Gingerol (BioDeep_00000398432)

Main id: BioDeep_00000000238

 

PANOMIX_OTCML-2023


代谢物信息卡片


3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-

化学式: C17H26O4 (294.1830996)
中文名称: [6]-姜辣素, 6-姜酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(O)=C(OC)C=C1CCC(=O)C[C@@H](O)CCCCC
InChI: InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1

描述信息

Gingerol is a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-hydroxy ketone and a member of guaiacols.
Gingerol is a natural product found in Illicium verum, Piper nigrum, and other organisms with data available.
See also: Ginger (part of).
A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.
Annotation level-1
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

同义名列表

39 个代谢物同义名

3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-; 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-; 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-; (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one; (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one; (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one; (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl-3-decanone; [1-(4-hydroxy-3-methoxyphenyl)-5-hydroxy-3-decanone]; 5S-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one; 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; 6-GINGEROL (CONSTITUENT OF GINGER) [DSC]; 6-GINGEROL (CONSTITUENT OF GINGER); [6]-Gingerol, analytical standard; (S)-(+)-[6]Gingerol;6-Gingerol; [6]-Gingerol, >=98\\% (HPLC); (S)-(+)-[6]Gingerol; (6)-GINGEROL [MI]; (+)-[6]-Gingerol; (S)-(6)-Gingerol; KBio2_005203; KBio3_000133; KBio2_002635; KBio3_000134; (6)-gingerol; [6]-Gingerol; KBio2_000067; Bio1_000561; Bio2_000067; Bio1_000072; 10-gingerol; Bio1_001050; IDI1_033817; Bio2_000547; C17-H26-O4; 6-Gingerol; Gingerol



