P-CRESOL (BioDeep_00000405468)

Main id: BioDeep_00000002893

 

PANOMIX_OTCML-2023


代谢物信息卡片


P-CRESOL

化学式: C7H8O (108.0575118)
中文名称: 对甲酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)O
InChI: InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3

描述信息

A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.

同义名列表

1 个代谢物同义名

P-CRESOL



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

32 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kimberly C Paul, Keren Zhang, Douglas I Walker, Janet Sinsheimer, Yu Yu, Cynthia Kusters, Irish Del Rosario, Aline Duarte Folle, Adrienne M Keener, Jeff Bronstein, Dean P Jones, Beate Ritz. Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson's disease. Molecular neurodegeneration. 2023 Dec; 18(1):100. doi: 10.1186/s13024-023-00694-5. [PMID: 38115046]
  • Tripti Singh, Dan Bahadur Pal, Ashok Kumar Bhatiya, Pradeep Kumar Mishra, Abeer Hashem, Abdulaziz Abdullah Alqarawi, Elsayed Fathi AbdAllah, Vijai Kumar Gupta, Neha Srivastava. Integrated process approach for degradation of p-cresol pollutant under photocatalytic reactor using activated carbon/TiO2 nanocomposite: application in wastewater treatment. Environmental science and pollution research international. 2022 Sep; 29(41):61811-61820. doi: 10.1007/s11356-021-15454-5. [PMID: 34415523]
  • Kaden K Fujita, Jon A Doering, Eric Stock, Zhe Lu, Tony Montina, Steve Wiseman. Effects of dietary 2-(2H-benzotriazol-2-yl)-4-methylphenol (UV-P) exposure on Japanese medaka (Oryzias latipes) in a short-term reproduction assay. Aquatic toxicology (Amsterdam, Netherlands). 2022 Jul; 248(?):106206. doi: 10.1016/j.aquatox.2022.106206. [PMID: 35635984]
  • Milad Moradi, Jafar Soleymani, Abolghasem Jouyban. A combination of amino-functionalized fibrous silica (KCC-1-NH2)/effectively and efficiently oxidized graphene oxide (EEGO) nanocomposite for dispersive solid-phase extraction, pre-concentration and fluorescence determination of total para-cresol in plasma samples of chronic kidney disease patients. Journal of pharmaceutical and biomedical analysis. 2022 May; 214(?):114746. doi: 10.1016/j.jpba.2022.114746. [PMID: 35378367]
  • Sofía Campillo, Lourdes Bohorquez, Elena Gutiérrez-Calabrés, Diego García-Ayuso, Verónica Miguel, Mercedes Griera, Yolanda Calle, Sergio de Frutos, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Laura Calleros. Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation. Experimental & molecular medicine. 2022 03; 54(3):226-238. doi: 10.1038/s12276-022-00738-8. [PMID: 35246616]
  • F Blachier, M Andriamihaja. Effects of the L-tyrosine-derived bacterial metabolite p-cresol on colonic and peripheral cells. Amino acids. 2022 Mar; 54(3):325-338. doi: 10.1007/s00726-021-03064-x. [PMID: 34468872]
  • Laura Turriziani, Arianna Ricciardello, Francesca Cucinotta, Fabiana Bellomo, Giada Turturo, Maria Boncoddo, Silvestro Mirabelli, Maria Luisa Scattoni, Maddalena Rossi, Antonio M Persico. Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study. Autism research : official journal of the International Society for Autism Research. 2022 01; 15(1):56-69. doi: 10.1002/aur.2639. [PMID: 34813183]
  • Nour Jalaleddine, Mahmood Hachim, Hamza Al-Hroub, Narjes Saheb Sharif-Askari, Abiola Senok, Adel Elmoselhi, Bassam Mahboub, Nimmi Moni Samuel Kurien, Richard K Kandasamy, Mohammad H Semreen, Rabih Halwani, Nelson C Soares, Saba Al Heialy. N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients. Frontiers in immunology. 2022; 13(?):827603. doi: 10.3389/fimmu.2022.827603. [PMID: 35663953]
  • Fatima Guerrero, Andres Carmona, Maria Jose Jimenez, Teresa Obrero, Victoria Pulido, Juan Antonio Moreno, Sagrario Soriano, Alejandro Martín-Malo, Pedro Aljama. Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins. Toxins. 2021 10; 13(10):. doi: 10.3390/toxins13100738. [PMID: 34679030]
