maprotiline (BioDeep_00000405891)
Main id: BioDeep_00000002020
代谢物信息卡片
maprotiline
化学式: C20H23N (277.1830398)
中文名称: 马普替林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=1C=CC2=C(C1)C3C=4C=CC=CC4C2(CCCNC)CC3
InChI: InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; INTERNAL_ID 2221
同义名列表
1 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:6690
- KEGG: C07107
- KEGGdrug: D02566
- PubChem: 4011
- DrugBank: DB00934
- ChEMBL: CHEMBL1201257
- ChEMBL: CHEMBL21731
- MeSH: Maprotiline
- CAS: 10262-69-8
- MoNA: WA002086
- MoNA: WA002085
- MoNA: WA002084
- MoNA: WA002083
- MoNA: WA002082
- MoNA: WA002081
- MoNA: AU222111
- MoNA: AU222110
- MoNA: AU222109
- MoNA: AU222108
- MoNA: AU222107
- MoNA: FiehnHILIC000503
- PubChem: 9318
- PDB-CCD: A1LX3
- NIKKAJI: J9.818C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ute Krügel, Isabelle Straub, Holger Beckmann, Michael Schaefer. Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Pain.
2017 05; 158(5):856-867. doi:
10.1097/j.pain.0000000000000846. [PMID: 28106668] - Guoxun Zheng, Weiwei Xue, Panpan Wang, Fengyuan Yang, Bo Li, Xiaofeng Li, Yinghong Li, Xiaojun Yao, Feng Zhu. Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study.
Scientific reports.
2016 05; 6(?):26883. doi:
10.1038/srep26883. [PMID: 27230580] - Y M McNamara, S A Bright, A J Byrne, S M Cloonan, T McCabe, D C Williams, M J Meegan. Synthesis and antiproliferative action of a novel series of maprotiline analogues.
European journal of medicinal chemistry.
2014 Jan; 71(?):333-53. doi:
10.1016/j.ejmech.2013.10.076. [PMID: 24333581] - Lynette Hui-Wen Lee, Chay-Hoon Tan, Guanghou Shui, Markus R Wenk, Wei-Yi Ong. Role of prefrontal cortical calcium independent phospholipase A₂ in antidepressant-like effect of maprotiline.
The international journal of neuropsychopharmacology.
2012 Sep; 15(8):1087-98. doi:
10.1017/s1461145711001234. [PMID: 21835087] - Laia Tolosa, Sandra Pinto, M Teresa Donato, Agustín Lahoz, José V Castell, J Enrique O'Connor, M José Gómez-Lechón. Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 May; 127(1):187-98. doi:
10.1093/toxsci/kfs083. [PMID: 22331495] - María del Mar Ramírez Fernández, Sarah M R Wille, Nele Samyn. Quantitative method validation for the analysis of 27 antidepressants and metabolites in plasma with ultraperformance liquid chromatography-tandem mass spectrometry.
Therapeutic drug monitoring.
2012 Feb; 34(1):11-24. doi:
10.1097/ftd.0b013e31823bf0fd. [PMID: 22210095] - Gerile, Chiharu Sogawa, Kazumi Ohyama, Takashi Masuko, Tadashi Kusama, Katsuya Morita, Norio Sogawa, Shigeo Kitayama. Inhibitory action of antidepressants on mouse Betaine/GABA transporter (BGT1) heterologously expressed in cell cultures.
International journal of molecular sciences.
2012; 13(3):2578-2589. doi:
10.3390/ijms13032578. [PMID: 22489112] - Guilherme A Behr, José C F Moreira, Benicio N Frey. Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder.
Oxidative medicine and cellular longevity.
2012; 2012(?):609421. doi:
10.1155/2012/609421. [PMID: 22693652] - Paul W Andrews, J Anderson Thomson, Ananda Amstadter, Michael C Neale. Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good.
Frontiers in psychology.
2012; 3(?):117. doi:
10.3389/fpsyg.2012.00117. [PMID: 22536191] - Marco Antonioli, Joanna Rybka, Livia A Carvalho. Neuroimmune endocrine effects of antidepressants.
Neuropsychiatric disease and treatment.
2012; 8(?):65-83. doi:
10.2147/ndt.s16409. [PMID: 22347798] - Wilfried Dimpfel, Klaus Koch, Gabriele Weiss. Early effect of NEURAPAS® balance on current source density (CSD) of human EEG.
