Inosine (BioDeep_00000398720)

Main id: BioDeep_00000000227

Secondary id: BioDeep_00000229605

natural product PANOMIX_OTCML-2023 Chemicals and Drugs Antibiotics BioNovoGene_Lab2019


代谢物信息卡片


9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

化学式: C10H12N4O5 (268.0808)
中文名称: 肌苷, 肌酐
谱图信息: 最多检出来源 Homo sapiens(blood) 46.35%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c2ncnc3O)O1)O)O)O
InChI: InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

描述信息

G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals
Formula(Parent): C10H12N4O5; Bottle Name:Inosine; PRIME Parent Name:Inosine; PRIME in-house No.:0256, Purines
COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials
S - Sensory organs > S01 - Ophthalmologicals
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; UGQMRVRMYYASKQ_STSL_0164_Inosine_2000fmol_180430_S2_LC02_MS02_125; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.054
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.053
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].

同义名列表

6 个代谢物同义名

Inosine; INO; Trophicardyl; 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one; Inosine; Inosine



数据库引用编号

70 个数据库交叉引用编号

分类词条

109 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ADA, ADAR, ADARB1, ADAT3, ENDOV, PNP, XDH
Peripheral membrane protein 1 ADA
Nucleus 5 ADAR, ADARB1, ADAT3, ADK, TRIM33
cytosol 8 ADA, ADAR, ADARB1, ADK, GPT, NT5E, PNP, XDH
dendrite 2 ADORA2A, GRIA2
nucleoplasm 7 ADAR, ADARB1, ADAT2, ADAT3, ADK, NT5E, TRIM33
Cell membrane 6 ADA, ADORA2A, GRIA2, NT5E, SLC29A1, TNF
Multi-pass membrane protein 3 ADORA2A, GRIA2, SLC29A1
Synapse 1 ADARB1
cell junction 1 ADA
cell surface 3 ADA, NT5E, TNF
glutamatergic synapse 1 ADORA2A
Golgi membrane 1 INS
neuronal cell body 3 ADORA2A, GRIA2, TNF
postsynapse 2 GRIA2, SLC29A1
presynaptic membrane 1 ADORA2A
Lysosome 1 ADA
Presynapse 1 SLC29A1
plasma membrane 8 ADA, ADK, ADORA2A, GRIA2, IFNLR1, NT5E, SLC29A1, TNF
presynaptic active zone 1 ADORA2A
Membrane 7 ADA, ADAR, ADORA2A, GRIA2, IFNLR1, NT5E, SLC29A1
apical plasma membrane 1 SLC29A1
basolateral plasma membrane 1 SLC29A1
extracellular exosome 3 GPT, NT5E, PNP
extracellular space 6 IL10, IL6, INS, PNP, TNF, XDH
mitochondrion 1 ADAR
postsynaptic density 1 GRIA2
Single-pass type I membrane protein 1 IFNLR1
Secreted 4 IL10, IL6, INS, PNP
extracellular region 5 IL10, IL6, INS, PNP, TNF
excitatory synapse 1 GRIA2
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
external side of plasma membrane 4 ADA, GRIA2, NT5E, TNF
dendritic spine 1 GRIA2
nucleolus 3 ADAR, ADARB1, ENDOV
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 2 ADORA2A, GRIA2
Apical cell membrane 1 SLC29A1
Membrane raft 1 TNF
axolemma 1 ADORA2A
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
intermediate filament 1 ADORA2A
lateral plasma membrane 1 SLC29A1
Postsynaptic cell membrane 1 GRIA2
chromatin 1 TRIM33
phagocytic cup 1 TNF
[Isoform 5]: Cytoplasm 1 ADAR
Nucleus, nucleolus 3 ADAR, ADARB1, ENDOV
Basolateral cell membrane 1 SLC29A1
Lipid-anchor, GPI-anchor 1 NT5E
endosome lumen 1 INS
AMPA glutamate receptor complex 1 GRIA2
Cytoplasm, Stress granule 1 ENDOV
cytoplasmic stress granule 1 ENDOV
side of membrane 1 NT5E
[Isoform 1]: Cytoplasm 2 ADAR, ENDOV
ficolin-1-rich granule lumen 1 PNP
secretory granule lumen 2 INS, PNP
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
endocytic vesicle membrane 1 GRIA2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRIA2
postsynaptic endocytic zone 1 GRIA2
[Isoform 2]: Cytoplasm 1 ADK
[Isoform 2]: Nucleus 1 ADARB1
[Isoform 1]: Nucleus 2 ADARB1, ADK
