Uracil (BioDeep_00000400033)

Main id: BioDeep_00000002133

Secondary id: BioDeep_00000860824

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


Uracil-5-d

化学式: C4H4N2O2 (112.02727639999999)
中文名称: 尿嘧啶-5-D, 尿嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 1.71%

分子结构信息

SMILES: C1=CNC(=O)NC1=O
InChI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

描述信息

A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; ISAKRJDGNUQOIC_STSL_0177_Uracil_8000fmol_180430_S2_LC02_MS02_198; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.

同义名列表

4 个代谢物同义名

Uracil-5-d; Uracil; Uracil; Uracil



数据库引用编号

67 个数据库交叉引用编号

分类词条

85 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yaning Wu, Hongwei Zhang, Jianguang Zhu, Zhenling Zhang, Songbo Ma, Yongqi Zhao, Yiming Wang, Jun Yuan, Xing Guo, Yajing Li, Shuai Zhang. The Effect of Fermentation on the Chemical Constituents of Gastrodia Tuber Hallimasch Powder (GTHP) Estimated by UHPLC-Q-Orbitrap HRMS and HPLC. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071663. [PMID: 38611942]
  • Di-Zao Li, Zhao-Di Fu, Hong-Yan Liu, Xian-Dao Pan. Facile synthesis and cytotoxicity of substituted uracil-1'(N)-acetic acid and 4-pyridone-1'(N)-acetic acid esters of 20(S)-camptothecins. Journal of Asian natural products research. 2024 Feb; 26(2):259-268. doi: 10.1080/10286020.2023.2300374. [PMID: 38347748]
  • Huan Zhou, Qing X Li, Lei Zeng, Congwang Cao, Tuotuo Zhang, Yuan Zhou, Hongwu He. Uracil hydrazones: design, synthesis, antimicrobial activities, and putative mode of action. Pest management science. 2023 Sep; ?(?):. doi: 10.1002/ps.7771. [PMID: 37708309]
  • Kevin Xiao, Homa Ghalei, Sohail Khoshnevis. RNA structural probing of guanine and uracil nucleotides in yeast. PloS one. 2023; 18(7):e0288070. doi: 10.1371/journal.pone.0288070. [PMID: 37418367]
  • Alexey A Chistov, Stepan P Chumakov, Igor E Mikhnovets, Timofei D Nikitin, Nikita A Slesarchuk, Victoria I Uvarova, Anna A Rubekina, Yulia V Nikolaeva, Eugene V Radchenko, Evgeny V Khvatov, Alexey A Orlov, Vasilisa S Frolenko, Maksim V Sukhorukov, Ekaterina S Kolpakova, Elena Y Shustova, Anastasiya V Galochkina, Philipp P Streshnev, Eugene M Osipov, Ksenia A Sapozhnikova, Andrey V Moiseenko, Vladimir A Brylev, Gleb V Proskurin, Yuri S Dokukin, Sergey V Kutyakov, Andrey V Aralov, Vladimir A Korshun, Sergei V Strelkov, Vladimir A Palyulin, Aydar A Ishmukhametov, Evgeny A Shirshin, Dmitry I Osolodkin, Anna A Shtro, Liubov I Kozlovskaya, Vera A Alferova, Alexey V Ustinov. 5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro. Antiviral research. 2023 01; 209(?):105508. doi: 10.1016/j.antiviral.2022.105508. [PMID: 36581049]
  • Lai Wong, Alina Sami, Linda Chelico. Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases. Nucleic acids research. 2022 11; 50(21):12039-12057. doi: 10.1093/nar/gkac1121. [PMID: 36444883]
  • Tahmineh Peirouvi, Mazdak Razi. Molecular mechanism behind methamphetamine-induced damages in testicular tissue: Evidences for oxidative stress, autophagy, and apoptosis. Andrologia. 2022 Nov; 54(10):e14534. doi: 10.1111/and.14534. [PMID: 35801363]
  • Chenchen Ma, Peng Liu, Siyuan Cui, Chang Gao, Xing Tan, Zhaopeng Liu, Ruirong Xu. The Identification of APOBEC3G as a Potential Prognostic Biomarker in Acute Myeloid Leukemia and a Possible Drug Target for Crotonoside. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185804. [PMID: 36144542]
  • Hae Jin Kim, In Kyung Jeong, Kyu Yeon Hur, Soo-Kyung Kim, Jung Hyun Noh, Sung Wan Chun, Eun Seok Kang, Eun-Jung Rhee, Sung Hee Choi. Comparison of Efficacy of Glimepiride, Alogliptin, and Alogliptin-Pioglitazone as the Initial Periods of Therapy in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Open-Label, Multicenter, Randomized, Controlled Study. Diabetes & metabolism journal. 2022 09; 46(5):689-700. doi: 10.4093/dmj.2021.0183. [PMID: 35295073]
  • Kelly E Sullivan, Sheetal Kumar, Xin Liu, Ye Zhang, Emily de Koning, Yanfei Li, Jing Yuan, Fan Fan. Uncovering the roles of dihydropyrimidine dehydrogenase in fatty-acid induced steatosis using human cellular models. Scientific reports. 2022 08; 12(1):14109. doi: 10.1038/s41598-022-17860-2. [PMID: 35982095]
