maprotiline (BioDeep_00000405891)
Main id: BioDeep_00000002020
Volatile Flavor Compounds
代谢物信息卡片
maprotiline
化学式: C20H23N (277.1830398)
中文名称: 马普替林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=1C=CC2=C(C1)C3C=4C=CC=CC4C2(CCCNC)CC3
InChI: InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; INTERNAL_ID 2221
同义名列表
2 个代谢物同义名
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:6690
- KEGG: C07107
- KEGGdrug: D02566
- PubChem: 4011
- DrugBank: DB00934
- ChEMBL: CHEMBL1201257
- ChEMBL: CHEMBL21731
- MeSH: Maprotiline
- CAS: 10262-69-8
- MoNA: WA002086
- MoNA: WA002085
- MoNA: WA002084
- MoNA: WA002083
- MoNA: WA002082
- MoNA: WA002081
- MoNA: AU222111
- MoNA: AU222110
- MoNA: AU222109
- MoNA: AU222108
- MoNA: AU222107
- MoNA: FiehnHILIC000503
- PubChem: 9318
- PDB-CCD: A1LX3
- NIKKAJI: J9.818C
- KNApSAcK: 6690
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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Molecular pharmacology.
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Scientific reports.
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European journal of medicinal chemistry.
2014 Jan; 71(?):333-53. doi:
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The international journal of neuropsychopharmacology.
2012 Sep; 15(8):1087-98. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
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BMC psychiatry.
2011 Aug; 11(?):123. doi:
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2011 Jul; 54(13):4548-58. doi:
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2010 Nov; 2(6):330-4. doi:
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Psychiatrike = Psychiatriki.
2010 Oct; 21(4):332-8. doi:
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Leukemia & lymphoma.
2010 Mar; 51(3):523-39. doi:
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BMC neuroscience.
2010 Jan; 11(?):10. doi:
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International journal of legal medicine.
2009 Nov; 123(6):451-8. doi:
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2009 Oct; 63(10):871-80. doi:
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The international journal of neuropsychopharmacology.
2009 Aug; 12(7):953-64. doi:
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2009 Mar; 52(6):1693-700. doi:
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2009 Mar; 23(2):143-56. doi:
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Autonomic neuroscience : basic & clinical.
2009 Jan; 145(1-2):104-7. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2008 Oct; 32(7):1682-7. doi:
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2008 Sep; 872(1-2):38-42. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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2008 Jun; 32(5):355-63. doi:
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Journal of neural transmission (Vienna, Austria : 1996).
2008 May; 115(5):721-9. doi:
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Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2008 Mar; 28(3):214-8. doi:
. [PMID: 18447224] - Murat Pinar, Murat Gulsun, Ilker Tasci, Ahmet Erdil, Erol Bolu, Cengizhan Acikel, Ali Doruk. Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Jan; 32(1):135-9. doi:
10.1016/j.pnpbp.2007.07.028. [PMID: 17825464] - Sarah M R Wille, Paul Van Hee, Hugo M Neels, Carlos H Van Peteghem, Willy E Lambert. Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.
Journal of chromatography. A.
2007 Dec; 1176(1-2):236-45. doi:
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Neuro endocrinology letters.
2007 Oct; 28(5):614-20. doi:
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Life sciences.
2007 Aug; 81(11):933-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):128-34. doi:
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Neuroscience letters.
2007 May; 417(3):234-9. doi:
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The journal of pain.
2007 Apr; 8(4):315-24. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
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Synapse (New York, N.Y.).
2007 Jan; 61(1):17-23. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Oct; 843(1):100-13. doi:
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Forensic science international.
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2006 Mar; 26(3):212-4. doi:
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Therapeutic drug monitoring.
2006 Feb; 28(1):123-30. doi:
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2005 Dec; 1098(1-2):19-29. doi:
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Synapse (New York, N.Y.).
2005 Dec; 58(3):173-83. doi:
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Bioorganic & medicinal chemistry.
2005 Aug; 13(15):4658-66. doi:
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Journal of neurochemistry.
2005 Jul; 94(2):337-51. doi:
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General physiology and biophysics.
2005 Jun; 24(2):221-36. doi:
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Sudebno-meditsinskaia ekspertiza.
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Dialogues in clinical neuroscience.
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2004 Sep; 24(3):172-6. doi:
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Archives of toxicology.
2004 Aug; 78(8):453-9. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 May; 24(5):415-7. doi:
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Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
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Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2003 Nov; 28(11):2010-9. doi:
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European journal of nuclear medicine and molecular imaging.
2003 Sep; 30(9):1220-30. doi:
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