[Isoform 7]: Cytoplasm 1 ENDOV
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
asymmetric synapse 2 ADORA2A, GRIA2
[Isoform 6]: Cytoplasm 1 ENDOV
supraspliceosomal complex 1 ADAR
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tianyou Zhao, Ling Ma, Shiwen Xu, Wanzhi Cai, Hu Li, Yuange Duan. Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts. Nucleus (Austin, Tex.). 2024 Dec; 15(1):2304503. doi: 10.1080/19491034.2024.2304503. [PMID: 38286757]
  • Yi-Hao Min, Wen-Xuan Shao, Qiu-Shuang Hu, Neng-Bin Xie, Shan Zhang, Yu-Qi Feng, Xi-Wen Xing, Bi-Feng Yuan. Simultaneous Detection of Adenosine-to-Inosine Editing and N6-Methyladenosine at Identical RNA Sites through Deamination-Assisted Reverse Transcription Stalling. Analytical chemistry. 2024 May; 96(21):8730-8739. doi: 10.1021/acs.analchem.4c01022. [PMID: 38743814]
  • You Wu, Wenna Shao, Mengxiao Yan, Yuqin Wang, Pengfei Xu, Guoqiang Huang, Xiaofei Li, Brian D Gregory, Jun Yang, Hongxia Wang, Xiang Yu. Transfer learning enables identification of multiple types of RNA modifications using nanopore direct RNA sequencing. Nature communications. 2024 May; 15(1):4049. doi: 10.1038/s41467-024-48437-4. [PMID: 38744925]
  • Chanjing Feng, Kaiyun Xin, Yanfei Du, Jingwen Zou, Xiaoxing Xing, Qi Xiu, Yijie Zhang, Rui Zhang, Weiwei Huang, Qinhu Wang, Cong Jiang, Xiaojie Wang, Zhensheng Kang, Jin-Rong Xu, Huiquan Liu. Unveiling the A-to-I mRNA editing machinery and its regulation and evolution in fungi. Nature communications. 2024 May; 15(1):3934. doi: 10.1038/s41467-024-48336-8. [PMID: 38729938]
  • Jiyao Liu, Caiqing Zheng, Yuange Duan. New comparative genomic evidence supporting the proteomic diversification role of A-to-I RNA editing in insects. Molecular genetics and genomics : MGG. 2024 Apr; 299(1):46. doi: 10.1007/s00438-024-02141-6. [PMID: 38642133]
  • Yuange Duan, Ling Ma, Jiyao Liu, Xinzhi Liu, Fan Song, Li Tian, Wanzhi Cai, Hu Li. The first A-to-I RNA editome of hemipteran species Coridius chinensis reveals overrepresented recoding and prevalent intron editing in early-diverging insects. Cellular and molecular life sciences : CMLS. 2024 Mar; 81(1):136. doi: 10.1007/s00018-024-05175-6. [PMID: 38478033]
  • Ye Xu, Jiyao Liu, Tianyou Zhao, Fan Song, Li Tian, Wanzhi Cai, Hu Li, Yuange Duan. Identification and Interpretation of A-to-I RNA Editing Events in Insect Transcriptomes. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417126. [PMID: 38138955]
  • Rafael Itzhakov, Hagit Hak, Sudharsan Sadhasivam, Eduard Belausov, Elazar Fallik, Ziv Spiegelman, Edward Sionov, Elena Poverenov. Nanogel Particles Based on Modified Nucleosides and Oligosaccharides as Advanced Delivery System. ACS nano. 2023 11; 17(22):23020-23031. doi: 10.1021/acsnano.3c08627. [PMID: 37934119]
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  • Yuchen Zhang, Yuange Duan. Genome-Wide Analysis on Driver and Passenger RNA Editing Sites Suggests an Underestimation of Adaptive Signals in Insects. Genes. 2023 10; 14(10):. doi: 10.3390/genes14101951. [PMID: 37895300]
  • Yuange Duan, Ling Ma, Fan Song, Li Tian, Wanzhi Cai, Hu Li. Autorecoding A-to-I RNA editing sites in the Adar gene underwent compensatory gains and losses in major insect clades. RNA (New York, N.Y.). 2023 10; 29(10):1509-1519. doi: 10.1261/rna.079682.123. [PMID: 37451866]
  • Bin Zhang, Yang Xu, Jinyan Liu, Chongming Wu, Xiaohong Zhao, Lidong Zhou, Yong Xie. Oral Intake of Inosine 5'-Monophosphate in Mice Promotes the Absorption of Exogenous Fatty Acids and Their Conversion into Triglycerides though Enhancing the Phosphorylation of Adenosine 5'-Monophosphate-Activated Protein Kinase in the Liver, Leading to Lipohyperplasia. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914588. [PMID: 37834038]
