Colchicine (BioDeep_00000398558)

Main id: BioDeep_00000000135

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(1e)-N-[(7s)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl] ethanimidic acid

化学式: C22H25NO6 (399.168179)
中文名称: 秋水仙碱, 秋水仙素
谱图信息: 最多检出来源 Homo sapiens(urine) 0.06%

分子结构信息

SMILES: C/C(=N\[C@H]1CCc2cc(c(c(c2-c3c1cc(=O)c(cc3)OC)OC)OC)OC)/O
InChI: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

描述信息

An alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.
Colchicine appears as odorless or nearly odorless pale yellow needles or powder that darkens on exposure to light. Used to treat gouty arthritis, pseudogout, sarcoidal arthritis and calcific tendinitis. (EPA, 1998)
(S)-colchicine is a colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions. It has a role as a mutagen, an anti-inflammatory agent and a gout suppressant. It is a colchicine and an alkaloid. It is an enantiomer of a (R)-colchicine.
Colchicine is an Alkaloid.
Colchicine is a plant alkaloid that is widely used for treatment of gout. Colchicine has not been associated with acute liver injury or liver test abnormalities except with serious overdoses.
Colchicine is a natural product found in Colchicum arenarium, Colchicum bivonae, and other organisms with data available.
Colchicine is an alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals.
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
See also: Colchicine; probenecid (component of).
A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
M - Musculo-skeletal system > M04 - Antigout preparations > M04A - Antigout preparations > M04AC - Preparations with no effect on uric acid metabolism
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, Guide to PHARMACOLOGY
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2258
CONFIDENCE standard compound; INTERNAL_ID 1172
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.982
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.979
Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].
Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

