Tetrandrine (BioDeep_00000398673)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

化学式: C38H42N2O6 (622.3042712000001)
中文名称: 汉防己甲素, 汉防己碱, 粉防己碱, 汉防己硷, 粉防乙碱, 汉防己甲素
谱图信息: 最多检出来源 Ailuropoda melanoleuca(viridiplantae) 17.02%

分子结构信息

SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
InChI: InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

描述信息

(+)-Tetrandrine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.
Tetrandrine is a natural product found in Pachygone dasycarpa, Cyclea barbata, and other organisms with data available.
Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant Radix stephania tetrandrae. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. This agent also increases glucose utilization by enhancing hepatocyte glycogen synthesis, resulting in the lowering of plasma glucose. (NCI04)
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D000970 - Antineoplastic Agents
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.689
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.683
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.

同义名列表

99 个代谢物同义名

(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyc lo[22.6.2.2<3,6>.1<8,12>.1<14,18>.0<22,36>.0<27,31>]hexatriaconta-3(33),4,6(34 ),8(35),9,11,18(36),19,21,24,26,31-dodecaene; 16H-1,24:6,9-DIETHENO-11,15-METHENO-2H-PYRIDO(2,3:17,18)(1,11)DIOXACYCLOEICOSINO(2,3,4-IJ)ISOQUINOLINE, 3,4,4A,5,16A,17,18,19-OCTAHYDRO-12,21,22,26-TETRAMETHOXY-4,17-DIMETHYL-, (4AR,16AR)-REL-; (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene; 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2,3:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-; (11S,31S)-16,36,37,54-tetramethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane; BERBAMAN, 6,6,7,12-TETRAMETHOXY-2,2-DIMETHYL-, (1.BETA.)-(+/-)-; Berbaman, 6,6,7,12-trtramethoxy-2,2-dimethyl-, (1beta)-(PM)-; Berbaman, 6,6,7,12-trtramethoxy-2,2-dimethyl-, (1beta)-(+-)-; Tetrandrine, European Pharmacopoeia (EP) Reference Standard; Berbaman,6,7,12-trtramethoxy-2,2-dimethyl-, (1.beta.)-(PM)-; Berbaman, 6,6,7,12-tetramethoxy-2,2-dimethyl-, (1-beta)-; Berbaman, 6,6,7,12-tetramethoxy-2,2-dimethyl-, (1beta)-; (1BETA,1XI)-6,6,7,12-TETRAMETHOXY-2,2-DIMETHYLBERBAMAN; Berbaman,6,7,12-tetramethoxy-2,2-dimethyl-, (1.beta.)-; (1.beta.)-6,6,7,12-Tetramethoxy-2,2-dimethylberbaman; 6,6,7,12-tetramethoxy-2,2-dimethyl-(1beta)-berbaman; Tetrandrine, analytical standard, for drug analysis; 6,6,7,12-TETRAMETHOXY-2,2-DIMETHYL-1-BETA-BERBAMAN; (1beta)-6,6,7,12-Tetramethoxy-2,2-dimethylberbaman; 2-27-00-00889 (Beilstein Handbook Reference); tetrandrine dihydrochloride, (1beta)-isomer; isotetrandrine dihydrochloride; tetrandrine dihydrochloride; tetrandrine, (1beta)-isomer; WVTKBKWTSCPRNU-KYJUHHDHSA-N; tetramethoxy(dimethyl)[?]; Tetrandrine (Fanchinine); Tetrandrine(Fanchinine); (S,S)-(+)-Tetrandrine; TETRANDRINE [WHO-DD]; S,S-(+)-Tetrandrine; Tetrandrine, (+/-)-; (.+-.)-Tetrandrine; TETRANDRINE [INCI]; Prestwick2_000670; Prestwick0_000670; Prestwick3_000670; (R,S)-Tetrandrine; TETRANDRINE, (+)-; TETRANDRINE, (DL); S-(+)-Tetrandrine; (S,S)-tetrandrine; Prestwick1_000670; (+/-)-Tetrandrine; Spectrum4_000619; Spectrum5_001366; Spectrum2_000025; TETRANDRINE [MI]; (+-)-tetrandrine; (+/-)-Tetrandine; Spectrum3_000659; UNII-29EX23D5AJ; UNII-VS4W77H3SD; (+)-tetrandrine; Tetrandrine,(S); (-)-tetrandrine; (+-)-Tetrandine; TETRANDRINE, D-; isotetrandrine; dl-Tetrandrine; DivK1c_006757; d-tetrandrine; Hanfangchin A; DL-Tetrandine; L-tetrandrine; BPBio1_000813; DL-Tetandrine; NCI60_041696; KBio3_001517; KBio2_005335; KBio2_002767; KBio2_003363; Sinomenine A; NCI60_042029; KBio2_000795; HSCI1_000014; KBio1_001701; KBio3_000397; KBio2_000199; KBio2_005931; KBio3_000398; IDI1_033949; Bio2_000679; phaeanthine; Bio1_001178; Bio1_000689; Bio1_000200; Tetrandrine; Bio2_000199; 29EX23D5AJ; VS4W77H3SD; Fanchinine; Tetrandrin; d-Tetrandr; Tetrandine; FANCHININ; hanjisong; CHEBI:49; NSC-77037

