piroxicam (BioDeep_00000398951)
Main id: BioDeep_00000002067
natural product Chemicals and Drugs
代谢物信息卡片
Piroxicam (Feldene)
化学式: C15H13N3O4S (331.0626738)
中文名称: 吡罗昔康
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c(c3)cnc(c3)NC(=O)C(=C(O)1)N(C)S(=O)(=O)c(c2)c(ccc2)1
InChI: InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
描述信息
A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AC - Oxicams
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:8249
- KEGG: C01608
- KEGGdrug: D70554
- KEGGdrug: D00127
- PubChem: 54676228
- DrugBank: DB00554
- ChEMBL: CHEMBL1518938
- ChEMBL: CHEMBL527
- MeSH: Piroxicam
- CAS: 1044566-76-8
- CAS: 36322-90-4
- MoNA: WA002542
- MoNA: WA002541
- MoNA: WA002540
- MoNA: WA002539
- MoNA: WA002538
- MoNA: WA002537
- MoNA: FiehnHILIC002938
- MoNA: FiehnHILIC002266
- MoNA: FiehnHILIC001458
- MoNA: FiehnHILIC000700
- MoNA: CCMSLIB00000078248
- MoNA: CCMSLIB00000078247
- MetaboLights: MTBLC8249
- PubChem: 4761
- NIKKAJI: J3.498C
- RefMet: Piroxicam
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Farah Abid, Mohammad Saleem, Talha Jamshaid, Usama Jamshaid, Fadia S Youssef, Reem M Diri, Sameh S Elhady, Mohamed L Ashour. Opuntia monacantha: Validation of the anti-inflammatory and anti-arthritic activity of its polyphenolic rich extract in silico and in vivo via assessment of pro- and anti-inflammatory cytokines.
Journal of ethnopharmacology.
2024 May; 326(?):117884. doi:
10.1016/j.jep.2024.117884. [PMID: 38350502] - Viviane Lazari Simomura, Daniela Miorando, Beatriz Monteiro Magalhães de Oliveira, Aline Mânica, Lilian Caroline Bohnen, Maike Valentin Buzatto, Francine Mantelli Kunst, Lucas Damo Ansolin, Lincon Bordignon Somensi, Max Vidal Gutiérrez, Larissa Venzon, Thiago Farias de Queiroz E Silva, Luisa Mota da Silva, Walter Antônio Roman Junior. Aqueous extract of the bark of Uncaria tomentosa, an amazonian medicinal plant, promotes gastroprotection and accelerates gastric healing in rats.
Journal of ethnopharmacology.
2024 Mar; 321(?):117542. doi:
10.1016/j.jep.2023.117542. [PMID: 38056537] - Na Zhu, Xu-Dong Zhu, Yi-Sheng Yang, Fei-Xia Yan, Peng Zhang, Lin-Chun Wan, Yi Wu, Li-Ping Huang. [Different processed products of Polygonati Rhizoma treat Alzheimer's disease in rats: urine metabolomics based on UPLC-Q/TOF-MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Dec; 48(24):6663-6675. doi:
10.19540/j.cnki.cjcmm.20231019.301. [PMID: 38212026] - Rahul Maheshwari, Mayank Sharma, Vijay R Chidrawar. Niosomes based formulation containing tenoxicam: A newer solution for the rheumatic diseases.
Annales pharmaceutiques francaises.
2023 Nov; ?(?):. doi:
10.1016/j.pharma.2023.10.010. [PMID: 37923009] - Abdul Aleem, Bilal Aslam, Muhammad Bilal Alim, Asif Hussain, Muhammad Naeem Faisal, Zia-Ud-Din Sindhu. Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5):1425-1434. doi:
. [PMID: 37869918] - Jiayu Zhang, Qing Li, Ziteng Liu, Longshan Zhao. Rapid and sensitive determination of Piroxicam by N-doped carbon dots prepared by plant soot.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2023 May; 299(?):122833. doi:
10.1016/j.saa.2023.122833. [PMID: 37187150] - Beatriz Monteiro Magalhães de Oliveira, Patrícia Zanotelli Serpa, Maria Eduarda da Costa Zanatta, Bruna Agnoatto Aires, Amanda Maria Steffler, Lincon Bordignon Somensi, Benhur Judah Cury, Ana Caroline Dos Santos, Larissa Venzon, Thaise Boeing, Luisa Mota da Silva, Walter Antônio Roman Junior. Gastroprotective and gastric healing effects of the aqueous extract of Casearia sylvestris in rodents: Ultrasound, histological and biochemical analyzes.
Journal of ethnopharmacology.
2022 Nov; 298(?):115660. doi:
10.1016/j.jep.2022.115660. [PMID: 35995277] - Khaoula Bel Haj Ali, Adel Sekma, Saoussen Ben Abdallah, Hajer Yaakoubi, Imen Trabelsi, Nourzed Frikha, Houda Ben Soltane, Mohamed Habib Grissa, Hamdi Boubaker, Mohamed Amine Msolli, Zied Mezgar, Kaouthar Beltaief, Riadh Boukef, Semir Nouira. Analgesic effect of topical piroxicam versus phytotherapy gel in the treatment of acute soft tissues injuries: a randomized controlled non-inferiority study.