  • Xenia Bacinschi, Gabriel Cristian Popescu, Anca Zgura, Laurentia Gales, Anghel Rodica, Adriana Mercan, Dragos Serban, Bogdan Haineala, Letitia Toma, Laura Iliescu. A Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, with or without Ribavirin, in 587 Patients with Chronic Hepatitis C at the Fundeni Clinical Institute, Bucharest, Romania. Medical science monitor : international medical journal of experimental and clinical research. 2022 Jul; 28(?):e936706. doi: 10.12659/msm.936706. [PMID: 35787600]
  • Mirjam de With, Jonathan Knikman, Femke M de Man, Carin A T C Lunenburg, Linda M Henricks, André B P van Kuilenburg, Jan G Maring, Maurice C van Staveren, Niels de Vries, Hilde Rosing, Jos H Beijnen, Dick Pluim, Anil Modak, Alex L T Imholz, Ron H N van Schaik, Jan H M Schellens, Hans Gelderblom, Annemieke Cats, Henk-Jan Guchelaar, Ron H J Mathijssen, Jesse J Swen, Didier Meulendijks. Dihydropyrimidine Dehydrogenase Phenotyping Using Pretreatment Uracil: A Note of Caution Based on a Large Prospective Clinical Study. Clinical pharmacology and therapeutics. 2022 07; 112(1):62-68. doi: 10.1002/cpt.2608. [PMID: 35397172]
  • Beatrice Campanella, Tommaso Lomonaco, Edoardo Benedetti, Massimo Onor, Riccardo Nieri, Federica Marmorino, Chiara Cremolini, Emilia Bramanti. Fast, Direct Dihydrouracil Quantitation in Human Saliva: Method Development, Validation, and Application. International journal of environmental research and public health. 2022 05; 19(10):. doi: 10.3390/ijerph19106033. [PMID: 35627569]
  • Xenia Bacinschi, Adriana Mercan-Stanciu, Letitia Toma, Anca Zgura, Nicolae Bacalbasa, Chen-Peng Ifrim, Camelia Diaconu, Laura Iliescu, Radu Valeriu Toma. Glycemic Control in Patients Undergoing Treatment With Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir for Chronic Hepatitis C Infection. In vivo (Athens, Greece). 2022 May; 36(3):1438-1443. doi: 10.21873/invivo.12849. [PMID: 35478152]
  • Hikari Araki, Toru Takenaka, Koichi Takahashi, Fumiaki Yamashita, Kazuaki Matsuoka, Kunihiro Yoshisue, Ichiro Ieiri. A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS-114. CPT: pharmacometrics & systems pharmacology. 2022 05; 11(5):604-615. doi: 10.1002/psp4.12747. [PMID: 34951129]
  • Rania M Salama, Merihane M Nasr, Jannatullah I Abdelhakeem, Omar K Roshdy, Mohamed A ElGamal. Alogliptin attenuates cyclophosphamide-induced nephrotoxicity: a novel therapeutic approach through modulating MAP3K/JNK/SMAD3 signaling cascade. Drug and chemical toxicology. 2022 May; 45(3):1254-1263. doi: 10.1080/01480545.2020.1814319. [PMID: 32869669]
  • Sara Capiau, Anniek Van Landschoot, Tim Reyns, Hedwig Stepman. Pre-analytical considerations for the analysis of uracil and 5,6-dihydrouracil in heparin plasma. Clinical chemistry and laboratory medicine. 2022 04; 60(5):e112-e115. doi: 10.1515/cclm-2021-0921. [PMID: 35073467]
  • Yong Wang, Xin-Yu Chen, Liu Yang, Qin Yao, K P Chen. Human SARS-CoV-2 has evolved to increase U content and reduce genome size. International journal of biological macromolecules. 2022 Apr; 204(?):356-363. doi: 10.1016/j.ijbiomac.2022.02.034. [PMID: 35149094]
  • Deep Dutta, Ritin Mohindra, Vineet Surana, Meha Sharma. Safety and efficacy of once weekly dipeptidyl-peptidase-4 inhibitor trelagliptin in type-2 diabetes: A meta-analysis. Diabetes & metabolic syndrome. 2022 Apr; 16(4):102469. doi: 10.1016/j.dsx.2022.102469. [PMID: 35344848]
  • Azza S Tammam, Ahmed A Gahlan, Mahmoud A Taher, Ahmed M Haredy. Hantzsch condensation reaction as a spectrofluorometric method for determination of alogliptin, an antidiabetic drug, in pure form, tablet form, and human and rat plasma. Luminescence : the journal of biological and chemical luminescence. 2022 Apr; 37(4):543-550. doi: 10.1002/bio.4178. [PMID: 34907663]
  • Beatriz Chamorro, Iwona E Głowacka, Joanna Gotkowska, Rafał Gulej, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, Dorota G Piotrowska, María Jesús Oset-Gasque. Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia-Reperfusion. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063411. [PMID: 35328832]