数据库引用编号

23 个数据库交叉引用编号

ChEBI: CHEBI:49
KEGG: C09654
PubChem: 73078
DrugBank: DB14066
ChEMBL: CHEMBL176045
Wikipedia: Tetrandrine
MeSH: tetrandrine
ChemIDplus: 0000518343
chemspider: 4479515
CAS: 23495-89-8
CAS: 518-34-3
MoNA: Bruker_HCD_library001133
MoNA: CCMSLIB00005720185
MoNA: VF-NPL-LTQ006726
MoNA: VF-NPL-LTQ006725
MoNA: BML80097
MoNA: BML80095
medchemexpress: HY-13764
MetaboLights: MTBLC49
PubChem: 11844
KNApSAcK: C00001919
3DMET: B03167
NIKKAJI: J130.138A

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

33090 防己: -
49683 Menispermum dauricum: 10.1248/CPB.31.3091
425106 Stephania tetrandra:
1489764 Pachygone dasycarpa: 10.1021/NP960568E
2893873 Cyclea peltata:
152373 Cyclea barbata: 10.1021/NP50101A020
527501 Cocculus pendulus:
432643 Isopyrum thalictroides:
46968 Thalictrum: 10.1007/BF02492316
461636 Strychnopsis thouarsii: 10.1016/0305-1978(95)00051-8
461646 Triclisia subcordata: 10.1016/0031-9422(75)80390-6
3455 Menispermaceae: 10.1248/BPB.30.59
85282 Stemona japonica: 10.1002/BMC.1474
49683 Menispermum dauricum: 10.1248/CPB.31.3091
425106 Stephania tetrandra:
1489764 Pachygone dasycarpa: 10.1021/NP960568E
2893873 Cyclea peltata:
152373 Cyclea barbata: 10.1021/NP50101A020
527501 Cocculus pendulus:
432643 Isopyrum thalictroides:
46968 Thalictrum: 10.1007/BF02492316
461636 Strychnopsis thouarsii: 10.1016/0305-1978(95)00051-8
461646 Triclisia subcordata: 10.1016/0031-9422(75)80390-6
3455 Menispermaceae: 10.1248/BPB.30.59
85282 Stemona japonica: 10.1002/BMC.1474
425106 Stephania tetrandra S. Moore: -
258202 Berberis soulieana Schneid.: -
1026947 Berberis poiretii Schneid.: -
258207 Berberis vernae Schneid.: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Jiawen Song, Yushi Liu, Yurou Guo, Minghao Yuan, Wenxiao Zhong, Jiamei Tang, Yiping Guo, Li Guo. Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review. Inflammopharmacology. 2024 Jun; 32(3):1743-1757. doi: 10.1007/s10787-024-01452-9. [PMID: 38568399]
Li Fang, Rong Shen, Yao Lu, Xiangfeng Xu, Fang Huang. Tetrandrine alleviates inflammation and promotes macrophage M2 polarization in gouty arthritis by NF-κB-mediated Lcp1. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Feb; 70(2):205-211. doi: 10.14715/cmb/2024.70.2.29. [PMID: 38430024]
Jie Ling, Xiao Li, Maolin Wang, Chaozheng Zhang, Yilan Liu, Xin Zhang, Changqun Liu, Qing Ren, Yingjie Zeng, Chuanqi Wang, Ying Chen, Chen Sun, Hongyu Chen, Yi Zuo, Xiujun Cao, Yun Deng, Bo Ren, Defang Li, Jun Lu. Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K/AKT/mTOR pathway. Bioorganic chemistry. 2024 Feb; 143(?):107069. doi: 10.1016/j.bioorg.2023.107069. [PMID: 38160477]
Yang Liu, Jia-Yu Cai, Yang Liu, Lu Zhang, Rui-Bo Guo, Xue-Tao Li, Ling-Yue Ma, Liang Kong. Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma. Drug development and industrial pharmacy. 2024 Jan; ?(?):1-15. doi: 10.1080/03639045.2024.2302886. [PMID: 38235554]