BMC psychiatry.
2011 Aug; 11(?):123. doi:
10.1186/1471-244x-11-123. [PMID: 21810233] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Hai-Hong Zhou, Fan Lu, Shao-Dong Chen, Zhi-Hua Zhou, Yong-Zhu Han, Ji-Yuan Hu. Effect of electroacupuncture on serum copper, zinc, calcium and magnesium levels in the depression rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2011 Jun; 31(2):112-4. doi:
10.1016/s0254-6272(11)60023-x. [PMID: 21977810] - Toni-Lee Sterley, Fleur M Howells, Vivienne A Russell. Effects of early life trauma are dependent on genetic predisposition: a rat study.
Behavioral and brain functions : BBF.
2011 May; 7(?):11. doi:
10.1186/1744-9081-7-11. [PMID: 21548935] - Z-Y Jia, H-F Deng, R Huang, Y-Y Yang, X-C Yang, Z-Z Qi, X-H Ou. In vitro and in vivo studies of adenovirus-mediated human norepinephrine transporter gene transduction to hepatocellular carcinoma.
Cancer gene therapy.
2011 Mar; 18(3):196-205. doi:
10.1038/cgt.2010.70. [PMID: 21072068] - Julio Licinio, Ma-Li Wong. Pharmacogenomics of antidepressant treatment effects.
Dialogues in clinical neuroscience.
2011; 13(1):63-71. doi:
NULL. [PMID: 21485747] - D Jaya Prakash, S Arulkumar, M Sabesan. Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stressinduced behavioral and biochemical alteration in male albino mice.
Pharmacognosy research.
2010 Nov; 2(6):330-4. doi:
10.4103/0974-8490.75450. [PMID: 21713134] - C I Istikoglou, V Mavreas, G Geroulanos. History and therapeutic properties of Hypericum Perforatum from antiquity until today.
Psychiatrike = Psychiatriki.
2010 Oct; 21(4):332-8. doi:
". [PMID: 21914616] - Suzanne M Cloonan, Aleksandra Drozgowska, Darren Fayne, D Clive Williams. The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters.
Leukemia & lymphoma.
2010 Mar; 51(3):523-39. doi:
10.3109/10428190903552112. [PMID: 20141432] - Marwa A Aboukhatwa, Ashiwel S Undieh. Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition.
BMC neuroscience.
2010 Jan; 11(?):10. doi:
10.1186/1471-2202-11-10. [PMID: 20105322] - Yi-Chyan Chen, Wei-Win Lin, Yu-Jung Chen, Wei-Chung Mao, Yi-Jen Hung. Antidepressant effects on insulin sensitivity and proinflammatory cytokines in the depressed males.
Mediators of inflammation.
2010; 2010(?):573594. doi:
10.1155/2010/573594. [PMID: 20490354] - Sarah M R Wille, Els A De Letter, Michel H A Piette, Lien K Van Overschelde, Carlos H Van Peteghem, Willy E Lambert. Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry.
International journal of legal medicine.
2009 Nov; 123(6):451-8. doi:
10.1007/s00414-008-0287-6. [PMID: 18839201] - Andrea Varrone, Carsten Steiger, Magnus Schou, Akihiro Takano, Sjoerd J Finnema, Denis Guilloteau, Balázs Gulyás, Christer Halldin. In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand.
Synapse (New York, N.Y.).
2009 Oct; 63(10):871-80. doi:
10.1002/syn.20670. [PMID: 19562698] - Lynette Hui-Wen Lee, Guanghou Shui, Akhlaq A Farooqui, Markus R Wenk, Chay-Hoon Tan, Wei-Yi Ong. Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids?.
The international journal of neuropsychopharmacology.
2009 Aug; 12(7):953-64. doi:
10.1017/s146114570900995x. [PMID: 19203412] - Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
10.1021/jm801441s. [PMID: 19256501] - J E Warnick, C J Huang, E O Acevedo, K J Sufka. Modelling the anxiety-depression continuum in chicks.
Journal of psychopharmacology (Oxford, England).
2009 Mar; 23(2):143-56. doi:
10.1177/0269881108089805. [PMID: 18515452] - Natasa Spasojevic, Ljubica Gavrilovic, Ivan Kovacevic, Sladjana Dronjak. Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats.