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yoon-Tae Kim, Jae-Sung Shin, Sang-Jin Ye, Ji Hye Kim, Seok Hyun Eom, Moo-Yeol Baik. Conversion of gingerols to shogaols in ginger (Zingiber officinale roscoe) by puffing. Food chemistry. 2024 Sep; 452(?):139425. doi: 10.1016/j.foodchem.2024.139425. [PMID: 38744128]
  • Xiaoliang He, Yingya Zhou, Jingtao Yu, Qinpo Huang, Zhengyuan Chen, Ru Xiao, Changhui Liu, Shuhua Gui, Tianqin Xiong. JiaGaSongTang improves chronic cholestasis via enhancing FXR-mediated bile acid metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155347. doi: 10.1016/j.phymed.2024.155347. [PMID: 38493717]
  • Ze Peng, Yan Zeng, Qi Tan, Qifeng He, Shang Wang, Jianwei Wang. 6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function. Biochemical and biophysical research communications. 2024 May; 708(?):149786. doi: 10.1016/j.bbrc.2024.149786. [PMID: 38493545]
  • Zarrin Basharat, Zainab Murtaza, Aisha Siddiqa, Sulaiman Mohammed Alnasser, Alotaibi Meshal. Therapeutic target mapping from the genome of Kingella negevensis and biophysical inhibition assessment through PNP synthase binding with traditional medicinal compounds. Molecular diversity. 2024 Apr; 28(2):581-594. doi: 10.1007/s11030-023-10604-y. [PMID: 36645537]
  • Kitti Pázmándi, Beatrix Ágics, Attila Gábor Szöllősi, Attila Bácsi, Tünde Fekete. Ginger-derived bioactive compounds attenuate the Toll-like receptor mediated responses of human dendritic cells. European journal of pharmacology. 2024 Mar; 967(?):176399. doi: 10.1016/j.ejphar.2024.176399. [PMID: 38331338]
  • Eka Munika, Shirly Gunawan, Puspita Eka Wuyung, Vivian Soetikno. Beneficial Effects of 6-Gingerol on Fatty Pancreas Disease in High-Fat High-Fructose Diet-Induced Metabolic Syndrome Rat Model. Pancreas. 2024 Feb; 53(2):e193-e198. doi: 10.1097/mpa.0000000000002287. [PMID: 38127814]
  • Zijing Chen, Ling Zhang, Yao Lv, Shenyang Qu, Wenjun Liu, Kai Wang, Song Gao, Feng Zhu, Bili Cao, Kun Xu. A genome assembly of ginger (Zingiber officinale Roscoe) provides insights into genome evolution and 6-gingerol biosynthesis. The Plant journal : for cell and molecular biology. 2024 Jan; ?(?):. doi: 10.1111/tpj.16625. [PMID: 38251816]
  • Qingsong Xia, Fuer Lu, Yu Chen, Jingbin Li, Zhaoyi Huang, Ke Fang, Meilin Hu, Yujin Guo, Hui Dong, Lijun Xu, Jing Gong. 6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116060. doi: 10.1016/j.biopha.2023.116060. [PMID: 38147735]
  • Fatemeh Pashizeh, Afsoun Mansouri, Saina Bazzazan, Mohammadreza Abdihaji, Mohammad Khaleghian, Saba Bazzazan, Niloufar Rezei, Alireza Eskandari, Farzaneh Mashayekhi, Maryam Heydari, Mohammad Tavakkoli Yaraki. Bioresponsive gingerol-loaded alginate-coated niosomal nanoparticles for targeting intracellular bacteria and cancer cells. International journal of biological macromolecules. 2023 Dec; 258(Pt 2):128957. doi: 10.1016/j.ijbiomac.2023.128957. [PMID: 38154726]
  • Zhimin Song, Hongbin Fang, Xiaojuan Zhang, Yong-Ming Yan, Yufei Liu, Jingjing Miao, Huiying Niu, Weisheng Feng, Yong-Xian Cheng, Yanzhi Wang. Renoprotective Glycoside Derivatives from Zingiber officinale (Ginger) Peels. Journal of agricultural and food chemistry. 2023 Oct; ?(?):. doi: 10.1021/acs.jafc.3c05224. [PMID: 37811859]
  • Wenlin Zhang, Yang Yang, Xuedong Zhu, Suyu Yang, Ximei Liao, Honglei Li, Zhexin Li, Qinhong Liao, Jianmin Tang, Guohua Zhao, Lin Wu. Integrated analyses of metabolomics and transcriptomics reveal the potential regulatory roles of long non-coding RNAs in gingerol biosynthesis. BMC genomics. 2023 Aug; 24(1):490. doi: 10.1186/s12864-023-09553-5. [PMID: 37633894]
  • Anita Chando, Vivek Basudkar, Sankalp Gharat, Munira Momin, Tabassum Khan. Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis. Drug delivery and translational research. 2023 Aug; ?(?):. doi: 10.1007/s13346-023-01416-6. [PMID: 37606759]