  • Marcel Schneider, Marina F Grossi, Darshak Gadara, Zdeněk Spáčil, Pavel Babica, Luděk Bláha. Treatment of cylindrospermopsin by hydroxyl and sulfate radicals: Does degradation equal detoxification?. Journal of hazardous materials. 2022 02; 424(Pt B):127447. doi: 10.1016/j.jhazmat.2021.127447. [PMID: 34688008]
  • Ke Feng, Wenjie Dai, Ling Liu, Shengming Li, Yi Gou, Zhongwei Chen, Guodong Chen, Xufeng Fu. Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics. Frontiers in public health. 2022; 10(?):923170. doi: 10.3389/fpubh.2022.923170. [PMID: 35991069]
  • Ning Guo, Na Li, Yan Zhao, Huaibin Sun, Kao Liu. Effects of Systematic Diet Education Combined with Multidisciplinary Nursing on Nutritional Status and Calcium and Phosphorus Metabolism in Patients with Diabetic Kidney Disease in Uremic Phase after Treatment with Alogliptin. Journal of healthcare engineering. 2022; 2022(?):1120242. doi: 10.1155/2022/1120242. [PMID: 35340239]
  • Yikelamu Alimu, Yoko Kusuya, Takako Yamamoto, Kana Arita, Naofumi Shigemune, Hiroki Takahashi, Takashi Yaguchi. Mechanism of Polyhexamethylene Biguanide Resistance in Purpureocillium lilacinum Strains. Biocontrol science. 2022; 27(3):117-130. doi: 10.4265/bio.27.117. [PMID: 36216563]
  • Tsuyoshi Hayashi, Kosuke Murakami, Junki Hirano, Yoshiki Fujii, Yoko Yamaoka, Hirofumi Ohashi, Koichi Watashi, Mary K Estes, Masamichi Muramatsu. Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids. mSphere. 2021 12; 6(6):e0062321. doi: 10.1128/msphere.00623-21. [PMID: 34730374]
  • Li-Qing Xu, Li-Jie Yao, Dan Jiang, Li-Juan Zhou, Min Chen, Wen-Zhong Liao, Wei-Hao Zou, Hong-Juan Peng. A uracil auxotroph Toxoplasma gondii exerting immunomodulation to inhibit breast cancer growth and metastasis. Parasites & vectors. 2021 Dec; 14(1):601. doi: 10.1186/s13071-021-05032-6. [PMID: 34895326]
  • Andrea Caddeo, Marta Anna Kowalik, Marina Serra, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli, Amedeo Columbano, Andrea Perra. TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD. International journal of molecular sciences. 2021 Dec; 22(23):. doi: 10.3390/ijms222313105. [PMID: 34884910]
  • Clotilde Gaible, Céline Narjoz, Marie-Anne Loriot, Stéphane Roueff, Nicolas Pallet. Pretherapeutic screening for Dihydropyrimidine deshydrogenase deficiency in measuring uracilemia in dialysis patients leads to a high rate of falsely positive results. Cancer chemotherapy and pharmacology. 2021 12; 88(6):1049-1053. doi: 10.1007/s00280-021-04354-7. [PMID: 34515833]
  • Fabrizio Fabrizi, Cristina Alonso, Ana Palazzo, Margarita Anders, Maria Virginia Reggiardo, Hugo Cheinquer, Maria Grazia Videla Zuain, Sebastian Figueroa, Manuel Mendizabal, Marcelo Silva, Ezequiel Ridruejo. 'Real-life' experience with direct-acting antiviral agents for HCV after kidney transplant. Annals of hepatology. 2021 Nov; 25(?):100337. doi: 10.1016/j.aohep.2021.100337. [PMID: 33684523]
  • A M Kabel, H H Arab, M A Abd Elmaaboud. Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. Human & experimental toxicology. 2021 Oct; 40(10):1710-1720. doi: 10.1177/09603271211008496. [PMID: 33840231]
  • Alisha Wehdnesday Bernardo Reyes, Heejin Kim, Tran Xuan Ngoc Huy, Son Hai Vu, Trang Thi Nguyen, Chang Keun Kang, Wongi Min, Hu Jang Lee, John Hwa Lee, Suk Kim. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microbial pathogenesis. 2021 Sep; 158(?):105079. doi: 10.1016/j.micpath.2021.105079. [PMID: 34245824]
  • Chu Thanh Binh, Hanh-Dung Thai, Bui Thi Viet Ha, Van-Tuan Tran. Establishment of a new and efficient Agrobacterium-mediated transformation system in the nematicidal fungus Purpureocillium lilacinum. Microbiological research. 2021 Aug; 249(?):126773. doi: 10.1016/j.micres.2021.126773. [PMID: 33940365]
  • Ahmed M Ramadan, Afnan A Alnufaei, Thana K Khan, Hani M Ali, Hala F Eissa, Sabah M Hassan. The first report of RNA U to C or G editing in the mitochondrial NADH dehydrogenase subunit 5 (Nad5) transcript of wild barley. Molecular biology reports. 2021 Aug; 48(8):6057-6064. doi: 10.1007/s11033-021-06609-1. [PMID: 34374896]
  • Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey Y W Mak, Sidonia B G Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, Alexandra J Corbett, Zhenjun Chen. Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection. Nature communications. 2021 07; 12(1):4355. doi: 10.1038/s41467-021-24570-2. [PMID: 34272362]
  • Vivian Rodriguez-Cruz, Marilyn E Morris. γ-Hydroxybutyric Acid-Ethanol Drug-Drug Interaction: Reversal of Toxicity with Monocarboxylate Transporter 1 Inhibitors. The Journal of pharmacology and experimental therapeutics. 2021 07; 378(1):42-50. doi: 10.1124/jpet.121.000566. [PMID: 33963018]
  • Laining Zhang, Tetyana Smertenko, Deirdre Fahy, Nuria Koteyeva, Natalia Moroz, Anna Kuchařová, Dominik Novák, Eduard Manoilov, Petro Smertenko, Charitha Galva, Jozef Šamaj, Alla S Kostyukova, John C Sedbrook, Andrei Smertenko. Analysis of formin functions during cytokinesis using specific inhibitor SMIFH2. Plant physiology. 2021 06; 186(2):945-963. doi: 10.1093/plphys/kiab085. [PMID: 33620500]
  • Herbert Nar, Gisela Schnapp, Oliver Hucke, Timothy C Hardman, Thomas Klein. Action of Dipeptidyl Peptidase-4 Inhibitors on SARS-CoV-2 Main Protease. ChemMedChem. 2021 05; 16(9):1425-1426. doi: 10.1002/cmdc.202000921. [PMID: 33348462]
  • Kathryn E Burns, Ottiniel Chavani, Soo Hee Jeong, John A Duley, David Porter, Michael Findlay, R Matthew Strother, Nuala A Helsby. Comparison of a thymine challenge test and endogenous uracil-dihydrouracil levels for assessment of fluoropyrimidine toxicity risk. Cancer chemotherapy and pharmacology. 2021 05; 87(5):711-716. doi: 10.1007/s00280-021-04240-2. [PMID: 33687515]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Halina Falfushynska, Oksana Horyn, Inna Osypenko, Piotr Rzymski, Łukasz Wejnerowski, Marcin K Dziuba, Inna M Sokolova. Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Water research. 2021 Apr; 194(?):116923. doi: 10.1016/j.watres.2021.116923. [PMID: 33631698]
  • Guang Wang, Bing Wu, Lening Zhang, Xuefei Jin, Kun Wang, Wenzhou Xu, Bo Zhang, Heyuan Wang. The protective effects of trelagliptin on high-fat diet-induced nonalcoholic fatty liver disease in mice. Journal of biochemical and molecular toxicology. 2021 Apr; 35(4):e22696. doi: 10.1002/jbt.22696. [PMID: 33421258]
  • Kornelia Duchnik, Jan Bialczyk, Ewelina Chrapusta-Srebrny, Beata Bober. Inhibition of growth rate and cylindrospermopsin synthesis by Raphidiopsis raciborskii upon exposure to macrophyte Lemna trisulca (L). Ecotoxicology (London, England). 2021 Apr; 30(3):470-477. doi: 10.1007/s10646-021-02377-7. [PMID: 33710451]
  • Fumitaka Okajima, Hitoshi Sugihara, Naoya Emoto. Efficacy and Safety of Miglitol- or Repaglinide-Based Combination Therapy with Alogliptin for Drug-Naïve Patients with Type 2 Diabetes: An Open-Label, Single-Center, Parallel, Randomized Controlled Pilot Study. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 2021 Mar; 88(1):71-79. doi: 10.1272/jnms.jnms.2021_88-205. [PMID: 32475902]
  • Jonathan E Knikman, Hans Gelderblom, Jos H Beijnen, Annemieke Cats, Henk-Jan Guchelaar, Linda M Henricks. Individualized Dosing of Fluoropyrimidine-Based Chemotherapy to Prevent Severe Fluoropyrimidine-Related Toxicity: What Are the Options?. Clinical pharmacology and therapeutics. 2021 03; 109(3):591-604. doi: 10.1002/cpt.2069. [PMID: 33020924]
  • Yu-Hang Zhang, Shu-Xiang Cui, Sheng-Biao Wan, Shu-Hua Wu, Xian-Jun Qu. Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation. Acta pharmacologica Sinica. 2021 Mar; 42(3):460-469. doi: 10.1038/s41401-020-0460-0. [PMID: 32647340]
  • Shuangshuang Zhang, Ruixue Gan, Ludan Zhao, Qiaomei Sun, Hongzhao Xiang, Xi Xiang, Gang Zhao, Hui Li. Unveiling the interaction mechanism of alogliptin benzoate with human serum albumin: Insights from spectroscopy, microcalorimetry, and molecular docking and molecular dynamics analyses. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Feb; 246(?):119040. doi: 10.1016/j.saa.2020.119040. [PMID: 33068900]
  • Ken Shiraiwa, Yosuke Suzuki, Hiroki Uchida, Yukio Iwashita, Ryota Tanaka, Motoshi Iwao, Kazuhiro Tada, Teijiro Hirashita, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Hiroki Itoh. Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy. Scientific reports. 2021 02; 11(1):3132. doi: 10.1038/s41598-021-82908-8. [PMID: 33542452]