  • Md Moshfekus Saleh-E-In, Paromik Bhattacharyya, Johannes Van Staden. Chemical Composition and Cytotoxic Activity of the Essential Oil and Oleoresins of In Vitro Micropropagated Ansellia africana Lindl: A Vulnerable Medicinal Orchid of Africa. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154556. [PMID: 34361724]
  • Patricia Bermudez-Martin, Jérôme A J Becker, Nicolas Caramello, Sebastian P Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurélia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joëlle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic. The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome. 2021 07; 9(1):157. doi: 10.1186/s40168-021-01103-z. [PMID: 34238386]
  • Yu Wang, Guo Zhu, Muyang Li, Ragini Singh, Carlos Marques, Rui Min, Brajesh Kumar Kaushik, Bingyuan Zhang, Rajan Jha, Santosh Kumar. Water Pollutants p-Cresol Detection Based on Au-ZnO Nanoparticles Modified Tapered Optical Fiber. IEEE transactions on nanobioscience. 2021 07; 20(3):377-384. doi: 10.1109/tnb.2021.3082856. [PMID: 34018936]
  • Lee D Chaves, Sham Abyad, Amanda M Honan, Mark A Bryniarski, Daniel I McSkimming, Corrine M Stahura, Steven C Wells, Donna M Ruszaj, Marilyn E Morris, Richard J Quigg, Rabi Yacoub. Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake. JCI insight. 2021 06; 6(11):. doi: 10.1172/jci.insight.144410. [PMID: 33914709]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Marine P M Letertre, Antonis Myridakis, Luke Whiley, Stéphane Camuzeaux, Matthew R Lewis, Katie E Chappell, Annie Thaikkatil, Marc-Emmanuel Dumas, Jeremy K Nicholson, Jonathan R Swann, Ian D Wilson. A targeted ultra performance liquid chromatography - Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Feb; 1164(?):122511. doi: 10.1016/j.jchromb.2020.122511. [PMID: 33460909]
  • S J Kim, X Zhang, S B Cho, C H Kim, H C Park, S J Moon. Uremic solutes of indoxyl sulfate and p-cresol enhance protease-activated receptor-2 expression in vitro and in vivo in keratinocytes. Human & experimental toxicology. 2021 Jan; 40(1):113-123. doi: 10.1177/0960327120945758. [PMID: 32757783]
  • Witchayapon Kamprom, Tulyapruek Tawonsawatruk, Sumana Mas-Oodi, Korrarit Anansilp, Manoch Rattanasompattikul, Aungkura Supokawej. P-cresol and Indoxyl Sulfate Impair Osteogenic Differentiation by Triggering Mesenchymal Stem Cell Senescence. International journal of medical sciences. 2021; 18(3):744-755. doi: 10.7150/ijms.48492. [PMID: 33437209]
  • Muthu Vijayasarathy, Gopikrishnan Kalarikkal Kiran, Sivaraman Balaji, Jayamanohar Jabastin, Palanisamy Bruntha Devi, Venkatesan Brindha Priyadarisini. In Vitro Detoxification Studies of p-Cresol by Intestinal Bacteria Isolated from Human Feces. Current microbiology. 2020 Oct; 77(10):3000-3012. doi: 10.1007/s00284-020-02124-x. [PMID: 32683469]
  • Federica Gevi, Antonio Belardo, Lello Zolla. A metabolomics approach to investigate urine levels of neurotransmitters and related metabolites in autistic children. Biochimica et biophysica acta. Molecular basis of disease. 2020 10; 1866(10):165859. doi: 10.1016/j.bbadis.2020.165859. [PMID: 32512190]
  • Susane Oshiro, Marta Ramalho, Paloma Cristina Durães, Raissa Andrade, Karolina Silva, Flaviano Silvério, Gevany Pinho. p-Cresol in cheese: Is it a flavouring compound or chemical contaminant?. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1510-1519. doi: 10.1080/19440049.2020.1778190. [PMID: 32679005]
  • Yan Rong, Tony K L Kiang. Characterizations of Human UDP-Glucuronosyltransferase Enzymes in the Conjugation of p-Cresol. Toxicological sciences : an official journal of the Society of Toxicology. 2020 08; 176(2):285-296. doi: 10.1093/toxsci/kfaa072. [PMID: 32421801]
  • Fatima Guerrero, Andres Carmona, Teresa Obrero, Maria Jose Jiménez, Sagrario Soriano, Juan Antonio Moreno, Alejandro Martín-Malo, Pedro Aljama. Role of endothelial microvesicles released by p-cresol on endothelial dysfunction. Scientific reports. 2020 06; 10(1):10657. doi: 10.1038/s41598-020-67574-6. [PMID: 32606426]
  • Shanshan Li, Yintang Zhang, Shuai Mu, Minrui Ma, Xiaoyan Liu, Haixia Zhang. Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC. Mikrochimica acta. 2020 06; 187(7):388. doi: 10.1007/s00604-020-04362-z. [PMID: 32542460]