  • Jisheng Li, Qiqi Wang, Yao Wang, Mencuo La, Ruisha Mian, Liangliang He, Ji Suonan, Denglang Zou. An efficient strategy for large-scale preparation of low polarity gingerols directly from ginger crude extract by high-speed countercurrent chromatography with different rotation mode. Journal of separation science. 2023 Aug; ?(?):e2300320. doi: 10.1002/jssc.202300320. [PMID: 37541285]
  • Yajing Wang, Tao Zhang, Jie Liu, Xianfeng Huang, Xiaojing Yan. Investigations of the gingerol oil colon targeting pellets for the treatment of ulcerative colitis. Fitoterapia. 2023 Jul; ?(?):105607. doi: 10.1016/j.fitote.2023.105607. [PMID: 37442485]
  • Zahra Asghari Lalami, Farzaneh Tafvizi, Vahid Naseh, Masoud Salehipour. Fabrication, optimization, and characterization of pH-responsive PEGylated nanoniosomes containing gingerol for enhanced treatment of breast cancer. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jun; ?(?):. doi: 10.1007/s00210-023-02579-2. [PMID: 37368028]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Youdong Hu, Tingting Liu, Guangzhen Zheng, Li Zhou, Ke Ma, Xiaolian Xiong, Cheng Zheng, Jin Li, Yong Zhu, Wenhui Bian, Xiangde Zheng, Qingping Xiong, Jiafeng Lin. Mechanism exploration of 6-Gingerol in the treatment of atherosclerosis based on network pharmacology, molecular docking and experimental validation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 115(?):154835. doi: 10.1016/j.phymed.2023.154835. [PMID: 37121058]
  • Monisha A, Praveena A, Monisha Baby B. Investigation on the Anticancer Activity of [6]-Gingerol of Zingiber officinale and its Structural Analogs against Skin Cancer. Current computer-aided drug design. 2023 Apr; ?(?):. doi: 10.2174/1573409919666230418095105. [PMID: 37076965]
  • Suparna Ghosh, Bhaskar Das, Pallab Kanti Haldar, Amit Kar, Sushil K Chaudhary, Keithellakpam Ojit Singh, Pardeep K Bhardwaj, Nanaocha Sharma, Pulok K Mukherjee. 6-Gingerol contents of several ginger varieties of Northeast India and correlation of their antioxidant activity in respect to phenolics and flavonoids contents. Phytochemical analysis : PCA. 2023 Apr; 34(3):259-268. doi: 10.1002/pca.3201. [PMID: 36594354]
  • Yuzhe Liu, Dong Li, Shang Wang, Ze Peng, Qi Tan, Qifeng He, Jianwei Wang. 6-Gingerol Ameliorates Hepatic Steatosis, Inflammation and Oxidative Stress in High-Fat Diet-Fed Mice through Activating LKB1/AMPK Signaling. International journal of molecular sciences. 2023 Mar; 24(7):. doi: 10.3390/ijms24076285. [PMID: 37047258]
  • Shou-Jia Wang, Wen Ye, Wan-Yi Li, Wen Tian, Meng Zhang, Yang Sun, Ying-Da Feng, Chen-Xu Liu, Shao-Yuan Liu, Wei Cao, Jing-Ru Meng, Xiao-Qiang Li. Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: An integration of network pharmacology, molecular docking and experimental validation. Journal of ethnopharmacology. 2023 Mar; 303(?):116053. doi: 10.1016/j.jep.2022.116053. [PMID: 36529247]
  • Clarissa Garza-Cadena, Daniela Marian Ortega-Rivera, Gerson Machorro-García, Eloy Mauricio Gonzalez-Zermeño, Diego Homma-Dueñas, Maksymilian Plata-Gryl, Roberto Castro-Muñoz. A comprehensive review on Ginger (Zingiber officinale) as a potential source of nutraceuticals for food formulations: Towards the polishing of gingerol and other present biomolecules. Food chemistry. 2023 Feb; 413(?):135629. doi: 10.1016/j.foodchem.2023.135629. [PMID: 36753787]
  • Quanli Pan, Peng Liu, Min Wan. 6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation. Folia histochemica et cytobiologica. 2023 Feb; ?(?):. doi: 10.5603/fhc.a2023.0002. [PMID: 36734635]
  • Kanta Keosaeng, Weerasak Songoen, Thitaree Yooboon, Vasakorn Bullangpoti, Wanchai Pluempanupat. Insecticidal activity of isolated gingerols and shogaols from Zingiber officinale Roscoe rhizomes against Spodoptera spp. (Lepidoptera: Noctuidae). Natural product research. 2023 Feb; 37(4):669-674. doi: 10.1080/14786419.2022.2078818. [PMID: 35608145]
  • Muhamad Syafiq Hakimi Kamaruddin, Gun Hean Chong, Nurizzati Mohd Daud, Nicky Rahmana Putra, Liza Md Salleh, Norhidayah Suleiman. Bioactivities and green advanced extraction technologies of ginger oleoresin extracts: A review. Food research international (Ottawa, Ont.). 2023 Feb; 164(?):112283. doi: 10.1016/j.foodres.2022.112283. [PMID: 36737895]
