Dicyclohexylamine (BioDeep_00000004094)

 

Secondary id: BioDeep_00001871715

human metabolite blood metabolite


代谢物信息卡片


Cyclohexanamine, N-cyclohexyl-, sulfate (1:1)

化学式: C12H23N (181.1830398)
中文名称: 二环己胺(DCHA), 二环己胺
谱图信息: 最多检出来源 Homo sapiens(blood) 1.78%

分子结构信息

SMILES: C1CCC(CC1)NC1CCCCC1
InChI: InChI=1S/C12H23N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h11-13H,1-10H2

描述信息

INTERNAL_ID 2356; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2356
D004791 - Enzyme Inhibitors

同义名列表

13 个代谢物同义名

Cyclohexanamine, N-cyclohexyl-, sulfate (1:1); Dicyclohexylamine phosphate (3:1); Dicyclohexylamine sulfate (1:1); Dicyclohexylamine hydrochloride; N-Cyclohexylcyclohexanamine; Dicyclohexylamine sulfate; Dicyclohexylamine nitrite; Dicyclohexylamine nitrate; Dicyclohexylammonium; DICYCLOHEXYLAMINE; dicha; Dicyclohexylamine; Dicyclohexylamine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ting Zhou, Pei Wang, Zhenxin Gu, Meng Ma, Runqiang Yang. Spermidine improves antioxidant activity and energy metabolism in mung bean sprouts. Food chemistry. 2020 Mar; 309(?):125759. doi: 10.1016/j.foodchem.2019.125759. [PMID: 31706672]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ting Zhou, Pei Wang, Runqiang Yang, Zhenxin Gu. Polyamines regulating phytic acid degradation in mung bean sprouts. Journal of the science of food and agriculture. 2018 Jul; 98(9):3299-3308. doi: 10.1002/jsfa.8833. [PMID: 29239473]
  • Dandan Peng, Xiaojuan Wang, Zhou Li, Yan Zhang, Yan Peng, Yaping Li, Xiaoshuang He, Xinquan Zhang, Xiao Ma, Linkai Huang, Yanhong Yan. NO is involved in spermidine-induced drought tolerance in white clover via activation of antioxidant enzymes and genes. Protoplasma. 2016 Sep; 253(5):1243-54. doi: 10.1007/s00709-015-0880-8. [PMID: 26338203]
  • Elisabetta Teodori, Silvia Dei, Elisa Floriddia, Maria Grazia Perrone, Dina Manetti, Maria Novella Romanelli, Marialessandra Contino, Nicola Antonio Colabufo. Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity. ChemMedChem. 2015 Aug; 10(8):1339-43. doi: 10.1002/cmdc.201500143. [PMID: 26012726]
  • Jin-Yun Liu, Zhong Liu, Dong-Mei Wang, Man-Mei Li, Shao-Xiang Wang, Rui Wang, Jian-Ping Chen, Yi-Fei Wang, De-Po Yang. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chemico-biological interactions. 2011 Apr; 190(2-3):91-101. doi: 10.1016/j.cbi.2011.02.026. [PMID: 21376709]
  • Isabella Dell'Aica, Raffaele Niero, Francesco Piazza, Anna Cabrelle, Luigi Sartor, Cristiano Colalto, Enrico Brunetta, Girieca Lorusso, Roberto Benelli, Adriana Albini, Fiorella Calabrese, Carlo Agostini, Spiridione Garbisa. Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis. The Journal of pharmacology and experimental therapeutics. 2007 May; 321(2):492-500. doi: 10.1124/jpet.106.116459. [PMID: 17289834]
  • Silvio Sosa, Roberto Pace, Anna Bornancin, Paolo Morazzoni, Antonella Riva, Aurelia Tubaro, Roberto Della Loggia. Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. The Journal of pharmacy and pharmacology. 2007 May; 59(5):703-9. doi: 10.1211/jpp.59.5.0011. [PMID: 17524236]
  • Marco Gobbi, Manuela Moia, Marcella Funicello, Antonella Riva, Paolo Morazzoni, Tiziana Mennini. In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models. Planta medica. 2004 Jul; 70(7):680-2. doi: 10.1055/s-2004-827194. [PMID: 15303261]
  • Yoffi Segall, Gary B Quistad, Susan E Sparks, John E Casida. Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation. Chemical research in toxicology. 2003 Mar; 16(3):350-6. doi: 10.1021/tx020094l. [PMID: 12641435]
  • Luigi Cervo, Marco Rozio, C B Ekalle-Soppo, Giovanna Guiso, Paolo Morazzoni, Silvio Caccia. Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology. 2002 Dec; 164(4):423-8. doi: 10.1007/s00213-002-1229-5. [PMID: 12457273]
  • A F Tiburcio, R Kaur-Sawhney, A W Galston. Effect of polyamine biosynthetic inhibitors on alkaloids and organogenesis in tobacco callus cultures. Plant cell, tissue and organ culture. 1987; 9(?):111-20. doi: 10.1007/bf00044246. [PMID: 11539719]
  • J L Mitchell, D W Mahan, P P McCann, P Qasba. Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity. Biochimica et biophysica acta. 1985 Jul; 840(3):309-16. doi: 10.1016/0304-4165(85)90210-7. [PMID: 4005290]
  • R Kaur Sawhney, N S Shekhawat, A W Galston. Polyamine levels as related to growth, differentiation and senescence in protoplast-derived cultures of Vigna aconitifolia and Avena sativa. Plant growth regulation. 1985; 3(?):329-37. doi: 10.1007/bf00117590. [PMID: 11539806]
  • G V LOMONOVA. TOXICITY OF CYCLOHEXYLAMINE AND DICYCLOHEXYLAMINE. Federation proceedings. Translation supplement; selected translations from medical-related science. 1965 Jan; 24(?):96-8. doi: . [PMID: 14275609]