PIRIMICARB (BioDeep_00000403469)

Main id: BioDeep_00000001171

 

natural product Industrial Pollutants


代谢物信息卡片


Pesticide3_Pirimicarb_C11H18N4O2_2-(Dimethylamino)-5,6-dimethyl-4-pyrimidinyl dimethylcarbamate

化学式: C11H18N4O2 (238.143)
中文名称: 甲醇中抗蚜威溶液, 抗蚜威
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(N=C(N=C1OC(=O)N(C)C)N(C)C)C
InChI: InChI=1S/C11H18N4O2/c1-7-8(2)12-10(14(3)4)13-9(7)17-11(16)15(5)6/h1-6H3

描述信息

C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

4 个代谢物同义名

PIRIMICARB; Pesticide3_Pirimicarb_C11H18N4O2_2-(Dimethylamino)-5,6-dimethyl-4-pyrimidinyl dimethylcarbamate; PMC; Pirimicarb



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ACE2, AIP, AR, AXIN2, CAST, CAT, HPGDS, IGF2BP3, MME, NR5A2, PAK1, PHB1, PRKCA, SP1
Peripheral membrane protein 4 ACHE, FLOT1, PAK1, PRKCA
Mitochondrion membrane 1 PRKCA
Nucleus 12 ACHE, AIP, AR, AXIN2, IGF2BP3, KDR, NR5A2, PAK1, PHB1, PRKCA, SOX9, SP1
cytosol 9 AIP, AR, AXIN2, CAST, CAT, HPGDS, IGF2BP3, PAK1, PRKCA
dendrite 2 MME, PAK1
mitochondrial membrane 1 PRKCA
trans-Golgi network 1 MME
centrosome 2 AXIN2, PAK1
nucleoplasm 10 AIP, AR, CAST, HPGDS, NR5A2, PAK1, PHB1, PRKCA, SOX9, SP1
RNA polymerase II transcription regulator complex 1 NR5A2
Cell membrane 8 ACE2, ACHE, FLOT1, KDR, MME, PAK1, PHB1, PRKCA
Cleavage furrow 1 PAK1
lamellipodium 2 FLOT1, PAK1
ruffle membrane 1 PAK1
Multi-pass membrane protein 1 FLOT1
Synapse 2 ACHE, MME
cell junction 1 KDR
cell surface 4 ACE2, ACHE, MME, PHB1
glutamatergic synapse 1 FLOT1
Golgi apparatus 3 ACHE, ATRN, KDR
lysosomal membrane 1 FLOT1
mitochondrial inner membrane 2 AIP, PHB1
neuromuscular junction 1 ACHE
neuronal cell body 1 MME
sarcolemma 1 FLOT1
synaptic vesicle 1 MME
Presynapse 1 MME
endosome 3 FLOT1, KDR, PAK1
plasma membrane 12 ACE2, ACHE, AR, ATRN, AXIN2, BCHE, FLOT1, KDR, MME, PAK1, PHB1, PRKCA
presynaptic active zone 1 FLOT1
Membrane 10 ACE2, ACHE, AIP, AR, CAST, CAT, FLOT1, MME, PHB1, PRKCA
apical plasma membrane 2 ACE2, FLOT1
axon 2 MME, PAK1
basolateral plasma membrane 1 FLOT1
brush border 1 MME
caveola 1 FLOT1
extracellular exosome 7 ACE2, ATRN, CAT, FLOT1, MME, PHB1, PRKCA
endoplasmic reticulum 3 CAST, KDR, PRKCA
extracellular space 5 ACE2, ACHE, ATRN, BCHE, SP1
perinuclear region of cytoplasm 2 ACHE, PRKCA
adherens junction 1 FLOT1
intercalated disc 1 PAK1
mitochondrion 5 AIP, CAST, CAT, PHB1, PRKCA
protein-containing complex 4 AR, CAT, PAK1, SOX9
intracellular membrane-bounded organelle 3 AIP, CAT, HPGDS
Single-pass type I membrane protein 2 ACE2, ATRN
Secreted 4 ACE2, ACHE, BCHE, SP1
extracellular region 6 ACE2, ACHE, BCHE, CAT, KDR, SP1
[Isoform 2]: Secreted 2 ATRN, KDR
Mitochondrion matrix 1 AIP
mitochondrial matrix 2 AIP, CAT
Extracellular side 1 ACHE
anchoring junction 1 KDR
transcription regulator complex 1 SOX9
Cell projection, cilium 1 ACE2
centriolar satellite 1 FLOT1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PAK1
nuclear membrane 1 PAK1
external side of plasma membrane 2 FLOT1, KDR
Z disc 1 PAK1
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 2 FLOT1, MME
nucleolus 1 CAST
midbody 1 PAK1
Cytoplasm, P-body 1 IGF2BP3
P-body 1 IGF2BP3
Early endosome 4 FLOT1, KDR, MME, PHB1
cell-cell junction 2 FLOT1, PAK1
Single-pass type II membrane protein 1 MME
Apical cell membrane 2 ACE2, FLOT1
Cell projection, lamellipodium 1 PAK1
Cell projection, ruffle membrane 1 PAK1
Mitochondrion inner membrane 1 PHB1