  • Jiannan Qiu, Lin Chen, Ling Zhang, Fangying Xu, Congcong Zhang, Guilin Ren, Kaixin Chang, Guonong He, Zhongyan Du, Yifei Le, Zhiling Yu, Songtao Li, Qingsheng Liu, Xiaobing Dou. Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155111. doi: 10.1016/j.phymed.2023.155111. [PMID: 37804819]
  • Pei Liu, Xiao-Ying Tan, Huang-Qin Zhang, Ke-Lei Su, Er-Xin Shang, Qing-Ling Xiao, Sheng Guo, Jin-Ao Duan. Optimal compatibility proportional screening of Trichosanthis Pericarpium - Trichosanthis Radix and its anti - Inflammatory components effect on experimental zebrafish and coughing mice. Journal of ethnopharmacology. 2023 Aug; ?(?):117096. doi: 10.1016/j.jep.2023.117096. [PMID: 37634750]
  • Chen Wang, Leiye Yu, Jiying Zhang, Yanxia Zhou, Bo Sun, Qingjie Xiao, Minhua Zhang, Huayi Liu, Jinhong Li, Jialu Li, Yunzi Luo, Jie Xu, Zhong Lian, Jingwen Lin, Xiang Wang, Peng Zhang, Li Guo, Ruobing Ren, Dong Deng. Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. Nature communications. 2023 Mar; 14(1):1727. doi: 10.1038/s41467-023-37411-1. [PMID: 36977719]
  • Lei Yan, Yong Tang. Increasing inosine/decreasing ENT1: promising strategies for anti-obesity therapy. Purinergic signalling. 2023 Jan; ?(?):. doi: 10.1007/s11302-023-09920-7. [PMID: 36633804]
  • Xiaoguang Chen, Sang-Hoon Kim, Sangkee Rhee, Claus-Peter Witte. A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis. The Plant cell. 2023 Jan; 35(1):510-528. doi: 10.1093/plcell/koac320. [PMID: 36342213]
  • Wei Fu, Jin Ding, Xujun You, Qixin Li, Xiaohua Pei, Guozheng Qin. Four types of RNA modification writers predict the prognosis of prostate cancer. Andrologia. 2022 Nov; 54(10):e14552. doi: 10.1111/and.14552. [PMID: 36177790]
  • Chanjing Feng, Xinyu Cao, Yanfei Du, Yitong Chen, Kaiyun Xin, Jingwen Zou, Qiaojun Jin, Jin-Rong Xu, Huiquan Liu. Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum. mBio. 2022 10; 13(5):e0187222. doi: 10.1128/mbio.01872-22. [PMID: 36102513]
  • Husheem Michael, Vishal Srivastava, Loic Deblais, Joshua O Amimo, Juliet Chepngeno, Linda J Saif, Gireesh Rajashekara, Anastasia N Vlasova. The Combined Escherichia coli Nissle 1917 and Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model. mSphere. 2022 Oct; 7(5):e0027022. doi: 10.1128/msphere.00270-22. [PMID: 36073800]
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  • Nicola Dalbeth, Borislav Mihov, Angela Stewart, Gregory D Gamble, Tony R Merriman, David Mount, Ian R Reid, Lisa K Stamp, Anne Horne. Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation. Scientific reports. 2022 07; 12(1):12887. doi: 10.1038/s41598-022-17257-1. [PMID: 35902652]
  • Preeti Verma, Ritu Varshney, Shiv Pratap Singh Yadav, Bibekananda Kar, Partha Roy, Ashwani K Sharma. SAXS Analysis and Characterization of Anticancer Activity of PNP-UDP Family Protein from Putranjiva roxburghii. The protein journal. 2022 06; 41(3):381-393. doi: 10.1007/s10930-022-10060-x. [PMID: 35674860]
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  • Mirolyuba Ilieva, Shizuka Uchida. Epitranscriptomics in fibroblasts and fibrosis. American journal of physiology. Cell physiology. 2022 06; 322(6):C1110-C1116. doi: 10.1152/ajpcell.00121.2022. [PMID: 35508185]
  • Asmin Andries, Alan Feyaerts, Djalila Mekahli, Ann Van Schepdael. Quantification of allantoin and other metabolites of the purine degradation pathway in human plasma samples using a newly developed HILIC-LC-MS/MS method. Electrophoresis. 2022 05; 43(9-10):1010-1018. doi: 10.1002/elps.202100265. [PMID: 35050532]
