Bufogein (BioDeep_00000004001)

Main id: BioDeep_00000398486

 

PANOMIX_OTCML-2023 Toxin


代谢物信息卡片


5-[(1R,2S,4R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.0(2),?.0(2),?.0(1)(1),(1)?]octadecan-6-yl]-2H-pyran-2-one

化学式: C24H32O4 (384.23)
中文名称: 脂蟾毒配基, 酯蟾毒配基
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@]([H])(C5=COC(=O)C=C5)C[C@H]5O[C@@]45[C@]3([H])CC[C@]2([H])C[C@@H](O)C1
InChI: InChI=1S/C24H32O4/c1-22-9-7-16(25)11-15(22)4-5-18-17(22)8-10-23(2)19(12-20-24(18,23)28-20)14-3-6-21(26)27-13-14/h3,6,13,15-20,25H,4-5,7-12H2,1-2H3/t15-,16+,17+,18-,19-,20-,22+,23-,24-/m1/s1

描述信息

Bufogenin is a steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a steroid lactone and an epoxy steroid. It is functionally related to a bufanolide.
Resibufogenin is a natural product found in Sclerophrys mauritanica, Bufo gargarizans, and other organisms with data available.
Bufogenin is a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans; it is also one of the glycosides in the traditional Chinese medicine ChanSu, with potential cardiotonic activity. Although the mechanism of action of bufogenin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and has been shown to reduce blood pressure in a rat model of preeclampsia.
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002018 - Bufanolides
D002317 - Cardiovascular Agents
C471 - Enzyme Inhibitor
Resibufogenin is a component of cinobufogenin and has the function of inhibiting oxidative stress and tumor regeneration.
Resibufogenin is a component of cinobufogenin and has the function of inhibiting oxidative stress and tumor regeneration.

