Pyridoxine (BioDeep_00000001420)

 

Secondary id: BioDeep_00000399887, BioDeep_00000869388

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine

化学式: C8H11NO3 (169.0738896)
中文名称: 维生素B6, 吡哆素, 维生素B6盐酸盐, 吡哆醇
谱图信息: 最多检出来源 Viridiplantae(plant) 0.4%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Pyridoxine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/pyridoxine (retrieved 2024-11-11) (BioDeep RN: BioDeep_00000001420). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1=C(O)C(CO)=C(CO)C=N1
InChI: InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3

描述信息

Pyridoxine, also known vitamin B6, is commonly found in food and is used as a dietary supplement. Pyridoxine is an essential nutrient, meaning the body cannot synthesize it, and it must be obtained from the diet. Sources in the diet include fruit, vegetables, and grain. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is sometimes misleading (PMID: 2192605). Technically, pyridoxine is one of the compounds that can be called vitamin B6 or it is a member of the family of B6 vitamins. Healthy human blood levels of pyridoxine are 2.1 - 21.7 ng/mL. Pyridoxine is readily converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids and aminolevulinic acid. Pyridoxine assists in the balancing of sodium and potassium as well as promoting red blood cell production. Therefore pyridoxine is required by the body to make amino acids, carbohydrates, and lipids. It is linked to cancer immunity and helps fight the formation of homocysteine. It has been suggested that pyridoxine might help children with learning difficulties, and may also prevent dandruff, eczema, and psoriasis. In addition, pyridoxine can help balance hormonal changes in women and aid in immune system. Lack of pyridoxine may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth (Wikipedia). Deficiency of pyridoxine, though rare because of widespread distribution in foods, leads to the development of peripheral neuritis in adults and affects the central nervous system in children (DOSE - 3rd edition). As a supplement pyridoxine is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, problems from isoniazid, and certain types of mushroom poisoning. Pyridoxine in combination with doxylamine is used as a treatment for morning sickness in pregnant women.
Found in rice husks, cane molasses, yeast, wheat germ and cod liver oils. Vitamin, dietary supplement, nutrient. Pyridoxine is one of the compounds that can be called vitamin B6, along with pyridoxal and pyridoxamine. It differs from pyridoxamine by the substituent at the 4 position. It is often used as pyridoxine hydrochloride. Pyridoxine in the urine is a biomarker for the consumption of soy products.
Acquisition and generation of the data is financially supported in part by CREST/JST.
A - Alimentary tract and metabolism > A11 - Vitamins
D018977 - Micronutrients > D014815 - Vitamins
COVID info from COVID-19 Disease Map
KEIO_ID P053
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

同义名列表

27 个代谢物同义名

3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine; 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine; 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine; 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine; 2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol; 5-Hydroxy-6-methyl-3,4-pyridinedimethanol; 3-Hydroxy-4,5-dimethylol-alpha-picoline; 3-Hydroxy-2-picoline-4,5-dimethanol; 3-Hydroxy-4,5-dimethylol-α-picoline; 3-Hydroxy-4,5-dimethylol-a-picoline; Pyridoxine hydrochloride; Pyridoxol hydrochloride; Pyridoxine (Vitamin B6); Pyridoxolum; Pyridoxinum; Piridossina; Piridoxina; Pyridoxine; Vitamin B6; Pyridoxin; Pyridoxol; Gravidox; Adermine; Hydoxin; Rodex; Pyridoxine



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(1)

PlantCyc(0)

代谢反应

348 个相关的代谢反应过程信息。

Reactome(72)

BioCyc(56)

WikiPathways(1)

Plant Reactome(3)

INOH(1)

PlantCyc(203)

COVID-19 Disease Map(1)

PathBank(11)

  • Vitamin B6 Metabolism: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Hypophosphatasia: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Vitamin B6: 2-Oxo-3-hydroxy-4-phosphobutanoic acid + L-Glutamic acid ⟶ O-Phospho-4-hydroxy-L-threonine + Oxoglutaric acid
  • Vitamin B6 Metabolism: Oxygen + Pyridoxamine 5'-phosphate + Water ⟶ Ammonia + Hydrogen peroxide + Pyridoxal 5'-phosphate
  • Vitamin B6 Metabolism: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Hypophosphatasia: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Vitamin B6 Metabolism: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Vitamin B6 Metabolism: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Vitamin B6 Metabolism: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Vitamin B6 Metabolism: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
  • Hypophosphatasia: 4-Pyridoxic acid ⟶ 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna S Frolova, Anna D Fokina, Irina S Milentyeva, Lyudmila K Asyakina, Larisa A Proskuryakova, Alexander Y Prosekov. The Biological Active Substances of Taraxacum officinale and Arctium lappa from the Siberian Federal District. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063263. [PMID: 38542237]
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  • Priscille Steensma, Marion Eisenhut, Maite Colinas, Laise Rosado-Souza, Alisdair R Fernie, Andreas P M Weber, Teresa B Fitzpatrick. PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions. Plant physiology. 2023 09; 193(2):1433-1455. doi: 10.1093/plphys/kiad411. [PMID: 37453131]
  • Rui-Peng Xie, Xu-Fang Liang, Di Peng, Qi-Wei Zhang, Dong-Liang Wu, Jun-Liang Chen, Ming Zeng. Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi). Fish physiology and biochemistry. 2023 Aug; ?(?):. doi: 10.1007/s10695-023-01223-3. [PMID: 37542702]
  • Lina Yang, Xiaohong Liu, Jie Wang, Lianwei Li, Wanzhen Feng, Zhaolin Ji. Pyridoxine biosynthesis protein MoPdx1 affects the development and pathogenicity of Magnaporthe oryzae. Frontiers in cellular and infection microbiology. 2023; 13(?):1099967. doi: 10.3389/fcimb.2023.1099967. [PMID: 36824685]
  • Je Won Ko, Sookyoung Jeon, Young Hye Kwon. Dietary vitamin B6 restriction aggravates neurodegeneration in mice fed a high-fat diet. Life sciences. 2022 Nov; 309(?):121041. doi: 10.1016/j.lfs.2022.121041. [PMID: 36208656]
  • Serap Andac-Ozturk, Gökçen Garipoğlu, Jale Çatak, Mustafa Yaman. Investigation of the vitamins B1, B2, and B6 vitamers bioaccessibilities of canned, dried legumes after in vitro gastrointestinal digestion system. Food research international (Ottawa, Ont.). 2022 10; 160(?):111671. doi: 10.1016/j.foodres.2022.111671. [PMID: 36076445]
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  • Isaac Duah Boateng. A critical review of current technologies used to reduce ginkgotoxin, ginkgotoxin-5'-glucoside, ginkgolic acid, allergic glycoprotein, and cyanide in Ginkgo biloba L. seed. Food chemistry. 2022 Jul; 382(?):132408. doi: 10.1016/j.foodchem.2022.132408. [PMID: 35176549]
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