Na Kou, Yi-Bing Chen, Xian-Wen Li, Dong Xu, Yue Wang, Xin-Ran Dong, Yuan-Lu Cui, Qiangsong Wang. Pulmonary administration of tetrandrine loaded Zinc-Alginate nanogels attenuates pulmonary fibrosis in rats. International journal of pharmaceutics. 2024 Jan; 649(?):123625. doi: 10.1016/j.ijpharm.2023.123625. [PMID: 37984618]
Yunyan Chen, Ziwei Zhang, Zhilei Qian, Rui Ma, Minna Luan, Yu Sun. Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil. International journal of nanomedicine. 2024; 19(?):727-742. doi: 10.2147/ijn.s446895. [PMID: 38288265]
Zhengyu Fang, Peihong Lin, Rui Gao, Wenjing Yang, Aizhen Zhou, Wenying Yu. Preparation, Characterization, and Anti-Lung Cancer Activity of Tetrandrine-Loaded Stealth Liposomes. International journal of nanomedicine. 2024; 19(?):787-803. doi: 10.2147/ijn.s431599. [PMID: 38293606]
Kaitao Wang, Jiapeng Deng, Jialong Yang, An Wang, Minle Ye, Qingyu Chen, Guodong Chen, Dingsheng Lin. Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway. Phytotherapy research : PTR. 2023 Nov; ?(?):. doi: 10.1002/ptr.8058. [PMID: 37909161]
Hui Jiang, Chunming Tang, Yuanyuan Wen, Qianqian Zhao, Mingyuan Xu, Jinting Fan, Zhiji Wang, Lifeng Wang, Huae Xu, Gang Chen. Enhanced Antitumor Efficacy of Novel Biomimetic Platelet Membrane-Coated Tetrandrine Nanoparticles in Nonsmall Cell Lung Cancer. Molecular pharmaceutics. 2023 Oct; ?(?):. doi: 10.1021/acs.molpharmaceut.3c00310. [PMID: 37823637]
Yi Li, Song He, Youdan Zhao, Hongzhan Jiang, Zhi Lyu. Unraveling the mechanism of tetrandrine combined with Buyang Huanwu Decoction against silicosis using network pharmacology and molecular docking analyses. Medicine. 2023 Aug; 102(32):e34716. doi: 10.1097/md.0000000000034716. [PMID: 37565873]
Min Wang, Kai Liu, Zhongming Zhou, Huizhuan Geng. miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under the treatment of Tetrandrine. Histology and histopathology. 2023 Aug; ?(?):18657. doi: 10.14670/hh-18-657. [PMID: 37702425]
Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
Ting Liu, Kangdi Li, Zhenxing Zhang, Jinghui Peng, Jingzhao Yang, Betty Yuen Kwan Law, Xin Liu, Wenhua Li. Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway. The American journal of Chinese medicine. 2023 Jan; ?(?):1-20. doi: 10.1142/s0192415x23500222. [PMID: 36692485]
Wanli Xue, Rui Sun, Zheng Hao, Zhenzhen Xing, Hongjie Cheng, Lei Shao. Tetrandrine inhibits migration and invasion of BGC-823 and MKN-45 cells by regulating PI3K/AKT/mTOR signaling pathway. Chemical biology & drug design. 2023 Jan; ?(?):. doi: 10.1111/cbdd.14202. [PMID: 36593659]
Salma El-Sayed Radwan, Riham M El-Moslemany, Radwa A Mehanna, Eman H Thabet, Elsayeda-Zeinab A Abdelfattah, Amal El-Kamel. Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment. Drug delivery. 2022 Dec; 29(1):1150-1163. doi: 10.1080/10717544.2022.2058648. [PMID: 35384774]
Simeng Chu, Yujie Lu, Wenjuan Liu, Xiaoyao Ma, Jiamin Peng, Xiaoying Wang, Min Jiang, Gang Bai. Ursolic acid alleviates tetrandrine-induced hepatotoxicity by competitively binding to the substrate-binding site of glutathione S-transferases. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154325. doi: 10.1016/j.phymed.2022.154325. [PMID: 35820303]