同义名列表

42 个代谢物同义名

5-[(1R,2S,4R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.0(2),?.0(2),?.0(1)(1),(1)?]octadecan-6-yl]-2H-pyran-2-one; 5-[(1R,2S,4R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one; Bufa-20,22-dienolide, 14,15-epoxy-3-hydroxy-, (3beta,5beta,15beta)-; 5-beta-BUFA-20,22-DIENOLIDE, 14,15-beta-EPOXY-3-beta-HYDROXY-; 3beta-hydroxy-14beta,15beta-epoxy-5beta-bufa-20,22-dienolide; 3-beta-Hydroxy-14,15-beta-epoxy-5-beta-bufa-20,22-dienolide; 14,15-beta-Epoxy-3-beta-hydroxy-5-beta-bufa-20,22-dienolide; 5beta-Bufa-20,22-dienolide, 14,15beta-epoxy-3beta-hydroxy-; 3beta-hydroxy-5beta,15beta-14,15-epoxybufa-20,22-dienolide; Bufa-20,22-dienolide, 14,15-epoxy-3-hydroxy-, (3b,5b,15b)-; 3beta-Hydroxy-14,15beta-epoxy-5beta-bufa-20,22-dienolide; 14,15beta-Epoxy-3beta-hydroxy-5beta-bufa-20,22-dienolide; Bufogenin; Resibufogenin; Recibufogenin; Resibufogenin, >=98\\% (HPLC); Bufogenina [INN-Spanish]; Bufogenine [INN-French]; Bufogenin;Recibufogenin; Bufogeninum [INN-Latin]; Bufogenina [Spanish]; Bufogenin [INN:JAN]; Bufogenin;Respigon; RESIBUFOGENIN [MI]; BUFOGENIN [WHO-DD]; Bufogenin [INN]; BUFOGENIN [JAN]; UNII-3K654P2M4J; recibufogenin; Resibufogenin; Tox21_112671; Bufogeninum; Bufogenine; 3K654P2M4J; Bufogenina; ST 24:5;O4; Resi (VAN); bufogenin; Bufogein; Respigon; RBG; 6JI; Resi; Resibufogenin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ANXA5, CASP3, CASP8, CCND1, CDH1, CDH2, CTNNB1, CYP3A4, PIK3CA, PIM1
Peripheral membrane protein 4 ANXA5, CYP1B1, GORASP1, HK2
Endoplasmic reticulum membrane 2 CYP1B1, CYP3A4
Nucleus 7 CASP3, CASP8, CCND1, CDH1, CTNNB1, JUND, PIM1
cytosol 9 ANXA5, CASP3, CASP8, CCND1, CDH1, CTNNB1, HK2, PIK3CA, PIM1
trans-Golgi network 1 CDH1
centrosome 3 CCND1, CTNNB1, HK2
nucleoplasm 7 CASP3, CASP8, CCND1, CDH1, CTNNB1, JUND, PIM1
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 4 CDH1, CDH2, CTNNB1, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 5 CASP8, CDH1, CDH2, CTNNB1, PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 3 CDH1, CDH2, CTNNB1
cell surface 2 CDH2, TNF
glutamatergic synapse 3 CASP3, CDH1, CTNNB1
Golgi apparatus 2 CDH1, GORASP1
Golgi membrane 1 GORASP1
neuronal cell body 2 CASP3, TNF
postsynapse 1 CDH1
presynaptic membrane 1 CTNNB1
sarcolemma 2 ANXA5, CDH2
Cytoplasm, cytosol 1 HK2
endosome 1 CDH1
plasma membrane 7 CDH1, CDH2, CTNNB1, PIK3CA, PIM1, REN, TNF
Membrane 8 ANXA5, CDH1, CDH2, CTNNB1, CYP1B1, CYP3A4, HK2, REN
apical plasma membrane 1 CDH2
axon 1 CCK
basolateral plasma membrane 2 CDH2, CTNNB1
extracellular exosome 3 ANXA5, CDH1, CTNNB1
extracellular space 4 CCK, IGF1, REN, TNF
perinuclear region of cytoplasm 3 CDH1, CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 3 CDH1, CDH2, CTNNB1
apicolateral plasma membrane 2 CDH2, CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
intercalated disc 2 CDH2, PIK3CA
mitochondrion 3 CASP8, CYP1B1, HK2
protein-containing complex 2 CASP8, CTNNB1
intracellular membrane-bounded organelle 3 CYP1B1, CYP3A4, HK2
Microsome membrane 2 CYP1B1, CYP3A4
postsynaptic density 2 CASP3, CDH2
Single-pass type I membrane protein 2 CDH1, CDH2
Secreted 4 CCK, HK2, IGF1, REN
extracellular region 6 ANXA5, CCK, CDH1, IGF1, REN, TNF
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 HK2
mitochondrial outer membrane 2 CASP8, HK2
transcription regulator complex 2 CTNNB1, JUND
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, CDH1
external side of plasma membrane 2 ANXA5, TNF
actin cytoskeleton 1 CDH1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 PIM1
Wnt signalosome 1 CTNNB1
apical part of cell 3 CDH2, CTNNB1, REN
cell-cell junction 2 CDH2, CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
presynaptic active zone membrane 1 CDH2
Cell membrane, sarcolemma 1 CDH2
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 3 ANXA5, CDH2, CTNNB1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 3 CDH1, CDH2, CTNNB1
flotillin complex 2 CDH1, CTNNB1