同义名列表

148 个代谢物同义名

Colchicine; (1e)-N-[(7s)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl] ethanimidic acid; N-[(7S,12aP)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-; Acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-; Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-; ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-,(S)-; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide; N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide; N-((7S)-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo(a)heptalen-7-yl))acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; N-((7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo(a)heptalen-7-yl)acetamide; N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(ALPHA)HEPTALEN-7-YL)-ACETAMIDE; N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-((7S)-5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZ(A)HEPTALEN-7-YL)-ACETAMIDE; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)ACETAMIDE; N-[(7s)-1,2,3,10-Tetramethoxy-9-Oxo-6,7-Dihydro-5h-Benzo[d]heptalen-7-Yl]ethanamide; Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(.alpha.)heptalen-7-yl)-; Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide; ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL); N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; Colchicine for system suitability, European Pharmacopoeia (EP) Reference Standard; N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-ACETAMIDE; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; Colchicine, Pharmaceutical Secondary Standard; Certified Reference Material; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-; 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo(a)heptalen-9(5H)-one; 7-ACETAMIDO-6,7-DIHYDRO-1,2,3,10-TETRAMETHOXYBENZO(A)HEPTALEN-9(5H)-ONE; Colchicine, BioReagent, plant cell culture tested, >=95\\% (HPLC); Colchicine, United States Pharmacopeia (USP) Reference Standard; Colchicine, (European Pharmacopoeia (EP) Reference Standard); N-((7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo; Benzo[a]heptalen-9(5H)-one,7-dihydro-1,2,3,10-tetramethoxy-; Colchicine (contains 5\\% Ethyl Acetate at maximum); N-ACETYL TRIMETHYLCOLCHICINIC ACID, METHYL ETHER; binds to tubulin; inhibits microtubular assembly; N-ACETYLTRIMETHYLCOLCHICINIC ACID METHYL ETHER; N-Acetyl trimethylcolchicinic acid methylether; Colchicine; Thiocolchicoside Impurity A; COLCHICINE COMPONENT OF COL-PROBENECID; COL-PROBENECID COMPONENT COLCHICINE; COLCHICINE IMPURITY B [EP IMPURITY]; BENZO(A)HEPTALENE, ACETAMIDE DERIV.; COLCHICINE COMPONENT OF COLBENEMID; Colchicine, >=95\\% (HPLC), powder; Colchicine conformational isomer; COLCHICINE COMPONENT OF MITIGARE; COLCHICINE COMPONENT OF PROBEN-C; COLBENEMID COMPONENT COLCHICINE; PROBEN-C COMPONENT COLCHICINE; MITIGARE COMPONENT COLCHICINE; Colchicine, >=96.0\\% (HPLC); COLCHICINE [USP MONOGRAPH]; COLCHICINE (USP MONOGRAPH); COLCHICINUM [WHO-IP LATIN]; COLCHICINE [EP MONOGRAPH]; COLCHICINE (EP MONOGRAPH); Colchicine Tablets 0.5 mg; COLCHICINE [EP IMPURITY]; COLCHICEINE METHYL ETHER; COLCHICINE [ORANGE BOOK]; COLCHICINE (EP IMPURITY); Colchicine, (+-)-Isomer; Colchicine, (R)-Isomer; Colchicine (JP17/USP); 7.alpha.H-Colchicine; 7-alpha-H-Colchicine; Colchicine [USP:JAN]; Colchicine (USP:JAN); (S)-Colchicine >95\\%; Colchicina [Italian]; COLCHICINE [WHO-DD]; COLCHICINE [WHO-IP]; COLCHICINE (USP-RS); COLCHICINE [USP-RS]; 7alpha-H-Colchicine; COLCHICINUM [HPUS]; 7alphaH-Colchicine; Colchicin [German]; COLCHICINE [MART.]; COLCHICINE (MART.); Prestwick2_000363; COLCHICINE [HSDB]; Prestwick1_000363; Prestwick3_000363; COLCHCINE [VANDF]; Prestwick0_000363; Spectrum5_000787; Spectrum2_000075; Spectrum4_000298; Colchicine [JAN]; Spectrum3_000362; COLCHICINE [MI]; UNII-SML2Y3J35T; Colchicine (TN); (S)-colchicine; (S)-colchicina; (-)-colchicine; Tox21_110947_1; spindle poison; COLCHICINUM 4x; BPBio1_000535; DivK1c_000753; Lopac0_000310; (S)-colchicin; MEGxp0_001879; KBio2_001322; KBio1_000753; KBio2_006458; KBio3_001303; Tox21_110947; ACon1_000353; KBio2_003890; Tox21_300582; Tox21_500310; Tox21_201547; NCI60_041659; IDI1_000753; Colchicinum; COLCHICENOS; CAS-64-86-8; 7JX9WZ3SJ5; SML2Y3J35T; Colchicina; Colchineos; Colchisol; Colsaloid; Colchysat; AI3-31149; Colchcine; Colchicin; COLCIGEL; Mitigare; Condylon; GLOPERBA; Kolkicin; Goutnil; Colstat; Colcrys; LODOCO; Colcin; (-)-N-; XD25; 4o2b; 4lzr; LOC