Membrane raft 4 ACE2, FLOT1, KDR, MME
Cell junction, focal adhesion 1 PAK1
focal adhesion 4 CAT, FLOT1, MME, PAK1
GABA-ergic synapse 1 FLOT1
flotillin complex 1 FLOT1
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
nuclear speck 1 AR
ruffle 1 PAK1
receptor complex 1 KDR
ciliary basal body 1 PRKCA
cilium 1 ACE2
chromatin 4 AR, NR5A2, SOX9, SP1
Chromosome 2 CAST, PAK1
brush border membrane 2 ACE2, FLOT1
Nucleus, nucleolus 1 CAST
actin filament 1 PAK1
blood microparticle 1 BCHE
Basolateral cell membrane 1 FLOT1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
fibrillar center 1 CAST
Endomembrane system 1 FLOT1
sorting endosome 1 KDR
Membrane, caveola 1 FLOT1
microtubule organizing center 1 FLOT1
aryl hydrocarbon receptor complex 1 AIP
Nucleus, nucleoplasm 1 PAK1
Melanosome 1 FLOT1
Cytoplasm, Stress granule 1 IGF2BP3
cytoplasmic stress granule 1 IGF2BP3
euchromatin 1 SP1
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
secretory granule membrane 1 MME
endoplasmic reticulum lumen 2 ACE2, BCHE
transcription repressor complex 1 SP1
endocytic vesicle membrane 1 ACE2
nuclear envelope lumen 1 BCHE
uropod 1 FLOT1
RNA polymerase I complex 1 CAST
synaptic cleft 1 ACHE
protein-DNA complex 1 SP1
RNA polymerase I transcription regulator complex 1 CAST
[Isoform 1]: Cell membrane 1 ATRN
dopaminergic synapse 1 FLOT1
mitochondrial small ribosomal subunit 1 AIP
cell-cell contact zone 1 FLOT1
catalase complex 1 CAT
alphav-beta3 integrin-PKCalpha complex 1 PRKCA
neuron projection terminus 1 MME
[Isoform H]: Cell membrane 1 ACHE
mitochondrial prohibitin complex 1 PHB1
Cell projection, invadopodium 1 PAK1
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Tuba Albayrak, Sibel Yorulmaz, Emre İnak, Umut Toprak, Thomas Van Leeuwen. Pirimicarb resistance and associated mechanisms in field-collected and selected populations of Neoseiulus californicus. Pesticide biochemistry and physiology. 2022 Jan; 180(?):104984. doi: 10.1016/j.pestbp.2021.104984. [PMID: 34955177]
  • Nariman Maroofpour, Mahdieh Mousavi, Mir Jalil Hejazi, Shahzad Iranipour, Hamed Hamishehkar, Nicolas Desneux, Antonio Biondi, Khalid Haddi. Comparative selectivity of nano and commercial formulations of pirimicarb on a target pest, Brevicoryne brassicae, and its predator Chrysoperla carnea. Ecotoxicology (London, England). 2021 Mar; 30(2):361-372. doi: 10.1007/s10646-021-02349-x. [PMID: 33566273]
  • Mohammad Homayoonzadeh, Mojtaba Esmaeily, Khalil Talebi, Hossein Allahyari, Jamasb Nozari, J P Michaud. Micronutrient Fertilization of Greenhouse Cucumbers Mitigates Pirimicarb Resistance in Aphis gossypii (Hemiptera: Aphididae). Journal of economic entomology. 2020 12; 113(6):2864-2872. doi: 10.1093/jee/toaa202. [PMID: 32964224]
  • Nariman Maroofpour, Mir Jalil Hejazi, Hamed Hamishehkar, Shahzad Iranipour. Relative Toxicity and Residual Activity of Nanocapsules and Commercial Formulations of Pirimicarb and Pymetrozine Against Myzus persicae (Hemiptera: Aphididae). Journal of economic entomology. 2019 12; 112(6):2670-2675. doi: 10.1093/jee/toz203. [PMID: 31365743]
  • Martina Beránková, Jarmila Hojerová, Linda Melegová. Exposure of amateur gardeners to pesticides via the non-gloved skin per day. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Oct; 108(Pt A):224-235. doi: 10.1016/j.fct.2017.07.060. [PMID: 28778749]
