maprotiline (BioDeep_00000405891)
Main id: BioDeep_00000002020
代谢物信息卡片
maprotiline
化学式: C20H23N (277.183)
中文名称: 马普替林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=1C=CC2=C(C1)C3C=4C=CC=CC4C2(CCCNC)CC3
InChI: InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; INTERNAL_ID 2221
同义名列表
2 个代谢物同义名
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:6690
- KEGG: C07107
- KEGGdrug: D02566
- PubChem: 4011
- DrugBank: DB00934
- ChEMBL: CHEMBL1201257
- ChEMBL: CHEMBL21731
- MeSH: Maprotiline
- CAS: 10262-69-8
- MoNA: WA002086
- MoNA: WA002085
- MoNA: WA002084
- MoNA: WA002083
- MoNA: WA002082
- MoNA: WA002081
- MoNA: AU222111
- MoNA: AU222110
- MoNA: AU222109
- MoNA: AU222108
- MoNA: AU222107
- MoNA: FiehnHILIC000503
- PubChem: 9318
- PDB-CCD: A1LX3
- NIKKAJI: J9.818C
- KNApSAcK: 6690
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ute Krügel, Isabelle Straub, Holger Beckmann, Michael Schaefer. Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Pain.
2017 05; 158(5):856-867. doi:
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Scientific reports.
2016 05; 6(?):26883. doi:
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European journal of medicinal chemistry.
2014 Jan; 71(?):333-53. doi:
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The international journal of neuropsychopharmacology.
2012 Sep; 15(8):1087-98. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2012 May; 127(1):187-98. doi:
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Therapeutic drug monitoring.
2012 Feb; 34(1):11-24. doi:
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International journal of molecular sciences.
2012; 13(3):2578-2589. doi:
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Oxidative medicine and cellular longevity.
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Frontiers in psychology.
2012; 3(?):117. doi:
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Neuropsychiatric disease and treatment.
2012; 8(?):65-83. doi:
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BMC psychiatry.
2011 Aug; 11(?):123. doi:
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Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2011 Jun; 31(2):112-4. doi:
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Behavioral and brain functions : BBF.
2011 May; 7(?):11. doi:
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Cancer gene therapy.
2011 Mar; 18(3):196-205. doi:
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Dialogues in clinical neuroscience.
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Pharmacognosy research.
2010 Nov; 2(6):330-4. doi:
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Psychiatrike = Psychiatriki.
2010 Oct; 21(4):332-8. doi:
". [PMID: 21914616] - Suzanne M Cloonan, Aleksandra Drozgowska, Darren Fayne, D Clive Williams. The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters.
Leukemia & lymphoma.
2010 Mar; 51(3):523-39. doi:
10.3109/10428190903552112. [PMID: 20141432] - Marwa A Aboukhatwa, Ashiwel S Undieh. Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition.
BMC neuroscience.
2010 Jan; 11(?):10. doi:
10.1186/1471-2202-11-10. [PMID: 20105322] - Yi-Chyan Chen, Wei-Win Lin, Yu-Jung Chen, Wei-Chung Mao, Yi-Jen Hung. Antidepressant effects on insulin sensitivity and proinflammatory cytokines in the depressed males.
Mediators of inflammation.
2010; 2010(?):573594. doi:
10.1155/2010/573594. [PMID: 20490354] - Sarah M R Wille, Els A De Letter, Michel H A Piette, Lien K Van Overschelde, Carlos H Van Peteghem, Willy E Lambert. Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry.
International journal of legal medicine.
2009 Nov; 123(6):451-8. doi:
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Synapse (New York, N.Y.).
2009 Oct; 63(10):871-80. doi:
10.1002/syn.20670. [PMID: 19562698] - Lynette Hui-Wen Lee, Guanghou Shui, Akhlaq A Farooqui, Markus R Wenk, Chay-Hoon Tan, Wei-Yi Ong. Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids?.
The international journal of neuropsychopharmacology.
2009 Aug; 12(7):953-64. doi:
10.1017/s146114570900995x. [PMID: 19203412] - Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
10.1021/jm801441s. [PMID: 19256501] - J E Warnick, C J Huang, E O Acevedo, K J Sufka. Modelling the anxiety-depression continuum in chicks.
Journal of psychopharmacology (Oxford, England).
2009 Mar; 23(2):143-56. doi:
10.1177/0269881108089805. [PMID: 18515452] - Natasa Spasojevic, Ljubica Gavrilovic, Ivan Kovacevic, Sladjana Dronjak. Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats.
Autonomic neuroscience : basic & clinical.
2009 Jan; 145(1-2):104-7. doi:
10.1016/j.autneu.2008.11.002. [PMID: 19083273] - Stefan Gebhardt, Philip Heiser, Sabine Fischer, Thomas Schneyer, Jürgen-Christian Krieg, Helmut Vedder. Relationships among endocrine and signaling-related responses to antidepressants in human monocytic U-937 blood cells: analysis of factors and response patterns.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Oct; 32(7):1682-7. doi:
10.1016/j.pnpbp.2008.07.002. [PMID: 18664374] - Xiang Yang Qin, Jin Meng, Xiao Ye Li, Jun Zhou, Xiao Li Sun, Ai Dong Wen. Determination of venlafaxine in human plasma by high-performance liquid chromatography using cloud-point extraction and spectrofluorimetric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Sep; 872(1-2):38-42. doi:
10.1016/j.jchromb.2008.06.052. [PMID: 18675598] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Sumandeep Rana, Victor P Uralets, Wayne Ross. A new method for simultaneous determination of cyclic antidepressants and their metabolites in urine using enzymatic hydrolysis and fast GC-MS.
