mevinphos (BioDeep_00000403991)

Main id: BioDeep_00000002053

 

natural product


代谢物信息卡片


Pesticide1_Mevinphos Isomer 1*_C7H13O6P_2-Butenoic acid, 3-[(dimethoxyphosphinyl)oxy]-, methyl ester, (2E)-

化学式: C7H13O6P (224.045)
中文名称: 顺-速灭磷, 速灭磷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CC(=O)OC)OP(=O)(OC)OC
InChI: InChI=1S/C7H13O6P/c1-6(5-7(8)10-2)13-14(9,11-3)12-4/h5H,1-4H3/b6-5+

描述信息

D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

7 个代谢物同义名

methyl 3-[(dimethoxyphosphinyl)oxy]crotonate; (E)-trans-mevinphos; mevinphos; Pesticide1_Mevinphos Isomer 1*_C7H13O6P_2-Butenoic acid, 3-[(dimethoxyphosphinyl)oxy]-, methyl ester, (2E)-; Mevinphos; Mevinphos; Mevinphos



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 CEP55, ELANE, GRB2, NTRK2, OLIG2, PARK7, PIK3CA, PPP1R13B, PRKX, PTEN, RAF1, SART3, UCHL1
Peripheral membrane protein 1 ACHE
Endosome membrane 2 HLA-A, NTRK2
Endoplasmic reticulum membrane 4 CHRM3, HLA-A, HMOX1, UCHL1
Nucleus 12 ACHE, FLI1, GRB2, HMOX1, OLIG2, PARK7, PPP1R13B, PRKX, PTEN, RAF1, SART3, SLC25A5
cytosol 11 ELANE, FLI1, GRB2, HMOX1, NTRK2, PARK7, PIK3CA, PPP1R13B, PTEN, RAF1, UCHL1
dendrite 2 CHRM3, NTRK2
nuclear body 1 FLI1
phagocytic vesicle 1 ELANE
centrosome 1 CEP55
nucleoplasm 9 FLI1, GRB2, HMOX1, PARK7, PPP1R13B, PRKX, PTEN, SART3, UCHL1
Cell membrane 6 ACHE, CHRM3, HLA-A, NTRK2, PARK7, RAF1
Lipid-anchor 2 PARK7, UCHL1
Cytoplasmic side 1 HMOX1
Cleavage furrow 1 CEP55
lamellipodium 1 PIK3CA
Cell projection, axon 1 NTRK2
Early endosome membrane 2 HLA-A, NTRK2
Multi-pass membrane protein 2 CHRM3, SLC25A5
Synapse 2 ACHE, CHRM3
cell cortex 1 GRB2
cell surface 3 ACHE, ELANE, HLA-A
Golgi apparatus 4 ACHE, GRB2, HLA-A, RAF1
Golgi membrane 1 HLA-A
lysosomal membrane 1 HLA-A
mitochondrial inner membrane 1 SLC25A5
neuromuscular junction 1 ACHE
neuronal cell body 1 UCHL1
synaptic vesicle 1 PARK7
endosome 1 GRB2
plasma membrane 12 ACHE, BCHE, CHRM3, GRB2, HLA-A, NTRK2, PARK7, PIK3CA, PPP1R13B, PTEN, RAF1, SLC25A5
terminal bouton 1 NTRK2
Membrane 7 ACHE, CEP55, HLA-A, HMOX1, NTRK2, PARK7, SLC25A5
apical plasma membrane 1 PTEN
axon 2 NTRK2, PARK7
basolateral plasma membrane 1 CHRM3
extracellular exosome 4 ELANE, GRB2, HLA-A, PARK7
Lysosome membrane 1 HLA-A
endoplasmic reticulum 3 HLA-A, HMOX1, PARK7
extracellular space 5 ACHE, BCHE, ELANE, HLA-A, HMOX1
perinuclear region of cytoplasm 6 ACHE, HMOX1, NTRK2, PARK7, PIK3CA, PPP1R13B
adherens junction 1 PARK7
intercalated disc 1 PIK3CA
mitochondrion 3 PARK7, RAF1, SLC25A5
postsynaptic density 2 NTRK2, PTEN
Single-pass type I membrane protein 2 HLA-A, NTRK2
