Uracil (BioDeep_00000400033)

Main id: BioDeep_00000002133

Secondary id: BioDeep_00000860824

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Uracil-5-d

化学式: C4H4N2O2 (112.02727639999999)
中文名称: 尿嘧啶-5-D, 尿嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 1.71%

分子结构信息

SMILES: C1=CNC(=O)NC1=O
InChI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

描述信息

A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; ISAKRJDGNUQOIC_STSL_0177_Uracil_8000fmol_180430_S2_LC02_MS02_198; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.

同义名列表

2 个代谢物同义名

Uracil-5-d; Uracil



数据库引用编号

64 个数据库交叉引用编号

分类词条

85 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yaning Wu, Hongwei Zhang, Jianguang Zhu, Zhenling Zhang, Songbo Ma, Yongqi Zhao, Yiming Wang, Jun Yuan, Xing Guo, Yajing Li, Shuai Zhang. The Effect of Fermentation on the Chemical Constituents of Gastrodia Tuber Hallimasch Powder (GTHP) Estimated by UHPLC-Q-Orbitrap HRMS and HPLC. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071663. [PMID: 38611942]
  • Di-Zao Li, Zhao-Di Fu, Hong-Yan Liu, Xian-Dao Pan. Facile synthesis and cytotoxicity of substituted uracil-1'(N)-acetic acid and 4-pyridone-1'(N)-acetic acid esters of 20(S)-camptothecins. Journal of Asian natural products research. 2024 Feb; 26(2):259-268. doi: 10.1080/10286020.2023.2300374. [PMID: 38347748]
  • Huan Zhou, Qing X Li, Lei Zeng, Congwang Cao, Tuotuo Zhang, Yuan Zhou, Hongwu He. Uracil hydrazones: design, synthesis, antimicrobial activities, and putative mode of action. Pest management science. 2023 Sep; ?(?):. doi: 10.1002/ps.7771. [PMID: 37708309]
  • Kevin Xiao, Homa Ghalei, Sohail Khoshnevis. RNA structural probing of guanine and uracil nucleotides in yeast. PloS one. 2023; 18(7):e0288070. doi: 10.1371/journal.pone.0288070. [PMID: 37418367]
  • Alexey A Chistov, Stepan P Chumakov, Igor E Mikhnovets, Timofei D Nikitin, Nikita A Slesarchuk, Victoria I Uvarova, Anna A Rubekina, Yulia V Nikolaeva, Eugene V Radchenko, Evgeny V Khvatov, Alexey A Orlov, Vasilisa S Frolenko, Maksim V Sukhorukov, Ekaterina S Kolpakova, Elena Y Shustova, Anastasiya V Galochkina, Philipp P Streshnev, Eugene M Osipov, Ksenia A Sapozhnikova, Andrey V Moiseenko, Vladimir A Brylev, Gleb V Proskurin, Yuri S Dokukin, Sergey V Kutyakov, Andrey V Aralov, Vladimir A Korshun, Sergei V Strelkov, Vladimir A Palyulin, Aydar A Ishmukhametov, Evgeny A Shirshin, Dmitry I Osolodkin, Anna A Shtro, Liubov I Kozlovskaya, Vera A Alferova, Alexey V Ustinov. 5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro. Antiviral research. 2023 01; 209(?):105508. doi: 10.1016/j.antiviral.2022.105508. [PMID: 36581049]
  • Lai Wong, Alina Sami, Linda Chelico. Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases. Nucleic acids research. 2022 11; 50(21):12039-12057. doi: 10.1093/nar/gkac1121. [PMID: 36444883]
  • Tahmineh Peirouvi, Mazdak Razi. Molecular mechanism behind methamphetamine-induced damages in testicular tissue: Evidences for oxidative stress, autophagy, and apoptosis. Andrologia. 2022 Nov; 54(10):e14534. doi: 10.1111/and.14534. [PMID: 35801363]
