Pyridoxine (BioDeep_00000399887)

Main id: BioDeep_00000001420

Secondary id: BioDeep_00000869388

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

化学式: C8H11NO3 (169.0738896)
中文名称: 维生素B6盐酸盐, 维生素B6, 吡多素
谱图信息: 最多检出来源 Homo sapiens(blood) 0.13%

分子结构信息

SMILES: CC1=C(O)C(CO)=C(CO)C=N1
InChI: InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3

描述信息

A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.
A - Alimentary tract and metabolism > A11 - Vitamins
D018977 - Micronutrients > D014815 - Vitamins
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

同义名列表

3 个代谢物同义名

Pyridoxine; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol; Pyridoxol



数据库引用编号

74 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna S Frolova, Anna D Fokina, Irina S Milentyeva, Lyudmila K Asyakina, Larisa A Proskuryakova, Alexander Y Prosekov. The Biological Active Substances of Taraxacum officinale and Arctium lappa from the Siberian Federal District. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063263. [PMID: 38542237]
  • Samah Ali, Marwa Dayo, Sana Alahmadi, Amr Mohamed. Chitosan-Supported ZnO Nanoparticles: Their Green Synthesis, Characterization, and Application for the Removal of Pyridoxine HCl (Vitamin B6) from Aqueous Media. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040828. [PMID: 38398580]
  • Priscille Steensma, Marion Eisenhut, Maite Colinas, Laise Rosado-Souza, Alisdair R Fernie, Andreas P M Weber, Teresa B Fitzpatrick. PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions. Plant physiology. 2023 09; 193(2):1433-1455. doi: 10.1093/plphys/kiad411. [PMID: 37453131]
  • Rui-Peng Xie, Xu-Fang Liang, Di Peng, Qi-Wei Zhang, Dong-Liang Wu, Jun-Liang Chen, Ming Zeng. Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi). Fish physiology and biochemistry. 2023 Aug; ?(?):. doi: 10.1007/s10695-023-01223-3. [PMID: 37542702]
  • Lina Yang, Xiaohong Liu, Jie Wang, Lianwei Li, Wanzhen Feng, Zhaolin Ji. Pyridoxine biosynthesis protein MoPdx1 affects the development and pathogenicity of Magnaporthe oryzae. Frontiers in cellular and infection microbiology. 2023; 13(?):1099967. doi: 10.3389/fcimb.2023.1099967. [PMID: 36824685]
  • Je Won Ko, Sookyoung Jeon, Young Hye Kwon. Dietary vitamin B6 restriction aggravates neurodegeneration in mice fed a high-fat diet. Life sciences. 2022 Nov; 309(?):121041. doi: 10.1016/j.lfs.2022.121041. [PMID: 36208656]
  • Serap Andac-Ozturk, Gökçen Garipoğlu, Jale Çatak, Mustafa Yaman. Investigation of the vitamins B1, B2, and B6 vitamers bioaccessibilities of canned, dried legumes after in vitro gastrointestinal digestion system. Food research international (Ottawa, Ont.). 2022 10; 160(?):111671. doi: 10.1016/j.foodres.2022.111671. [PMID: 36076445]
  • Thayse Evellyn Silva do Nascimento, Jorge A López, Eder Alves Barbosa, Marcela Abbott Galvão Ururahy, Adriana da Silva Brito, Gabriel Araujo-Silva, Jefferson Romáryo Duarte da Luz, Maria das Graças Almeida. Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196291. [PMID: 36234829]
  • Isaac Duah Boateng. A critical review of current technologies used to reduce ginkgotoxin, ginkgotoxin-5'-glucoside, ginkgolic acid, allergic glycoprotein, and cyanide in Ginkgo biloba L. seed. Food chemistry. 2022 Jul; 382(?):132408. doi: 10.1016/j.foodchem.2022.132408. [PMID: 35176549]