数据库引用编号

66 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

77 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Khairuzzaman, Md Mehedi Hasan, Mohammad Tuhin Ali, Abdullah Al Mamun, Sheuly Akter, Papia Nasrin, Md Khirul Islam, Akhlak Un Nahar, Dipto Kumer Sarker, Omer Abdalla Ahmed Hamdi, Shaikh Jamal Uddin, Veronique Seidel, Jamil A Shilpi. Anthelmintic screening of Bangladeshi medicinal plants and related phytochemicals using in vitro and in silico methods: An ethnobotanical perspective. Journal of ethnopharmacology. 2024 Jun; 328(?):118132. doi: 10.1016/j.jep.2024.118132. [PMID: 38565411]
  • Xin Zhang, Ziyu Zheng, Jing Wang, Yuwen Li, Yan Gao, Lixia Li, Yujuan Pang, Fuhua Bian. In vitro induction of tetraploids and their phenotypic and transcriptome analysis in Glehnia littoralis. BMC plant biology. 2024 May; 24(1):439. doi: 10.1186/s12870-024-05154-w. [PMID: 38778255]
  • Muhammad Wasim Haider, Muhammad Nafees, Rashid Iqbal, Habat Ullah Asad, Farrukh Azeem, Muhammad Samsam Raza, Abdel-Rhman Z Gaafar, Mohamed S Elshikh, Muhammad Arslan, Muhammad Habib Ur Rahman, Ayman M S Elshamly. Exploring the mechanism of transformation in Acacia nilotica (Linn.) triggered by colchicine seed treatment. BMC plant biology. 2024 May; 24(1):428. doi: 10.1186/s12870-024-05139-9. [PMID: 38773358]
  • Shuliang Song, Yan Wang, Hongming Wang, Xiao Tian, Xiao Zhang, Qian Zhang, Qiang Wei, Kai Ji. Fucoidan-induced reduction of lipid accumulation in foam cells through overexpression of lysosome genes. International journal of biological macromolecules. 2024 Apr; 263(Pt 2):130451. doi: 10.1016/j.ijbiomac.2024.130451. [PMID: 38408582]
  • Artemio García-Escobar, Rosa Lázaro-García, José-Ángel Cabrera, Alfonso Jurado-Román, Raúl Moreno. High systemic inflammation as a novel cardiovascular risk factor and target for anti-cytokine therapy: comment regarding the triglyceride glucose index. The international journal of cardiovascular imaging. 2024 Apr; 40(4):945-948. doi: 10.1007/s10554-024-03046-6. [PMID: 38558330]
  • Robert W Suppa, Ryan J Andres, Jeffrey C Dunne, Ramsey F Arram, Thomas B Morgan, Hsuan Chen. Autotetraploid Induction of Three A-Genome Wild Peanut Species, Arachis cardenasii, A. correntina, and A. diogoi. Genes. 2024 Feb; 15(3):. doi: 10.3390/genes15030303. [PMID: 38540363]
  • Mohammed Bouhadi, Oussama Abchir, Imane Yamari, Amal El Hamsas El Youbi, Anas Azgaoui, Samir Chtita, Houda El Hajjouji, M'hammed El Kouali, Mohammed Talbi, Hassan Fougrach. Genotoxic effects and mitosis aberrations of chromium (VI) on root cells of Vicia faba and its molecular docking analysis. Plant physiology and biochemistry : PPB. 2024 Feb; 207(?):108361. doi: 10.1016/j.plaphy.2024.108361. [PMID: 38237423]
  • Yue Gao, Fei Li, Zhengshan Luo, Zhiwei Deng, Yan Zhang, Zhenbo Yuan, Changmei Liu, Yijian Rao. Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids. Nature communications. 2024 Jan; 15(1):30. doi: 10.1038/s41467-023-44420-7. [PMID: 38167860]
  • Jiali Liu, Yan Wu, Yuanying Zhu, Cuicui Yu, Ying Zhang, Ting Luo, Juanna Wei, Hongjie Mu, Hui Xu. A new insight into mechanism of colchicine poisoning based on untargeted metabolomics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155122. doi: 10.1016/j.phymed.2023.155122. [PMID: 37863002]
