Suberic acid (BioDeep_00000405392)
Main id: BioDeep_00000001696
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
化学式: C8H14O4 (174.0892)
中文名称: 辛二酸
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 39.48%
分子结构信息
SMILES: C(C(O)=O)CCCCCC(O)=O
InChI: InChI=1S/C8H14O4/c9-7(10)5-3-1-2-4-6-8(11)12/h1-6H2,(H,9,10)(H,11,12)
描述信息
An alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.
Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency.
Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency.
同义名列表
4 个代谢物同义名
数据库引用编号
63 个数据库交叉引用编号
- ChEBI: CHEBI:9300
- KEGG: C08278
- PubChem: 10457
- ChEMBL: CHEMBL1162491
- CAS: 68937-72-4
- CAS: 505-48-6
- MoNA: CCMSLIB00005720842
- MoNA: MoNA038896
- MoNA: MoNA038410
- MoNA: MoNA038050
- MoNA: MoNA037736
- MoNA: MoNA037676
- MoNA: MoNA037672
- MoNA: MoNA037311
- MoNA: MoNA037310
- MoNA: MoNA037041
- MoNA: MoNA037038
- MoNA: MoNA036931
- MoNA: MoNA036930
- MoNA: MoNA036929
- MoNA: MoNA036466
- MoNA: MoNA036465
- MoNA: MoNA036464
- MoNA: MoNA036330
- MoNA: MoNA036326
- MoNA: MoNA036324
- MoNA: MoNA035667
- MoNA: MoNA035664
- MoNA: MoNA035660
- MoNA: MoNA034899
- MoNA: MoNA034898
- MoNA: MoNA034897
- MoNA: MoNA034539
- MoNA: MoNA034537
- MoNA: MoNA034535
- MoNA: MoNA033550
- MoNA: MoNA033548
- MoNA: MoNA032463
- MoNA: MoNA032462
- MoNA: MoNA031888
- MoNA: MoNA031887
- MoNA: MoNA031886
- MoNA: EMBL-MCF_spec303726
- MoNA: EMBL-MCF_spec303687
- MoNA: EMBL-MCF_spec303676
- MoNA: EMBL-MCF_spec303669
- MoNA: MoNA016923
- MoNA: MoNA016617
- MoNA: HMDB0000893_ms_ms_1258
- MoNA: HMDB0000893_ms_ms_1257
- MoNA: HMDB0000893_ms_ms_1256
- MetaboLights: MTBLC9300
- PubChem: 10476
- LipidMAPS: LMFA01170001
- KNApSAcK: C00001204
- PDB-CCD: OCE
- 3DMET: B02156
- NIKKAJI: J6.225A
- RefMet: Suberic acid
- medchemexpress: HY-W015300
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-493
- KNApSAcK: 9300
- LOTUS: LTS0275043
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
75 个相关的物种来源信息
- 25641 - Aloe: LTS0275043
- 1080010 - Aloe africana: 10.1021/JF071110T
- 1080010 - Aloe africana: LTS0275043
- 7458 - Apidae: LTS0275043
- 7459 - Apis: LTS0275043
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 7461 - Apis cerana: LTS0275043
- 4056 - Apocynaceae: LTS0275043
- 3701 - Arabidopsis: LTS0275043
- 3702 - Arabidopsis thaliana: 10.1074/JBC.RA118.003351
- 3702 - Arabidopsis thaliana: 10.1104/PP.114.240986
- 3702 - Arabidopsis thaliana: 10.1111/TPJ.14311
- 3702 - Arabidopsis thaliana: LTS0275043
- 13342 - Arbutus: LTS0275043
- 84005 - Arbutus unedo: 10.1006/JFCA.1999.0868
- 84005 - Arbutus unedo: LTS0275043
- 6656 - Arthropoda: LTS0275043
- 51383 - Asphodelaceae: LTS0275043
- 2 - Bacteria: LTS0275043
- 3700 - Brassicaceae: LTS0275043
- 3568 - Caryophyllaceae: LTS0275043
- 3781 - Crassulaceae: LTS0275043
- 3650 - Cucurbitaceae: LTS0275043
- 4345 - Ericaceae: LTS0275043