sarcoplasmic reticulum 1 HK2
collagen-containing extracellular matrix 2 ANXA5, CDH2
fascia adherens 2 CDH2, CTNNB1
lateral plasma membrane 2 CDH1, CTNNB1
Zymogen granule membrane 1 ANXA5
neuron projection 1 CDH2
chromatin 1 JUND
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
cytoskeleton 1 CASP8
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
Endomembrane system 1 CTNNB1
euchromatin 1 CTNNB1
cell body 1 CASP8
exocytic vesicle 1 IGF1
plasma membrane raft 1 CDH2
endoplasmic reticulum lumen 1 CDH2
transcription repressor complex 2 CCND1, JUND
platelet alpha granule lumen 1 IGF1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
beta-catenin-TCF complex 1 CTNNB1
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
[Isoform 2]: Nucleus 1 CDH1
protein-DNA complex 1 CTNNB1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
postsynaptic specialization membrane 1 CDH2
apical junction complex 1 CDH1
Cell junction, desmosome 2 CDH1, CDH2
desmosome 2 CDH1, CDH2
catenin complex 3 CDH1, CDH2, CTNNB1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
endothelial microparticle 1 ANXA5
cyclin D1-CDK4 complex 1 CCND1
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Hao Zhang, Baiyu Jian. Resibufogenin: An Emerging Therapeutic Compound with Multifaceted Pharmacological Effects - A Comprehensive Review. Medical science monitor : international medical journal of experimental and clinical research. 2024 Feb; 30(?):e942783. doi: 10.12659/msm.942783. [PMID: 38369741]
  • Kento Takaya, Toru Asou, Kazuo Kishi. Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice. Biogerontology. 2023 12; 24(6):889-900. doi: 10.1007/s10522-023-10043-0. [PMID: 37395866]
  • Yuan Gao, Zhenlu Xu, Ximeng Li, Zhuangzhuang Liu, Wenjing Li, Yuan Kang, Xiaoyu Zhang, Yun Qi. Resibufogenin, one of bufadienolides in toad venom, suppresses LPS-induced inflammation via inhibiting NF-κB and AP-1 pathways. International immunopharmacology. 2022 Dec; 113(Pt A):109312. doi: 10.1016/j.intimp.2022.109312. [PMID: 36252491]
  • Tao Song, Jiajia Li, Mingye Wang, Min Su, Dengfeng Xu, Luheng Zhou, Xiaopei Zhang, Hongtao Wang, Yunlong Hou. Analysis of Resibufogenin on Cardiac conduction reveals a species difference in the cardiac electrophysiology: Rats versus guinea pigs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111581. doi: 10.1016/j.biopha.2021.111581. [PMID: 33895523]
  • Maryam Jameelah Md Hassan, Nor Salmah Bakar, Mardiana Abdul Aziz, Norizan Kamal Basah, Harbindar Jeet Singh. Leptin-induced increase in blood pressure and markers of endothelial activation during pregnancy in Sprague Dawley rats is prevented by resibufogenin, a marinobufagenin antagonist. Reproductive biology. 2020 Jun; 20(2):184-190. doi: 10.1016/j.repbio.2020.03.004. [PMID: 32253169]
  • Qian Li, Chuanwu Jiang, Yan Wang, Minghua Wei, Huijin Zheng, Yanqi Xu, Xuegang Xu, Fengyu Jia, Kai Liu, Gang Sun, Jianhua Zang, Ping Mo. Resibufogenin suppresses tumor growth and inhibits glycolysis in ovarian cancer by modulating PIM1. Naunyn-Schmiedeberg's archives of pharmacology. 2019 12; 392(12):1477-1489. doi: 10.1007/s00210-019-01687-2. [PMID: 31292669]
  • Yueting Cao, Jiheng Wu, Hongye Pan, Longhu Wang. Chemical Profile and Multicomponent Quantitative Analysis for the Quality Evaluation of Toad Venom from Different Origins. Molecules (Basel, Switzerland). 2019 Oct; 24(19):. doi: 10.3390/molecules24193595. [PMID: 31590467]
  • Wen-Long Wei, Ya-Ling An, Zhen-Wei Li, Ying-Ying Wang, Hong-Jian Ji, Jin-Jun Hou, Wan-Ying Wu, De-An Guo. Simultaneous determination of resibufogenin and its eight metabolites in rat plasma by LC-MS/MS for metabolic profiles and pharmacokinetic study. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jul; 60(?):152971. doi: 10.1016/j.phymed.2019.152971. [PMID: 31178234]