  • Alan M Rice, Atahualpa Castillo Morales, Alexander T Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D Hurst. Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design. Molecular biology and evolution. 2021 01; 38(1):67-83. doi: 10.1093/molbev/msaa188. [PMID: 32687176]
  • Suzanna L Attia, Samir Softic, Marialena Mouzaki. Evolving Role for Pharmacotherapy in NAFLD/NASH. Clinical and translational science. 2021 01; 14(1):11-19. doi: 10.1111/cts.12839. [PMID: 32583961]
  • Takayuki Shibata, Ryosuke Shimamura, Yuji Yamamoto, Hiroki Sakurai, Junya Fujita, Asako Yamayoshi, Toshimitsu Nemoto, Tsutomu Kabashima. A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-Specific Fluorescence Derivatization Reaction. Chemical & pharmaceutical bulletin. 2021; 69(8):768-772. doi: 10.1248/cpb.c21-00221. [PMID: 34334520]
  • Matthew D Edmans, Timothy K Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Jeffrey Y W Mak, Ligong Liu, David P Fairlie, Emmanuel Atangana Maze, Tiphany Chrun, Paul Klenerman, Sidonia B G Eckle, Elma Tchilian, Lindert Benedictus. Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections. Frontiers in immunology. 2021; 12(?):627173. doi: 10.3389/fimmu.2021.627173. [PMID: 33777010]
  • Ryszard Olinski, Rafal Rozalski, Daniel Gackowski. Mass Spectrometry-Based Analysis of DNA Modifications: Potential Applications in Basic Research and Clinic. Methods in molecular biology (Clifton, N.J.). 2021; 2198(?):27-35. doi: 10.1007/978-1-0716-0876-0_3. [PMID: 32822020]
  • Zhihua Ou, Christos Ouzounis, Daxi Wang, Wanying Sun, Junhua Li, Weijun Chen, Philippe Marlière, Antoine Danchin. A Path toward SARS-CoV-2 Attenuation: Metabolic Pressure on CTP Synthesis Rules the Virus Evolution. Genome biology and evolution. 2020 12; 12(12):2467-2485. doi: 10.1093/gbe/evaa229. [PMID: 33125064]
  • Yanzhou Wang, Siyuan Zhu, Touming Liu, Bing Guo, Fu Li, Xuehua Bai. Identification of the rhizospheric microbe and metabolites that led by the continuous cropping of ramie (Boehmeria nivea L. Gaud). Scientific reports. 2020 11; 10(1):20408. doi: 10.1038/s41598-020-77475-3. [PMID: 33230149]
  • Marcel Schneider, Raphael Rataj, Juergen F Kolb, Luděk Bláha. Cylindrospermopsin is effectively degraded in water by pulsed corona-like and dielectric barrier discharges. Environmental pollution (Barking, Essex : 1987). 2020 Nov; 266(Pt 2):115423. doi: 10.1016/j.envpol.2020.115423. [PMID: 32829127]
  • Yingmin Zeng, Meiling Liu, Yong Xia, Xingyu Jiang. Uracil-DNA-glycosylase-assisted loop-mediated isothermal amplification for detection of bacteria from urine samples with reduced contamination. The Analyst. 2020 Oct; 145(21):7048-7055. doi: 10.1039/d0an01001d. [PMID: 32894274]
  • Masato Kosuge, Emi Furusawa-Nishii, Koyu Ito, Yoshiro Saito, Kouetsu Ogasawara. Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses. Scientific reports. 2020 10; 10(1):17766. doi: 10.1038/s41598-020-74843-x. [PMID: 33082451]
  • Jichun Yang, Aiying Guan, Qiao Wu, Dongliang Cui, Changling Liu. Design, synthesis and herbicidal evaluation of novel uracil derivatives containing an isoxazoline moiety. Pest management science. 2020 Oct; 76(10):3395-3402. doi: 10.1002/ps.5970. [PMID: 32578296]
  • Amanda J Bittner, Regan B Huntley, George S Mourad, Neil P Schultes. An Erwinia amylovora uracil transporter mutant retains virulence on immature apple and pear fruit. Microbial pathogenesis. 2020 Oct; 147(?):104363. doi: 10.1016/j.micpath.2020.104363. [PMID: 32615243]
  • Shereen Mowaka, Nermeen Ashoush, Mariam Tadros, Noha El Zahar, Bassam Ayoub. Enhanced Extraction Technique of Omarigliptin from Human Plasma-Applied to Biological Samples from Healthy Human Volunteers. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184232. [PMID: 32942678]
  • Donald D Anthony, Mark S Sulkowski, Laura M Smeaton, Sofi Damjanovska, Carey L Shive, Corinne M Kowal, Daniel E Cohen, Debika Bhattacharya, Beverly L Alston-Smith, Ashwin Balagopal, David L Wyles. Hepatitis C Virus (HCV) Direct-Acting Antiviral Therapy in Persons With Human Immunodeficiency Virus-HCV Genotype 1 Coinfection Resulting in High Rate of Sustained Virologic Response and Variable in Normalization of Soluble Markers of Immune Activation. The Journal of infectious diseases. 2020 09; 222(8):1334-1344. doi: 10.1093/infdis/jiaa254. [PMID: 32406487]