- 33682 - Euglenozoa: LTS0275043
- 2759 - Eukaryota: LTS0275043
- 1236 - Gammaproteobacteria: LTS0275043
- 47605 - Hibiscus: LTS0275043
- 106335 - Hibiscus syriacus: 10.1007/BF00565786
- 106335 - Hibiscus syriacus: LTS0275043
- 50557 - Insecta: LTS0275043
- 161755 - Isatis: LTS0275043
- 161756 - Isatis tinctoria: 10.1055/S-2006-958019
- 161756 - Isatis tinctoria: LTS0275043
- 5653 - Kinetoplastea: LTS0275043
- 4447 - Liliopsida: LTS0275043
- 3398 - Magnoliopsida: LTS0275043
- 3629 - Malvaceae: LTS0275043
- 33208 - Metazoa: LTS0275043
- 3689 - Populus: LTS0275043
- 113636 - Populus tremula: 10.1186/S12864-017-4411-1
- 113636 - Populus tremula: LTS0275043
- 135621 - Pseudomonadaceae: LTS0275043
- 286 - Pseudomonas: LTS0275043
- 287 - Pseudomonas aeruginosa: LTS0275043
- 202994 - Rhodiola: LTS0275043
- 202998 - Rhodiola chrysanthemifolia: LTS0275043
- 203000 - Rhodiola sacra: 10.1016/S0378-8741(98)00245-1
- 203000 - Rhodiola sacra: 10.1248/BPB.22.157
- 203000 - Rhodiola sacra: LTS0275043
- 3988 - Ricinus communis L.: -
- 3688 - Salicaceae: LTS0275043
- 4070 - Solanaceae: LTS0275043
- 4107 - Solanum: LTS0275043
- 4081 - Solanum lycopersicum: 10.1038/SDATA.2014.29
- 4081 - Solanum lycopersicum: LTS0275043
- 13273 - Stellaria: LTS0275043
- 1826902 - Stellaria dichotoma: 10.1021/NP040080A
- 35493 - Streptophyta: LTS0275043
- 58023 - Tracheophyta: LTS0275043
- 3676 - Trichosanthes: LTS0275043
- 3677 - Trichosanthes kirilowii: 10.1248/YAKUSHI1947.109.4_250
- 3677 - Trichosanthes kirilowii: LTS0275043
- 654837 - Trichosanthes tricuspidata: 10.1248/YAKUSHI1947.109.4_265
- 654837 - Trichosanthes tricuspidata: LTS0275043
- 5690 - Trypanosoma: LTS0275043
- 5691 - Trypanosoma brucei: 10.1128/AAC.00044-13
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
- 5691 - Trypanosoma brucei: LTS0275043
- 5654 - Trypanosomatidae: LTS0275043
- 63501 - Vincetoxicum: LTS0275043
- 157443 - Vincetoxicum atratum: 10.1002/HLCA.200390047
- 157443 - Vincetoxicum atratum: LTS0275043
- 33090 - Viridiplantae: LTS0275043
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Suchitra K Panigrahy, Awanish Kumar, Renu Bhatt. Hedychium coronarium Rhizomes: Promising Antidiabetic and Natural Inhibitor of α-Amylase and α-Glucosidase.
Journal of dietary supplements.
2020; 17(1):81-87. doi:
10.1080/19390211.2018.1483462
. [PMID: 30325249] - Carmen Puig-Alcaraz, Milagros Fuentes-Albero, Omar Cauli. Relationship between adipic acid concentration and the core symptoms of autism spectrum disorders.
Psychiatry research.
2016 Aug; 242(?):39-45. doi:
10.1016/j.psychres.2016.05.027
. [PMID: 27259135] - Xiaowei Sun, Wei Xu, Yan Zeng, Yurong Hou, Lin Guo, Xiujuan Zhao, Changhao Sun. Metabonomics evaluation of urine from rats administered with phorate under long-term and low-level exposure by ultra-performance liquid chromatography-mass spectrometry.