Pain medicine (Malden, Mass.).
2022 Nov; ?(?):. doi:
10.1093/pm/pnac176. [PMID: 36355573] - Ceyda Tuba Sengel-Turk, Erva Ozkan, Filiz Bakar-Ates. Box-Behnken design optimization and in vitro cell based evaluation of piroxicam loaded core-shell type hybrid nanocarriers for prostate cancer.
Journal of pharmaceutical and biomedical analysis.
2022 Jul; 216(?):114799. doi:
10.1016/j.jpba.2022.114799. [PMID: 35525111] - Moataz B Zewail, Gihan F Asaad, Salma M Swellam, Sama M Abd-Allah, Sahar K Hosny, Salma K Sallah, Jehan E Eissa, Salma S Mohamed, Walaa A El-Dakroury. Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation.
International journal of pharmaceutics.
2022 Jul; 624(?):122006. doi:
10.1016/j.ijpharm.2022.122006. [PMID: 35820515] - Maryam Moallemi Bahmani, Ali Mohammad Haji Shabani, Shayessteh Dadfarnia, Roya Afsharipour. Selective and Sensitive Fluorometric Determination of Piroxicam Based on Nitrogen-doped Graphene Quantum Dots and Gold Nanoparticles Coated with Phenylalanine.
Journal of fluorescence.
2022 Jul; 32(4):1337-1346. doi:
10.1007/s10895-022-02907-4. [PMID: 35366163] - Nguyen-Thach Tung, Thi-Hoang-Yen Dong, Cao-Son Tran, Thi-Kim-Thuy Nguyen, Sang-Cheol Chi, Danh-Son Dao, Dang-Hoa Nguyen. Integration of lornoxicam nanocrystals into hydroxypropyl methylcellulose-based sustained release matrix to form a novel biphasic release system.
International journal of biological macromolecules.
2022 Jun; 209(Pt A):441-451. doi:
10.1016/j.ijbiomac.2022.04.041. [PMID: 35413313] - Chang-Keun Cho, Pureum Kang, Hye-Jung Park, Eunvin Ko, Chou Yen Mu, Yun Jeong Lee, Chang-Ik Choi, Hyung Sik Kim, Choon-Gon Jang, Jung-Woo Bae, Seok-Yong Lee. Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism.
Archives of pharmacal research.
2022 May; 45(5):352-366. doi:
10.1007/s12272-022-01388-0. [PMID: 35639246] - Sabry M El-Bahr, Rabab R Elzoghby, Mohammed A Alfattah, Mahmoud Kandeel, Ahlam F Hamouda. Aqueous Ginger (Zingiber officinale) Extract Ameliorates the Harmful Effects of High-Dose Lornoxicam in Albino Male Rats.
BioMed research international.
2022; 2022(?):1546734. doi:
10.1155/2022/1546734. [PMID: 35958816] - Nobuaki Ishihama, Seung-Won Choi, Yoshiteru Noutoshi, Ivana Saska, Shuta Asai, Kaori Takizawa, Sheng Yang He, Hiroyuki Osada, Ken Shirasu. Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway.
Nature communications.
2021 12; 12(1):7303. doi:
10.1038/s41467-021-27489-w. [PMID: 34911942] - Xavier Mas-Orea, Morgane Sebert, Mehdi Benamar, Camille Petitfils, Catherine Blanpied, Abdelhadi Saoudi, Céline Deraison, Frederick Barreau, Nicolas Cenac, Gilles Dietrich. Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147387. [PMID: 34299013] - Nehal Salahuddin, Mohamed Gaber, Sahar Elneanaey, Michael R Snowdon, Mohamed A Abdelwahab. Co-delivery of norfloxacin and tenoxicam in Ag-TiO2/poly(lactic acid) nanohybrid.
International journal of biological macromolecules.
2021 Jun; 180(?):771-781. doi:
10.1016/j.ijbiomac.2021.03.033. [PMID: 33705836] - Maria Elaine Araruna, Pablo Silva, Maria Almeida, Renaly Rêgo, Raiff Dantas, Hilton Albuquerque, Ingrid Cabral, Nadjaele Apolinário, Francinalva Medeiros, Ana Medeiros, Vanda Santos. Tablet of Spondias mombin L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects.
Molecules (Basel, Switzerland).
2021 Mar; 26(6):. doi:
10.3390/molecules26061581. [PMID: 33809398] - Shin-Ichiro Karaki, Ryo Tanaka. Role of PGE2 in colonic motility: PGE2 attenuates spontaneous contractions of circular smooth muscle via EP4 receptors in the rat colon.
The journal of physiological sciences : JPS.