Secreted 2 ACHE, BCHE
extracellular region 4 ACHE, BCHE, ELANE, PTEN
cytoplasmic side of plasma membrane 1 PTEN
Single-pass membrane protein 1 HLA-A
mitochondrial outer membrane 2 HMOX1, RAF1
mitochondrial matrix 1 PARK7
Extracellular side 1 ACHE
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CEP55
external side of plasma membrane 1 HLA-A
dendritic spine 2 NTRK2, PTEN
nucleolus 1 GRB2
axon cytoplasm 1 UCHL1
midbody 1 CEP55
Early endosome 1 NTRK2
cell-cell junction 1 GRB2
postsynaptic membrane 1 CHRM3
Cytoplasm, perinuclear region 1 NTRK2
Mitochondrion inner membrane 1 SLC25A5
Membrane raft 1 PARK7
mitochondrial nucleoid 1 SLC25A5
basement membrane 1 ACHE
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 2 PARK7, PTEN
mitochondrial intermembrane space 1 PARK7
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
lateral plasma membrane 1 CHRM3
nuclear speck 1 SART3
Postsynaptic cell membrane 1 CHRM3
receptor complex 1 NTRK2
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
chromatin 3 FLI1, OLIG2, PARK7
cell projection 1 PTEN
phagocytic vesicle membrane 1 HLA-A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CEP55
centriole 1 CEP55
COP9 signalosome 1 GRB2
Flemming body 1 CEP55
blood microparticle 1 BCHE
Basolateral cell membrane 1 CHRM3
Lipid-anchor, GPI-anchor 1 ACHE
intercellular bridge 1 CEP55
Recycling endosome membrane 1 HLA-A
Nucleus, nucleoplasm 1 SART3
Cell projection, dendrite 1 NTRK2
Nucleus speckle 1 SART3
cell body 1 PARK7
side of membrane 1 ACHE
pseudopodium 1 RAF1
Midbody, Midbody ring 1 CEP55
basal plasma membrane 1 CHRM3
endoplasmic reticulum lumen 1 BCHE
transcription repressor complex 1 ELANE
axon terminus 1 NTRK2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 ELANE
ASAP complex 1 SART3
Schmidt-Lanterman incisure 1 PTEN
azurophil granule lumen 1 ELANE
endoplasmic reticulum exit site 1 HLA-A
Single-pass type IV membrane protein 1 HMOX1
ER to Golgi transport vesicle membrane 1 HLA-A
nuclear envelope lumen 1 BCHE
vesicle membrane 1 GRB2
Cajal body 1 SART3
synaptic cleft 1 ACHE
lumenal side of endoplasmic reticulum membrane 1 HLA-A
MHC class I peptide loading complex 1 HLA-A
Cytoplasmic vesicle, phagosome 1 ELANE
Nucleus, Cajal body 1 SART3
MMXD complex 1 SLC25A5
Golgi medial cisterna 1 HLA-A
MHC class I protein complex 1 HLA-A
MHC class II protein complex 1 HLA-A
mitochondrial permeability transition pore complex 1 SLC25A5
myelin sheath adaxonal region 1 PTEN
neuron projection terminus 1 UCHL1
[Isoform alpha]: Secreted 1 PTEN
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
Grb2-EGFR complex 1 GRB2