  • Chenchen Ma, Peng Liu, Siyuan Cui, Chang Gao, Xing Tan, Zhaopeng Liu, Ruirong Xu. The Identification of APOBEC3G as a Potential Prognostic Biomarker in Acute Myeloid Leukemia and a Possible Drug Target for Crotonoside. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185804. [PMID: 36144542]
  • Hae Jin Kim, In Kyung Jeong, Kyu Yeon Hur, Soo-Kyung Kim, Jung Hyun Noh, Sung Wan Chun, Eun Seok Kang, Eun-Jung Rhee, Sung Hee Choi. Comparison of Efficacy of Glimepiride, Alogliptin, and Alogliptin-Pioglitazone as the Initial Periods of Therapy in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Open-Label, Multicenter, Randomized, Controlled Study. Diabetes & metabolism journal. 2022 09; 46(5):689-700. doi: 10.4093/dmj.2021.0183. [PMID: 35295073]
  • Kelly E Sullivan, Sheetal Kumar, Xin Liu, Ye Zhang, Emily de Koning, Yanfei Li, Jing Yuan, Fan Fan. Uncovering the roles of dihydropyrimidine dehydrogenase in fatty-acid induced steatosis using human cellular models. Scientific reports. 2022 08; 12(1):14109. doi: 10.1038/s41598-022-17860-2. [PMID: 35982095]
  • Xenia Bacinschi, Gabriel Cristian Popescu, Anca Zgura, Laurentia Gales, Anghel Rodica, Adriana Mercan, Dragos Serban, Bogdan Haineala, Letitia Toma, Laura Iliescu. A Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, with or without Ribavirin, in 587 Patients with Chronic Hepatitis C at the Fundeni Clinical Institute, Bucharest, Romania. Medical science monitor : international medical journal of experimental and clinical research. 2022 Jul; 28(?):e936706. doi: 10.12659/msm.936706. [PMID: 35787600]
  • Mirjam de With, Jonathan Knikman, Femke M de Man, Carin A T C Lunenburg, Linda M Henricks, André B P van Kuilenburg, Jan G Maring, Maurice C van Staveren, Niels de Vries, Hilde Rosing, Jos H Beijnen, Dick Pluim, Anil Modak, Alex L T Imholz, Ron H N van Schaik, Jan H M Schellens, Hans Gelderblom, Annemieke Cats, Henk-Jan Guchelaar, Ron H J Mathijssen, Jesse J Swen, Didier Meulendijks. Dihydropyrimidine Dehydrogenase Phenotyping Using Pretreatment Uracil: A Note of Caution Based on a Large Prospective Clinical Study. Clinical pharmacology and therapeutics. 2022 07; 112(1):62-68. doi: 10.1002/cpt.2608. [PMID: 35397172]
  • Beatrice Campanella, Tommaso Lomonaco, Edoardo Benedetti, Massimo Onor, Riccardo Nieri, Federica Marmorino, Chiara Cremolini, Emilia Bramanti. Fast, Direct Dihydrouracil Quantitation in Human Saliva: Method Development, Validation, and Application. International journal of environmental research and public health. 2022 05; 19(10):. doi: 10.3390/ijerph19106033. [PMID: 35627569]
  • Xenia Bacinschi, Adriana Mercan-Stanciu, Letitia Toma, Anca Zgura, Nicolae Bacalbasa, Chen-Peng Ifrim, Camelia Diaconu, Laura Iliescu, Radu Valeriu Toma. Glycemic Control in Patients Undergoing Treatment With Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir for Chronic Hepatitis C Infection. In vivo (Athens, Greece). 2022 May; 36(3):1438-1443. doi: 10.21873/invivo.12849. [PMID: 35478152]
  • Hikari Araki, Toru Takenaka, Koichi Takahashi, Fumiaki Yamashita, Kazuaki Matsuoka, Kunihiro Yoshisue, Ichiro Ieiri. A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS-114. CPT: pharmacometrics & systems pharmacology. 2022 05; 11(5):604-615. doi: 10.1002/psp4.12747. [PMID: 34951129]