2021 Feb; 71(1):8. doi:
10.1186/s12576-021-00791-4. [PMID: 33622238] - Mohammad Saleem, Muhammad Asif, Anum Parveen, Hafiza Sidra Yaseen, Malik Saadullah, Asiya Bashir, Jawaria Asif, Mehwish Arif, Ikram Ullah Khan, Rizwan Ullah Khan. Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus.
Inflammopharmacology.
2021 Feb; 29(1):281-293. doi:
10.1007/s10787-020-00703-9. [PMID: 32297069] - Mahmoud H Teaima, Khaled M Abdel-Haleem, Rewan Osama, Mohamed A El-Nabarawi, Osama S Elnahas. A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam Using Co-Processed Excipients: Formulation, Characterization and Pharmacokinetic Study.
Drug design, development and therapy.
2021; 15(?):4229-4242. doi:
10.2147/dddt.s332729. [PMID: 34675486] - Hajra Afeera Hamid, Shahzeb Khan, Syed Muhammad Noor Shah, Muhammad Asghar, Muhammad Shahid, Zahid Hussain, Muhammad Sohail, Barkat Ali Khan, Fazli Amin, Syed Umer Jan, Abdelbary Elhissi, Syed Muhammad Hassan Shah, Muhammad Usman Minhas, Syed Wadood Ali Shah, Naveed Ahmad. Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation.
Pakistan journal of pharmaceutical sciences.
2021 Jan; 34(1(Supplementary)):327-335. doi:
. [PMID: 34275858] - Saud Bawazeer, Dalia Farag A El-Telbany, Majid Mohammad Al-Sawahli, Gamal Zayed, Ahmed Abdallah A Keed, Abdelaziz E Abdelaziz, Doaa H Abdel-Naby. Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats.
Drug delivery.
2020 Dec; 27(1):1218-1230. doi:
10.1080/10717544.2020.1803448. [PMID: 32772730] - Roxana Sandulovici, Ion Mircioiu, Hassan Y Aboul-Enein, Mihai Manolache, Constantin Mircioiu, Victor Voicu, Valentina Anuta. Sources of outlier data in the bioanalytical and clinical part of a piroxicam bioequivalence study.
International journal of clinical pharmacology and therapeutics.
2020 Nov; 58(11):652-663. doi:
10.5414/cp203794. [PMID: 32870154] - M I Oraebosi, G M Good, T Chia, O I Oyeniran. Bombax Costatum extract abrogates piroxicam-mediated hepatic and gastric toxicities in rats.
Annales pharmaceutiques francaises.
2020 Nov; 78(6):507-514. doi:
10.1016/j.pharma.2020.06.002. [PMID: 32565156] - Edvaldo Balbino Alves Júnior, Rodrigo de Oliveira Formiga, Catarina Alves de Lima Serafim, Maria Elaine Cristina Araruna, Michele Liz de Souza Pessoa, Roseane Carvalho Vasconcelos, Thais Gomes de Carvalho, Tamires Gonçalves de Jesus, Aurigena Antunes Araújo, Raimundo Fernandes de Araujo Junior, Giciane Carvalho Vieira, Marianna Vieira Sobral, Leônia Maria Batista. Estragole prevents gastric ulcers via cytoprotective, antioxidant and immunoregulatory mechanisms in animal models.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110578. doi:
10.1016/j.biopha.2020.110578. [PMID: 32750650] - Ahmed Abdeen, Afaf Abdelkader, Dina Elgazzar, Mohamed Aboubakr, Omnia A Abdulah, Khaled Shoghy, Mohamed Abdel-Daim, Hamed A El-Serehy, Agnieszka Najda, Amany El-Mleeh. Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110627. doi:
10.1016/j.biopha.2020.110627. [PMID: 34321156] - Jiani Huang, Fang Wen, Wenjie Huang, Yingfeng Bai, Xiaona Lu, Peng Shu. Identification of hub genes and discovery of promising compounds in gastric cancer based on bioinformatics analysis.
Biomarkers in medicine.
2020 08; 14(12):1069-1084. doi:
10.2217/bmm-2019-0608. [PMID: 32969243] - Ludmila Aricov, Daniel George Angelescu, Adriana Băran, Anca Ruxandra Leontieş, Vlad Tudor Popa, Aurica Precupaş, Romică Sandu, Gabriela Stîngă, Dan-Florin Anghel. Interaction of piroxicam with bovine serum albumin investigated by spectroscopic, calorimetric and computational molecular methods.
Journal of biomolecular structure & dynamics.
2020 Jun; 38(9):2659-2671. doi:
10.1080/07391102.2019.1645733. [PMID: 31315508] - Gergő Dargó, Dávid Bajusz, Kristóf Simon, Judit Müller, György T Balogh. Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Journal of medicinal chemistry.