  • Iacopo Olivotto, Artur Oreziak, Roberto Barriales-Villa, Theodore P Abraham, Ahmad Masri, Pablo Garcia-Pavia, Sara Saberi, Neal K Lakdawala, Matthew T Wheeler, Anjali Owens, Milos Kubanek, Wojciech Wojakowski, Morten K Jensen, Juan Gimeno-Blanes, Kia Afshar, Jonathan Myers, Sheila M Hegde, Scott D Solomon, Amy J Sehnert, David Zhang, Wanying Li, Mondira Bhattacharya, Jay M Edelberg, Cynthia Burstein Waldman, Steven J Lester, Andrew Wang, Carolyn Y Ho, Daniel Jacoby. Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet (London, England). 2020 09; 396(10253):759-769. doi: 10.1016/s0140-6736(20)31792-x. [PMID: 32871100]
  • Duan Chu, Lai Wei. Systematic analysis reveals cis and trans determinants affecting C-to-U RNA editing in Arabidopsis thaliana. BMC genetics. 2020 09; 21(1):98. doi: 10.1186/s12863-020-00907-6. [PMID: 32883207]
  • Michal Adamski, Konrad Wołowski, Ariel Kaminski, Alica Hindáková. Cyanotoxin cylindrospermopsin producers and the catalytic decomposition process: A review. Harmful algae. 2020 09; 98(?):101894. doi: 10.1016/j.hal.2020.101894. [PMID: 33129452]
  • Nicolas Pallet, Salma Hamdane, Simon Garinet, Hélène Blons, Aziz Zaanan, Elena Paillaud, Julien Taieb, Olivier Laprevote, Marie-Anne Loriot, Céline Narjoz. A comprehensive population-based study comparing the phenotype and genotype in a pretherapeutic screen of dihydropyrimidine dehydrogenase deficiency. British journal of cancer. 2020 09; 123(5):811-818. doi: 10.1038/s41416-020-0962-z. [PMID: 32595208]
  • Lindokuhle Patience Mabuza, Mlindeli Wilkinson Gamede, Sanam Maikoo, Irvin Noel Booysen, Phikelelani Siphosethu Ngubane, Andile Khathi. Amelioration of risk factors associated with diabetic nephropathy in diet-induced pre-diabetic rats by an uracil-derived diimine ruthenium(II) compound. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110483. doi: 10.1016/j.biopha.2020.110483. [PMID: 32768965]
  • Marina V Shestakova, Ekaterina A Shestakova, Vera A Kachko. [Specific features of the use of alogliptin in various groups of patients with type 2 diabetes mellitus: additional results of the ENTIRE study]. Problemy endokrinologii. 2020 08; 66(2):49-60. doi: 10.14341/probl12273. [PMID: 33351348]
  • Jessica L Irons, Kelsey Hodge-Hanson, Diana M Downs. RidA Proteins Protect against Metabolic Damage by Reactive Intermediates. Microbiology and molecular biology reviews : MMBR. 2020 08; 84(3):. doi: 10.1128/mmbr.00024-20. [PMID: 32669283]
  • Riccardo Zucchi. Thyroid Hormone Analogues: An Update. Thyroid : official journal of the American Thyroid Association. 2020 08; 30(8):1099-1105. doi: 10.1089/thy.2020.0071. [PMID: 32098589]
  • Naima Tafzi, Jean-Baptiste Woillard, Aurélie Fleytoux, Nicolas Picard, Pierre Marquet. Phenotyping of Uracil and 5-Fluorouracil Metabolism Using LC-MS/MS for Prevention of Toxicity and Dose Adjustment of Fluoropyrimidines. Therapeutic drug monitoring. 2020 08; 42(4):540-547. doi: 10.1097/ftd.0000000000000768. [PMID: 32384537]
  • Shiro Watanabe, Ken-Ichi Nishijima, Shozo Okamoto, Keiichi Magota, Kenji Hirata, Takuya Toyonaga, Tohru Shiga, Yuji Kuge, Nagara Tamaki. Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers. Annals of nuclear medicine. 2020 Aug; 34(8):595-599. doi: 10.1007/s12149-020-01469-4. [PMID: 32361818]
  • Aneta Żabka, Konrad Winnicki, Justyna Teresa Polit, Joanna Bernasińska-Słomczewska, Janusz Maszewski. 5-Aminouracil and other inhibitors of DNA replication induce biphasic interphase-mitotic cells in apical root meristems of Allium cepa. Plant cell reports. 2020 Aug; 39(8):1013-1028. doi: 10.1007/s00299-020-02545-9. [PMID: 32328702]
  • Ashwin Balagopal, Laura M Smeaton, Jeffrey Quinn, Charles S Venuto, Gene D Morse, Vincent Vu, Beverly Alston-Smith, Daniel E Cohen, Jorge L Santana-Bagur, Donald D Anthony, Mark S Sulkowski, David L Wyles, Andrew H Talal. Intrahepatic Viral Kinetics During Direct-Acting Antivirals for Hepatitis C in Human Immunodeficiency Virus Coinfection: The AIDS Clinical Trials Group A5335S Substudy. The Journal of infectious diseases. 2020 07; 222(4):601-610. doi: 10.1093/infdis/jiaa126. [PMID: 32201883]