  • Yue-Ting Cao, Ke-Ke Cui, Ji-Heng Wu, Hong-Ye Pan, Zheng-Yu Lu, Jia-Feng Shao, Long-Hu Wang. [Correlative study of bufogenin constituents in venom of Bufo bufo gargarizans]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 May; 44(9):1850-1856. doi: 10.19540/j.cnki.cjcmm.20190222.003. [PMID: 31342712]
  • Lu Liu, Yang Liu, Xiaojia Liu, Na Zhang, Genxiang Mao, Qingxuan Zeng, Mingxiao Yin, Danqing Song, Hongbin Deng. Resibufogenin suppresses transforming growth factor-β-activated kinase 1-mediated nuclear factor-κB activity through protein kinase C-dependent inhibition of glycogen synthase kinase 3. Cancer science. 2018 Nov; 109(11):3611-3622. doi: 10.1111/cas.13788. [PMID: 30168902]
  • Qinrui Han, Ye Ma, Hao Wang, Yu Dai, Chunhui Chen, Yawei Liu, Linlin Jing, Xuegang Sun. Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis. Journal of translational medicine. 2018 07; 16(1):201. doi: 10.1186/s12967-018-1580-x. [PMID: 30029665]
  • Hao Dong, Li Tian, Meng Gao, Hong Xu, Chenghong Zhang, Li Lv, Jianbin Zhang, Changyuan Wang, Yan Tian, Xiaochi Ma. Promising galactose-decorated biodegradable poloxamer 188-PLGA diblock copolymer nanoparticles of resibufogenin for enhancing liver cancer therapy. Drug delivery. 2017 Nov; 24(1):1302-1316. doi: 10.1080/10717544.2017.1373165. [PMID: 28895767]
  • Mir M K Abbas, B Patel, Q Chen, W Jiang, B Moorthy, R Barrios, J B Puschett. Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome. Lung. 2017 06; 195(3):323-332. doi: 10.1007/s00408-017-9989-1. [PMID: 28260175]
  • Qiuchen Chu, Hong Xu, Meng Gao, Xin Guan, Hongyan Liu, Sa Deng, Xiaokui Huo, Kexin Liu, Yan Tian, Xiaochi Ma. Liver-targeting Resibufogenin-loaded poly(lactic-co-glycolic acid)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy. International journal of nanomedicine. 2016; 11(?):449-63. doi: 10.2147/ijn.s93541. [PMID: 26869788]
  • Jing Ning, Zhen-Long Yu, Liang-Hai Hu, Chao Wang, Xiao-Kui Huo, Sa Deng, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Chi Ma, Ling Yang. Characterization of phase I metabolism of resibufogenin and evaluation of the metabolic effects on its antitumor activity and toxicity. Drug metabolism and disposition: the biological fate of chemicals. 2015 Mar; 43(3):299-308. doi: 10.1124/dmd.114.060996. [PMID: 25504504]
  • Masami Ichikawa, Yoshihiro Sowa, Yosuke Iizumi, Yuichi Aono, Toshiyuki Sakai. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PloS one. 2015; 10(6):e0129851. doi: 10.1371/journal.pone.0129851. [PMID: 26121043]
  • Hai-Yan Tian, Shi-Lin Luo, Jun-Shan Liu, Lei Wang, Ying Wang, Dong-Mei Zhang, Xiao-Qi Zhang, Ren-Wang Jiang, Wen-Cai Ye. C23 steroids from the venom of Bufo bufo gargarizans. Journal of natural products. 2013 Oct; 76(10):1842-7. doi: 10.1021/np400174f. [PMID: 24050254]
  • Jules B Puschett. Marinobufagenin predicts and resibufogenin prevents preeclampsia: a review of the evidence. American journal of perinatology. 2012 Nov; 29(10):777-85. doi: 10.1055/s-0032-1316447. [PMID: 22814872]
  • Wei Cao, Yan Chen, Ling Yuan, Jun-Jie He. [Determination of protein binding rates of cinobufagin and resibufogenin with different plasmas by HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Sep; 47(9):1200-4. doi: . [PMID: 23227551]
  • Rui-Fang Xie, Zhi-Cheng Li, Bo Gao, Zhi-Na Shi, Xin Zhou. Bufothionine, a possible effective component in cinobufocini injection for hepatocellular carcinoma. Journal of ethnopharmacology. 2012 Jun; 141(2):692-700. doi: 10.1016/j.jep.2011.12.018. [PMID: 22210051]
  • Bo Jiang, Fei Cai, Shouhong Gao, Liyuan Meng, Fengying Liang, Xiao Dai, Wen Xu, Wansheng Chen. Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components. Chemico-biological interactions. 2012 Jan; 195(2):105-13. doi: 10.1016/j.cbi.2011.12.001. [PMID: 22178124]
  • Zongyun Li, Huimin Gao, Jinhua Wang, Ting Qu, Liangmian Chen, Zhimin Wang, Qiwei Zhang. [Inhibitory effect of total bufadienolides from toad venom against H22 tumor in mice and their metabolites]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Nov; 36(21):2987-93. doi: . [PMID: 22308689]