  • Emiko Sato, Koji Hosomi, Akiyo Sekimoto, Eikan Mishima, Yuji Oe, Daisuke Saigusa, Sadayoshi Ito, Takaaki Abe, Hiroshi Sato, Jun Kunisawa, Toshimitsu Niwa, Nobuyuki Takahashi. Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition. Biochemical and biophysical research communications. 2020 05; 525(3):773-779. doi: 10.1016/j.bbrc.2020.02.141. [PMID: 32147096]
  • Yan Rong, Tony K L Kiang. Mechanisms of Metabolism Interaction Between p-Cresol and Mycophenolic Acid. Toxicological sciences : an official journal of the Society of Toxicology. 2020 02; 173(2):267-279. doi: 10.1093/toxsci/kfz231. [PMID: 31742356]
  • Yeo Min Yoon, Gyeongyun Go, Chul Won Yun, Ji Ho Lim, Sang Hun Lee. Knockdown of CK2α reduces P-cresol-induced fibrosis in human renal proximal tubule epithelial cells via the downregulation of profilin-1. International journal of medical sciences. 2020; 17(17):2850-2860. doi: 10.7150/ijms.48429. [PMID: 33162813]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Natalia Korytowska, Aleksandra Wyczałkowska-Tomasik, Agnieszka Wiśniewska, Leszek Pączek, Joanna Giebułtowicz. Development of the LC-MS/MS method for determining the p-cresol level in plasma. Journal of pharmaceutical and biomedical analysis. 2019 Apr; 167(?):149-154. doi: 10.1016/j.jpba.2019.01.041. [PMID: 30772758]
  • Marc Vila Cuenca, Jan van Bezu, Rob H J Beelen, Marc G Vervloet, Peter L Hordijk. Stabilization of cell-cell junctions by active vitamin D ameliorates uraemia-induced loss of human endothelial barrier function. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2019 02; 34(2):252-264. doi: 10.1093/ndt/gfy111. [PMID: 29718431]
  • Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee. TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model. International journal of molecular sciences. 2019 Jan; 20(3):. doi: 10.3390/ijms20030613. [PMID: 30708974]
  • Amber Crowley-Gall, Mary Shaw, Stephanie M Rollmann. Host Preference and Olfaction in Drosophila mojavensis. The Journal of heredity. 2019 01; 110(1):68-79. doi: 10.1093/jhered/esy052. [PMID: 30299456]
  • Yi Shi, Jingyi Zhang, Jia He, Donghao Liu, Xiaoyan Meng, Tao Huang, Hua He. A method of detecting two tumor markers (p-hydroxybenzoic acid and p-cresol) in human urine using a porous magnetic -cyclodextrine polymer as solid phase extractant, an alternative for early gastric cancer diagnosis. Talanta. 2019 Jan; 191(?):133-140. doi: 10.1016/j.talanta.2018.08.036. [PMID: 30262042]
  • Natsuki Ikematsu, Masayuki Kashiwagi, Kenji Hara, Brian Waters, Aya Matsusue, Mio Takayama, Shin-Ichi Kubo. Organ distribution of endogenous p-cresol in hemodialysis patients. The journal of medical investigation : JMI. 2019; 66(1.2):81-85. doi: 10.2152/jmi.66.81. [PMID: 31064961]
  • Eiman Abdulla Al Hinai, Piyarach Kullamethee, Ian R Rowland, Jonathan Swann, Gemma E Walton, Daniel M Commane. Modelling the role of microbial p-cresol in colorectal genotoxicity. Gut microbes. 2019; 10(3):398-411. doi: 10.1080/19490976.2018.1534514. [PMID: 30359553]
  • Subramanian Muthukumar, Samuthirapandi Muniasamy, Mahalingam Srinivasan, Andivelu Ilangovan, Soundarapandian Satheshkumar, Thangavel Rajagopal, Velusamy Ramesh Saravana Kumar, Karuppusamy Sivakumar, Govindaraju Archunan. Evaluation of pheromone-based kit: A noninvasive approach of estrus detection in buffalo. Reproduction in domestic animals = Zuchthygiene. 2018 Dec; 53(6):1466-1472. doi: 10.1111/rda.13281. [PMID: 30043999]
  • Yeo Min Yoon, Yong-Seok Han, Chul Won Yun, Jun Hee Lee, Rang Kim, Sang Hun Lee. Pioglitazone Protects Mesenchymal Stem Cells against P-Cresol-Induced Mitochondrial Dysfunction via Up-Regulation of PINK-1. International journal of molecular sciences. 2018 Sep; 19(10):. doi: 10.3390/ijms19102898. [PMID: 30250007]
  • David E Bartlett, Richard B Miller, Scott Thiesfeldt, Hari Vishal Lakhani, Tilak Khanal, Rebecca D Pratt, Cameron L Cottrill, Rebecca L Klug, Nathaniel Seth Adkins, Paul C Bown, D Blaine Nease, Joseph I Shapiro, Komal Sodhi. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092685. [PMID: 30201874]