Journal of applied toxicology : JAT.
2014 Feb; 34(2):176-83. doi:
10.1002/jat.2848
. [PMID: 23280859] - Lindsay Tomlinson, Mark A Tirmenstein, Evan B Janovitz, Nelly Aranibar, Karl-Heinz Ott, John C Kozlosky, Laura M Patrone, William E Achanzar, Karen A Augustine, Kimberly C Brannen, Kenneth E Carlson, Jeffrey H Charlap, Katherine M Dubrow, Liya Kang, Laura T Rosini, Julieta M Panzica-Kelly, Oliver P Flint, Frederic J Moulin, John R Megill, Haiying Zhang, Michael J Bennett, Joseph J Horvath. Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):268-79. doi:
10.1093/toxsci/kfs217
. [PMID: 22821849] - Joanna Kałużna-Czaplińska, Ewa Socha, Jacek Rynkowski. B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children.
Nutrition research (New York, N.Y.).
2011 Jul; 31(7):497-502. doi:
10.1016/j.nutres.2011.06.002
. [PMID: 21840465] - Jia Liu, Lawrence Litt, Mark R Segal, Mark J S Kelly, Jeffrey G Pelton, Myungwon Kim. Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.
International journal of molecular sciences.
2011; 12(10):6469-501. doi:
10.3390/ijms12106469
. [PMID: 22072900] - Hye In Woo, Hyung-Doo Park, Yong-Wha Lee, Dong Hwan Lee, Chang-Seok Ki, Soo-Youn Lee, Jong-Won Kim. Clinical, biochemical and genetic analyses in two Korean patients with medium-chain acyl-CoA dehydrogenase deficiency.
The Korean journal of laboratory medicine.
2011 Jan; 31(1):54-60. doi:
10.3343/kjlm.2011.31.1.54
. [PMID: 21239873] - Hui Sun, Alla Lapidus, Matt Nolan, Susan Lucas, Tijana Glavina Del Rio, Hope Tice, Jan-Fang Cheng, Roxane Tapia, Cliff Han, Lynne Goodwin, Sam Pitluck, Ioanna Pagani, Natalia Ivanova, Konstantinos Mavromatis, Natalia Mikhailova, Amrita Pati, Amy Chen, Krishna Palaniappan, Miriam Land, Loren Hauser, Yun-Juan Chang, Cynthia D Jeffries, Olivier Duplex Ngatchou Djao, Manfred Rohde, Johannes Sikorski, Markus Göker, Tanja Woyke, James Bristow, Jonathan A Eisen, Victor Markowitz, Philip Hugenholtz, Nikos C Kyrpides, Hans-Peter Klenk. Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509).
Standards in genomic sciences.
2010 Nov; 3(3):325-36. doi:
10.4056/sigs.1363462
. [PMID: 21304737] - Heli Salmi, Mikael Kuitunen, Mirva Viljanen, Risto Lapatto. Cow's milk allergy is associated with changes in urinary organic acid concentrations.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2010 Mar; 21(2 Pt 2):e401-6. doi:
10.1111/j.1399-3038.2009.00881.x
. [PMID: 19397753] - Christian Lanz, Andrew D Patterson, Josef Slavík, Kristopher W Krausz, Monika Ledermann, Frank J Gonzalez, Jeffrey R Idle. Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm.
Radiation research.
2009 Aug; 172(2):198-212. doi:
10.1667/rr1796.1
. [PMID: 19630524] - Shiek Ssj Ahmed, Winkins Santosh, Suresh Kumar, Hema T Thanka Christlet. Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection.
Journal of biomedical science.
2009 Jul; 16(?):63. doi:
10.1186/1423-0127-16-63
. [PMID: 19594911] - J Shearer, G Duggan, A Weljie, D S Hittel, D H Wasserman, H J Vogel. Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse.
Diabetes, obesity & metabolism.