2020 02; 63(4):1763-1774. doi:
10.1021/acs.jmedchem.0c00046. [PMID: 31995375] - V V Popov, G N Gildeeva, D V Butuzova, E A Ezhova, A V Belostotskiy, N A Bulanova. [A study of the efficacy and safety of lornoxicam in patients with acute sciatica].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2020; 120(5):42-49. doi:
10.17116/jnevro202012005142. [PMID: 32621467] - Lin Zhao, Omer Mustapha, Shumaila Shafique, Talha Jamshaid, Fakhar Ud Din, Yasir Mehmood, Khaleeq Anwer, Qurrat Ul Ain Yousafi, Talib Hussain, Ikram Ullah Khan, Muhammad Usman Ghori, Yasser Shahzad, Abid Mehmood Yousaf. Electrospun Gelatin Nanocontainers for Enhanced Biopharmaceutical Performance of Piroxicam: In Vivo and In Vitro Investigations.
International journal of nanomedicine.
2020; 15(?):8819-8828. doi:
10.2147/ijn.s271938. [PMID: 33204090] - Sajedeh Salandari, Tahoora Shomali, Najmeh Mosleh, Saeed Nazifi. A comparative study on anti-inflammatory drug combinations in domestic pigeons with experimentally induced acute arthritis.
Acta veterinaria Hungarica.
2019 12; 67(4):588-601. doi:
10.1556/004.2019.058. [PMID: 31842592] - Zhipei Sang, Keren Wang, Pengfei Zhang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2019 Oct; 180(?):238-252. doi:
10.1016/j.ejmech.2019.07.021. [PMID: 31310916] - Zhipei Sang, Keren Wang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2019 Sep; 178(?):726-739. doi:
10.1016/j.ejmech.2019.06.026. [PMID: 31229875] - Mohammed Gamal, Hazim M Ali, Safwan M Fraihat, T A Seaf Elnasr. Simultaneous determination of piroxicam and norfloxacin in biological fluids by high-performance liquid chromatography with fluorescence detection at zero-order emission mode.
Luminescence : the journal of biological and chemical luminescence.
2019 Sep; 34(6):644-650. doi:
10.1002/bio.3648. [PMID: 31184428] - Ahmed Abdeen, Omayma A Abou-Zaid, Hussein A Abdel-Maksoud, Mohamed Aboubakr, Afaf Abdelkader, Amany Abdelnaby, Ahmed I Abo-Ahmed, Amany El-Mleeh, Ola Mostafa, Mohamed Abdel-Daim, Lotfi Aleya. Cadmium overload modulates piroxicam-regulated oxidative damage and apoptotic pathways.
Environmental science and pollution research international.
2019 Aug; 26(24):25167-25177. doi:
10.1007/s11356-019-05783-x. [PMID: 31256392] - David Meriwether, Dawoud Sulaiman, Carmen Volpe, Anna Dorfman, Victor Grijalva, Nasrin Dorreh, R Sergio Solorzano-Vargas, Jifang Wang, Ellen O'Connor, Jeremy Papesh, Muriel Larauche, Hannah Trost, Mayakonda N Palgunachari, G M Anantharamaiah, Harvey R Herschman, Martin G Martin, Alan M Fogelman, Srinivasa T Reddy. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.
The Journal of clinical investigation.
2019 06; 129(9):3670-3685. doi:
10.1172/jci123700. [PMID: 31184596] - Karuppusamy Arunachalam, Amilcar Sabino Damazo, Eduarda Pavan, Darley Maria Oliveira, Fabiana de Freitas Figueiredo, Marco Tulio Marra Machado, Sikiru Olaitan Balogun, Ilsamar Mendes Soares, Robson Dos Santos Barbosa, Tarso da Costa Alvim, Sérgio Donizeti Ascêncio, Domingos Tabajara de Oliveira Martins. Cochlospermum regium (Mart. ex Schrank) Pilg.: Evaluation of chemical profile, gastroprotective activity and mechanism of action of hydroethanolic extract of its xylopodium in acute and chronic experimental models.
Journal of ethnopharmacology.
2019 Apr; 233(?):101-114. doi:
10.1016/j.jep.2019.01.002. [PMID: 30611907] - Hongyan Liu, Xiaoming Qiang, Qing Song, Wei Li, Yuxi He, Chanyuan Ye, Zhenghuai Tan, Yong Deng. Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Bioorganic & medicinal chemistry.
2019 03; 27(6):991-1001. doi:
10.1016/j.bmc.2019.01.040. [PMID: 30772129] - Silvia Imre, Amelia Tero-Vescan, Maria Titica Dogaru, László Kelemen, Daniela-Lucia Muntean, Augustin Curticapean, Noémi Szegedi, Camil-Eugen Vari. With or Without Internal Standard in HPLC Bioanalysis. A Case Study.
Journal of chromatographic science.
2019 Mar; 57(3):243-248. doi:
10.1093/chromsci/bmy106. [PMID: 30615090] - Yan Yan Yeap, Jaclyn Lock, Sean Lerkvikarn, Tanner Semin, Nicholas Nguyen, Rebecca L Carrier. Intestinal mucus is capable of stabilizing supersaturation of poorly water-soluble drugs.
Journal of controlled release : official journal of the Controlled Release Society.