Journal of analytical toxicology.
2008 Jun; 32(5):355-63. doi:
10.1093/jat/32.5.355. [PMID: 18544221] - V Caretti, D Stoffers, A Winogrodzka, I-U Isaias, G Costantino, G Pezzoli, C Ferrarese, A Antonini, E-Ch Wolters, J Booij. Loss of thalamic serotonin transporters in early drug-naïve Parkinson's disease patients is associated with tremor: an [(123)I]beta-CIT SPECT study.
Journal of neural transmission (Vienna, Austria : 1996).
2008 May; 115(5):721-9. doi:
10.1007/s00702-007-0015-2. [PMID: 18335163] - Fan Lu, Hong-mei Zhu, Jun-jie Xie, Hai-hong Zhou, Yan-ling Chen, Ji-yuan Hu. [Effects of electroacupuncture on behavior, plasma COR and expressions of PKA and PKC in hippocampus of the depression model rat].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2008 Mar; 28(3):214-8. doi:
. [PMID: 18447224] - Murat Pinar, Murat Gulsun, Ilker Tasci, Ahmet Erdil, Erol Bolu, Cengizhan Acikel, Ali Doruk. Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Jan; 32(1):135-9. doi:
10.1016/j.pnpbp.2007.07.028. [PMID: 17825464] - Sarah M R Wille, Paul Van Hee, Hugo M Neels, Carlos H Van Peteghem, Willy E Lambert. Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.
Journal of chromatography. A.
2007 Dec; 1176(1-2):236-45. doi:
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Neuro endocrinology letters.
2007 Oct; 28(5):614-20. doi:
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Life sciences.
2007 Aug; 81(11):933-8. doi:
10.1016/j.lfs.2007.08.003. [PMID: 17804020] - Wei Guo, Wenbiao Li, Guixin Guo, Jun Zhang, Beilei Zhou, Yimin Zhai, Chuanyue Wang. Determination of atomoxetine in human plasma by a high performance liquid chromatographic method with ultraviolet detection using liquid-liquid extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):128-34. doi:
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Neuroscience letters.
2007 May; 417(3):234-9. doi:
10.1016/j.neulet.2007.02.048. [PMID: 17379404] - Ivy E Dick, Richard M Brochu, Yamini Purohit, Gregory J Kaczorowski, William J Martin, Birgit T Priest. Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.
The journal of pain.
2007 Apr; 8(4):315-24. doi:
10.1016/j.jpain.2006.10.001. [PMID: 17175203] - Yu-juan Li, He-chun Luo, Rui-qin Qian. [Effect of Danzhi Xiaoyao Powder on neuro-immuno-endocrine system in patients with depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2007 Mar; 27(3):197-200. doi:
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Synapse (New York, N.Y.).
2007 Jan; 61(1):17-23. doi:
10.1002/syn.20337. [PMID: 17068778] - H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Oct; 843(1):100-13. doi:
10.1016/j.jchromb.2006.05.031. [PMID: 16798119] - Tatsuo Shinozuka, Masaru Terada, Einosuke Tanaka. Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method.
Forensic science international.
2006 Oct; 162(1-3):108-12. doi:
10.1016/j.forsciint.2006.03.038. [PMID: 16859851] - He-Chun Luo, Rui-Qin Qian, Xue-Ying Zhao, Juan Bi, Hongling Xin, Xuezhu Jiang, Ke Xu, Shaoxiao Yan. [Clinical observation on effect of danzhi xiaoyao powder in treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2006 Mar; 26(3):212-4. doi:
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Therapeutic drug monitoring.
2006 Feb; 28(1):123-30. doi:
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Journal of chromatography. A.
2005 Dec; 1098(1-2):19-29. doi:
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Synapse (New York, N.Y.).
2005 Dec; 58(3):173-83. doi:
10.1002/syn.20189. [PMID: 16138320] - Kuo-Shyan Lin, Yu-Shin Ding. Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons.
Bioorganic & medicinal chemistry.
2005 Aug; 13(15):4658-66. doi:
10.1016/j.bmc.2005.04.062. [PMID: 15914010] - Yu-Shin Ding, Kuo-Shyan Lin, Jean Logan, Helene Benveniste, Pauline Carter. Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine.
Journal of neurochemistry.
2005 Jul; 94(2):337-51. doi:
10.1111/j.1471-4159.2005.03202.x. [PMID: 15998285] - Z Fisar, M Anders, E Tvrzická, B Stanková. Effect of long-term administration of antidepressants on the lipid composition of brain plasma membranes.
General physiology and biophysics.
2005 Jun; 24(2):221-36. doi:
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Sudebno-meditsinskaia ekspertiza.
2005 Mar; 48(2):42-3. doi:
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Dialogues in clinical neuroscience.
2005; 7(3):231-47. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2004 Sep; 24(3):172-6. doi:
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Archives of toxicology.
2004 Aug; 78(8):453-9. doi:
10.1007/s00204-004-0564-1. [PMID: 15057508] - Zhen-ming Shen, Mei-lan Zhu, An-quan Zhao. [Comparative observation on efficacy of jieyu pill and maprotiline in treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 May; 24(5):415-7. doi:
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Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
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Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2003 Nov; 28(11):2010-9. doi:
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European journal of nuclear medicine and molecular imaging.
2003 Sep; 30(9):1220-30. doi:
10.1007/s00259-003-1212-3. [PMID: 12811422] - Christine Frahnert, Marie Luise Rao, Katja Grasmäder. Analysis of eighteen antidepressants, four atypical antipsychotics and active metabolites in serum by liquid chromatography: a simple tool for therapeutic drug monitoring.
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