2008 Sep; 10(10):950-8. doi:
10.1111/j.1463-1326.2007.00837.x
. [PMID: 18215169] - Gregory Kaler, David M Truong, Akash Khandelwal, Megha Nagle, Satish A Eraly, Peter W Swaan, Sanjay K Nigam. Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
The Journal of biological chemistry.
2007 Aug; 282(33):23841-53. doi:
10.1074/jbc.m703467200
. [PMID: 17553798] - Li-Ping Dai, Hui-Min Gao, Zhi-Min Wang, Wei-Hao Wang. [Isolation and structure identification of chemical constituents from the skin of Bufo bufo gargarizans].
Yao xue xue bao = Acta pharmaceutica Sinica.
2007 Aug; 42(8):858-61. doi:
. [PMID: 17944235]
- Michael Devereux, Malachy McCann, Denis O'shea, Mark O'connor, Eileen Kiely, Vickie McKee, Declan Naughton, Anna Fisher, Andrew Kellett, Maureen Walsh, Denise Egan, Carol Deegan. Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine).
Bioinorganic chemistry and applications.
2006; ?(?):80283. doi:
10.1155/bca/2006/80283
. [PMID: 17497019] - Xiuling Lu, Chunyang Zheng, Yuhong Xu, Zhiguo Su. Disuccinimidyl suberate cross-linked hemoglobin as a novel red blood cell substitute.
Science in China. Series C, Life sciences.
2005 Feb; 48(1):49-60. doi:
10.1360/04yc0014
. [PMID: 15844357] - Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.
Chemical research in toxicology.
2003 Oct; 16(10):1338-58. doi:
10.1021/tx030011g
. [PMID: 14565775] - Eric E Boros, Vicente Samano, John A Ray, James B Thompson, David K Jung, Istvan Kaldor, Cecilia S Koble, Michael T Martin, Virgil L Styles, Robert A Mook, Paul L Feldman, John J Savarese, Matthew R Belmont, Eric C Bigham, G Evan Boswell, Mir A Hashim, Sanjay S Patel, James C Wisowaty, Gary D Bowers, Caroline L Moseley, John S Walsh, Mindy J Reese, Randy D Rutkowske, Andrea M Sefler, Timothy D Spitzer. Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.
Journal of medicinal chemistry.
2003 Jun; 46(12):2502-15. doi:
10.1021/jm020574+
. [PMID: 12773054] - N Weber, P Weitkamp, K D Mukherjee. Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya.
Journal of agricultural and food chemistry.
2001 Nov; 49(11):5210-6. doi:
10.1021/jf0107407
. [PMID: 11714305] - E Capristo, G Mingrone, A De Gaetano, G Addolorato, A V Greco, G Gasbarrini. A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples.
Clinica chimica acta; international journal of clinical chemistry.
1999 Nov; 289(1-2):11-21. doi:
10.1016/s0009-8981(99)00145-x
. [PMID: 10556649] - A A van Landeghem, Y T Somers-Pijnenburg, W J Somers, C Stokwielder, W de Bruyn, G B van den Berg. Adsorption of small hydroxy acids on glass: a pitfall in quantitative urinary organic acid analysis by GC-MS.
Journal of inherited metabolic disease.
1999 May; 22(3):293-6. doi:
10.1023/a:1005527315019
. [PMID: 10384390] - T Hagen, M S Korson, M Sakamoto, J E Evans. A GC/MS/MS screening method for multiple organic acidemias from urine specimens.
Clinica chimica acta; international journal of clinical chemistry.
1999 May; 283(1-2):77-88. doi:
10.1016/s0009-8981(99)00037-6
. [PMID: 10404733] - K Yoshioka, N Shimojo, T Nakanishi, K Naka, K Okuda. Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1994 May; 655(2):189-93. doi:
10.1016/0378-4347(94)80022-7
. [PMID: 8081464] - J J Pitt, A Poulos. Excretion of 3,6-epoxydicarboxylic acids in peroxisomal disorders.