Autonomic neuroscience : basic & clinical.
2009 Jan; 145(1-2):104-7. doi:
10.1016/j.autneu.2008.11.002. [PMID: 19083273] - Stefan Gebhardt, Philip Heiser, Sabine Fischer, Thomas Schneyer, Jürgen-Christian Krieg, Helmut Vedder. Relationships among endocrine and signaling-related responses to antidepressants in human monocytic U-937 blood cells: analysis of factors and response patterns.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Oct; 32(7):1682-7. doi:
10.1016/j.pnpbp.2008.07.002. [PMID: 18664374] - Xiang Yang Qin, Jin Meng, Xiao Ye Li, Jun Zhou, Xiao Li Sun, Ai Dong Wen. Determination of venlafaxine in human plasma by high-performance liquid chromatography using cloud-point extraction and spectrofluorimetric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Sep; 872(1-2):38-42. doi:
10.1016/j.jchromb.2008.06.052. [PMID: 18675598] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Sumandeep Rana, Victor P Uralets, Wayne Ross. A new method for simultaneous determination of cyclic antidepressants and their metabolites in urine using enzymatic hydrolysis and fast GC-MS.
Journal of analytical toxicology.
2008 Jun; 32(5):355-63. doi:
10.1093/jat/32.5.355. [PMID: 18544221] - V Caretti, D Stoffers, A Winogrodzka, I-U Isaias, G Costantino, G Pezzoli, C Ferrarese, A Antonini, E-Ch Wolters, J Booij. Loss of thalamic serotonin transporters in early drug-naïve Parkinson's disease patients is associated with tremor: an [(123)I]beta-CIT SPECT study.
Journal of neural transmission (Vienna, Austria : 1996).
2008 May; 115(5):721-9. doi:
10.1007/s00702-007-0015-2. [PMID: 18335163] - Fan Lu, Hong-mei Zhu, Jun-jie Xie, Hai-hong Zhou, Yan-ling Chen, Ji-yuan Hu. [Effects of electroacupuncture on behavior, plasma COR and expressions of PKA and PKC in hippocampus of the depression model rat].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2008 Mar; 28(3):214-8. doi:
. [PMID: 18447224] - Murat Pinar, Murat Gulsun, Ilker Tasci, Ahmet Erdil, Erol Bolu, Cengizhan Acikel, Ali Doruk. Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Jan; 32(1):135-9. doi:
10.1016/j.pnpbp.2007.07.028. [PMID: 17825464] - Sarah M R Wille, Paul Van Hee, Hugo M Neels, Carlos H Van Peteghem, Willy E Lambert. Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.
Journal of chromatography. A.
2007 Dec; 1176(1-2):236-45. doi:
10.1016/j.chroma.2007.10.096. [PMID: 18022628] - Sladjana Dronjak, Natasa Spasojevic, Ljubica Gavrilovic, Vladislav Varagic. Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats.
Neuro endocrinology letters.
2007 Oct; 28(5):614-20. doi:
. [PMID: 17984940] - Wen-Huang Peng, Kuan-Lin Lo, Yi-Hsuen Lee, Tai-Huang Hung, Ying-Chih Lin. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice.
Life sciences.
2007 Aug; 81(11):933-8. doi:
10.1016/j.lfs.2007.08.003. [PMID: 17804020] - Wei Guo, Wenbiao Li, Guixin Guo, Jun Zhang, Beilei Zhou, Yimin Zhai, Chuanyue Wang. Determination of atomoxetine in human plasma by a high performance liquid chromatographic method with ultraviolet detection using liquid-liquid extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):128-34. doi:
10.1016/j.jchromb.2007.04.007. [PMID: 17509951] - Elena Rybnikova, Vera Mironova, Svetlana Pivina, Ekaterina Tulkova, Natalia Ordyan, Ludmila Vataeva, Elena Vershinina, Eugeny Abritalin, Alexandr Kolchev, Natalia Nalivaeva, Anthony J Turner, Michail Samoilov. Antidepressant-like effects of mild hypoxia preconditioning in the learned helplessness model in rats.
Neuroscience letters.
2007 May; 417(3):234-9. doi:
10.1016/j.neulet.2007.02.048. [PMID: 17379404] - Ivy E Dick, Richard M Brochu, Yamini Purohit, Gregory J Kaczorowski, William J Martin, Birgit T Priest. Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.
