Dicyclohexylamine (BioDeep_00000004094)

 

Secondary id: BioDeep_00001871715

human metabolite blood metabolite


代谢物信息卡片


Cyclohexanamine, N-cyclohexyl-, sulfate (1:1)

化学式: C12H23N (181.183)
中文名称: 二环己胺(DCHA), 二环己胺
谱图信息: 最多检出来源 Homo sapiens(blood) 10.96%

分子结构信息

SMILES: C1CCC(CC1)NC1CCCCC1
InChI: InChI=1S/C12H23N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h11-13H,1-10H2

描述信息

INTERNAL_ID 2356; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2356
D004791 - Enzyme Inhibitors

同义名列表

13 个代谢物同义名

Cyclohexanamine, N-cyclohexyl-, sulfate (1:1); Dicyclohexylamine phosphate (3:1); Dicyclohexylamine sulfate (1:1); Dicyclohexylamine hydrochloride; N-Cyclohexylcyclohexanamine; Dicyclohexylamine sulfate; Dicyclohexylamine nitrite; Dicyclohexylamine nitrate; Dicyclohexylammonium; DICYCLOHEXYLAMINE; dicha; Dicyclohexylamine; Dicyclohexylamine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ANXA5, ARG1, AZIN2, CASP3, CASP8, CASP9, CAT, HPGDS, ODC1, PGD
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 1 HSP90B1
Mitochondrion membrane 1 ABCG2
Nucleus 8 ARG1, AZIN2, CASP3, CASP8, CASP9, HSP90B1, PARP1, PGD
cytosol 14 AMD1, ANXA5, ARG1, AZIN2, CASP3, CASP8, CASP9, CAT, HPGDS, HSP90B1, ODC1, PARP1, PGD, SRM
dendrite 1 AZIN2
mitochondrial membrane 1 ABCG2
nuclear body 1 PARP1
trans-Golgi network 1 AZIN2
nucleoplasm 5 ABCG2, CASP3, CASP8, HPGDS, PARP1
Cell membrane 3 ABCC1, ABCG2, MINPP1
lamellipodium 1 CASP8
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 2 ABCC1, ABCG2
glutamatergic synapse 1 CASP3
mitochondrial inner membrane 1 ATP5ME
neuronal cell body 1 CASP3
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 PARP1
plasma membrane 3 ABCC1, ABCG2, MINPP1
Membrane 7 ABCC1, ABCG2, ANXA5, AZIN2, CAT, HSP90B1, PARP1
apical plasma membrane 2 ABCC1, ABCG2
axon 1 AZIN2
basolateral plasma membrane 1 ABCC1
extracellular exosome 6 ABCC1, ANXA5, CAT, HSP90B1, MINPP1, PGD
endoplasmic reticulum 1 HSP90B1
extracellular space 2 ARG1, MINPP1
perinuclear region of cytoplasm 2 AZIN2, HSP90B1
mitochondrion 6 ATP5ME, AZIN2, CASP8, CASP9, CAT, PARP1
protein-containing complex 5 CASP8, CASP9, CAT, HSP90B1, PARP1
intracellular membrane-bounded organelle 2 CAT, HPGDS
postsynaptic density 1 CASP3
Secreted 1 MINPP1
extracellular region 4 ANXA5, ARG1, CAT, HSP90B1
mitochondrial outer membrane 1 CASP8
mitochondrial matrix 1 CAT
transcription regulator complex 1 PARP1
external side of plasma membrane 1 ANXA5
perikaryon 1 AZIN2
cytoplasmic vesicle 1 AZIN2
nucleolus 1 PARP1
midbody 1 HSP90B1
Apical cell membrane 1 ABCG2
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 ABCG2
focal adhesion 3 ANXA5, CAT, HSP90B1
cis-Golgi network 1 AZIN2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ANXA5, HSP90B1
lateral plasma membrane 1 ABCC1
Zymogen granule membrane 1 ANXA5
chromatin 1 PARP1
Chromosome 1 PARP1
cytoskeleton 1 CASP8
brush border membrane 1 ABCG2
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Melanosome 1 HSP90B1
cell body 1 CASP8
sperm plasma membrane 1 HSP90B1
basal plasma membrane 1 ABCC1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 HSP90B1, MINPP1
specific granule lumen 1 ARG1
transport vesicle 1 AZIN2
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 AZIN2
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
Sarcoplasmic reticulum lumen 1 HSP90B1
endoplasmic reticulum-Golgi intermediate compartment 1 AZIN2
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCG2
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
Golgi apparatus, cis-Golgi network 1 AZIN2
site of DNA damage 1 PARP1
proton-transporting ATP synthase complex 1 ATP5ME
endocytic vesicle lumen 1 HSP90B1
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
caspase complex 1 CASP9
granular vesicle 1 AZIN2