Jia-Wen Song, Yu-Shi Liu, Yu-Rou Guo, Wen-Xiao Zhong, Yi-Ping Guo, Li Guo. Nano-Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti-Tumor Effects. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126858. [PMID: 35743311]
Jiao Guan, Liming Wang, Yuan Ji, Tianyi Zhang, Ye Sang, Sheng Chang, Bo Feng, Heyun Zhu. UHPLC-MS/MS Method for Quantifying Fangchinoline, Tetrandrine and Calycosin-7-O-β-D-Glucoside of Fangji Huangqi Decoction in Rat Plasma and Its Application to a Pharmacokinetic Study. Journal of chromatographic science. 2022 Jun; 60(5):458-464. doi: 10.1093/chromsci/bmab116. [PMID: 34734235]
Hyo-Seon Lee, Dae Hwan Kim, In-Seon Lee, Ji-Hyun Park, Gregory Martin, Stephen Safe, Keuk-Jun Kim, Joung-Hee Kim, Byung Ik Jang, Syng-Ook Lee. Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo. International journal of molecular sciences. 2022 May; 23(9):. doi: 10.3390/ijms23095280. [PMID: 35563670]
Fang Shi, Lei Ni, Ye-Mei Gao. Tetrandrine Attenuates Cartilage Degeneration, Osteoclast Proliferation, and Macrophage Transformation through Inhibiting P65 Phosphorylation in Ovariectomy-induced Osteoporosis. Immunological investigations. 2022 Apr; 51(3):465-479. doi: 10.1080/08820139.2020.1837864. [PMID: 33140671]
Lichan Mao, Yin Ding, Dongrong Yu, Jiazhen Yin, Jin Yu. Tetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway. Analytical cellular pathology (Amsterdam). 2022; 2022(?):7534181. doi: 10.1155/2022/7534181. [PMID: 36247873]
Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen. Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4+Foxp3+ Regulatory T Cells and Alleviates Imiquimod-Induced Psoriasis in Mice. Frontiers in immunology. 2022; 13(?):800283. doi: 10.3389/fimmu.2022.800283. [PMID: 35464441]
Jui-Feng Lin, Yen-Shuo Liu, Yu-Chuen Huang, Chih-Wen Chi, Cheng-Chia Tsai, Tung-Hu Tsai, Yu-Jen Chen. Borneol and Tetrandrine Modulate the Blood-Brain Barrier and Blood-Tumor Barrier to Improve the Therapeutic Efficacy of 5-Fluorouracil in Brain Metastasis. Integrative cancer therapies. 2022 Jan; 21(?):15347354221077682. doi: 10.1177/15347354221077682. [PMID: 35168384]
Yin Ding, Xuanli Tang, Yuhui Wang, Dongrong Yu, Caifeng Zhu, Jin Yu. Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade. BMC complementary medicine and therapies. 2021 Dec; 21(1):296. doi: 10.1186/s12906-021-03469-x. [PMID: 34906112]
Xin-Yu Lu, Zhong-Ze Wang, Si-Cheng Wan, Er-Hu Zhao, Hong-Juan Cui. [Effects of tetrandrine on proliferation, migration, and invasion of glioblastoma cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Dec; 46(24):6520-6529. doi: 10.19540/j.cnki.cjcmm.20210824.703. [PMID: 34994145]
Hong Wang, Lu Chen, Shaoxia Wang, Xiaoxuan Tian, Lusha Zhang, Huiying Li, Chunxiao Li, Yuejin Xue, Qianyi Wang, Leyu Fang, Wenjie Yang, Wei Sun, Yuze Leng, Mengyao Li, Xiumei Gao. Tetrandrine promotes angiogenesis via transcriptional regulation of VEGF-A. Vascular pharmacology. 2021 12; 141(?):106920. doi: 10.1016/j.vph.2021.106920. [PMID: 34592429]