2019 02; 296(?):107-113. doi:
10.1016/j.jconrel.2018.11.023. [PMID: 30527813] - Anderson Martin Santos, Ademar Wong, Fernando Campanhã Vicentini, Orlando Fatibello-Filho. Simultaneous voltammetric sensing of levodopa, piroxicam, ofloxacin and methocarbamol using a carbon paste electrode modified with graphite oxide and β-cyclodextrin.
Mikrochimica acta.
2019 02; 186(3):174. doi:
10.1007/s00604-019-3296-x. [PMID: 30771008] - Monika Mishra, Viney Chawla, Pooja Chawla. Pectin, beta-cyclodextrin, chitosan and albumin based gastroprotective systems for piroxicam maleate: Synthesis, characterization and biological evaluation.
International journal of biological macromolecules.
2019 Feb; 122(?):127-136. doi:
10.1016/j.ijbiomac.2018.10.069. [PMID: 30340003] - Ahmed Abdeen, Mohamed Aboubakr, Dina Elgazzar, Mohamed Abdo, Afaf Abdelkader, Samar Ibrahim, Ashraf Elkomy. Rosuvastatin attenuates piroxicam-mediated gastric ulceration and hepato-renal toxicity in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Feb; 110(?):895-905. doi:
10.1016/j.biopha.2018.11.004. [PMID: 30572194] - Marwa Sayed Badawi. Histological study of the protective role of ginger on piroxicam-induced liver toxicity in mice.
Journal of the Chinese Medical Association : JCMA.
2019 Jan; 82(1):11-18. doi:
10.1016/j.jcma.2018.06.006. [PMID: 30839397] - Syed Nisar Hussain Shah, Kashif Sohail, Zeeshan Javaid, Muhammad Zaman, Ejaz Basheer. Development and validation of RP-HPLC method for determination of Lornoxicam in rabbit's plasma.
Pakistan journal of pharmaceutical sciences.
2019 Jan; 32(1(Supplementary)):333-338. doi:
NULL. [PMID: 30829212] - Ruby Christian, Vaishali Thakkar, Tushar Patel, Mukesh Gohel, Lalji Baldaniya, Purvi Shah, Tosha Pandya, Tejal Gandhi. Development of Biodegradable Injectable In situ Forming Implants for Sustained Release of Lornoxicam.
Current drug delivery.
2019; 16(1):66-78. doi:
10.2174/1567201815666180927155710. [PMID: 30264681] - Shanshan Gao, Baocheng Tian, Jingtian Han, Jing Zhang, Yanan Shi, Qingzhi Lv, Keke Li. Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema.
International journal of nanomedicine.
2019; 14(?):6135-6150. doi:
10.2147/ijn.s205295. [PMID: 31447556] - Qing Song, Yan Li, Zhongcheng Cao, Hongyan Liu, Chaoquan Tian, Ziyi Yang, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2018 12; 26(23-24):6115-6127. doi:
10.1016/j.bmc.2018.11.015. [PMID: 30470598] - Giulia Auriemma, Andrea Cerciello, Francesca Sansone, Aldo Pinto, Silvana Morello, Rita P Aquino. Polysaccharides based gastroretentive system to sustain piroxicam release: Development and in vivo prolonged anti-inflammatory effect.
International journal of biological macromolecules.
2018 Dec; 120(Pt B):2303-2312. doi:
10.1016/j.ijbiomac.2018.08.140. [PMID: 30171948] - Xiaoting Li, Yan Gao, Jia Liu, Gongtian Zhang, Tianhong Zhang. A rapid analysis of piroxicam in beagle plasma applying evaporation-free liquid-liquid extraction by supercritical fluid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Nov; 1100-1101(?):93-99. doi:
10.1016/j.jchromb.2018.10.001. [PMID: 30296720] - Rui Xu, Ganyuan Xiao, Yan Li, Hongyan Liu, Qing Song, Xiaoyu Zhang, Ziyi Yang, Yunxiaozhu Zheng, Zhenghuai Tan, Yong Deng. Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2018 05; 26(8):1885-1895. doi:
10.1016/j.bmc.2018.02.037. [PMID: 29500132] - Zhongcheng Cao, Jie Yang, Rui Xu, Qin Song, Xiaoyu Zhang, Hongyan Liu, Xiaoming Qiang, Yan Li, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Bioorganic & medicinal chemistry.
2018 03; 26(5):1102-1115. doi:
10.1016/j.bmc.2018.01.030. [PMID: 29409707] - Neng Jiang, Qichun Huang, Jing Liu, Ningsheng Liang, Qing Li, Qinghua Li, Sai-Sai Xie. Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2018 Feb; 146(?):287-298. doi:
10.1016/j.ejmech.2018.01.055. [PMID: 29407958] - C J Henry, B K Flesner, S A Bechtel, J N Bryan, D J Tate, K A Selting, J C Lattimer, M E Bryan, L Grubb, F Hausheer. Clinical Evaluation of Tavocept to Decrease Diuresis Time and Volume in Dogs with Bladder Cancer Receiving Cisplatin.