  • Christopher J Cifelli, Sanjiv Agarwal, Victor L Fulgoni Iii. Association between Intake of Total Dairy and Individual Dairy Foods and Markers of Folate, Vitamin B6 and Vitamin B12 Status in the U.S. Population. Nutrients. 2022 Jun; 14(12):. doi: 10.3390/nu14122441. [PMID: 35745171]
  • D X Li, Z H Chen, Y Jin, J Q Song, M Q Li, Y P Liu, X Y Li, Y X Chen, Y N Zhang, G Y Lyu, L Y Sun, Z J Zhu, Y Zhang, Y L Yang. [Clinical characteristics and CBS gene analysis of 13 cases with classic homocystinuria]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2022 Jun; 60(6):533-538. doi: 10.3760/cma.j.cn112140-20220305-00180. [PMID: 35658358]
  • Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa. Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine. Drug metabolism and pharmacokinetics. 2022 Jun; 44(?):100456. doi: 10.1016/j.dmpk.2022.100456. [PMID: 35512554]
  • Tetiana Kovalchuk, Oksana Boyarchuk. Serum pyridoxine, folate, cobalamin, and homocysteine levels in children presenting with vasovagal syncope. Cardiology in the young. 2022 May; 32(5):762-768. doi: 10.1017/s1047951121003036. [PMID: 34321136]
  • Eri Ogawa, Kazuhiro Shimura, Hiroshi Yoshihashi, Sahoko Miyama. Status Epilepticus due to Asfotase Alfa Interruption in Perinatal Severe Hypophosphatasia. Pediatric neurology. 2022 05; 130(?):4-6. doi: 10.1016/j.pediatrneurol.2021.12.009. [PMID: 35303588]
  • Laura A Tseng, Jose E Abdenur, Ashley Andrews, Verena G Aziz, Levinus A Bok, Monica Boyer, Daniela Buhas, Hans Hartmann, Emma J Footitt, Sabine Grønborg, Mirian C H Janssen, Nicola Longo, Roelineke J Lunsing, Alex E MacKenzie, Frits A Wijburg, Sidney M Gospe, Curtis R Coughlin, Clara D M van Karnebeek. Timing of therapy and neurodevelopmental outcomes in 18 families with pyridoxine-dependent epilepsy. Molecular genetics and metabolism. 2022 04; 135(4):350-356. doi: 10.1016/j.ymgme.2022.02.005. [PMID: 35279367]
  • Sarah L Stewart, Simone Thomas, Erol Höke, David Simpson, J Robinson Singleton, Ahmet Höke. Vitamin B6 levels do not correlate with severity of neuropathy in chronic idiopathic axonal polyneuropathy. Journal of the peripheral nervous system : JPNS. 2022 03; 27(1):31-37. doi: 10.1111/jns.12480. [PMID: 34931740]
  • Prakriti Kashyap, Sanjay Kumar. Ice structuring protein extract of Hordeum vulgare var. dolma grain reduces drip loss and loss of soluble vitamin content in peas during frozen storage. Cryobiology. 2022 Feb; 104(?):1-7. doi: 10.1016/j.cryobiol.2021.11.178. [PMID: 34826400]
  • Jin-Peng Zhu, Hao Gong, Faiza Labreche, Xiao-Hong Kou, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang, Dong-Bei Shen. Age-dependent alteration in metabolism of vitamin B6 , neurotransmitters, and amino acids after 4'-O-methylpyridoxine administration in rats. Journal of food science. 2022 Jan; 87(1):466-480. doi: 10.1111/1750-3841.15997. [PMID: 34914095]
  • Tomoya Sano, Yasushi Masuda, Hironobu Yasuno, Tadahiro Shinozawa, Takeshi Watanabe, Masaaki Kakehi. Blood Neurofilament Light Chain as a Potential Biomarker for Central and Peripheral Nervous Toxicity in Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2021 12; 185(1):10-18. doi: 10.1093/toxsci/kfab122. [PMID: 34677616]
  • Xian Wu, Per M Ueland, Jatin Roper, Gar Yee Koh, Xu Liang, Jimmy W Crott, Ömer H Yilmaz, Roderick T Bronson, Joel B Mason. Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. The Journal of nutrition. 2021 12; 151(12):3678-3688. doi: 10.1093/jn/nxab320. [PMID: 34590119]