  • Brent S Weber, Aaron M De Jong, Amelia B Y Guo, Srinivas Dharavath, Shawn French, Aline A Fiebig-Comyn, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae. Cell reports. 2020 07; 32(3):107927. doi: 10.1016/j.celrep.2020.107927. [PMID: 32698013]
  • Clémence Marin, Anis Krache, Chloé Palmaro, Mathilde Lucas, Valentin Hilaire, Renée Ugdonne, Bénédicte De Victor, Sylvie Quaranta, Caroline Solas, Bruno Lacarelle, Joseph Ciccolini. A Simple and Rapid UPLC-UV Method for Detecting DPD Deficiency in Patients With Cancer. Clinical and translational science. 2020 07; 13(4):761-768. doi: 10.1111/cts.12762. [PMID: 32058656]
  • Hind Alsharhan, Hana Alharbi, Jessica Priestley, Rebecca Ganetzky, Miao He. Urinary Uracil: A Useful Marker for Ornithine Transcarbamylase Deficiency in Affected Males. Clinical chemistry. 2020 07; 66(7):988-989. doi: 10.1093/clinchem/hvaa101. [PMID: 32628763]
  • Xandra García-González, Bartosz Kaczmarczyk, Judith Abarca-Zabalía, Fabienne Thomas, Pilar García-Alfonso, Luis Robles, Vanessa Pachón, Ángeles Vaz, Sara Salvador-Martín, María Sanjurjo-Sáez, Luis A López-Fernández. New DPYD variants causing DPD deficiency in patients treated with fluoropyrimidine. Cancer chemotherapy and pharmacology. 2020 07; 86(1):45-54. doi: 10.1007/s00280-020-04093-1. [PMID: 32529295]
  • Shinji Kobuchi, Eisuke Matsumura, Yukako Ito, Toshiyuki Sakaeda. Population Pharmacokinetic Model-Based Evaluation of Circadian Variations in Plasma 5-Fluorouracil Concentrations During Long-Term Infusion in Rats: A Comparison With Oral Anticancer Prodrugs. Journal of pharmaceutical sciences. 2020 07; 109(7):2356-2361. doi: 10.1016/j.xphs.2020.04.005. [PMID: 32311368]
  • Clemens L Weiß, Marie-Theres Gansauge, Ayinuer Aximu-Petri, Matthias Meyer, Hernán A Burbano. Mining ancient microbiomes using selective enrichment of damaged DNA molecules. BMC genomics. 2020 Jun; 21(1):432. doi: 10.1186/s12864-020-06820-7. [PMID: 32586278]
  • P Simmonds. Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories. mSphere. 2020 06; 5(3):. doi: 10.1128/msphere.00408-20. [PMID: 32581081]
  • YueTao Liu, XinQi Li, AiPing Li, Ke Li, XueMei Qin. UHPLC Q-Exactive MS-based spleen metabolomics and lipidomics to explore the effect mechanisms of Danggui Buxue Decoction in anemia mice. Journal of pharmaceutical and biomedical analysis. 2020 Jun; 185(?):113234. doi: 10.1016/j.jpba.2020.113234. [PMID: 32171146]
  • João Pedro Ferreira, Cyrus Mehta, Abhinav Sharma, Steven E Nissen, Patrick Rossignol, Faiez Zannad. Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial. BMC medicine. 2020 06; 18(1):165. doi: 10.1186/s12916-020-01616-8. [PMID: 32493335]
  • Cancan Yang, Jing Li, Zhenling Huang, Xuefa Zhang, Xiaolei Gao, Chunyuang Zhu, Paul F Morris, XiuGuo Zhang. Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici. Scientific reports. 2020 06; 10(1):9051. doi: 10.1038/s41598-020-65935-9. [PMID: 32493959]
  • Carolyn Y Ho, Matthew E Mealiffe, Richard G Bach, Mondira Bhattacharya, Lubna Choudhury, Jay M Edelberg, Sheila M Hegde, Daniel Jacoby, Neal K Lakdawala, Steven J Lester, Yanfei Ma, Ali J Marian, Sherif F Nagueh, Anjali Owens, Florian Rader, Sara Saberi, Amy J Sehnert, Mark V Sherrid, Scott D Solomon, Andrew Wang, Omar Wever-Pinzon, Timothy C Wong, Stephen B Heitner. Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology. 2020 06; 75(21):2649-2660. doi: 10.1016/j.jacc.2020.03.064. [PMID: 32466879]
  • Yayoi Nishida, Yasuo Takahashi, Kotoe Tezuka, Hayato Akimoto, Tomohiro Nakayama, Satoshi Asai. Comparative effect of dipeptidyl-peptidase 4 inhibitors on laboratory parameters in patients with diabetes mellitus. BMC pharmacology & toxicology. 2020 04; 21(1):28. doi: 10.1186/s40360-020-00407-4. [PMID: 32317005]
  • Meng-Yao Wang, Xin-Yang Liu, Li Shi, Jia-Lu Liu, Guang-Mao Shen, Ping Zhang, Wen-Cai Lu, Lin He. Functional analysis of UGT201D3 associated with abamectin resistance in Tetranychus cinnabarinus (Boisduval). Insect science. 2020 Apr; 27(2):276-291. doi: 10.1111/1744-7917.12637. [PMID: 30136378]