Journal of veterinary internal medicine.
2018 Jan; 32(1):370-376. doi:
10.1111/jvim.14848. [PMID: 29080252] - Keke Li, Shanshan Gao, Baocheng Tian, Yanan Shi, Qingzhi Lv, Jingtian Han. Formulation Optimization and In-vitro and In-vivo Evaluation of Lornoxicam Ethosomal Gels with Penetration Enhancers.
Current drug delivery.
2018; 15(3):424-435. doi:
10.2174/1567201815666171207163010. [PMID: 29219057] - E I Akogwu, S A Saganuwan, P A Onyeyili. Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats.
Human & experimental toxicology.
2018 Jan; 37(1):61-68. doi:
10.1177/0960327117692135. [PMID: 28176534] - Jadwiga Maniewska, Justyna Gąsiorowska, Berenika Szczęśniak-Sięga, Krystyna Michalak. The interaction of new oxicam derivatives with lipid bilayers as measured by calorimetry and fluorescence spectroscopy.
Acta biochimica Polonica.
2018; 65(2):185-191. doi:
10.18388/abp.2018_2604. [PMID: 29796443] - L R Eichstadt, G E Moore, M O Childress. Risk factors for treatment-related adverse events in cancer-bearing dogs receiving piroxicam.
Veterinary and comparative oncology.
2017 Dec; 15(4):1346-1353. doi:
10.1111/vco.12276. [PMID: 27714960] - Jin-Shuai Lan, Yue Ding, Yun Liu, Ping Kang, Jian-Wei Hou, Xin-Yu Zhang, Sai-Sai Xie, Tong Zhang. Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2017 Oct; 139(?):48-59. doi:
10.1016/j.ejmech.2017.07.055. [PMID: 28797883] - Naomi L Keiper, Sherry K Cox, Grayson A Doss, Betsy Elsmo, Dana Franzen-Klein, Barry K Hartup. PHARMACOKINETICS OF PIROXICAM IN CRANES (FAMILY GRUIDAE).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2017 09; 48(3):886-890. doi:
10.1638/2016-0182.1. [PMID: 28920805] - Mohamed Yousif Moutasim, Aliaa Nabil ElMeshad, Mohamed Ahmed El-Nabarawi. A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation.
Drug delivery and translational research.
2017 06; 7(3):450-459. doi:
10.1007/s13346-017-0367-6. [PMID: 28283842] - Amira Motawea, Thanaa Borg, Manal Tarshoby, Abd El-Gawad H Abd El-Gawad. Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam.
Pharmaceutical development and technology.
2017 May; 22(3):445-456. doi:
10.1080/10837450.2016.1231810. [PMID: 27583581] - Zhipei Sang, Wanli Pan, Keren Wang, Qinge Ma, Lintao Yu, Yan Yang, Ping Bai, Chaoliang Leng, Qian Xu, Xiaoqing Li, Zhenghuai Tan, Wenmin Liu. Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2017 Apr; 130(?):379-392. doi:
10.1016/j.ejmech.2017.02.039. [PMID: 28279845] - Mohammed H Elkomy, Shahira F El Menshawe, Hussein M Eid, Ahmed M A Ali. Development of a nanogel formulation for transdermal delivery of tenoxicam: a pharmacokinetic-pharmacodynamic modeling approach for quantitative prediction of skin absorption.
Drug development and industrial pharmacy.
2017 Apr; 43(4):531-544. doi:
10.1080/03639045.2016.1268153. [PMID: 27910712] - Natalia Wilkosz, Sami Rissanen, Małgorzata Cyza, Renata Szybka, Maria Nowakowska, Alex Bunker, Tomasz Róg, Mariusz Kepczynski. Effect of piroxicam on lipid membranes: Drug encapsulation and gastric toxicity aspects.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Mar; 100(?):116-125. doi:
10.1016/j.ejps.2017.01.007. [PMID: 28087354] - Li Luo, Yan Li, Xiaoming Qiang, Zhongcheng Cao, Rui Xu, Xia Yang, Ganyuan Xiao, Qing Song, Zhenghuai Tan, Yong Deng. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2017 03; 25(6):1997-2009. doi:
10.1016/j.bmc.2017.02.027. [PMID: 28237559] - Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Bioorganic & medicinal chemistry letters.
2017 02; 27(4):718-722. doi:
10.1016/j.bmcl.2017.01.050. [PMID: 28131710] - Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng. Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2017 Jan; 126(?):762-775. doi:
10.1016/j.ejmech.2016.12.009. [PMID: 27951485] - Saganuwan Alhaji Saganuwan. Piroxicam: Source for Synthesis of Central Nervous System (CNS) Acting Drugs.
Central nervous system agents in medicinal chemistry.