  • Rania M Salama, Merihane M Nasr, Jannatullah I Abdelhakeem, Omar K Roshdy, Mohamed A ElGamal. Alogliptin attenuates cyclophosphamide-induced nephrotoxicity: a novel therapeutic approach through modulating MAP3K/JNK/SMAD3 signaling cascade. Drug and chemical toxicology. 2022 May; 45(3):1254-1263. doi: 10.1080/01480545.2020.1814319. [PMID: 32869669]
  • Sara Capiau, Anniek Van Landschoot, Tim Reyns, Hedwig Stepman. Pre-analytical considerations for the analysis of uracil and 5,6-dihydrouracil in heparin plasma. Clinical chemistry and laboratory medicine. 2022 04; 60(5):e112-e115. doi: 10.1515/cclm-2021-0921. [PMID: 35073467]
  • Yong Wang, Xin-Yu Chen, Liu Yang, Qin Yao, K P Chen. Human SARS-CoV-2 has evolved to increase U content and reduce genome size. International journal of biological macromolecules. 2022 Apr; 204(?):356-363. doi: 10.1016/j.ijbiomac.2022.02.034. [PMID: 35149094]
  • Deep Dutta, Ritin Mohindra, Vineet Surana, Meha Sharma. Safety and efficacy of once weekly dipeptidyl-peptidase-4 inhibitor trelagliptin in type-2 diabetes: A meta-analysis. Diabetes & metabolic syndrome. 2022 Apr; 16(4):102469. doi: 10.1016/j.dsx.2022.102469. [PMID: 35344848]
  • Azza S Tammam, Ahmed A Gahlan, Mahmoud A Taher, Ahmed M Haredy. Hantzsch condensation reaction as a spectrofluorometric method for determination of alogliptin, an antidiabetic drug, in pure form, tablet form, and human and rat plasma. Luminescence : the journal of biological and chemical luminescence. 2022 Apr; 37(4):543-550. doi: 10.1002/bio.4178. [PMID: 34907663]
  • Beatriz Chamorro, Iwona E Głowacka, Joanna Gotkowska, Rafał Gulej, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, Dorota G Piotrowska, María Jesús Oset-Gasque. Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia-Reperfusion. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063411. [PMID: 35328832]
  • Marcel Schneider, Marina F Grossi, Darshak Gadara, Zdeněk Spáčil, Pavel Babica, Luděk Bláha. Treatment of cylindrospermopsin by hydroxyl and sulfate radicals: Does degradation equal detoxification?. Journal of hazardous materials. 2022 02; 424(Pt B):127447. doi: 10.1016/j.jhazmat.2021.127447. [PMID: 34688008]
  • Ke Feng, Wenjie Dai, Ling Liu, Shengming Li, Yi Gou, Zhongwei Chen, Guodong Chen, Xufeng Fu. Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics. Frontiers in public health. 2022; 10(?):923170. doi: 10.3389/fpubh.2022.923170. [PMID: 35991069]
  • Ning Guo, Na Li, Yan Zhao, Huaibin Sun, Kao Liu. Effects of Systematic Diet Education Combined with Multidisciplinary Nursing on Nutritional Status and Calcium and Phosphorus Metabolism in Patients with Diabetic Kidney Disease in Uremic Phase after Treatment with Alogliptin. Journal of healthcare engineering. 2022; 2022(?):1120242. doi: 10.1155/2022/1120242. [PMID: 35340239]
  • Yikelamu Alimu, Yoko Kusuya, Takako Yamamoto, Kana Arita, Naofumi Shigemune, Hiroki Takahashi, Takashi Yaguchi. Mechanism of Polyhexamethylene Biguanide Resistance in Purpureocillium lilacinum Strains. Biocontrol science. 2022; 27(3):117-130. doi: 10.4265/bio.27.117. [PMID: 36216563]
