Tetrandrine (BioDeep_00000398673)

Main id: BioDeep_00000000329

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyc lo[22.6.2.2<3,6>.1<8,12>.1<14,18>.0<22,36>.0<27,31>]hexatriaconta-3(33),4,6(34 ),8(35),9,11,18(36),19,21,24,26,31-dodecaene

化学式: C38H42N2O6 (622.3043)
中文名称: 汉防己甲素, 汉防己碱, 粉防己碱, 汉防己硷, 粉防乙碱
谱图信息: 最多检出来源 Homo sapiens(viridiplantae) 10.1%

分子结构信息

SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
InChI: InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

描述信息

(+)-Tetrandrine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.
Tetrandrine is a natural product found in Pachygone dasycarpa, Cyclea barbata, and other organisms with data available.
Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant Radix stephania tetrandrae. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. This agent also increases glucose utilization by enhancing hepatocyte glycogen synthesis, resulting in the lowering of plasma glucose. (NCI04)
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D000970 - Antineoplastic Agents
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.689
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.683
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.

同义名列表

100 个代谢物同义名

(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyc lo[22.6.2.2<3,6>.1<8,12>.1<14,18>.0<22,36>.0<27,31>]hexatriaconta-3(33),4,6(34 ),8(35),9,11,18(36),19,21,24,26,31-dodecaene; 16H-1,24:6,9-DIETHENO-11,15-METHENO-2H-PYRIDO(2,3:17,18)(1,11)DIOXACYCLOEICOSINO(2,3,4-IJ)ISOQUINOLINE, 3,4,4A,5,16A,17,18,19-OCTAHYDRO-12,21,22,26-TETRAMETHOXY-4,17-DIMETHYL-, (4AR,16AR)-REL-; (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene; 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2,3:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-; (11S,31S)-16,36,37,54-tetramethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane; BERBAMAN, 6,6,7,12-TETRAMETHOXY-2,2-DIMETHYL-, (1.BETA.)-(+/-)-; Berbaman, 6,6,7,12-trtramethoxy-2,2-dimethyl-, (1beta)-(PM)-; Berbaman, 6,6,7,12-trtramethoxy-2,2-dimethyl-, (1beta)-(+-)-; Tetrandrine, European Pharmacopoeia (EP) Reference Standard; Berbaman,6,7,12-trtramethoxy-2,2-dimethyl-, (1.beta.)-(PM)-; Berbaman, 6,6,7,12-tetramethoxy-2,2-dimethyl-, (1-beta)-; Berbaman, 6,6,7,12-tetramethoxy-2,2-dimethyl-, (1beta)-; (1BETA,1XI)-6,6,7,12-TETRAMETHOXY-2,2-DIMETHYLBERBAMAN; Berbaman,6,7,12-tetramethoxy-2,2-dimethyl-, (1.beta.)-; (1.beta.)-6,6,7,12-Tetramethoxy-2,2-dimethylberbaman; 6,6,7,12-tetramethoxy-2,2-dimethyl-(1beta)-berbaman; Tetrandrine, analytical standard, for drug analysis; 6,6,7,12-TETRAMETHOXY-2,2-DIMETHYL-1-BETA-BERBAMAN; (1beta)-6,6,7,12-Tetramethoxy-2,2-dimethylberbaman; 2-27-00-00889 (Beilstein Handbook Reference); tetrandrine dihydrochloride, (1beta)-isomer; isotetrandrine dihydrochloride; tetrandrine dihydrochloride; tetrandrine, (1beta)-isomer; WVTKBKWTSCPRNU-KYJUHHDHSA-N; tetramethoxy(dimethyl)[?]; Tetrandrine (Fanchinine); Tetrandrine(Fanchinine); (S,S)-(+)-Tetrandrine; TETRANDRINE [WHO-DD]; S,S-(+)-Tetrandrine; Tetrandrine, (+/-)-; (.+-.)