文献列表

  • Jia-Ruei Yu, Yi-Chou Hou, Jen-Fen Fu, I-Kuan Wang, Ming-Jen Chan, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Huang-Yu Yang, Ching-Wei Hsu, Tzung-Hai Yen. Outcomes of elderly patients with organophosphate intoxication. Scientific reports. 2021 06; 11(1):11615. doi: 10.1038/s41598-021-91230-2. [PMID: 34079035]
  • Ching-Yi Tsai, Jacqueline C C Wu, Chi Fang, Alice Y W Chang. PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication. Neuropharmacology. 2017 Sep; 123(?):175-185. doi: 10.1016/j.neuropharm.2017.06.007. [PMID: 28601397]
  • Shih-Chia Yeh, Chia-Li Lin, Cheng Chang, Hai-Tung Feng, Shu-Mei Dai. Amino acid substitutions and intron polymorphism of acetylcholinesterase1 associated with mevinphos resistance in diamondback moth, Plutella xylostella (L.). Pesticide biochemistry and physiology. 2014 Jun; 112(?):7-12. doi: 10.1016/j.pestbp.2014.04.009. [PMID: 24974111]
  • Chi Chang, Alice Y W Chang, Samuel H H Chan. Neuroprotective role of heat shock protein 70 in the rostral ventrolateral medulla during acute mevinphos intoxication in the rat. Journal of biomedical science. 2004 Nov; 11(6):748-55. doi: 10.1007/bf02254359. [PMID: 15591771]
  • K Tuovinen, H Paakkanen, O Hänninen, J Ruuskanen. Ion mobility spectrometric monitoring of phosdrin from foliage in greenhouse. AIHAJ : a journal for the science of occupational and environmental health and safety. 2001 Jan; 62(1):80-6. doi: 10.1080/15298660108984613. [PMID: 11258872]
  • M B Sweeden, P J McLeod. Aphicide persistence on spinach and mustard greens. Journal of economic entomology. 1997 Feb; 90(1):195-8. doi: 10.1093/jee/90.1.195. [PMID: 9071890]
  • C T Hsiao, C C Yang, J F Deng, M J Bullard, S J Liaw. Acute pancreatitis following organophosphate intoxication. Journal of toxicology. Clinical toxicology. 1996; 34(3):343-7. doi: 10.3109/15563659609013800. [PMID: 8667474]
  • J Kangas, S Laitinen, A Jauhiainen, K Savolainen. Exposure of sprayers and plant handlers to mevinphos in Finnish greenhouses. American Industrial Hygiene Association journal. 1993 Apr; 54(4):150-7. doi: 10.1080/15298669391354496. [PMID: 8480630]
  • A Jauhiainen, J Kangas, S Laitinen, K Savolainen. Biological monitoring of workers exposed to mevinphos in greenhouses. Bulletin of environmental contamination and toxicology. 1992 Jul; 49(1):37-43. doi: 10.1007/bf00193338. [PMID: 1392293]
  • M J Coye, P G Barnett, J E Midtling, A R Velasco, P Romero, C L Clements, T G Rose. Clinical confirmation of organophosphate poisoning by serial cholinesterase analyses. Archives of internal medicine. 1987 Mar; 147(3):438-42. doi: NULL. [PMID: 3827420]
  • S Haider, N Upadhyaya. Effect of commercial formulation of four organophosphorus insecticides on the ovaries of a freshwater teleost, Mystus vittatus (bloch)--a histological and histochemical study. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1985 Jun; 20(3):321-40. doi: 10.1080/03601238509372482. [PMID: 3861690]
  • R L Reece, P Handson. Observations on the accidental poisoning of birds by organophosphate insecticides and other toxic substances. The Veterinary record. 1982 Nov; 111(20):453-5. doi: 10.1136/vr.111.20.453. [PMID: 7179689]
  • P Dimova, S Boyadjiev. Cytological and cytochemical changes in reactive connective tissue cells following exposure to phosdrin. Folia medica. 1982; 24(4):23-31. doi: ". [PMID: 6821056]
  • P S Kahlon, M R Banerjee. Evaluation of Bravo, Phosdrin and Telvar as possible environmental mutagens. Bulletin of environmental contamination and toxicology. 1979 Jun; 22(3):365-70. doi: 10.1007/bf02026956. [PMID: 465804]
  • J F Lewin, J L Love. A death caused by the ingestion of mevinphos. Forensic science. 1974 Dec; 4(3):253-5. doi: 10.1016/0300-9432(74)90115-0. [PMID: 4461453]
  • J H Holmes, H G Starr, K N von Kaulla, R C Hanisch. Short-term toxicity of mevinphos in man. Archives of environmental health. 1974 Aug; 29(2):84-9. doi: 10.1080/00039896.1974.10666538. [PMID: 4835176]