  • Elisabeth Synnøve Nilsen Husebye, Bettina Riedel, Anne-Lise Bjørke-Monsen, Olav Spigset, Anne Kjersti Daltveit, Nils Erik Gilhus, Marte Helene Bjørk. Vitamin B status and association with antiseizure medication in pregnant women with epilepsy. Epilepsia. 2021 12; 62(12):2968-2980. doi: 10.1111/epi.17076. [PMID: 34590314]
  • Wen Zhang, Manman Shi, Fang Zhang, Fuliang Cao, Erzheng Su. A Facile Method to Determine the Native Contents of 4'-O-Methylpyridoxine and 4'-O-Methylpyridoxine-5'-glucoside in Ginkgo biloba Seeds. Journal of agricultural and food chemistry. 2021 Dec; 69(47):14270-14277. doi: 10.1021/acs.jafc.1c04937. [PMID: 34797654]
  • Paula A Guerrero, Yoshiko Murakami, Ankita Malik, Peter H Seeberger, Taroh Kinoshita, Daniel Varón Silva. Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides. ACS chemical biology. 2021 11; 16(11):2297-2306. doi: 10.1021/acschembio.1c00465. [PMID: 34618440]
  • Jin-Peng Zhu, Hao Gong, Faiza Labreche, Xiao-Hong Kou, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang. In vivo toxicity assessment of 4'-O-methylpyridoxine from Ginkgo biloba seeds: Growth, hematology, metabolism, and oxidative parameters. Toxicon : official journal of the International Society on Toxinology. 2021 Oct; 201(?):66-73. doi: 10.1016/j.toxicon.2021.08.015. [PMID: 34425140]
  • Abdou Madjid Olatounde Amoussa, Lixia Zhang, Camel Lagnika, Asad Riaz, Liuquan Zhang, Xianjin Liu, Trust Beta. Effects of preheating and drying methods on pyridoxine, phenolic compounds, ginkgolic acids, and antioxidant capacity of Ginkgo biloba nuts. Journal of food science. 2021 Sep; 86(9):4197-4208. doi: 10.1111/1750-3841.15864. [PMID: 34370293]
  • Alexandre R Lima, Florinda Gama, Viana Castañeda-Loaiza, Camila Costa, Lisa M Schüler, Tamára Santos, Miguel Salazar, Carla Nunes, Rui M S Cruz, João Varela, Luísa Barreira. Nutritional and Functional Evaluation of Inula crithmoides and Mesembryanthemum nodiflorum Grown in Different Salinities for Human Consumption. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154543. [PMID: 34361696]
  • Mathias D G Van den Eynde, Jean L J M Scheijen, Coen D A Stehouwer, Toshio Miyata, Casper G Schalkwijk. Quantification of the B6 vitamers in human plasma and urine in a study with pyridoxamine as an oral supplement; pyridoxamine as an alternative for pyridoxine. Clinical nutrition (Edinburgh, Scotland). 2021 07; 40(7):4624-4632. doi: 10.1016/j.clnu.2021.05.028. [PMID: 34229268]
  • Joseph Zhou, Utibe Effiong. Isolated Pyridoxine Deficiency Presenting as Muscle Spasms in a Patient With Type 2 Diabetes: A Case Report and Literature Review. The American journal of the medical sciences. 2021 06; 361(6):791-794. doi: 10.1016/j.amjms.2020.10.027. [PMID: 33958192]
  • Ning Hua, Yuxian Ning, Hui Zheng, Ledong Zhao, Xuehan Qian, Charles Wormington, Jingyun Wang. Recurrent dislocation of binocular crystal lenses in a patient with cystathionine beta-synthase deficiency. BMC ophthalmology. 2021 May; 21(1):212. doi: 10.1186/s12886-021-01974-8. [PMID: 33985475]
  • Viktor Kožich, Jitka Sokolová, Andrew A M Morris, Markéta Pavlíková, Florian Gleich, Stefan Kölker, Jakub Krijt, Carlo Dionisi-Vici, Matthias R Baumgartner, Henk J Blom, Martina Huemer. Cystathionine β-synthase deficiency in the E-HOD registry-part I: pyridoxine responsiveness as a determinant of biochemical and clinical phenotype at diagnosis. Journal of inherited metabolic disease. 2021 05; 44(3):677-692. doi: 10.1002/jimd.12338. [PMID: 33295057]