  • Tiphaine Robin, Franck Saint-Marcoux, Doriane Toinon, Naïma Tafzi, Pierre Marquet, Souleiman El Balkhi. Automatic quantification of uracil and dihydrouracil in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1142(?):122038. doi: 10.1016/j.jchromb.2020.122038. [PMID: 32169798]
  • Brian J Sandri, Gabriele R Lubach, Eric F Lock, Michael K Georgieff, Pamela J Kling, Christopher L Coe, Raghavendra B Rao. Early-Life Iron Deficiency and Its Natural Resolution Are Associated with Altered Serum Metabolomic Profiles in Infant Rhesus Monkeys. The Journal of nutrition. 2020 04; 150(4):685-693. doi: 10.1093/jn/nxz274. [PMID: 31722400]
  • Michael L Hayes, Paola I Santibanez. A plant pentatricopeptide repeat protein with a DYW-deaminase domain is sufficient for catalyzing C-to-U RNA editing in vitro. The Journal of biological chemistry. 2020 03; 295(11):3497-3505. doi: 10.1074/jbc.ra119.011790. [PMID: 31996373]
  • Heba A Aref, Sherin F Hammad, Khaled M Darwish, Mohammed S Elgawish. Novel spectrofluorimetric quantification of alogliptin benzoate in biofluids exploiting its interaction with 4-chloro-7-nitrobenzofurazan. Luminescence : the journal of biological and chemical luminescence. 2020 Mar; 35(2):284-291. doi: 10.1002/bio.3725. [PMID: 31762136]
  • Kohei Kaku, Kazuyuki Ishida, Kohei Shimizu, Meguru Achira, Yuusuke Umeda. Efficacy and safety of trelagliptin in Japanese patients with type 2 diabetes with severe renal impairment or end-stage renal disease: Results from a randomized, phase 3 study. Journal of diabetes investigation. 2020 Mar; 11(2):373-381. doi: 10.1111/jdi.13126. [PMID: 31389201]
  • Yin-Pan Chau, Philip C M Au, Gloria H Y Li, Chor-Wing Sing, Vincent K F Cheng, Kathryn C B Tan, Annie W C Kung, Ching-Lung Cheung. Serum Metabolome of Coffee Consumption and its Association With Bone Mineral Density: The Hong Kong Osteoporosis Study. The Journal of clinical endocrinology and metabolism. 2020 03; 105(3):. doi: 10.1210/clinem/dgz210. [PMID: 31750515]
  • Jihane Basbous, Antoine Aze, Laurent Chaloin, Rana Lebdy, Dana Hodroj, Cyril Ribeyre, Marion Larroque, Caitlin Shepard, Baek Kim, Alain Pruvost, Jérôme Moreaux, Domenico Maiorano, Marcel Mechali, Angelos Constantinou. Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites. Nucleic acids research. 2020 02; 48(4):1886-1904. doi: 10.1093/nar/gkz1162. [PMID: 31853544]
  • Aliyah Almomen, Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Shorog M Al-Taweel, Ashwaq A Alanazi. Development and validation of UPLC-MS/MS method for studying the pharmacokinetic interaction of dasabuvir and tamoxifen, 4-hydroxytamoxifen in Wistar rats. Scientific reports. 2020 02; 10(1):3521. doi: 10.1038/s41598-020-60613-2. [PMID: 32103133]
  • Yoichiro Yoshida, Yasuhiro Hashimoto, Makoto Miyazaki, Naoya Aisu, Teppei Yamada, Ryuji Kajitani, Taro Munechika, Yoshiko Matsumoto, Hideki Nagano, Hideki Shimaoka, Akira Komono, Ryohei Sakamoto, Gumpei Yoshimatsu, Fumihiro Yoshimura, Fumiaki Kiyomi, Suguru Hasegawa. 5-Nitrouracil stabilizes the plasma concentration values of 5-FU in colorectal cancer patients receiving capecitabine. Scientific reports. 2020 02; 10(1):2711. doi: 10.1038/s41598-020-59648-2. [PMID: 32066801]
  • Massimiliano Runfola, Simona Sestito, Lorenza Bellusci, Valeria La Pietra, Vincenzo Maria D'Amore, Marta Anna Kowalik, Grazia Chiellini, Sheraz Gul, Andrea Perra, Amedeo Columbano, Luciana Marinelli, Ettore Novellino, Simona Rapposelli. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis. European journal of medicinal chemistry. 2020 Feb; 188(?):112006. doi: 10.1016/j.ejmech.2019.112006. [PMID: 31931337]
  • Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim, In Joo Kim. Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study. Diabetes & metabolism journal. 2020 02; 44(1):67-77. doi: 10.4093/dmj.2018.0274. [PMID: 31339011]
  • Elena Laura Iliescu, Adriana Mercan-Stanciu, Letitia Toma. Safety and efficacy of direct-acting antivirals for chronic hepatitis C in patients with chronic kidney disease. BMC nephrology. 2020 01; 21(1):21. doi: 10.1186/s12882-020-1687-1. [PMID: 31948406]