  • Shusuke Uekusa, Mayu Onozato, Maho Umino, Tatsuya Sakamoto, Hideaki Ichiba, Naohisa Tsujino, Tomoyuki Funatogawa, Hiromi Tagata, Takahiro Nemoto, Masafumi Mizuno, Takeshi Fukushima. Increased inosine levels in drug-free individuals with at-risk mental state: A serum metabolomics study. Early intervention in psychiatry. 2022 03; 16(3):247-255. doi: 10.1111/eip.13148. [PMID: 33779047]
  • Thomas M Aune, John T Tossberg, Rachel M Heinrich, Krislyn P Porter, Philip S Crooke. Alu RNA Structural Features Modulate Immune Cell Activation and A-to-I Editing of Alu RNAs Is Diminished in Human Inflammatory Bowel Disease. Frontiers in immunology. 2022; 13(?):818023. doi: 10.3389/fimmu.2022.818023. [PMID: 35126398]
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  • Michael A Schwarzschild, Alberto Ascherio, Cindy Casaceli, Gary C Curhan, Rebecca Fitzgerald, Cornelia Kamp, Codrin Lungu, Eric A Macklin, Kenneth Marek, Dariush Mozaffarian, David Oakes, Alice Rudolph, Ira Shoulson, Aleksandar Videnovic, Burton Scott, Lisa Gauger, Jason Aldred, Melissa Bixby, Jill Ciccarello, Steven A Gunzler, Claire Henchcliffe, Matthew Brodsky, Kellie Keith, Robert A Hauser, Christopher Goetz, Mark S LeDoux, Vanessa Hinson, Rajeev Kumar, Alberto J Espay, Joohi Jimenez-Shahed, Christine Hunter, Chadwick Christine, Aaron Daley, Maureen Leehey, J Antonelle de Marcaida, Joseph Harold Friedman, Albert Hung, Grace Bwala, Irene Litvan, David K Simon, Tanya Simuni, Cynthia Poon, Mya C Schiess, Kelvin Chou, Ariane Park, Danish Bhatti, Carolyn Peterson, Susan R Criswell, Liana Rosenthal, Jennifer Durphy, Holly A Shill, Shyamal H Mehta, Anwar Ahmed, Andres F Deik, John Y Fang, Natividad Stover, Lin Zhang, Richard B Dewey, Ashley Gerald, James T Boyd, Emily Houston, Valerie Suski, Sherri Mosovsky, Leslie Cloud, Binit B Shah, Marie Saint-Hilaire, Raymond James, Sarah Elizabeth Zauber, Stephen Reich, David Shprecher, Rajesh Pahwa, April Langhammer, Kathrin LaFaver, Peter A LeWitt, Patricia Kaminski, John Goudreau, Doozie Russell, David J Houghton, Ashley Laroche, Karen Thomas, Martha McGraw, Zoltan Mari, Carmen Serrano, Karen Blindauer, Marcie Rabin, Roger Kurlan, John C Morgan, Michael Soileau, Melissa Ainslie, Ivan Bodis-Wollner, Ruth B Schneider, Cheryl Waters, Amber Servi Ratel, Christopher A Beck, Patrick Bolger, Katherine F Callahan, Grace F Crotty, David Klements, Melissa Kostrzebski, Gearoid Michael McMahon, Lindsay Pothier, Sushrut S Waikar, Anthony Lang, Tiago Mestre. Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial. JAMA. 2021 09; 326(10):926-939. doi: 10.1001/jama.2021.10207. [PMID: 34519802]
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  • Nicola Dalbeth, Anne Horne, Borislav Mihov, Angela Stewart, Gregory D Gamble, Tony R Merriman, Lisa K Stamp, Ian R Reid. Elevated Urate Levels Do Not Alter Bone Turnover Markers: Randomized Controlled Trial of Inosine Supplementation in Postmenopausal Women. Arthritis & rheumatology (Hoboken, N.J.). 2021 09; 73(9):1758-1764. doi: 10.1002/art.41691. [PMID: 33586367]
  • Weiling Guo, Qunran Xiang, Bingyong Mao, Xin Tang, Shumao Cui, Xiangfei Li, Jianxin Zhao, Hao Zhang, Wei Chen. Protective Effects of Microbiome-Derived Inosine on Lipopolysaccharide-Induced Acute Liver Damage and Inflammation in Mice via Mediating the TLR4/NF-κB Pathway. Journal of agricultural and food chemistry. 2021 Jul; 69(27):7619-7628. doi: 10.1021/acs.jafc.1c01781. [PMID: 34156842]
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