  • Sami Akbulut, Parviz Abbasov, Serdar Karakas, Aysun Bay Karabulut, Sezai Yilmaz. Evaluation of Serum Thiamine and Pyridoxine Levels in Patients Undergoing Liver Transplant: A Prospective Study. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2021 05; 19(5):457-461. doi: 10.6002/ect.2017.0102. [PMID: 29292683]
  • James B Mowry, Greene Shepherd, Robert S Hoffman, Valery Lavergne, Sophie Gosselin, Thomas D Nolin, Anitha Vijayan, Jan T Kielstein, Darren M Roberts, Marc Ghannoum. Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendations from the EXTRIP workgroup. Pharmacotherapy. 2021 05; 41(5):463-478. doi: 10.1002/phar.2519. [PMID: 33660266]
  • Elizabeth C Lorenz, John C Lieske, Barbara M Seide, Julie B Olson, Ramila Mehta, Dawn S Milliner. Recovery From Dialysis in Patients With Primary Hyperoxaluria Type 1 Treated With Pyridoxine: A Report of 3 Cases. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 05; 77(5):816-819. doi: 10.1053/j.ajkd.2020.07.017. [PMID: 32891627]
  • Kate Porter, John K Lodge. Determination of selected water-soluble vitamins (thiamine, riboflavin, nicotinamide and pyridoxine) from a food matrix using hydrophilic interaction liquid chromatography coupled with mass spectroscopy. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 May; 1171(?):122541. doi: 10.1016/j.jchromb.2021.122541. [PMID: 33773258]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Wen Zhang, Minmin Zou, Rong Wu, Huijuan Jiang, Fuliang Cao, Erzheng Su. Efficient removal of ginkgotoxin from Ginkgo biloba seed powder by combining endogenous enzymatic hydrolysis with resin adsorption. Journal of the science of food and agriculture. 2021 Mar; 101(4):1589-1597. doi: 10.1002/jsfa.10778. [PMID: 32869870]
  • Jin-Peng Zhu, Hao Gong, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang. 4'-O-methylpyridoxine: Preparation from Ginkgo biloba Seeds and Cytotoxicity in GES-1 Cells. Toxins. 2021 01; 13(2):. doi: 10.3390/toxins13020095. [PMID: 33530619]
  • Seyed Mohammad Ghani, Behzad Rezaei, Hamid Reza Jamei, Ali Asghar Ensafi. Novel synthesis of a dual fluorimetric sensor for the simultaneous analysis of levodopa and pyridoxine. Analytical and bioanalytical chemistry. 2021 Jan; 413(2):377-387. doi: 10.1007/s00216-020-03005-9. [PMID: 33106947]
  • Curtis R Coughlin, Laura A Tseng, Jose E Abdenur, Catherine Ashmore, François Boemer, Levinus A Bok, Monica Boyer, Daniela Buhas, Peter T Clayton, Anibh Das, Hanka Dekker, Athanasios Evangeliou, François Feillet, Emma J Footitt, Sidney M Gospe, Hans Hartmann, Majdi Kara, Erle Kristensen, Joy Lee, Rina Lilje, Nicola Longo, Roelineke J Lunsing, Philippa Mills, Maria T Papadopoulou, Phillip L Pearl, Flavia Piazzon, Barbara Plecko, Arushi G Saini, Saikat Santra, Damayanti R Sjarif, Sylvia Stockler-Ipsiroglu, Pasquale Striano, Johan L K Van Hove, Nanda M Verhoeven-Duif, Frits A Wijburg, Sameer M Zuberi, Clara D M van Karnebeek. Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyde dehydrogenase deficiency. Journal of inherited metabolic disease. 2021 01; 44(1):178-192. doi: 10.1002/jimd.12332. [PMID: 33200442]
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