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ting Zhou, Pei Wang, Zhenxin Gu, Meng Ma, Runqiang Yang. Spermidine improves antioxidant activity and energy metabolism in mung bean sprouts. Food chemistry. 2020 Mar; 309(?):125759. doi: 10.1016/j.foodchem.2019.125759. [PMID: 31706672]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ting Zhou, Pei Wang, Runqiang Yang, Zhenxin Gu. Polyamines regulating phytic acid degradation in mung bean sprouts. Journal of the science of food and agriculture. 2018 Jul; 98(9):3299-3308. doi: 10.1002/jsfa.8833. [PMID: 29239473]
  • Dandan Peng, Xiaojuan Wang, Zhou Li, Yan Zhang, Yan Peng, Yaping Li, Xiaoshuang He, Xinquan Zhang, Xiao Ma, Linkai Huang, Yanhong Yan. NO is involved in spermidine-induced drought tolerance in white clover via activation of antioxidant enzymes and genes. Protoplasma. 2016 Sep; 253(5):1243-54. doi: 10.1007/s00709-015-0880-8. [PMID: 26338203]
  • Elisabetta Teodori, Silvia Dei, Elisa Floriddia, Maria Grazia Perrone, Dina Manetti, Maria Novella Romanelli, Marialessandra Contino, Nicola Antonio Colabufo. Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity. ChemMedChem. 2015 Aug; 10(8):1339-43. doi: 10.1002/cmdc.201500143. [PMID: 26012726]
  • Jin-Yun Liu, Zhong Liu, Dong-Mei Wang, Man-Mei Li, Shao-Xiang Wang, Rui Wang, Jian-Ping Chen, Yi-Fei Wang, De-Po Yang. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chemico-biological interactions. 2011 Apr; 190(2-3):91-101. doi: 10.1016/j.cbi.2011.02.026. [PMID: 21376709]
  • Isabella Dell'Aica, Raffaele Niero, Francesco Piazza, Anna Cabrelle, Luigi Sartor, Cristiano Colalto, Enrico Brunetta, Girieca Lorusso, Roberto Benelli, Adriana Albini, Fiorella Calabrese, Carlo Agostini, Spiridione Garbisa. Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis. The Journal of pharmacology and experimental therapeutics. 2007 May; 321(2):492-500. doi: 10.1124/jpet.106.116459. [PMID: 17289834]
  • Silvio Sosa, Roberto Pace, Anna Bornancin, Paolo Morazzoni, Antonella Riva, Aurelia Tubaro, Roberto Della Loggia. Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. The Journal of pharmacy and pharmacology. 2007 May; 59(5):703-9. doi: 10.1211/jpp.59.5.0011. [PMID: 17524236]
  • Marco Gobbi, Manuela Moia, Marcella Funicello, Antonella Riva, Paolo Morazzoni, Tiziana Mennini. In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models. Planta medica. 2004 Jul; 70(7):680-2. doi: 10.1055/s-2004-827194. [PMID: 15303261]
  • Yoffi Segall, Gary B Quistad, Susan E Sparks, John E Casida. Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation. Chemical research in toxicology. 2003 Mar; 16(3):350-6. doi: 10.1021/tx020094l. [PMID: 12641435]
  • Luigi Cervo, Marco Rozio, C B Ekalle-Soppo, Giovanna Guiso, Paolo Morazzoni, Silvio Caccia. Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology. 2002 Dec; 164(4):423-8. doi: 10.1007/s00213-002-1229-5. [PMID: 12457273]
  • A F Tiburcio, R Kaur-Sawhney, A W Galston. Effect of polyamine biosynthetic inhibitors on alkaloids and organogenesis in tobacco callus cultures. Plant cell, tissue and organ culture. 1987; 9(?):111-20. doi: 10.1007/bf00044246. [PMID: 11539719]
  • J L Mitchell, D W Mahan, P P McCann, P Qasba. Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity. Biochimica et biophysica acta. 1985 Jul; 840(3):309-16. doi: 10.1016/0304-4165(85)90210-7. [PMID: 4005290]
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  • G V LOMONOVA. TOXICITY OF CYCLOHEXYLAMINE AND DICYCLOHEXYLAMINE. Federation proceedings. Translation supplement; selected translations from medical-related science. 1965 Jan; 24(?):96-8. doi: . [PMID: 14275609]