Nan Wang, Shengdong Yang, Tao Tan, Yanran Huang, Yangmei Chen, Chaoqun Dong, Jin Chen, Xiaoji Luo. Tetrandrine suppresses the growth of human osteosarcoma cells by regulating multiple signaling pathways. Bioengineered. 2021 12; 12(1):5870-5882. doi: 10.1080/21655979.2021.1967034. [PMID: 34477474]
Jiazhen Yin, Jiazhen Lin, Jin Yu, Xia Wei, Bin Zhu, Caifeng Zhu. Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model. Bioengineered. 2021 12; 12(1):6499-6515. doi: 10.1080/21655979.2021.1973862. [PMID: 34463195]
Ching-Lung Liao, Yi-Shih Ma, Te-Chun Hsia, Yu-Cheng Chou, Jin-Cherng Lien, Shu-Fen Peng, Chao-Lin Kuo, Fei-Ting Hsu. Tetrandrine Suppresses Human Brain Glioblastoma GBM 8401/luc2 Cell-Xenografted Subcutaneous Tumors in Nude Mice In Vivo. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237105. [PMID: 34885686]
Defang Ren, Yu Fu, Li Wang, Jianqin Liu, Xia Zhong, Jiyuan Yuan, Chaoli Jiang, Honglian Wang, Zhi Li. Tetrandrine ameliorated Alzheimer's disease through suppressing microglial inflammatory activation and neurotoxicity in the 5XFAD mouse. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Sep; 90(?):153627. doi: 10.1016/j.phymed.2021.153627. [PMID: 34247115]
Pingliang Li, Jian Zou, Yanhan Dong, Jintao Jiang, Wenxing Liang, Delong Li. Tetrandrine, a Potent Antifungal Agent, Inhibits Mycelial Growth and Virulence of Botrytis cinerea. Phytopathology. 2021 Jul; 111(7):1152-1157. doi: 10.1094/phyto-10-20-0446-r. [PMID: 33289404]
Xue-Tao Li, Ming Jing, Fu-Yi Cai, Xue-Min Yao, Liang Kong, Xiao-Bo Wang. Enhanced antitumour efficiency of R8GD-modified epirubicin plus tetrandrine liposomes in treatment of gastric cancer via inhibiting tumour metastasis. Journal of liposome research. 2021 Jun; 31(2):145-157. doi: 10.1080/08982104.2020.1748647. [PMID: 32223361]
Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Journal of natural products. 2021 03; 84(3):750-761. doi: 10.1021/acs.jnatprod.0c00946. [PMID: 33226219]
Bingyu Sun, Yongqiang Liu, Danhua He, Jinke Li, Jiawei Wang, Wulin Wen, Ming Hong. Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis. Journal of Zhejiang University. Science. B. 2021 Mar; 22(3):190-203. doi: 10.1631/jzus.b2000497. [PMID: 33719224]
Wencheng Xu, Junichi Kusano, Shuhe Chen, Ryusei Yamamoto, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Seiichi Hayashi, Sachiko Tanaka, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2021 Jan; 76(1-2):21-25. doi: 10.1515/znc-2020-0064. [PMID: 33119545]
Wenqian Shang, Jing Zhang, Haibo Song, Shunfei Zhu, Aimin Zhang, Yushuang Hua, Shujun Han, Yan Fu. Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology. Drug design, development and therapy. 2021; 15(?):2907-2919. doi: 10.2147/dddt.s307670. [PMID: 34262258]
Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases. Pharmacology & therapeutics. 2021 01; 217(?):107659. doi: 10.1016/j.pharmthera.2020.107659. [PMID: 32800789]
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