  • Karim Chahid, Amin Laglaoui, Said Zantar, Abdeslam Ennabili. Antioxidant-enzyme reaction to the oxidative stress due to alpha-cypermethrin, chlorpyriphos, and pirimicarb in tomato (Lycopersicon esculentum Mill.). Environmental science and pollution research international. 2015 Nov; 22(22):18115-26. doi: 10.1007/s11356-015-5024-3. [PMID: 26178835]
  • Siweon Choi, Sooyeon Kim, Jin Young Shin, MeeKyung Kim, Jeong-Han Kim. Development and verification for analysis of pesticides in eggs and egg products using QuEChERS and LC-MS/MS. Food chemistry. 2015 Apr; 173(?):1236-42. doi: 10.1016/j.foodchem.2014.10.143. [PMID: 25466149]
  • Pan Wang, Hui-Ping Wang, Ming-Yuan Xu, Yu-Jie Liang, Ying-Jian Sun, Lin Yang, Li Li, Wei Li, Yi-Jun Wu. Combined subchronic toxicity of dichlorvos with malathion or pirimicarb in mice liver and serum: a metabonomic study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Aug; 70(?):222-30. doi: 10.1016/j.fct.2014.05.027. [PMID: 24907623]
  • K Jones, M Everard, A-H Harding. Investigation of gastrointestinal effects of organophosphate and carbamate pesticide residues on young children. International journal of hygiene and environmental health. 2014 Mar; 217(2-3):392-8. doi: 10.1016/j.ijheh.2013.07.015. [PMID: 23992615]
  • Yizhou Chen, Flavie Vanlerberghe-Masutti, Lewis J Wilson, Idris Barchia, Martin O McLoon, Tanya Smith, Grant A Herron. Evidence of superclones in Australian cotton aphid Aphis gossypii Glover (Aphididae: Hemiptera). Pest management science. 2013 Aug; 69(8):938-48. doi: 10.1002/ps.3455. [PMID: 23292942]
  • Ron F van Toor, Gaynor L Malloch, Eric A Anderson, Greg Dawson, Brian Fenton. Insecticide resistance profiles can be misleading in predicting the survival of Myzus persicae genotypes on potato crops following the application of different insecticide classes. Pest management science. 2013 Jan; 69(1):93-103. doi: 10.1002/ps.3370. [PMID: 22848031]
  • Andrea X Silva, Leonardo D Bacigalupe, Manuela Luna-Rudloff, Christian C Figueroa. Insecticide resistance mechanisms in the green peach aphid Myzus persicae (Hemiptera: Aphididae) II: Costs and benefits. PloS one. 2012; 7(6):e36810. doi: 10.1371/journal.pone.0036810. [PMID: 22685539]
  • Craig Sams, Kate Jones. Human volunteer studies investigating the potential for toxicokinetic interactions between the pesticides deltamethrin; pirimicarb and chlorpyrifos-methyl following oral exposure at the acceptable daily intake. Toxicology letters. 2011 Jan; 200(1-2):41-5. doi: 10.1016/j.toxlet.2010.10.012. [PMID: 21035527]
  • D Goossens, E Bangels, T Belien, C Schoevaerts, L De Maeyer. Optimal profit of the parasitation by Aphelinus mali in an IPM complementary strategy for the control of Eriosoma lanigerum. Communications in agricultural and applied biological sciences. 2011; 76(3):457-65. doi: ". [PMID: 22696953]
  • Jinfang Zhou, Chao Ma, Shu Zhou, Peili Ma, Fangrong Chen, Yue Qi, Huaixia Chen. Preparation, evaluation and application of molecularly imprinted solid-phase microextraction monolith for selective extraction of pirimicarb in tomato and pear. Journal of chromatography. A. 2010 Nov; 1217(48):7478-83. doi: 10.1016/j.chroma.2010.09.079. [PMID: 20970141]
  • Manel Araoud, Wahiba Douki, Mohamed Fadhel Najjar, Abderraouf Kenani. Simple analytical method for determination of pesticide residues in human serum by liquid chromatography tandem mass spectrometry. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2010 Apr; 45(3):242-8. doi: 10.1080/03601231003613666. [PMID: 20390957]