  • Natsuki Ikematsu, Masayuki Kashiwagi, Kenji Hara, Brian Waters, Aya Matsusue, Mio Takayama, Shin-Ichi Kubo. Diagnostic meaning of blood p-cresol concentration in forensic autopsy cases. Legal medicine (Tokyo, Japan). 2018 Sep; 34(?):27-35. doi: 10.1016/j.legalmed.2018.08.003. [PMID: 30103078]
  • Eleonora Riccio, Massimo Sabbatini, Dario Bruzzese, Lucia Grumetto, Cristina Marchetiello, Maria Amicone, Michele Andreucci, Bruna Guida, Davide Passaretti, Giacomo Russo, Antonio Pisani. Plasma p-cresol lowering effect of sevelamer in non-dialysis CKD patients: evidence from a randomized controlled trial. Clinical and experimental nephrology. 2018 Jun; 22(3):529-538. doi: 10.1007/s10157-017-1504-8. [PMID: 29159529]
  • Jun Hee Lee, Chul Won Yun, Jin Hur, Sang Hun Lee. Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. Marine drugs. 2018 Apr; 16(4):. doi: 10.3390/md16040121. [PMID: 29642406]
  • Sruthi P Usha, Banshi D Gupta. Urinary p-cresol diagnosis using nanocomposite of ZnO/MoS2 and molecular imprinted polymer on optical fiber based lossy mode resonance sensor. Biosensors & bioelectronics. 2018 Mar; 101(?):135-145. doi: 10.1016/j.bios.2017.10.029. [PMID: 29055196]
  • Enrique Bosch-Panadero, Sebastian Mas, Esther Civantos, Pedro Abaigar, Vanesa Camarero, Alberto Ruiz-Priego, Alberto Ortiz, Jesus Egido, Emilio González-Parra. Bisphenol A is an exogenous toxin that promotes mitochondrial injury and death in tubular cells. Environmental toxicology. 2018 Mar; 33(3):325-332. doi: 10.1002/tox.22519. [PMID: 29214717]
  • Yang Liu, Jianping Li, Jingao Yu, Yingyi Wang, Jingbo Lu, Er-Xin Shang, Zhenhua Zhu, Jianming Guo, Jinao Duan. Disorder of gut amino acids metabolism during CKD progression is related with gut microbiota dysbiosis and metagenome change. Journal of pharmaceutical and biomedical analysis. 2018 Feb; 149(?):425-435. doi: 10.1016/j.jpba.2017.11.040. [PMID: 29169110]
  • Seung Pil Yun, Yeo Min Yoon, Jun Hee Lee, Minjee Kook, Yong-Seok Han, Seo Kyung Jung, Sang Hun Lee. Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein. International journal of molecular sciences. 2018 Jan; 19(2):. doi: 10.3390/ijms19020352. [PMID: 29370069]
  • Gao Chen, Wei-Chang Gong, Jia Ge, Johann Schinnerl, Bin Wang, Wei-Bang Sun. Variation in floral characters, particularly floral scent, in sapromyophilous Stemona species. Journal of integrative plant biology. 2017 Nov; 59(11):825-839. doi: 10.1111/jipb.12580. [PMID: 28836349]
  • Enrique Almanza-Aguilera, Mireia Urpi-Sarda, Rafael Llorach, Rosa Vázquez-Fresno, Mar Garcia-Aloy, Francesc Carmona, Alex Sanchez, Francisco Madrid-Gambin, Ramon Estruch, Dolores Corella, Cristina Andres-Lacueva. Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1H-NMR-based untargeted metabolomics approach. The Journal of nutritional biochemistry. 2017 10; 48(?):36-43. doi: 10.1016/j.jnutbio.2017.06.001. [PMID: 28692847]
  • Bruna Guida, Mauro Cataldi, Andrea Memoli, Rossella Trio, Martina di Maro, Lucia Grumetto, Ivana Capuano, Stefano Federico, Antonio Pisani, Massimo Sabbatini. Effect of a Short-Course Treatment with Synbiotics on Plasma p-Cresol Concentration in Kidney Transplant Recipients. Journal of the American College of Nutrition. 2017 Sep; 36(7):586-591. doi: 10.1080/07315724.2017.1334602. [PMID: 28895794]
  • Simone B Soso, Jacek A Koziel. Characterizing the scent and chemical composition of Panthera leo marking fluid using solid-phase microextraction and multidimensional gas chromatography-mass spectrometry-olfactometry. Scientific reports. 2017 07; 7(1):5137. doi: 10.1038/s41598-017-04973-2. [PMID: 28698649]
  • Elin Isberg, Daniel Peter Bray, Ylva Hillbur, Rickard Ignell. Evaluation of Host-Derived Volatiles for Trapping Culicoides Biting Midges (Diptera: Ceratopogonidae). Journal of chemical ecology. 2017 Jul; 43(7):662-669. doi: 10.1007/s10886-017-0860-x. [PMID: 28674827]