The journal of pain.
2007 Apr; 8(4):315-24. doi:
10.1016/j.jpain.2006.10.001. [PMID: 17175203] - Yu-juan Li, He-chun Luo, Rui-qin Qian. [Effect of Danzhi Xiaoyao Powder on neuro-immuno-endocrine system in patients with depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2007 Mar; 27(3):197-200. doi:
. [PMID: 17432674] - Wadad Saba, Héric Valette, Marie-Anne Schöllhorn-Peyronneau, Christine Coulon, Michele Ottaviani, Sylvie Chalon, Frédéric Dolle, Patrick Emond, Christer Halldin, Julie Helfenbein, Jean-Claude Madelmont, Jean-Bernard Deloye, Denis Guilloteau, Michel Bottlaender. [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET.
Synapse (New York, N.Y.).
2007 Jan; 61(1):17-23. doi:
10.1002/syn.20337. [PMID: 17068778] - H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Oct; 843(1):100-13. doi:
10.1016/j.jchromb.2006.05.031. [PMID: 16798119] - Tatsuo Shinozuka, Masaru Terada, Einosuke Tanaka. Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method.
Forensic science international.
2006 Oct; 162(1-3):108-12. doi:
10.1016/j.forsciint.2006.03.038. [PMID: 16859851] - He-Chun Luo, Rui-Qin Qian, Xue-Ying Zhao, Juan Bi, Hongling Xin, Xuezhu Jiang, Ke Xu, Shaoxiao Yan. [Clinical observation on effect of danzhi xiaoyao powder in treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2006 Mar; 26(3):212-4. doi:
". [PMID: 16613263] - F L Sauvage, J M Gaulier, G Lachâtre, P Marquet. A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum.
Therapeutic drug monitoring.
2006 Feb; 28(1):123-30. doi:
10.1097/01.ftd.0000194026.04483.c3. [PMID: 16418706] - Sarah M R Wille, Kristof E Maudens, Carlos H Van Peteghem, Willy E E Lambert. Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
Journal of chromatography. A.
2005 Dec; 1098(1-2):19-29. doi:
10.1016/j.chroma.2005.08.059. [PMID: 16314157] - Christer Halldin, Johan Lundberg, Judit Sóvágó, Balázs Gulyás, Denis Guilloteau, Johnny Vercouillie, Patrick Emond, Sylvie Chalon, Jari Tarkiainen, Jukka Hiltunen, Lars Farde. [(11)C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET.
Synapse (New York, N.Y.).
2005 Dec; 58(3):173-83. doi:
10.1002/syn.20189. [PMID: 16138320] - Kuo-Shyan Lin, Yu-Shin Ding. Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons.
Bioorganic & medicinal chemistry.
2005 Aug; 13(15):4658-66. doi:
10.1016/j.bmc.2005.04.062. [PMID: 15914010] - Yu-Shin Ding, Kuo-Shyan Lin, Jean Logan, Helene Benveniste, Pauline Carter. Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine.
Journal of neurochemistry.
2005 Jul; 94(2):337-51. doi:
10.1111/j.1471-4159.2005.03202.x. [PMID: 15998285] - Z Fisar, M Anders, E Tvrzická, B Stanková. Effect of long-term administration of antidepressants on the lipid composition of brain plasma membranes.
General physiology and biophysics.
2005 Jun; 24(2):221-36. doi:
. [PMID: 16118474] - G M Murav'eva. [Detection of maprotiline and proserine in forensic medical examination of cadaver].
Sudebno-meditsinskaia ekspertiza.
2005 Mar; 48(2):42-3. doi:
NULL. [PMID: 15881143] - Pierre Baumann, Sven Ulrich, Gabriel Eckermann, Manfred Gerlach, Hans-Joachim Kuss, Gerd Laux, Bruno Müller-Oerlinghausen, Marie Luise Rao, Peter Riederer, Gerald Zernig, Christoph Hiemke. The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants.
Dialogues in clinical neuroscience.
