Nordestgaard, Kausik K Ray, Zeljko Reiner, Marja-Riitta Taskinen, Lale Tokgözoglu, Anne Tybjærg-Hansen, Gerald F Watts. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management.
European heart journal.
2011 Jun; 32(11):1345-61. doi:
10.1093/eurheartj/ehr112. [PMID: 21531743] - Mohar Chattopadhyay, Elzbieta S Selinger, Lisa M Ballou, Richard Z Lin. Ablation of PI3K p110-α prevents high-fat diet-induced liver steatosis.
Diabetes.
2011 May; 60(5):1483-92. doi:
10.2337/db10-0869. [PMID: 21464441] - Kyoko Takahashi, Yuji Kamijo, Kazuhiko Hora, Koji Hashimoto, Makoto Higuchi, Takero Nakajima, Takashi Ehara, Hidekazu Shigematsu, Frank J Gonzalez, Toshifumi Aoyama. Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration.
Toxicology and applied pharmacology.
2011 May; 252(3):237-49. doi:
10.1016/j.taap.2011.02.012. [PMID: 21338618] - Che-Yi Chao, Mei-Chin Yin, Ching-Jang Huang. Wild bitter gourd extract up-regulates mRNA expression of PPARα, PPARγ and their target genes in C57BL/6J mice.
Journal of ethnopharmacology.
2011 Apr; 135(1):156-61. doi:
10.1016/j.jep.2011.03.001. [PMID: 21392566] - Céline Meriaux, Karim Arafah, Aurélie Tasiemski, Maxence Wisztorski, Jocelyne Bruand, Céline Boidin-Wichlacz, Annie Desmons, Delphine Debois, Olivier Laprévote, Alain Brunelle, Terry Gaasterland, Eduardo Macagno, Isabelle Fournier, Michel Salzet. Multiple changes in peptide and lipid expression associated with regeneration in the nervous system of the medicinal leech.
PloS one.
2011 Apr; 6(4):e18359. doi:
10.1371/journal.pone.0018359. [PMID: 21526169] - Kenneth R Feingold, Yan J Jiang. The mechanisms by which lipids coordinately regulate the formation of the protein and lipid domains of the stratum corneum: Role of fatty acids, oxysterols, cholesterol sulfate and ceramides as signaling molecules.
Dermato-endocrinology.
2011 Apr; 3(2):113-8. doi:
10.4161/derm.3.2.14996. [PMID: 21695021]