  • Tsuyoshi Hayashi, Kosuke Murakami, Junki Hirano, Yoshiki Fujii, Yoko Yamaoka, Hirofumi Ohashi, Koichi Watashi, Mary K Estes, Masamichi Muramatsu. Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids. mSphere. 2021 12; 6(6):e0062321. doi: 10.1128/msphere.00623-21. [PMID: 34730374]
  • Li-Qing Xu, Li-Jie Yao, Dan Jiang, Li-Juan Zhou, Min Chen, Wen-Zhong Liao, Wei-Hao Zou, Hong-Juan Peng. A uracil auxotroph Toxoplasma gondii exerting immunomodulation to inhibit breast cancer growth and metastasis. Parasites & vectors. 2021 Dec; 14(1):601. doi: 10.1186/s13071-021-05032-6. [PMID: 34895326]
  • Andrea Caddeo, Marta Anna Kowalik, Marina Serra, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli, Amedeo Columbano, Andrea Perra. TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD. International journal of molecular sciences. 2021 Dec; 22(23):. doi: 10.3390/ijms222313105. [PMID: 34884910]
  • Clotilde Gaible, Céline Narjoz, Marie-Anne Loriot, Stéphane Roueff, Nicolas Pallet. Pretherapeutic screening for Dihydropyrimidine deshydrogenase deficiency in measuring uracilemia in dialysis patients leads to a high rate of falsely positive results. Cancer chemotherapy and pharmacology. 2021 12; 88(6):1049-1053. doi: 10.1007/s00280-021-04354-7. [PMID: 34515833]
  • Fabrizio Fabrizi, Cristina Alonso, Ana Palazzo, Margarita Anders, Maria Virginia Reggiardo, Hugo Cheinquer, Maria Grazia Videla Zuain, Sebastian Figueroa, Manuel Mendizabal, Marcelo Silva, Ezequiel Ridruejo. 'Real-life' experience with direct-acting antiviral agents for HCV after kidney transplant. Annals of hepatology. 2021 Nov; 25(?):100337. doi: 10.1016/j.aohep.2021.100337. [PMID: 33684523]
  • A M Kabel, H H Arab, M A Abd Elmaaboud. Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. Human & experimental toxicology. 2021 Oct; 40(10):1710-1720. doi: 10.1177/09603271211008496. [PMID: 33840231]
  • Alisha Wehdnesday Bernardo Reyes, Heejin Kim, Tran Xuan Ngoc Huy, Son Hai Vu, Trang Thi Nguyen, Chang Keun Kang, Wongi Min, Hu Jang Lee, John Hwa Lee, Suk Kim. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microbial pathogenesis. 2021 Sep; 158(?):105079. doi: 10.1016/j.micpath.2021.105079. [PMID: 34245824]
  • Chu Thanh Binh, Hanh-Dung Thai, Bui Thi Viet Ha, Van-Tuan Tran. Establishment of a new and efficient Agrobacterium-mediated transformation system in the nematicidal fungus Purpureocillium lilacinum. Microbiological research. 2021 Aug; 249(?):126773. doi: 10.1016/j.micres.2021.126773. [PMID: 33940365]
  • Ahmed M Ramadan, Afnan A Alnufaei, Thana K Khan, Hani M Ali, Hala F Eissa, Sabah M Hassan. The first report of RNA U to C or G editing in the mitochondrial NADH dehydrogenase subunit 5 (Nad5) transcript of wild barley. Molecular biology reports. 2021 Aug; 48(8):6057-6064. doi: 10.1007/s11033-021-06609-1. [PMID: 34374896]
  • Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey Y W Mak, Sidonia B G Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, Alexandra J Corbett, Zhenjun Chen. Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection. Nature communications. 2021 07; 12(1):4355. doi: 10.1038/s41467-021-24570-2. [PMID: 34272362]