2005; 7(3):231-47. doi:
NULL. [PMID: 16156382] - Cui Han, Xiaohong Li, Hechun Luo, Xueying Zhao, Xuewu Li. Clinical study on electro-acupuncture treatment for 30 cases of mental depression.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2004 Sep; 24(3):172-6. doi:
". [PMID: 15510791] - Shu-Shong Hsu, Wei-Chung Chen, Bang-Ping Jiann, Jin-Shyr Chen, Jong-Khing Huang, Hong-Tai Chang, He-Hsiung Cheng, Yuk-Keung Lo, Chin-Man Ho, Chung-Ren Jan. Effect of the antidepressant maprotiline on calcium movement and the viability of renal tubular cells.
Archives of toxicology.
2004 Aug; 78(8):453-9. doi:
10.1007/s00204-004-0564-1. [PMID: 15057508] - Zhen-ming Shen, Mei-lan Zhu, An-quan Zhao. [Comparative observation on efficacy of jieyu pill and maprotiline in treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 May; 24(5):415-7. doi:
. [PMID: 15199625] - Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
10.1021/jm0309001. [PMID: 15027870] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - P Brust, R Hinz, H Kuwabara, S Hesse, J Zessin, B Pawelke, H Stephan, R Bergmann, J Steinbach, O Sabri. In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2003 Nov; 28(11):2010-9. doi:
10.1038/sj.npp.1300281. [PMID: 12931143] - Christer Halldin, Nina Erixon-Lindroth, Stefan Pauli, Yuan-Hwa Chou, Yoshiro Okubo, Per Karlsson, Camilla Lundkvist, Hans Olsson, Denis Guilloteau, Patrick Emond, Lars Farde. [(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain.
European journal of nuclear medicine and molecular imaging.
2003 Sep; 30(9):1220-30. doi:
10.1007/s00259-003-1212-3. [PMID: 12811422] - Christine Frahnert, Marie Luise Rao, Katja Grasmäder. Analysis of eighteen antidepressants, four atypical antipsychotics and active metabolites in serum by liquid chromatography: a simple tool for therapeutic drug monitoring.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Aug; 794(1):35-47. doi:
10.1016/s1570-0232(03)00393-3. [PMID: 12888196] - Yukari Sudoh, Elaine Elliott Cahoon, Peter Gerner, Ging Kuo Wang. Tricyclic antidepressants as long-acting local anesthetics.
Pain.
2003 May; 103(1-2):49-55. doi:
10.1016/s0304-3959(02)00375-5. [PMID: 12749958] - Shigeaki Arai, Katsuya Morita, Shigeo Kitayama, Kei Kumagai, Michio Kumagai, Kenji Kihira, Toshihiro Dohi. Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics.
Brain research.
2003 Feb; 964(1):83-90. doi:
10.1016/s0006-8993(02)04068-4. [PMID: 12573515] - Nathalie Ginovart, Alan A Wilson, Jeffrey H Meyer, Doug Hussey, Sylvain Houle. [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats.
Synapse (New York, N.Y.).
2003 Feb; 47(2):123-33. doi:
10.1002/syn.10155. [PMID: 12454950] - R Waschgler, M R Hubmann, A Conca, W Moll, P König. Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis.
International journal of clinical pharmacology and therapeutics.
2002 Dec; 40(12):554-9. doi:
10.5414/cpp40554. [PMID: 12503813] - Mylène Karramkam, Frédéric Dollé, Héric Valette, Laurent Besret, Yann Bramoullé, Françoise Hinnen, Françoise Vaufrey, Carine Franklin, Sébastien Bourg, Christine Coulon, Michèle Ottaviani, Marcel Delaforge, Christian Loc'h, Michel Bottlaender, Christian Crouzel. Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET.
Bioorganic & medicinal chemistry.
2002 Aug; 10(8):2611-23. doi:
10.1016/s0968-0896(02)00098-6. [PMID: 12057650] - Aysel Oztunc, Armagan Onal, Sidika Erturk. 7,7,8,8-Tetracyanoquinodimethane as a new derivatization reagent for high-performance liquid chromatography and thin-layer chromatography: rapid screening of plasma for some antidepressants.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Jul; 774(2):149-55. doi:
10.1016/s1570-0232(02)00166-6. [PMID: 12076684] - Volker Schulz. Clinical trials with hypericum extracts in patients with depression--results, comparisons, conclusions for therapy with antidepressant drugs.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2002 Jul; 9(5):468-74. doi:
10.1078/09447110260571742. [PMID: 12222670] - Cui Han, Xue-wu Li, He-chun Luo. [Comparative study of electro-acupuncture and maprotiline in treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2002 Jul; 22(7):512-4, 521. doi:
". [PMID: 12592685] - Lars Brachtendorf, Alexander Jetter, K Tobias Beckurts, Arnulf H Hölscher, Uwe Fuhr. Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Pharmacology & toxicology.