-Tetrandrine; TETRANDRINE [INCI]; Prestwick2_000670; Prestwick0_000670; Prestwick3_000670; (R,S)-Tetrandrine; TETRANDRINE, (+)-; TETRANDRINE, (DL); S-(+)-Tetrandrine; (S,S)-tetrandrine; Prestwick1_000670; (+/-)-Tetrandrine; Spectrum4_000619; Spectrum5_001366; Spectrum2_000025; TETRANDRINE [MI]; (+-)-tetrandrine; (+/-)-Tetrandine; Spectrum3_000659; UNII-29EX23D5AJ; UNII-VS4W77H3SD; (+)-tetrandrine; Tetrandrine,(S); (-)-tetrandrine; (+-)-Tetrandine; TETRANDRINE, D-; isotetrandrine; dl-Tetrandrine; DivK1c_006757; d-tetrandrine; Hanfangchin A; DL-Tetrandine; L-tetrandrine; BPBio1_000813; DL-Tetandrine; NCI60_041696; KBio3_001517; KBio2_005335; KBio2_002767; KBio2_003363; Sinomenine A; NCI60_042029; KBio2_000795; HSCI1_000014; KBio1_001701; KBio3_000397; KBio2_000199; KBio2_005931; KBio3_000398; IDI1_033949; Bio2_000679; phaeanthine; Bio1_001178; Bio1_000689; Bio1_000200; Tetrandrine; Bio2_000199; 29EX23D5AJ; VS4W77H3SD; Fanchinine; Tetrandrin; d-Tetrandr; Tetrandine; FANCHININ; hanjisong; CHEBI:49; NSC-77037; (+)-Tetrandrine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, AKT1, BIRC5, CASP9, CAT, MTOR, PIK3CA, PTGS2, STAT3, VEGFA
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 3 CD4, MTOR, PTGS2
Nucleus 6 AKT1, BIRC5, CASP9, MTOR, STAT3, VEGFA
autophagosome 1 MAP1LC3A
cytosol 9 AKT1, BIRC5, CASP9, CAT, IL1B, MAP1LC3A, MTOR, PIK3CA, STAT3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 5 AKT1, ATP2B1, BIRC5, MTOR, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 5 ABCB1, AKT1, ATP2B1, CD4, TNF
Lipid-anchor 1 MAP1LC3A
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 3 ABCB1, ATP2B1, CACNA1I
Golgi apparatus membrane 1 MTOR
Synapse 1 ATP2B1
cell cortex 1 AKT1
cell surface 3 ABCB1, TNF, VEGFA
glutamatergic synapse 3 AKT1, ATP2B1, MAP1LC3A
Golgi apparatus 1 VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 TNF
postsynapse 1 AKT1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 IL1B
Lysosome 2 IL1B, MTOR
plasma membrane 8 ABCB1, AKT1, ATP2B1, CACNA1I, CD4, PIK3CA, STAT3, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ABCB1, AKT1, ATP2B1, CACNA1I, CAT, MTOR, VEGFA
apical plasma membrane 1 ABCB1
axon 1 CCK
basolateral plasma membrane 1 ATP2B1
caveola 1 PTGS2
extracellular exosome 3 ABCB1, ATP2B1, CAT
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 PTGS2, VEGFA
extracellular space 6 CCK, IL10, IL1B, IL6, TNF, VEGFA
perinuclear region of cytoplasm 1 PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 2 CASP9, CAT
protein-containing complex 5 AKT1, BIRC5, CASP9, CAT, PTGS2
intracellular membrane-bounded organelle 3 ATP2B1, CAT, MAP1LC3A
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 CD4
Secreted 5 CCK, IL10, IL1B, IL6, VEGFA
extracellular region 7 CAT, CCK, IL10, IL1B, IL6, TNF, VEGFA
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 CAT
transcription regulator complex 1 STAT3
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 CD4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 2 AKT1, BIRC5
midbody 1 BIRC5
Early endosome 1 CD4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Membrane raft 2 CD4, TNF
Cytoplasm, cytoskeleton 1 MAP1LC3A
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 CAT
microtubule 2 BIRC5, MAP1LC3A
spindle 2 AKT1, BIRC5
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 2 IL1B, VEGFA
lateral plasma membrane 1 ATP2B1
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAP1LC3A
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 STAT3
Cytoplasmic vesicle, autophagosome membrane 1 MAP1LC3A
autophagosome membrane 1 MAP1LC3A
cell projection 1 ATP2B1
phagocytic cup 1 TNF
Chromosome 1 BIRC5
centriole 1 BIRC5
nuclear chromosome 1 BIRC5
Basolateral cell membrane 1 ATP2B1
organelle membrane 1 MAP1LC3A
nuclear envelope 1 MTOR
Endomembrane system 2 MAP1LC3A, MTOR
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Presynaptic cell membrane 1 ATP2B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 3 CD4, IL6, PTGS2
platelet alpha granule lumen 1 VEGFA
voltage-gated calcium channel complex 1 CACNA1I