2017; 17(2):135-140. doi:
10.2174/1871524916666160719102335. [PMID: 27439371] - Sandipan Dasgupta, Subhabrata Ray, Sanjay Dey, Paulami Pal, Bhaskar Mazumder. Transdermal Lipid Nanocarriers: A Potential Delivery System for Lornoxicam.
Pharmaceutical nanotechnology.
2017; 5(1):32-43. doi:
10.2174/2211738505666170105161336. [PMID: 28948909] - Hebatullah Samy Helmy, Ayman E El-Sahar, Rabab H Sayed, Rehab Nabil Shamma, Alaa Hamed Salama, Eman Maher Elbaz. Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis.
International journal of nanomedicine.
2017; 12(?):7015-7023. doi:
10.2147/ijn.s147738. [PMID: 29026298] - Li-Hua Peng, Wei Wei, Ying-Hui Shan, Yee-Song Chong, Lian Yu, Jian-Qing Gao. Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo.
Drug development and industrial pharmacy.
2017 Jan; 43(1):55-66. doi:
10.1080/03639045.2016.1220563. [PMID: 27498809] - Akiko Tanaka, Tomoyuki Furubayashi, Hitomi Yamasaki, Katsuko Takano, Mayuko Kawakami, Shunsuke Kimura, Daisuke Inoue, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto. The Enhancement of Nasal Drug Absorption From Powder Formulations by the Addition of Sodium Carboxymethyl Cellulose.
IEEE transactions on nanobioscience.
2016 12; 15(8):798-803. doi:
10.1109/tnb.2016.2612682. [PMID: 28060709] - Han Sol Kim, Ha Ra Cho, Myoung Jin Ho, Myung Joo Kang, Yong Seok Choi. Determination of piroxicam from rat articular tissue and plasma based on LC-MS/MS.
Archives of pharmacal research.
2016 Dec; 39(12):1653-1662. doi:
10.1007/s12272-016-0845-2. [PMID: 27752829] - Ismail Khan, Zafar Iqbal, Abad Khan, Muhammad Hassan, Fazle Nasir, Abida Raza, Lateef Ahmad, Amjad Khan, Muhammad Akhlaq Mughal. A simple, rapid and sensitive RP-HPLC-UV method for the simultaneous determination of sorafenib & paclitaxel in plasma and pharmaceutical dosage forms: Application to pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Oct; 1033-1034(?):261-270. doi:
10.1016/j.jchromb.2016.08.029. [PMID: 27592284] - Ingrid Bissinger, Gustavo Matute-Turizo, María Natalia Mejía-Barreneche. [Acute generalized exanthematous pustulosis induced by piroxicam].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).
2016 Oct; 63(4):408-412. doi:
10.29262/ram.v63i4.173. [PMID: 27795221] - So Young Um, Jung Hyun Park, Myeon Woo Chung, Ki Hwan Choi, Hwa Jeong Lee. (1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 129(?):492-501. doi:
10.1016/j.jpba.2016.07.045. [PMID: 27497650] - M Asadykkag Madni, Ahman Raza, Sikandar Abbas, Nayab Tahir, Mubashar Rehman, Prince Muhammad Kashif, Muhammad Imran Khan. DETERMINATION OF TENOXICAM IN THE PLASMA BY REVERSE PHASE HPLC METHOD USING SINGLE STEP EXTRACTION TECHNIQUE: A RELIABLE AND COST EFFECTIVE APPROACH.
Acta poloniae pharmaceutica.
2016 Sep; 73(5):1123-1128. doi:
NULL. [PMID: 29638052] - Jessica Otarola, Mariano Garrido, N Mariano Correa, Patricia G Molina. Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers.
Chemphyschem : a European journal of chemical physics and physical chemistry.
2016 Aug; 17(15):2322-8. doi:
10.1002/cphc.201600226. [PMID: 27128856] - Seby Elsy Varghese, Mayur K Fariya, Gopal Singh Rajawat, Frank Steiniger, Alfred Fahr, Mangal S Nagarsenker. Lecithin and PLGA-based self-assembled nanocomposite, Lecithmer: preparation, characterization, and pharmacokinetic/pharmacodynamic evaluation.
Drug delivery and translational research.
2016 08; 6(4):342-53. doi:
10.1007/s13346-016-0314-y. [PMID: 27371394] - Anupa Majumdar, Munna Sarkar. Small Mismatches in Fatty Acyl Tail Lengths Can Effect Non Steroidal Anti-Inflammatory Drug Induced Membrane Fusion.
The journal of physical chemistry. B.
2016 06; 120(21):4791-802. doi:
10.1021/acs.jpcb.6b03583. [PMID: 27153337] - Adriana Maria Calvo, Mariel Tavares de Oliveira Prado, Thiago José Dionísio, Maria Paula Marques, Daniel Thomas Brozoski, Vera Lúcia Lanchote, Flávio Augusto Cardoso Faria, Carlos Ferreira Santos. Effective method for the detection of piroxicam in human plasma using HPLC.
Brazilian oral research.