  • Pascal M Burger, Jannick A N Dorresteijn, Aernoud T L Fiolet, Stefan Koudstaal, John W Eikelboom, Stefan M Nidorf, Peter L Thompson, Jan H Cornel, Charley A Budgeon, Iris C D Westendorp, Driek P W Beelen, Fabrice M A C Martens, Philippe Gabriel Steg, Folkert W Asselbergs, Maarten J Cramer, Martin Teraa, Deepak L Bhatt, Frank L J Visseren, Arend Mosterd. Individual lifetime benefit from low-dose colchicine in patients with chronic coronary artery disease. European journal of preventive cardiology. 2023 12; 30(18):1950-1962. doi: 10.1093/eurjpc/zwad221. [PMID: 37409348]
  • Ying-Jie Cui, Yi Zhou, Xi-Wu Zhang, Bao-Kai Dou, Chen-Chen Ma, Jing Zhang. The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors. European journal of medicinal chemistry. 2023 Dec; 262(?):115870. doi: 10.1016/j.ejmech.2023.115870. [PMID: 37890199]
  • Jiana Lin, Bingnan Zhang, Jintuo Zou, Zhen Luo, Hao Yang, Peng Zhou, Xiaoyang Chen, Wei Zhou. Induction of tetraploids in Paper Mulberry (Broussonetia papyrifera (L.) L'Hér. ex Vent.) by colchicine. BMC plant biology. 2023 Nov; 23(1):574. doi: 10.1186/s12870-023-04487-2. [PMID: 37978431]
  • Huiqing Piao, Wanchen Xie, Shiqi Li, Jiaqi Wang, Chao Liu, Peng Quan, Liang Fang. Ternary Deep Eutectic Solvents System of Colchicine, 4-Hydroxyacetophenone, and Protocatechuic Acid and Characterization of Transdermal Enhancement Mechanism. AAPS PharmSciTech. 2023 Nov; 24(8):229. doi: 10.1208/s12249-023-02681-x. [PMID: 37964102]
  • Jian Wu, Qing Zhou, Yaru Sang, Yifan Zhao, Bo Kong, Liang Li, Jiahua Du, Lexun Ma, Min Lu, Pingdong Zhang. In vitro induction of tetraploidy and its effects on phenotypic variations in Populus hopeiensis. BMC plant biology. 2023 Nov; 23(1):557. doi: 10.1186/s12870-023-04578-0. [PMID: 37957587]
  • Sisi Zhang, Min Mo, Mengfan Lv, Wen Xia, Kun Liu, Gang Yu, Jia Yu, Guangcan Xu, Xiaoping Zeng, Sha Cheng, Bixue Xu, Heng Luo, Xueling Meng. Design, synthesis and bioevaluation of novel trifluoromethylquinoline derivatives as tubulin polymerization inhibitors. Future medicinal chemistry. 2023 11; 15(21):1967-1986. doi: 10.4155/fmc-2023-0151. [PMID: 37937524]
  • Xinming Wang, Hongpeng Shi, Shixing Huang, Yecen Zhang, Xiaojun He, Qiang Long, Bei Qian, Yiming Zhong, Zhaoxi Qi, Qiang Zhao, Xiaofeng Ye. Localized delivery of anti-inflammatory agents using extracellular matrix-nanostructured lipid carriers hydrogel promotes cardiac repair post-myocardial infarction. Biomaterials. 2023 11; 302(?):122364. doi: 10.1016/j.biomaterials.2023.122364. [PMID: 37883909]
  • N Mohammadnia, T S J Opstal, S El Messaoudi, W A Bax, J H Cornel. An Update on Inflammation in Atherosclerosis: How to Effectively Treat Residual Risk. Clinical therapeutics. 2023 11; 45(11):1055-1059. doi: 10.1016/j.clinthera.2023.08.016. [PMID: 37716836]
  • Saeed Arshad, Mengli Wei, Qurban Ali, Ghulam Mustafa, Zhengqiang Ma, Yuanxin Yan. Paclitaxel and Caffeine-Taurine, New Colchicine Alternatives for Chromosomes Doubling in Maize Haploid Breeding. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914659. [PMID: 37834106]
  • Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing He. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. 2023 Sep; 679(?):129-138. doi: 10.1016/j.bbrc.2023.09.006. [PMID: 37690423]
  • Xiaoxia Liu, Jinmei Jin, Ye Wu, Bolin Du, Lijun Zhang, Dong Lu, Yichen Liu, Xinyi Chen, Jiayi Lin, Hongzhuan Chen, Weidong Zhang, Chunlin Zhuang, Xin Luan. Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy. European journal of medicinal chemistry. 2023 Sep; 257(?):115540. doi: 10.1016/j.ejmech.2023.115540. [PMID: 37301075]