  • Pablo Hernández-Alonso, Daniel Cañueto, Simona Giardina, Jordi Salas-Salvadó, Nicolau Cañellas, Xavier Correig, Mònica Bulló. Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects. The Journal of nutritional biochemistry. 2017 07; 45(?):48-53. doi: 10.1016/j.jnutbio.2017.04.002. [PMID: 28432876]
  • Sonia Losada-Barreiro, Carlos Bravo-Díaz. Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. European journal of medicinal chemistry. 2017 Jun; 133(?):379-402. doi: 10.1016/j.ejmech.2017.03.061. [PMID: 28415050]
  • Limin Pan, Xiaoting Ye, Jiguang Ding, Yu Zhou. Antiproliferation effect of the uremic toxin para‑cresol on endothelial progenitor cells is related to its antioxidant activity. Molecular medicine reports. 2017 Apr; 15(4):2308-2312. doi: 10.3892/mmr.2017.6230. [PMID: 28260040]
  • Chien-Hsing Lee, Yi-Jen Hung, Yi-Shing Shieh, Chu-Yen Chien, Yu-Juei Hsu, Chih-Yuan Lin, Chi-Fu Chiang, Chia-Luen Huang, Chang-Hsun Hsieh. Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction: role of Axl signaling. American journal of physiology. Renal physiology. 2017 03; 312(3):F398-F406. doi: 10.1152/ajprenal.00258.2016. [PMID: 27927649]
  • Tanushree Banerjee, Timothy W Meyer, Tariq Shafi, Thomas H Hostetter, Michal Melamed, Yunnuo Zhu, Neil R Powe. Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO. Medicine. 2017 Feb; 96(6):e5799. doi: 10.1097/md.0000000000005799. [PMID: 28178126]
  • Katrin Matheis, Michael Granvogl. Characterization of Key Odorants Causing a Fusty/Musty Off-Flavor in Native Cold-Pressed Rapeseed Oil by Means of the Sensomics Approach. Journal of agricultural and food chemistry. 2016 Nov; 64(43):8168-8178. doi: 10.1021/acs.jafc.6b03527. [PMID: 27712066]
  • Bixiao Chen, Sahya Morioka, Tomoyuki Nakagawa, Takashi Hayakawa. Resistant starch reduces colonic and urinary p-cresol in rats fed a tyrosine-supplemented diet, whereas konjac mannan does not. Bioscience, biotechnology, and biochemistry. 2016 Oct; 80(10):1995-2000. doi: 10.1080/09168451.2016.1194183. [PMID: 27296718]
  • Stefano Gabriele, Roberto Sacco, Laura Altieri, Cristina Neri, Andrea Urbani, Carmela Bravaccio, Maria Pia Riccio, Maria Rosaria Iovene, Francesca Bombace, Laura De Magistris, Antonio M Persico. Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children. Autism research : official journal of the International Society for Autism Research. 2016 07; 9(7):752-9. doi: 10.1002/aur.1571. [PMID: 26437875]
  • Hai-Feng Wu, Yin-Di Zhu, Li-Jing Zhang, Qiong-Yu Zou, Li Chen, Ting Shen, Xin-Feng Wang, Guo-Xu Ma, Bo-Ran Hu, Wei-Cheng Hu, Xu-Dong Xu. A new phenylethanoid glycoside from Incarvillea compacta. Journal of Asian natural products research. 2016 Jun; 18(6):596-602. doi: 10.1080/10286020.2015.1096931. [PMID: 26630368]
  • Rayana Ariane Pereira Maciel, Lisienny Campoli Tono Rempel, Bruna Bosquetti, Alessandra Becker Finco, Roberto Pecoits-Filho, Wesley Mauricio de Souza, Andréa Emilia Marques Stinghen. p-cresol but not p-cresyl sulfate stimulate MCP-1 production via NF-κB p65 in human vascular smooth muscle cells. Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia. 2016 Jun; 38(2):153-60. doi: 10.5935/0101-2800.20160024. [PMID: 27438970]
  • Ximena Wong, Catalina Carrasco-Pozo, Elizabeth Escobar, Paola Navarrete, Franςois Blachier, Mireille Andriamihaja, Annaig Lan, Daniel Tomé, Marı́a José Cires, Edgar Pastene, Martin Gotteland. Deleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites. Journal of agricultural and food chemistry. 2016 May; 64(18):3574-83. doi: 10.1021/acs.jafc.6b00656. [PMID: 27039931]
  • Anelise Maria Bosco, Priscila Preve Pereira, Breno Fernando Martins Almeida, Luis Gustavo Narciso, Diego Borba Dos Santos, Álvaro José Dos Santos-Neto, Wagner Luis Ferreira, Paulo César Ciarlini. Free p-Cresol Alters Neutrophil Function in Dogs. Artificial organs. 2016 May; 40(5):480-8. doi: 10.1111/aor.12598. [PMID: 26496142]