  • Shuang Hao, Yong-Ming Bao, Rong-Guo Zhao, He-Shuang Wang, Jing Bi, Li-Jia An, Bo Jiang. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neuroscience letters. 2011 Aug; 501(2):112-6. doi: 10.1016/j.neulet.2011.06.059. [PMID: 21763753]
  • Fanghua Qi, Anyuan Li, Yoshinori Inagaki, Norihiro Kokudo, Sumihito Tamura, Munehiro Nakata, Wei Tang. Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor. International immunopharmacology. 2011 Mar; 11(3):342-9. doi: 10.1016/j.intimp.2010.12.007. [PMID: 21185919]
  • Xiaolin Xia, Huizi Jin, Shikai Yan, Weidong Zhang. Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection. Journal of pharmaceutical and biomedical analysis. 2010 Nov; 53(3):646-54. doi: 10.1016/j.jpba.2010.05.009. [PMID: 20570458]
  • Jules B Puschett, Enoch Agunanne, Mohammad N Uddin. Emerging role of the bufadienolides in cardiovascular and kidney diseases. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2010 Aug; 56(2):359-70. doi: 10.1053/j.ajkd.2010.01.023. [PMID: 20417001]
  • Dong-Liang Wang, Fang-Hua Qi, Huan-Li Xu, Yoshinori Inagaki, Yutaka Orihara, Kazuhisa Sekimizu, Norihiro Kokudo, Feng-Shan Wang, Wei Tang. Apoptosis-inducing activity of compounds screened and characterized from cinobufacini by bioassay-guided isolation. Molecular medicine reports. 2010 Jul; 3(4):717-22. doi: 10.3892/mmr_00000323. [PMID: 21472305]
  • Xiu Lan Xin, Junying Liu, Xiao Chi Ma, Qing Wei, Li Lv, Chang Yuan Wang, Ji Hong Yao, Jian Cui. Preparative separation of four major bufadienolides from the Chinese traditional medicine, Chansu, using high-speed counter-current chromatography. Natural product communications. 2010 Jul; 5(7):1031-4. doi: . [PMID: 20734934]
  • Mohammad Nasir Uddin, Enoch Agunanne, Darijana Horvat, Jules B Puschett. Alterations in the renin-angiotensin system in a rat model of human preeclampsia. American journal of nephrology. 2010; 31(2):171-7. doi: 10.1159/000267099. [PMID: 20016143]
  • E E Agunanne, M N Uddin, D Horvat, J B Puschett. Contribution of angiogenic factors in a rat model of pre-eclampsia. American journal of nephrology. 2010; 32(4):332-9. doi: 10.1159/000319463. [PMID: 20720407]
  • Fang Li, Rui Yang, Yan Weng, Xing Tang. Preparation and evaluation of lyophilized liposome-encapsulated bufadienolides. Drug development and industrial pharmacy. 2009 Sep; 35(9):1048-58. doi: 10.1080/03639040902762987. [PMID: 19365782]
  • Chris Kostakis, Roger W Byard. Sudden death associated with intravenous injection of toad extract. Forensic science international. 2009 Jul; 188(1-3):e1-5. doi: 10.1016/j.forsciint.2009.02.006. [PMID: 19303230]
  • Xiao Chi Ma, Bao Jing Zhang, Xin Lan Xin, Shan Shan Huang, Sha Deng, Hou Li Zhang, Xiao Hong Shu, Yun Peng Diao, Jian Cui. Simultaneous quantification of seven major bufadienolides in three traditional Chinese medicinal preparations of chansu by HPLC-DAD. Natural product communications. 2009 Feb; 4(2):179-84. doi: . [PMID: 19370919]
  • Yu Zhang, Xing Tang, Xiaoliang Liu, Fang Li, Xia Lin. Simultaneous determination of three bufadienolides in rat plasma after intravenous administration of bufadienolides extract by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry. Analytica chimica acta. 2008 Mar; 610(2):224-31. doi: 10.1016/j.aca.2008.01.029. [PMID: 18291133]
  • Yan Liang, Ai-hua Liu, Song Qin, Jiang-hao Sun, Min Yang, Ping Li, De-an Guo. Simultaneous determination and pharmacokinetics of five bufadienolides in rat plasma after oral administration of Chansu extract by SPE-HPLC method. Journal of pharmaceutical and biomedical analysis. 2008 Feb; 46(3):442-8. doi: 10.1016/j.jpba.2007.11.001. [PMID: 18093784]
  • S Danchuk, S Sukhanov, D Horvat, M N Uddin, J B Puschett. Effects of resibufogenin in experimental hypertension. American journal of nephrology. 2008; 28(1):8-13. doi: 10.1159/000108756. [PMID: 17890853]
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