Clinica chimica acta; international journal of clinical chemistry.
1993 Dec; 223(1-2):23-9. doi:
10.1016/0009-8981(93)90059-d
. [PMID: 7511488] - M J Bennett, M C Ragni, I Hood, D E Hale. Azelaic and pimelic acids: metabolic intermediates or artefacts?.
Journal of inherited metabolic disease.
1992; 15(2):220-3. doi:
10.1007/bf01799635
. [PMID: 1527989] - G Mingrone, A V Greco, A Bertuzzi, E Arcieri-Mastromattei, R M Tacchino, F Marino, E Finotti, M Castagneto. Tissue uptake and oxidation of disodium sebacate in man.
JPEN. Journal of parenteral and enteral nutrition.
1991 Jul; 15(4):454-9. doi:
10.1177/0148607191015004454
. [PMID: 1910110] - S Bergseth, B M Hokland, J Bremer. Metabolism of dicarboxylic acids in vivo and in the perfused kidney of the rat.
Biochimica et biophysica acta.
1988 Jul; 961(1):103-9. doi:
10.1016/0005-2760(88)90135-x
. [PMID: 3132982] - H Böhles, Z Akcetin, W Lehnert. The influence of i.v. MCT and carnitine on the excretion of dicarboxylic acids.
Beitrage zu Infusionstherapie und klinische Ernahrung.
1988; 20(?):69-74. doi:
NULL
. [PMID: 3132147] - J A Del Valle, M J Garcia, B Merinero, C Pérez-Cerdá, F Roman, A Jimenez, M Ugarte, M Martínez-Pardo, C Ludeña, C Camarero. A new patient with dicarboxylic aciduria suggestive of medium-chain Acyl-CoA dehydrogenase deficiency presenting as Reye's syndrome.
Journal of inherited metabolic disease.
1984; 7(2):62-4. doi:
10.1007/bf01805804
. [PMID: 6434827] - N Gregersen, P B Mortensen, S Kølvraa. On the biologic origin of C6-C10-dicarboxylic and C6-C10-omega-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the omega- and omega-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver.
Pediatric research.
1983 Oct; 17(10):828-34. doi:
10.1203/00006450-198310000-00013
. [PMID: 6634246] - N Gregersen, S Kølvraa, K Rasmussen, P B Mortensen, P Divry, M David, N Hobolth. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases.
Clinica chimica acta; international journal of clinical chemistry.
1983 Aug; 132(2):181-91. doi:
10.1016/0009-8981(83)90246-2
. [PMID: 6616873] - P B Mortensen. Urinary excretion of C4--C10-dicarboxylic acids and antiketogenic properties of adipic acid in ketogenic-stimulated rats due to diabetes, long-chain and short-chain monocarboxylic acids.
Biochimica et biophysica acta.
1981 May; 664(2):335-48. doi:
10.1016/0005-2760(81)90056-4
. [PMID: 7248329] - P B Mortensen. C6--C10-dicarboxylic aciduria in starved, fat-fed and diabetic rats receiving decanoic acid or medium-chain triacylglycerol. An in vivo measure of the rate of beta-oxidation of fatty acids.
Biochimica et biophysica acta.
1981 May; 664(2):349-55. doi:
10.1016/0005-2760(81)90057-6
. [PMID: 7248330] - P B Mortensen, N Gregersen, S Kølvraa, E Christensen. The occurrence of C6--C10-dicarboxylic acids in urine from patients and rats treated with dipropylacetate.
Biochemical medicine.
1980 Oct; 24(2):153-61. doi:
10.1016/0006-2944(80)90006-x
. [PMID: 6779814] - N Gregersen, F Rosleff, S Kølvraa, N Hobolth, K Rasmussen, R Lauritzen. Non-ketotic C6-C10-dicarboxylic aciduria: biochemical investigations of two cases.
Clinica chimica acta; international journal of clinical chemistry.
1980 Mar; 102(2-3):179-89. doi:
10.1016/0009-8981(80)90031-5
. [PMID: 6892795]