  • Dorothy A Kieffer, Brian D Piccolo, Nosratola D Vaziri, Shuman Liu, Wei L Lau, Mahyar Khazaeli, Sohrab Nazertehrani, Mary E Moore, Maria L Marco, Roy J Martin, Sean H Adams. Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats. American journal of physiology. Renal physiology. 2016 05; 310(9):F857-71. doi: 10.1152/ajprenal.00513.2015. [PMID: 26841824]
  • Christel Brunschwig, Sophie Rochard, Alexandre Pierrat, Anne Rouger, Perrine Senger-Emonnot, Gérard George, Phila Raharivelomanana. Volatile composition and sensory properties of Vanilla × tahitensis bring new insights for vanilla quality control. Journal of the science of food and agriculture. 2016 Feb; 96(3):848-58. doi: 10.1002/jsfa.7157. [PMID: 25754309]
  • Yuan Ren, Shao-Yi Chen, Hai-Yan Yao, Liu-Jie Deng. Lysinibacillus cresolivorans sp. nov., an m-cresol-degrading bacterium isolated from coking wastewater treatment aerobic sludge. International journal of systematic and evolutionary microbiology. 2015 Nov; 65(11):4250-4255. doi: 10.1099/ijsem.0.000569. [PMID: 26333922]
  • Mireille Andriamihaja, Annaïg Lan, Martin Beaumont, Marc Audebert, Ximena Wong, Kana Yamada, Yulong Yin, Daniel Tomé, Catalina Carrasco-Pozo, Martin Gotteland, Xiangfeng Kong, François Blachier. The deleterious metabolic and genotoxic effects of the bacterial metabolite p-cresol on colonic epithelial cells. Free radical biology & medicine. 2015 Aug; 85(?):219-27. doi: 10.1016/j.freeradbiomed.2015.04.004. [PMID: 25881551]
  • Younis A Salmean, Mark S Segal, Sergiu P Palii, Wendy J Dahl. Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2015 May; 25(3):316-20. doi: 10.1053/j.jrn.2014.09.002. [PMID: 25446837]
  • Renata P Assis, Juliana F A Castro, Vânia O Gutierres, Carlos A Arcaro, Renata S Brotto, Olga M M F Oliveira, Amanda M Baviera, Iguatemy L Brunetti. Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management. BMC nephrology. 2015 Apr; 16(?):50. doi: 10.1186/s12882-015-0029-1. [PMID: 25886160]
  • Hsin-Hung Lin, Chiu-Ching Huang, Tze-Yi Lin, Ching-Yuang Lin. p-Cresol mediates autophagic cell death in renal proximal tubular cells. Toxicology letters. 2015 Apr; 234(1):20-9. doi: 10.1016/j.toxlet.2015.02.003. [PMID: 25668154]
  • Xiaoqiong Li, Rikke Lassen Jensen, Ole Højberg, Nuria Canibe, Bent Borg Jensen. Olsenella scatoligenes sp. nov., a 3-methylindole- (skatole) and 4-methylphenol- (p-cresol) producing bacterium isolated from pig faeces. International journal of systematic and evolutionary microbiology. 2015 Apr; 65(Pt 4):1227-1233. doi: 10.1099/ijs.0.000083. [PMID: 25634945]
  • B McCuaig, S C Dufour, R A Raguso, A P Bhatt, P Marino. Structural changes in plastids of developing Splachnum ampullaceum sporophytes and relationship to odour production. Plant biology (Stuttgart, Germany). 2015 Mar; 17(2):466-73. doi: 10.1111/plb.12256. [PMID: 25213550]
  • Chiao-Yin Sun, Guang-Huar Young, Yu-Ting Hsieh, Yau-Hung Chen, Mai-Szu Wu, Vin-Cent Wu, Jia-Hung Lee, Chin-Chan Lee. Protein-bound uremic toxins induce tissue remodeling by targeting the EGF receptor. Journal of the American Society of Nephrology : JASN. 2015 Feb; 26(2):281-90. doi: 10.1681/asn.2014010021. [PMID: 25012179]
  • Tamotsu Kato, Shinji Fukuda, Akemi Fujiwara, Wataru Suda, Masahira Hattori, Jun Kikuchi, Hiroshi Ohno. Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation. DNA research : an international journal for rapid publication of reports on genes and genomes. 2014 Oct; 21(5):469-80. doi: 10.1093/dnares/dsu013. [PMID: 24848698]
  • B Guida, R Germanò, R Trio, D Russo, B Memoli, L Grumetto, F Barbato, M Cataldi. Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2014 Sep; 24(9):1043-9. doi: 10.1016/j.numecd.2014.04.007. [PMID: 24929795]
  • Hyunjin Noh, Mi Ra Yu, Hyun Joo Kim, Eun Jung Jang, Eun Sook Hwang, Jin Seok Jeon, Soon Hyo Kwon, Dong Cheol Han. Uremic toxin p-cresol induces Akt-pathway-selective insulin resistance in bone marrow-derived mesenchymal stem cells. Stem cells (Dayton, Ohio). 2014 Sep; 32(9):2443-53. doi: 10.1002/stem.1738. [PMID: 24805773]