2002 Mar; 90(3):144-9. doi:
10.1034/j.1600-0773.2002.900306.x. [PMID: 12071336] - Claus Normann, Klaus Lieb, Jörg Walden. Increased plasma concentration of maprotiline by coadministration of risperidone.
Journal of clinical psychopharmacology.
2002 Feb; 22(1):92-4. doi:
10.1097/00004714-200202000-00016. [PMID: 11799350] - M Cakrt, T Buzinkaiová, J Polonský, V Korínková. Spectrofluorimetric and isotachophoretic determination of maprotiline in human blood serum.
Electrophoresis.
2000 Aug; 21(14):2834-8. doi:
10.1002/1522-2683(20000801)21:14<2834::aid-elps2834>3.0.co;2-c. [PMID: 11001290] - A Ozkul, A Oztunç. Determination of maprotiline hydrochloride in tablets by ion-pair extraction using bromthymol blue.
Die Pharmazie.
2000 Apr; 55(4):321-2. doi:
NULL. [PMID: 10798251] - J Yamada, Y Sugimoto, K Inoue. Selective serotonin reuptake inhibitors fluoxetine and fluvoxamine induce hyperglycemia by different mechanisms.
European journal of pharmacology.
1999 Oct; 382(3):211-5. doi:
10.1016/s0014-2999(99)00593-2. [PMID: 10556672] - C Quiñones-Torrelo, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
Journal of medicinal chemistry.
1999 Aug; 42(16):3154-62. doi:
10.1021/jm9910369. [PMID: 10447960] - F Pisani, E Spina, G Oteri. Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice.
Epilepsia.
1999; 40 Suppl 10(?):S48-56. doi:
10.1111/j.1528-1157.1999.tb00885.x. [PMID: 10609604] - I Fukunishi, T Kitaoka, T Shirai, S Watanabe. Cardiac arrest caused by maprotiline in an elderly hemodialysis patient.
Nephron.
1998; 78(2):225. doi:
10.1159/000044917. [PMID: 9496744] - M Vrethem, J Boivie, H Arnqvist, H Holmgren, T Lindström, L H Thorell. A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics.
The Clinical journal of pain.
1997 Dec; 13(4):313-23. doi:
10.1097/00002508-199712000-00009. [PMID: 9430812] - G Aymard, P Livi, Y T Pham, B Diquet. Sensitive and rapid method for the simultaneous quantification of five antidepressants with their respective metabolites in plasma using high-performance liquid chromatography with diode-array detection.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Oct; 700(1-2):183-9. doi:
10.1016/s0378-4347(97)00327-7. [PMID: 9390728] - M Nakashita, K Sasaki, N Sakai, N Saito. Effects of tricyclic and tetracyclic antidepressants on the three subtypes of GABA transporter.
Neuroscience research.
1997 Sep; 29(1):87-91. doi:
10.1016/s0168-0102(97)00072-2. [PMID: 9293496] - F König, M Wolfersdorf, M Löble, S Wössner, B Hauger. Trimipramine and maprotiline plasma levels during combined treatment with moclobemide in therapy-resistant depression.
Pharmacopsychiatry.
1997 Jul; 30(4):125-7. doi:
10.1055/s-2007-979497. [PMID: 9271778] - H C Ko, R B Lu, I S Shiah, C C Hwang. Plasma free 3-methoxy-4-hydroxyphenylglycol predicts response to fluoxetine.
Biological psychiatry.
1997 Apr; 41(7):774-81. doi:
10.1016/s0006-3223(96)00207-7. [PMID: 9084896] - R Bolognesi, D Tsialtas, P Vasini, M Conti, C Manca. Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose.
The American journal of cardiology.
1997 Jan; 79(2):242-5. doi:
10.1016/s0002-9149(96)00727-8. [PMID: 9193039] - S V Vormfelde, A Bitsch, I Meineke, U M Gundert-Remy, C H Gleiter. Non-response to maprotiline caused by ultra-rapid metabolism that is different from CYP2D6?.