  • Craig Sams, Katan Patel, Kate Jones. Biological monitoring for exposure to pirimicarb: method development and a human oral dosing study. Toxicology letters. 2010 Jan; 192(1):56-60. doi: 10.1016/j.toxlet.2009.01.018. [PMID: 20117325]
  • Pedro Henrique Viana de Carvalho, Alysson Santos Barreto, Marcelo O Rodrigues, Vanessa de Menezes Prata, Péricles Barreto Alves, Maria Eliane de Mesquita, Severino Alves, Sandro Navickiene. Two-dimensional coordination polymer matrix for solid-phase extraction of pesticide residues from plant Cordia salicifolia. Journal of separation science. 2009 Jun; 32(12):2132-8. doi: 10.1002/jssc.200900076. [PMID: 19479754]
  • Qi Zhang, Yunru Wu, Limin Wang, Baishi Hu, Peiwu Li, Fengquan Liu. Effect of hapten structures on specific and sensitive enzyme-linked immunosorbent assays for N-methylcarbamate insecticide metolcarb. Analytica chimica acta. 2008 Sep; 625(1):87-94. doi: 10.1016/j.aca.2008.07.003. [PMID: 18721544]
  • Ulrich Hoffmann, Ute Hecker, Peter Abel. Acute poisoning by pirimicarb: clinical and toxicological features. Clinical toxicology (Philadelphia, Pa.). 2008 Aug; 46(7):694-96. doi: 10.1080/15563650701476961. [PMID: 18608305]
  • Helle R Andersen, Ida M Schmidt, Philippe Grandjean, Tina K Jensen, Esben Budtz-Jørgensen, Mia B Kjaerstad, Jesper Baelum, Jesper B Nielsen, Niels E Skakkebaek, Katharina M Main. Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environmental health perspectives. 2008 Apr; 116(4):566-72. doi: 10.1289/ehp.10790. [PMID: 18414644]
  • Marisol Vargas, Belén Martínez-García, José Ramón Díaz-Ruíz, Francisco Tenllado. Transient expression of homologous hairpin RNA interferes with PVY transmission by aphids. Virology journal. 2008 Mar; 5(?):42. doi: 10.1186/1743-422x-5-42. [PMID: 18353170]
  • Anna Machowska, Magdalena Słowik-Borowiec, Ewa Szpyrka, Stanisław Sadło. [Occurrence of plant protection product residues in apples in 2007]. Roczniki Panstwowego Zakladu Higieny. 2008; 59(3):293-300. doi: ". [PMID: 19143426]
  • Mao-hua Chen, Zhao-jun Han, Xian-feng Qiao, Ming-jing Qu. Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carbamate insecticides. Genome. 2007 Feb; 50(2):172-9. doi: 10.1139/g07-021. [PMID: 17546082]
  • Nina Cedergreen, Anja Kamper, Jens C Streibig. Is prochloraz a potent synergist across aquatic species? A study on bacteria, daphnia, algae and higher plants. Aquatic toxicology (Amsterdam, Netherlands). 2006 Jun; 78(3):243-52. doi: 10.1016/j.aquatox.2006.03.007. [PMID: 16672166]
  • Begoña Martín-López, Ianire Varela, Silvia Marnotes, Cristina Cabaleiro. Use of oils combined with low doses of insecticide for the control of Myzus persicae and PVY epidemics. Pest management science. 2006 Apr; 62(4):372-8. doi: 10.1002/ps.1168. [PMID: 16470683]
  • Jialun Wu, Liqing Li, Yaohua Zou. Determination of carbamate insecticides in Chinese medicinal herbs by gas chromatography with a nitrogen-phosphorus detector. Journal of AOAC International. 2005 Jul; 88(4):1261-4. doi: . [PMID: 16152951]
  • Sara Bogialli, Roberta Curini, Antonio Di Corcia, Manuela Nazzari, Davide Tamburro. A simple and rapid assay for analyzing residues of carbamate insecticides in vegetables and fruits: hot water extraction followed by liquid chromatography-mass spectrometry. Journal of agricultural and food chemistry. 2004 Feb; 52(4):665-71. doi: 10.1021/jf035195j. [PMID: 14969513]