  • Kyra J Barnes, Andrew Rowland, Thomas M Polasek, John O Miners. Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins. European journal of clinical pharmacology. 2014 Sep; 70(9):1097-106. doi: 10.1007/s00228-014-1709-7. [PMID: 24954688]
  • Stefano Gabriele, Roberto Sacco, Sonia Cerullo, Cristina Neri, Andrea Urbani, Gabriele Tripi, Joëlle Malvy, Catherine Barthelemy, Frédérique Bonnet-Brihault, Antonio M Persico. Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2014 Sep; 19(6):463-70. doi: 10.3109/1354750x.2014.936911. [PMID: 25010144]
  • Marta Idziak, Piotr Pędzisz, Anna Burdzińska, Kamila Gala, Leszek Pączek. Uremic toxins impair human bone marrow-derived mesenchymal stem cells functionality in vitro. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2014 Jul; 66(4):187-94. doi: 10.1016/j.etp.2014.01.003. [PMID: 24548687]
  • Ruben Poesen, Liesbeth Viaene, Kristin Verbeke, Patrick Augustijns, Bert Bammens, Kathleen Claes, Dirk Kuypers, Pieter Evenepoel, Björn Meijers. Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease. BMC nephrology. 2014 Jun; 15(?):87. doi: 10.1186/1471-2369-15-87. [PMID: 24912660]
  • F Baldacchino, S Manon, L Puech, B Buatois, L Dormont, P Jay-Robert. Olfactory and behavioural responses of tabanid horseflies to octenol, phenols and aged horse urine. Medical and veterinary entomology. 2014 Jun; 28(2):201-9. doi: 10.1111/mve.12038. [PMID: 24188243]
  • Teruaki Aoki, Takashi Asahara, Kazumasa Matsumoto, Toshihiko Takada, Osamu Chonan, Kazuki Nakamori, Chiaki Nonaka, Ichiro Yamaji, Tsuyoshi Hisamoto, Masanori Sato, Tomoko Matsuda, Koji Nomoto. Effects of the continuous intake of a milk drink containing Lactobacillus casei strain Shirota on abdominal symptoms, fecal microbiota, and metabolites in gastrectomized subjects. Scandinavian journal of gastroenterology. 2014 May; 49(5):552-63. doi: 10.3109/00365521.2013.848469. [PMID: 24621348]
  • M N Gallucci, M E Carezzano, M M Oliva, M S Demo, R P Pizzolitto, M P Zunino, J A Zygadlo, J S Dambolena. In vitro activity of natural phenolic compounds against fluconazole-resistant Candida species: a quantitative structure-activity relationship analysis. Journal of applied microbiology. 2014 Apr; 116(4):795-804. doi: 10.1111/jam.12432. [PMID: 24387763]
  • Tammy L Sirich, Benjamin A Funk, Natalie S Plummer, Thomas H Hostetter, Timothy W Meyer. Prominent accumulation in hemodialysis patients of solutes normally cleared by tubular secretion. Journal of the American Society of Nephrology : JASN. 2014 Mar; 25(3):615-22. doi: 10.1681/asn.2013060597. [PMID: 24231664]
  • Jakk Wong, Yvette M Piceno, Todd Z DeSantis, Madeleine Pahl, Gary L Andersen, Nosratola D Vaziri. Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD. American journal of nephrology. 2014; 39(3):230-237. doi: 10.1159/000360010. [PMID: 24643131]
  • Hushna Ara Naznin, Daigo Kiyohara, Minako Kimura, Mitsuo Miyazawa, Masafumi Shimizu, Mitsuro Hyakumachi. Systemic resistance induced by volatile organic compounds emitted by plant growth-promoting fungi in Arabidopsis thaliana. PloS one. 2014; 9(1):e86882. doi: 10.1371/journal.pone.0086882. [PMID: 24475190]
  • Tomonori Unno, Mina Sakuma, Shiho Mitsuhashi. Effect of dietary supplementation of (-)-epigallocatechin gallate on gut microbiota and biomarkers of colonic fermentation in rats. Journal of nutritional science and vitaminology. 2014; 60(3):213-9. doi: 10.3177/jnsv.60.213. [PMID: 25078378]
  • Eleonora Riccio, Mauro Cataldi, Maristella Minco, Gennaro Argentino, Roberta Russo, Stefania Brancaccio, Andrea Memoli, Lucia Grumetto, Loredana Postiglione, Bruna Guida, Bruno Memoli. Evidence that p-cresol and IL-6 are adsorbed by the HFR cartridge: towards a new strategy to decrease systemic inflammation in dialyzed patients?. PloS one. 2014; 9(4):e95811. doi: 10.1371/journal.pone.0095811. [PMID: 24755610]
  • Jason R Masoner, Dana W Kolpin, Edward T Furlong, Isabelle M Cozzarelli, James L Gray, Eric A Schwab. Contaminants of emerging concern in fresh leachate from landfills in the conterminous United States. Environmental science. Processes & impacts. 2014; 16(10):2335-54. doi: 10.1039/c4em00124a. [PMID: 25111596]