European journal of clinical pharmacology.
1997; 52(5):387-90. doi:
10.1007/s002280050306. [PMID: 9272409] - M el-Dakhakhny, H A Abdel el-Latif, H P Ammon. Different effects of the antidepressant drugs imipramine, maprotiline and bupropion on insulin secretion from mouse pancreatic islets.
Arzneimittel-Forschung.
1996 Jul; 46(7):667-9. doi:
. [PMID: 8842333] - J Ishida, N Horike, M Yamaguchi. Determination of maprotiline in plasma by high-performance liquid chromatography with chemiluminescence detection.
Journal of chromatography. B, Biomedical applications.
1995 Jul; 669(2):390-6. doi:
10.1016/0378-4347(95)00103-p. [PMID: 7581917] - B Szabo, A Obergfell, K Starke. Involvement of monoamine uptake inhibition and local anesthesia in the cardiovascular response to cocaine in conscious rabbits.
The Journal of pharmacology and experimental therapeutics.
1995 Apr; 273(1):128-37. doi:
NULL. [PMID: 7714758] - H Lefebvre, C Noblet, N Moore, L M Wolf. Pseudo-phaeochromocytoma after multiple drug interactions involving the selective monoamine oxidase inhibitor selegiline.
Clinical endocrinology.
1995 Jan; 42(1):95-8; discussion 98. doi:
10.1111/j.1365-2265.1995.tb02604.x. [PMID: 7889639] - W Hewer, W Rost, W F Gattaz. Cardiovascular effects of fluvoxamine and maprotiline in depressed patients.
European archives of psychiatry and clinical neuroscience.
1995; 246(1):1-6. doi:
10.1007/bf02191808. [PMID: 8773212] - G Harrer, W D Hübner, H Podzuweit. Effectiveness and tolerance of the hypericum extract LI 160 compared to maprotiline: a multicenter double-blind study.
Journal of geriatric psychiatry and neurology.
1994 Oct; 7 Suppl 1(?):S24-8. doi:
10.1177/089198879400700108. [PMID: 7857503] - D Johnson, H Ksciuk, H Woelk, E Sauerwein-Giese, A Frauendorf. Effects of hypericum extract LI 160 compared with maprotiline on resting EEG and evoked potentials in 24 volunteers.
Journal of geriatric psychiatry and neurology.
1994 Oct; 7 Suppl 1(?):S44-6. doi:
10.1177/089198879400700112. [PMID: 7857508] - H J Kuss, S Sirch, D Y Zhao. Assay for maprotiline in human serum with improved sensitivity and selectivity.
Journal of chromatography. B, Biomedical applications.
1994 Jun; 656(1):245-9. doi:
10.1016/0378-4347(94)00071-9. [PMID: 7952036] - L Firkusny, C H Gleiter. Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine.
British journal of clinical pharmacology.
1994 Apr; 37(4):383-8. doi:
10.1111/j.1365-2125.1994.tb04293.x. [PMID: 8018460] - B Szabo, T Auberle, K Starke. Inhibition of uptake 1 by (+)-oxaprotiline reveals a differential central regulation of noradrenaline and adrenaline release.
Naunyn-Schmiedeberg's archives of pharmacology.
1993 Sep; 348(3):249-57. doi:
10.1007/bf00169152. [PMID: 8232602] - J Keating, L Dratcu, M Lader, R A Sherwood. Measurement of plasma serotonin by high-performance liquid chromatography with electrochemical detection as an index of the in vivo activity of fluvoxamine.
Journal of chromatography.
1993 Jun; 615(2):237-42. doi:
10.1016/0378-4347(93)80337-4. [PMID: 8335701] - M Laruelle, R M Baldwin, R T Malison, Y Zea-Ponce, S S Zoghbi, M S al-Tikriti, E H Sybirska, R C Zimmermann, G Wisniewski, J L Neumeyer. SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates.
Synapse (New York, N.Y.).
1993 Apr; 13(4):295-309. doi:
10.1002/syn.890130402. [PMID: 7683143] - S Kasper, M Dötsch, H Kick, A Vieira, H J Möller. Plasma concentrations of fluvoxamine and maprotiline in major depression: implications on therapeutic efficacy and side effects.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
1993 Mar; 3(1):13-21. doi:
10.1016/0924-977x(93)90290-3. [PMID: 8471827]