  • Elena Jerschke, Andreas Eichinger, Arne Skerra. Drastic alterations in the loop structure around colchicine upon complex formation with an engineered lipocalin indicate a conformational selection mechanism. Acta crystallographica. Section F, Structural biology communications. 2023 Sep; 79(Pt 9):231-239. doi: 10.1107/s2053230x23006817. [PMID: 37584182]
  • Ainoa Escrich, Diego Hidalgo, Mercedes Bonfill, Javier Palazon, Raul Sanchez-Muñoz, Elisabeth Moyano. Polyploidy as a strategy to increase taxane production in yew cell cultures: Obtaining and characterizing a Taxus baccata tetraploid cell line. Plant science : an international journal of experimental plant biology. 2023 Sep; 334(?):111776. doi: 10.1016/j.plantsci.2023.111776. [PMID: 37343603]
  • Kyle Nelson, Valentin Fuster, Paul M Ridker. Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week. Journal of the American College of Cardiology. 2023 Aug; 82(7):648-660. doi: 10.1016/j.jacc.2023.05.055. [PMID: 37558377]
  • Stefan Mark Nidorf. Seeing Colchicine in a New Light: Repurposing Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease. Clinical therapeutics. 2023 Jul; ?(?):. doi: 10.1016/j.clinthera.2023.07.007. [PMID: 37516564]
  • Elena Jerschke, Mikhail Barkovsky, Nicole Jung, Heidi Neuberger, Jochen Stenzel, Florian Eyer, Arne Skerra, Stefanie Geith. In vivo neutralization of colchicine toxicity by a PASylated anticalin in a rat model. Toxicology. 2023 06; 492(?):153526. doi: 10.1016/j.tox.2023.153526. [PMID: 37116682]
  • Worasitikulya Taratima, Khoirista Noor Rohmah, Kongtong Plaikhuntod, Pitakpong Maneerattanarungroj, Attachai Trunjaruen. Optimal protocol for in vitro polyploid induction of Cymbidium aloifolium (L.) Sw. BMC plant biology. 2023 Jun; 23(1):295. doi: 10.1186/s12870-023-04314-8. [PMID: 37264309]
  • Yuanshui Liu, Hang Yang, Fei Zhu, Yanhong Ouyang, Pinhua Pan. Inhibition of STAT3 phosphorylation by colchicine regulates NLRP3 activation to alleviate sepsis-induced acute lung injury. Inflammopharmacology. 2023 Apr; ?(?):. doi: 10.1007/s10787-023-01199-9. [PMID: 37115345]
  • Nisha Schwarz, Sanuja Fernando, Yung-Chih Chen, Thalia Salagaras, Sushma R Rao, Sanuri Liyanage, Anna E Williamson, Deborah Toledo-Flores, Catherine Dimasi, Timothy J Sargeant, Jim Manavis, Eleanor Eddy, Peter Kanellakis, Peter L Thompson, Joanne T M Tan, Marten F Snel, Christina A Bursill, Stephen J Nicholls, Karlheinz Peter, Peter J Psaltis. Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 Apr; 37(4):e22846. doi: 10.1096/fj.202201469r. [PMID: 36856983]
  • Laura Espinosa Del Alba, Georg Petschenka. No physiological costs of dual sequestration of chemically different plant toxins in the milkweed bug Spilostethus saxatilis (Heteroptera: Lygaeidae). Journal of insect physiology. 2023 Apr; ?(?):104508. doi: 10.1016/j.jinsphys.2023.104508. [PMID: 37011856]
  • Zeyuan Wang, Xiaoman Zu, Shanshan Xiong, Ren Mao, Yun Qiu, Baili Chen, Zhirong Zeng, Minhu Chen, Yao He. The Role of Colchicine in Different Clinical Phenotypes of Behcet Disease. Clinical therapeutics. 2023 Jan; ?(?):. doi: 10.1016/j.clinthera.2023.01.004. [PMID: 36732153]
  • Giovanni Cimmino, Francesco S Loffredo, Gennaro De Rosa, Plinio Cirillo. Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032483. [PMID: 36768804]
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