  • Vivian Rodriguez-Cruz, Marilyn E Morris. γ-Hydroxybutyric Acid-Ethanol Drug-Drug Interaction: Reversal of Toxicity with Monocarboxylate Transporter 1 Inhibitors. The Journal of pharmacology and experimental therapeutics. 2021 07; 378(1):42-50. doi: 10.1124/jpet.121.000566. [PMID: 33963018]
  • Laining Zhang, Tetyana Smertenko, Deirdre Fahy, Nuria Koteyeva, Natalia Moroz, Anna Kuchařová, Dominik Novák, Eduard Manoilov, Petro Smertenko, Charitha Galva, Jozef Šamaj, Alla S Kostyukova, John C Sedbrook, Andrei Smertenko. Analysis of formin functions during cytokinesis using specific inhibitor SMIFH2. Plant physiology. 2021 06; 186(2):945-963. doi: 10.1093/plphys/kiab085. [PMID: 33620500]
  • Herbert Nar, Gisela Schnapp, Oliver Hucke, Timothy C Hardman, Thomas Klein. Action of Dipeptidyl Peptidase-4 Inhibitors on SARS-CoV-2 Main Protease. ChemMedChem. 2021 05; 16(9):1425-1426. doi: 10.1002/cmdc.202000921. [PMID: 33348462]
  • Kathryn E Burns, Ottiniel Chavani, Soo Hee Jeong, John A Duley, David Porter, Michael Findlay, R Matthew Strother, Nuala A Helsby. Comparison of a thymine challenge test and endogenous uracil-dihydrouracil levels for assessment of fluoropyrimidine toxicity risk. Cancer chemotherapy and pharmacology. 2021 05; 87(5):711-716. doi: 10.1007/s00280-021-04240-2. [PMID: 33687515]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Halina Falfushynska, Oksana Horyn, Inna Osypenko, Piotr Rzymski, Łukasz Wejnerowski, Marcin K Dziuba, Inna M Sokolova. Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Water research. 2021 Apr; 194(?):116923. doi: 10.1016/j.watres.2021.116923. [PMID: 33631698]
  • Guang Wang, Bing Wu, Lening Zhang, Xuefei Jin, Kun Wang, Wenzhou Xu, Bo Zhang, Heyuan Wang. The protective effects of trelagliptin on high-fat diet-induced nonalcoholic fatty liver disease in mice. Journal of biochemical and molecular toxicology. 2021 Apr; 35(4):e22696. doi: 10.1002/jbt.22696. [PMID: 33421258]
  • Kornelia Duchnik, Jan Bialczyk, Ewelina Chrapusta-Srebrny, Beata Bober. Inhibition of growth rate and cylindrospermopsin synthesis by Raphidiopsis raciborskii upon exposure to macrophyte Lemna trisulca (L). Ecotoxicology (London, England). 2021 Apr; 30(3):470-477. doi: 10.1007/s10646-021-02377-7. [PMID: 33710451]
  • Fumitaka Okajima, Hitoshi Sugihara, Naoya Emoto. Efficacy and Safety of Miglitol- or Repaglinide-Based Combination Therapy with Alogliptin for Drug-Naïve Patients with Type 2 Diabetes: An Open-Label, Single-Center, Parallel, Randomized Controlled Pilot Study. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 2021 Mar; 88(1):71-79. doi: 10.1272/jnms.jnms.2021_88-205. [PMID: 32475902]
  • Jonathan E Knikman, Hans Gelderblom, Jos H Beijnen, Annemieke Cats, Henk-Jan Guchelaar, Linda M Henricks. Individualized Dosing of Fluoropyrimidine-Based Chemotherapy to Prevent Severe Fluoropyrimidine-Related Toxicity: What Are the Options?. Clinical pharmacology and therapeutics. 2021 03; 109(3):591-604. doi: 10.1002/cpt.2069. [PMID: 33020924]