  • Hisae Tanaka, Yoshiko Iwasaki, Hideyuki Yamato, Yoshitaka Mori, Hirotaka Komaba, Hiroshi Watanabe, Toru Maruyama, Masafumi Fukagawa. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct; 56(2):347-54. doi: 10.1016/j.bone.2013.07.002. [PMID: 23851293]
  • Kandasamy Karthikeyan, Samuthirapandi Muniasamy, Devaraj SankarGanesh, Shanmugam Achiraman, Veluchamy Ramesh Saravanakumar, Govindaraju Archunan. Faecal chemical cues in water buffalo that facilitate estrus detection. Animal reproduction science. 2013 May; 138(3-4):163-7. doi: 10.1016/j.anireprosci.2013.02.017. [PMID: 23570909]
  • Yu-Sen Peng, Yen-Tung Lin, Sheng-De Wang, Kuan-Yu Hung, Ying Chen, Seu-Mei Wang. P-cresol induces disruption of cardiomyocyte adherens junctions. Toxicology. 2013 Apr; 306(?):176-84. doi: 10.1016/j.tox.2013.02.015. [PMID: 23466501]
  • Gloria Brusotti, Mohammed Farhad Ibrahim, Alessandra Dentamaro, Gianluca Gilardoni, Solveig Tosi, Pietro Grisoli, Cesare Dacarro, Maria Lidia Guglielminetti, Faiq Hama Saeed Hussain, Gabriele Caccialanza, Giovanni Vidari. Chemical composition and antimicrobial activity of the volatile fractions from leaves and flowers of the wild Iraqi Kurdish plant Prangos peucedanifolia FENZL. Chemistry & biodiversity. 2013 Feb; 10(2):274-80. doi: 10.1002/cbdv.201200202. [PMID: 23418174]
  • N Neirynck, R Vanholder, E Schepers, S Eloot, A Pletinck, G Glorieux. An update on uremic toxins. International urology and nephrology. 2013 Feb; 45(1):139-50. doi: 10.1007/s11255-012-0258-1. [PMID: 22893494]
  • Guoxiang Jiang, Sen Lin, Lingrong Wen, Yueming Jiang, Mouming Zhao, Feng Chen, K Nagendra Prasad, Xuewu Duan, Bao Yang. Identification of a novel phenolic compound in litchi (Litchi chinensis Sonn.) pericarp and bioactivity evaluation. Food chemistry. 2013 Jan; 136(2):563-8. doi: 10.1016/j.foodchem.2012.08.089. [PMID: 23122098]
  • Alessandra Brocca, Grazia Maria Virzì, Massimo de Cal, Vincenzo Cantaluppi, Claudio Ronco. Cytotoxic effects of p-cresol in renal epithelial tubular cells. Blood purification. 2013; 36(3-4):219-25. doi: 10.1159/000356370. [PMID: 24496194]
  • Bruna Guida, Mauro Cataldi, Eleonora Riccio, Lucia Grumetto, Andrea Pota, Silvio Borrelli, Andrea Memoli, Francesco Barbato, Gennaro Argentino, Giuliana Salerno, Bruno Memoli. Plasma p-cresol lowering effect of sevelamer in peritoneal dialysis patients: evidence from a Cross-Sectional Observational Study. PloS one. 2013; 8(8):e73558. doi: 10.1371/journal.pone.0073558. [PMID: 24015307]
  • H A M Mutsaers, M J G Wilmer, D Reijnders, J Jansen, P H H van den Broek, M Forkink, E Schepers, G Glorieux, R Vanholder, L P van den Heuvel, J G Hoenderop, R Masereeuw. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochimica et biophysica acta. 2013 Jan; 1832(1):142-50. doi: 10.1016/j.bbadis.2012.09.006. [PMID: 23017367]
  • Laetitia Koppe, Nicolas J Pillon, Roxane E Vella, Marine L Croze, Caroline C Pelletier, Stéphane Chambert, Ziad Massy, Griet Glorieux, Raymond Vanholder, Yann Dugenet, Hédi A Soula, Denis Fouque, Christophe O Soulage. p-Cresyl sulfate promotes insulin resistance associated with CKD. Journal of the American Society of Nephrology : JASN. 2013 Jan; 24(1):88-99. doi: 10.1681/asn.2012050503. [PMID: 23274953]
  • Isabelle E J A François, Olivier Lescroart, Wim S Veraverbeke, Massimo Marzorati, Sam Possemiers, Pieter Evenepoel, Henrike Hamer, Els Houben, Karen Windey, Gjalt W Welling, Jan A Delcour, Christophe M Courtin, Kristin Verbeke, Willem F Broekaert. Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial. The British journal of nutrition. 2012 Dec; 108(12):2229-42. doi: 10.1017/s0007114512000372. [PMID: 22370444]
  • G R Sampaio, T Saldanha, R A M Soares, E A F S Torres. Effect of natural antioxidant combinations on lipid oxidation in cooked chicken meat during refrigerated storage. Food chemistry. 2012 Dec; 135(3):1383-90. doi: 10.1016/j.foodchem.2012.05.103. [PMID: 22953870]