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
kinetochore 1 BIRC5
Secreted, extracellular exosome 1 IL1B
immunological synapse 1 ATP2B1
apoptosome 1 CASP9
chromosome, centromeric region 1 BIRC5
clathrin-coated endocytic vesicle membrane 1 CD4
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
Autolysosome 1 MAP1LC3A
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
photoreceptor ribbon synapse 1 ATP2B1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jiawen Song, Yushi Liu, Yurou Guo, Minghao Yuan, Wenxiao Zhong, Jiamei Tang, Yiping Guo, Li Guo. Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review. Inflammopharmacology. 2024 Jun; 32(3):1743-1757. doi: 10.1007/s10787-024-01452-9. [PMID: 38568399]
  • Li Fang, Rong Shen, Yao Lu, Xiangfeng Xu, Fang Huang. Tetrandrine alleviates inflammation and promotes macrophage M2 polarization in gouty arthritis by NF-κB-mediated Lcp1. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Feb; 70(2):205-211. doi: 10.14715/cmb/2024.70.2.29. [PMID: 38430024]
  • Jie Ling, Xiao Li, Maolin Wang, Chaozheng Zhang, Yilan Liu, Xin Zhang, Changqun Liu, Qing Ren, Yingjie Zeng, Chuanqi Wang, Ying Chen, Chen Sun, Hongyu Chen, Yi Zuo, Xiujun Cao, Yun Deng, Bo Ren, Defang Li, Jun Lu. Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K/AKT/mTOR pathway. Bioorganic chemistry. 2024 Feb; 143(?):107069. doi: 10.1016/j.bioorg.2023.107069. [PMID: 38160477]
  • Yang Liu, Jia-Yu Cai, Yang Liu, Lu Zhang, Rui-Bo Guo, Xue-Tao Li, Ling-Yue Ma, Liang Kong. Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma. Drug development and industrial pharmacy. 2024 Jan; ?(?):1-15. doi: 10.1080/03639045.2024.2302886. [PMID: 38235554]
  • Na Kou, Yi-Bing Chen, Xian-Wen Li, Dong Xu, Yue Wang, Xin-Ran Dong, Yuan-Lu Cui, Qiangsong Wang. Pulmonary administration of tetrandrine loaded Zinc-Alginate nanogels attenuates pulmonary fibrosis in rats. International journal of pharmaceutics. 2024 Jan; 649(?):123625. doi: 10.1016/j.ijpharm.2023.123625. [PMID: 37984618]
  • Yunyan Chen, Ziwei Zhang, Zhilei Qian, Rui Ma, Minna Luan, Yu Sun. Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil. International journal of nanomedicine. 2024; 19(?):727-742. doi: 10.2147/ijn.s446895. [PMID: 38288265]
  • Zhengyu Fang, Peihong Lin, Rui Gao, Wenjing Yang, Aizhen Zhou, Wenying Yu. Preparation, Characterization, and Anti-Lung Cancer Activity of Tetrandrine-Loaded Stealth Liposomes. International journal of nanomedicine. 2024; 19(?):787-803. doi: 10.2147/ijn.s431599. [PMID: 38293606]
  • Kaitao Wang, Jiapeng Deng, Jialong Yang, An Wang, Minle Ye, Qingyu Chen, Guodong Chen, Dingsheng Lin. Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway. Phytotherapy research : PTR. 2023 Nov; ?(?):. doi: 10.1002/ptr.8058. [PMID: 37909161]
  • Hui Jiang, Chunming Tang, Yuanyuan Wen, Qianqian Zhao, Mingyuan Xu, Jinting Fan, Zhiji Wang, Lifeng Wang, Huae Xu, Gang Chen. Enhanced Antitumor Efficacy of Novel Biomimetic Platelet Membrane-Coated Tetrandrine Nanoparticles in Nonsmall Cell Lung Cancer. Molecular pharmaceutics. 2023 Oct; ?(?):. doi: 10.1021/acs.molpharmaceut.3c00310. [PMID: 37823637]
  • Yi Li, Song He, Youdan Zhao, Hongzhan Jiang, Zhi Lyu. Unraveling the mechanism of tetrandrine combined with Buyang Huanwu Decoction against silicosis using network pharmacology and molecular docking analyses. Medicine. 2023 Aug; 102(32):e34716. doi: 10.1097/md.0000000000034716. [PMID: 37565873]
  • Min Wang, Kai Liu, Zhongming Zhou, Huizhuan Geng. miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under the treatment of Tetrandrine. Histology and histopathology. 2023 Aug; ?(?):18657. doi: 10.14670/hh-18-657. [PMID: 37702425]
  • Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
  • Ting Liu, Kangdi Li, Zhenxing Zhang, Jinghui Peng, Jingzhao Yang, Betty Yuen Kwan Law, Xin Liu, Wenhua Li. Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway. The American journal of Chinese medicine. 2023 Jan; ?(?):1-20. doi: 10.1142/s0192415x23500222. [PMID: 36692485]
  • Wanli Xue, Rui Sun, Zheng Hao, Zhenzhen Xing, Hongjie Cheng, Lei Shao. Tetrandrine inhibits migration and invasion of BGC-823 and MKN-45 cells by regulating PI3K/AKT/mTOR signaling pathway. Chemical biology & drug design. 2023 Jan; ?(?):. doi: 10.1111/cbdd.14202. [PMID: 36593659]
  • Salma El-Sayed Radwan, Riham M El-Moslemany, Radwa A Mehanna, Eman H Thabet, Elsayeda-Zeinab A Abdelfattah, Amal El-Kamel. Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment. Drug delivery. 2022 Dec; 29(1):1150-1163. doi: 10.1080/10717544.2022.2058648. [PMID: 35384774]
  • Simeng Chu, Yujie Lu, Wenjuan Liu, Xiaoyao Ma, Jiamin Peng, Xiaoying Wang, Min Jiang, Gang Bai. Ursolic acid alleviates tetrandrine-induced hepatotoxicity by competitively binding to the substrate-binding site of glutathione S-transferases. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154325. doi: 10.1016/j.phymed.2022.154325. [PMID: 35820303]
  • Jia-Wen Song, Yu-Shi Liu, Yu-Rou Guo, Wen-Xiao Zhong, Yi-Ping Guo, Li Guo. Nano-Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti-Tumor Effects. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126858. [PMID: 35743311]
  • Jiao Guan, Liming Wang, Yuan Ji, Tianyi Zhang, Ye Sang, Sheng Chang, Bo Feng, Heyun Zhu. UHPLC-MS/MS Method for Quantifying Fangchinoline, Tetrandrine and Calycosin-7-O-β-D-Glucoside of Fangji Huangqi Decoction in Rat Plasma and Its Application to a Pharmacokinetic Study. Journal of chromatographic science. 2022 Jun; 60(5):458-464. doi: 10.1093/chromsci/bmab116. [PMID: 34734235]
  • Hyo-Seon Lee, Dae Hwan Kim, In-Seon Lee, Ji-Hyun Park, Gregory Martin, Stephen Safe, Keuk-Jun Kim, Joung-Hee Kim, Byung Ik Jang, Syng-Ook Lee. Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo. International journal of molecular sciences. 2022 May; 23(9):. doi: 10.3390/ijms23095280. [PMID: 35563670]
  • Fang Shi, Lei Ni, Ye-Mei Gao. Tetrandrine Attenuates Cartilage Degeneration, Osteoclast Proliferation, and Macrophage Transformation through Inhibiting P65 Phosphorylation in Ovariectomy-induced Osteoporosis. Immunological investigations. 2022 Apr; 51(3):465-479. doi: 10.1080/08820139.2020.1837864. [PMID: 33140671]
  • Lichan Mao, Yin Ding, Dongrong Yu, Jiazhen Yin, Jin Yu. Tetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway. Analytical cellular pathology (Amsterdam). 2022; 2022(?):7534181. doi: 10.1155/2022/7534181. [PMID: 36247873]
  • Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen. Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4+Foxp3+ Regulatory T Cells and Alleviates Imiquimod-Induced Psoriasis in Mice. Frontiers in immunology. 2022; 13(?):800283. doi: 10.3389/fimmu.2022.800283. [PMID: 35464441]
  • Jui-Feng Lin, Yen-Shuo Liu, Yu-Chuen Huang, Chih-Wen Chi, Cheng-Chia Tsai, Tung-Hu Tsai, Yu-Jen Chen. Borneol and Tetrandrine Modulate the Blood-Brain Barrier and Blood-Tumor Barrier to Improve the Therapeutic Efficacy of 5-Fluorouracil in Brain Metastasis. Integrative cancer therapies. 2022 Jan; 21(?):15347354221077682. doi: 10.1177/15347354221077682. [PMID: 35168384]
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