2016 May; 30(1):. doi:
10.1590/1807-3107bor-2016.vol30.0058. [PMID: 27223141] - Yan Li, Xiaoming Qiang, Li Luo, Yuxing Li, Ganyuan Xiao, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2016 05; 24(10):2342-51. doi:
10.1016/j.bmc.2016.04.012. [PMID: 27079124] - Shanna L Karls, Kelli R Snyder, Peter J Neibert. Effectiveness of Corticosteroid Injections in the Treatment of Plantar Fasciitis.
Journal of sport rehabilitation.
2016 May; 25(2):202-7. doi:
10-1123/jsr.2014-0234. [PMID: 26062179] - Adriana Maria Calvo, Gabriel Mulinari Santos, Thiago José Dionísio, Maria Paula Marques, Daniel Thomas Brozoski, Vera Lúcia Lanchote, Maria Helena Raposo Fernandes, Flávio Augusto Cardoso Faria, Carlos Ferreira Santos. Quantification of piroxicam and 5'-hydroxypiroxicam in human plasma and saliva using liquid chromatography-tandem mass spectrometry following oral administration.
Journal of pharmaceutical and biomedical analysis.
2016 Feb; 120(?):212-20. doi:
10.1016/j.jpba.2015.12.042. [PMID: 26760238] - Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang. Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection.
Drug design, development and therapy.
2016; 10(?):3779-3787. doi:
10.2147/dddt.s118145. [PMID: 27895468] - Salma E El-Habashy, Ahmed N Allam, Amal H El-Kamel. Ethyl cellulose nanoparticles as a platform to decrease ulcerogenic potential of piroxicam: formulation and in vitro/in vivo evaluation.
International journal of nanomedicine.
2016; 11(?):2369-80. doi:
10.2147/ijn.s93354. [PMID: 27307735] - Hande Arpacı, Faruk Metin Çomu, Ayşegül Küçük, Bahadır Kösem, Seyfi Kartal, Volkan Şıvgın, Hüseyin Cihad Turgut, Muhammed Enes Aydın, Derya Sebile Koç, Mustafa Arslan. Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats.
Drug design, development and therapy.
2016; 10(?):2477-81. doi:
10.2147/dddt.s113806. [PMID: 27536068] - Bulus Adzu, Sikiru Olaitan Balogun, Eduarda Pavan, Sérgio Donizeti Ascêncio, Ilsamar Mendes Soares, Raimundo Wagner Souza Aguiar, Reginaldo Vicente Ribeiro, Ângela Márcia Selhorst e Silva Beserra, Ruberlei Godinho de Oliveira, Larissa Irene da Silva, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins. Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms.
Journal of ethnopharmacology.
2015 Dec; 175(?):378-89. doi:
10.1016/j.jep.2015.09.027. [PMID: 26408044] - Vincent Jannin, Stéphanie Chevrier, Matthieu Michenaud, Camille Dumont, Silvia Belotti, Yann Chavant, Frédéric Demarne. Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity.
International journal of pharmaceutics.
2015 Nov; 495(1):385-392. doi:
10.1016/j.ijpharm.2015.09.009. [PMID: 26364710] - Peter John, Waqar Azeem, Muhammad Ashfaq, Islam Ullah Khan, Syed Naeem Razzaq. Stability indicating RP-HPLC method for simultaneous determination of piroxicam and ofloxacin in binary combination.
Pakistan journal of pharmaceutical sciences.
2015 Sep; 28(5):1713-21. doi:
NULL. [PMID: 26408892] - Altug Tuncel, Melih Balci, Aysun Postaci, Yilmaz Aslan, Ali Atan. Comparıson of different postoperative paın managements in patients submitted to transperitoneal laparoscopic renal and adrenal surgery.
International braz j urol : official journal of the Brazilian Society of Urology.
2015 Jul; 41(4):669-75. doi:
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Die Pharmazie.
2015 May; 70(5):331-6. doi:
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Journal of ethnopharmacology.
2015 Apr; 163(?):142-8. doi:
10.1016/j.jep.2015.01.023. [PMID: 25625354] - Ümit Gönüllü, Melike Üner, Gülgün Yener, Ecem Fatma Karaman, Zeynep Aydoğmuş. Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery.
Acta pharmaceutica (Zagreb, Croatia).
2015 Mar; 65(1):1-13. doi:
10.1515/acph-2015-0009. [PMID: 25781700] - Zhipei Sang, Yan Li, Xiaoming Qiang, Ganyuan Xiao, Qiang Liu, Zhenghuai Tan, Yong Deng. Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2015 Feb; 23(4):668-80. doi:
10.1016/j.bmc.2015.01.005. [PMID: 25614117] - Zahra Jannesari, Hassan Hadadzadeh, Zahra Amirghofran, Jim Simpson, Taghi Khayamian, Batool Maleki. A mononuclear zinc(II) complex with piroxicam: crystal structure, DNA- and BSA-binding studies; in vitro cell cytotoxicity and molecular modeling of oxicam complexes.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Feb; 136 Pt B(?):1119-33. doi:
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