  • N Desneux, H Rafalimanana, L Kaiser. Dose-response relationship in lethal and behavioural effects of different insecticides on the parasitic wasp Aphidius ervi. Chemosphere. 2004 Feb; 54(5):619-27. doi: 10.1016/j.chemosphere.2003.09.007. [PMID: 14599507]
  • S Dahamna, N Sekfali, C H Walker. Biochemical indicators of hepatotoxic effects of pesticides. Communications in agricultural and applied biological sciences. 2004; 69(4):821-8. doi: . [PMID: 15756876]
  • Xiaoyi Wang, Zuorui Shen, Wenbing Xu, Jian Lu. [Sublethal effects of insecticides on fecundity of multicolored Asian ladybird Harmonia axyridis]. Ying yong sheng tai xue bao = The journal of applied ecology. 2003 Aug; 14(8):1354-8. doi: ". [PMID: 14655375]
  • J H Ahtiainen, P Vanhala, A Myllymäki. Effects of different plant protection programs on soil microbes. Ecotoxicology and environmental safety. 2003 Jan; 54(1):56-64. doi: 10.1016/s0147-6513(02)00020-9. [PMID: 12547636]
  • Bozena Morzycka. Simple method for the determination of trace levels of pesticides in honeybees using matrix solid-phase dispersion and gas chromatography. Journal of chromatography. A. 2002 Dec; 982(2):267-73. doi: 10.1016/s0021-9673(02)01505-4. [PMID: 12489883]
  • Fei Li, Zhaojun Han. Purification and characterization of acetylcholinesterase from cotton aphid (Aphis gossypii Glover). Archives of insect biochemistry and physiology. 2002 Sep; 51(1):37-45. doi: 10.1002/arch.10048. [PMID: 12210959]
  • Stephen P Foster, Ian Denholm, Alan L Devonshire. Field-simulator studies of insecticide resistance to dimethylcarbamates and pyrethroids conferred by metabolic- and target site-based mechanisms in peach-potato aphids, Myzus persicae (Hemiptera: Aphididae). Pest management science. 2002 Aug; 58(8):811-6. doi: 10.1002/ps.541. [PMID: 12192906]
  • Stephen P Foster, Ian Denholm, Robin Thompson. Bioassay and field-simulator studies of the efficacy of pymetrozine against peach-potato aphids, Myzus persicae (Hemiptera: Aphididae), possessing different mechanisms of insecticide resistance. Pest management science. 2002 Aug; 58(8):805-10. doi: 10.1002/ps.529. [PMID: 12192905]
  • P A Cooper, K M Jessop, F Moffatt. Capillary electrochromatography for pesticide analysis: effects of environmental matrices. Electrophoresis. 2000 May; 21(8):1574-9. doi: 10.1002/(sici)1522-2683(20000501)21:8<1574::aid-elps1574>3.0.co;2-6. [PMID: 10832890]
  • J Hardt, J Angerer. Determination of metabolites of pirimicarb in human urine by gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1999 Jul; 730(2):229-38. doi: 10.1016/s0378-4347(99)00218-2. [PMID: 10448958]
  • J Hardt, U Appl, J Angerer. Biological monitoring of exposure to pirimicarb: hydroxypyrimidines in human urine. Toxicology letters. 1999 Jun; 107(1-3):89-93. doi: 10.1016/s0378-4274(99)00035-1. [PMID: 10414785]
  • W Schwack, G Kopf. Photodegradation of the carbamate insecticide pirimicarb. Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. 1993 Sep; 197(3):264-8. doi: 10.1007/bf01185283. [PMID: 8237119]
  • T Burkova, A Baĭnova, L Ivanova. [Pathologicoanatomic and enzymatic histochemical changes in the body of white rats with chronic, intermittent pirimor pesticide poisoning]. Problemi na khigienata. 1976; 2(?):45-50. doi: . [PMID: 1032720]