  • Yu-Hang Zhang, Shu-Xiang Cui, Sheng-Biao Wan, Shu-Hua Wu, Xian-Jun Qu. Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation. Acta pharmacologica Sinica. 2021 Mar; 42(3):460-469. doi: 10.1038/s41401-020-0460-0. [PMID: 32647340]
  • Shuangshuang Zhang, Ruixue Gan, Ludan Zhao, Qiaomei Sun, Hongzhao Xiang, Xi Xiang, Gang Zhao, Hui Li. Unveiling the interaction mechanism of alogliptin benzoate with human serum albumin: Insights from spectroscopy, microcalorimetry, and molecular docking and molecular dynamics analyses. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Feb; 246(?):119040. doi: 10.1016/j.saa.2020.119040. [PMID: 33068900]
  • Ken Shiraiwa, Yosuke Suzuki, Hiroki Uchida, Yukio Iwashita, Ryota Tanaka, Motoshi Iwao, Kazuhiro Tada, Teijiro Hirashita, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Hiroki Itoh. Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy. Scientific reports. 2021 02; 11(1):3132. doi: 10.1038/s41598-021-82908-8. [PMID: 33542452]
  • Alan M Rice, Atahualpa Castillo Morales, Alexander T Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D Hurst. Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design. Molecular biology and evolution. 2021 01; 38(1):67-83. doi: 10.1093/molbev/msaa188. [PMID: 32687176]
  • Suzanna L Attia, Samir Softic, Marialena Mouzaki. Evolving Role for Pharmacotherapy in NAFLD/NASH. Clinical and translational science. 2021 01; 14(1):11-19. doi: 10.1111/cts.12839. [PMID: 32583961]
  • Takayuki Shibata, Ryosuke Shimamura, Yuji Yamamoto, Hiroki Sakurai, Junya Fujita, Asako Yamayoshi, Toshimitsu Nemoto, Tsutomu Kabashima. A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-Specific Fluorescence Derivatization Reaction. Chemical & pharmaceutical bulletin. 2021; 69(8):768-772. doi: 10.1248/cpb.c21-00221. [PMID: 34334520]
  • Matthew D Edmans, Timothy K Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Jeffrey Y W Mak, Ligong Liu, David P Fairlie, Emmanuel Atangana Maze, Tiphany Chrun, Paul Klenerman, Sidonia B G Eckle, Elma Tchilian, Lindert Benedictus. Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections. Frontiers in immunology. 2021; 12(?):627173. doi: 10.3389/fimmu.2021.627173. [PMID: 33777010]
  • Ryszard Olinski, Rafal Rozalski, Daniel Gackowski. Mass Spectrometry-Based Analysis of DNA Modifications: Potential Applications in Basic Research and Clinic. Methods in molecular biology (Clifton, N.J.). 2021; 2198(?):27-35. doi: 10.1007/978-1-0716-0876-0_3. [PMID: 32822020]
  • Zhihua Ou, Christos Ouzounis, Daxi Wang, Wanying Sun, Junhua Li, Weijun Chen, Philippe Marlière, Antoine Danchin. A Path toward SARS-CoV-2 Attenuation: Metabolic Pressure on CTP Synthesis Rules the Virus Evolution. Genome biology and evolution. 2020 12; 12(12):2467-2485. doi: 10.1093/gbe/evaa229. [PMID: 33125064]
  • Yanzhou Wang, Siyuan Zhu, Touming Liu, Bing Guo, Fu Li, Xuehua Bai. Identification of the rhizospheric microbe and metabolites that led by the continuous cropping of ramie (Boehmeria nivea L. Gaud). Scientific reports. 2020 11; 10(1):20408. doi: 10.1038/s41598-020-77475-3. [PMID: 33230149]
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