  • Jiasheng Li, Ying Zhang, Shurui Liu, Wangjun Li, Yue Sun, Hui Cao, Shumei Wang, Jiang Meng. A network pharmacology integrated pharmacokinetics strategy to investigate the pharmacological mechanism of absorbed components from crude and processed Zingiberis Rhizoma on deficiency-cold and hemorrhagic syndrome. Journal of ethnopharmacology. 2023 Jan; 301(?):115754. doi: 10.1016/j.jep.2022.115754. [PMID: 36195301]
  • Xiao-Juan Zhang, Zhi-Min Song, Pei-Pei Yuan, Yan-Zhi Wang, Man-Qian Li, Yu-Fei Liu, Xue-Yu Hu, Wei-Sheng Feng. Five new compounds from Zingiberis Rhizoma Recens and their anti-apoptotic activity. Journal of Asian natural products research. 2023 Jan; 25(1):1-10. doi: 10.1080/10286020.2022.2026335. [PMID: 35023415]
  • Yuto Nishidono, Ken Tanaka. Effect of drying and processing on diterpenes and other chemical constituents of ginger. Journal of natural medicines. 2023 Jan; 77(1):118-127. doi: 10.1007/s11418-022-01652-z. [PMID: 36209453]
  • Samridhi Sharma, Monu Kumar Shukla, Krishan Chander Sharma, Tirath, Lokender Kumar, Jasha Momo H Anal, Santosh Kumar Upadhyay, Sanjib Bhattacharyya, Deepak Kumar. Revisiting the therapeutic potential of gingerols against different pharmacological activities. Naunyn-Schmiedeberg's archives of pharmacology. 2022 Dec; ?(?):. doi: 10.1007/s00210-022-02372-7. [PMID: 36585999]
  • Imran Kazmi, Syed Sarim Imam, Fahad A Al-Abbasi, Muhammad Afzal, Muhammad Shahid Nadeem, Sultan Alshehri. Environment friendly green synthesis method based natural bioactive functional "catechin and gingerol" loaded nanomedicine for the management of obesity. International journal of pharmaceutics. 2022 Nov; 628(?):122340. doi: 10.1016/j.ijpharm.2022.122340. [PMID: 36341920]
  • Ngouana Moffo A Ivane, Fopa Kue Roméo Elysé, Suleiman A Haruna, Ngwasiri Pride, Ejoh Richard, Anuanwen Claris Foncha, Munir Abba Dandago. The anti-oxidative potential of ginger extract and its constituent on meat protein isolate under induced Fenton oxidation. Journal of proteomics. 2022 10; 269(?):104723. doi: 10.1016/j.jprot.2022.104723. [PMID: 36096434]
  • Jun Dang, Yue Lv, Chengzhao Li, Yan Fang, Gang Li, Qilan Wang. Integrated chromatographic approach for the discovery of gingerol antioxidants from Dracocephalum heterophyllum and their potential targets. Analytical methods : advancing methods and applications. 2022 10; 14(41):4133-4145. doi: 10.1039/d2ay01282k. [PMID: 36226573]
  • Yuge Gao, Yujia Lu, Na Zhang, Chibuike C Udenigwe, Yuhao Zhang, Yu Fu. Preparation, pungency and bioactivity of gingerols from ginger (Zingiber officinale Roscoe): a review. Critical reviews in food science and nutrition. 2022 Sep; ?(?):1-26. doi: 10.1080/10408398.2022.2124951. [PMID: 36135317]
  • Wenni Tian, Haonan Wang, Ying Zhu, Qun Wang, Mingyue Song, Yong Cao, Jie Xiao. Intervention effects of delivery vehicles on the therapeutic efficacy of 6-gingerol on colitis. Journal of controlled release : official journal of the Controlled Release Society. 2022 09; 349(?):51-66. doi: 10.1016/j.jconrel.2022.06.058. [PMID: 35792187]
  • S I Othman, M N Bin-Jumah, R S Suliman, S S Althobaiti, E A Alqhtani, S A Gabr. Gingerol fractions bioactivity against butanone cytotoxicity induced in newborns of mice. European review for medical and pharmacological sciences. 2022 09; 26(18):6512-6522. doi: 10.26355/eurrev_202209_29750. [PMID: 36196700]
  • Fei Gao, Fei Zhou, Shuai Gan, Ya-Lan Chen, Shu Fu, Mei-Si Lin, Chao-Mei Fu. [Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):5064-5070. doi: 10.19540/j.cnki.cjcmm.20220421.701. [PMID: 36164916]
  • Alieh Alipour, Vafa Baradaran Rahimi, Vahid Reza Askari. Promising influences of gingerols against metabolic syndrome: A mechanistic review. BioFactors (Oxford, England). 2022 Sep; 48(5):993-1004. doi: 10.1002/biof.1892. [PMID: 36191294]
  • Miaomaio Liu, Yakun Yang, Muqing Zhang, Yucong Xue, Bin Zheng, Yuanyuan Zhang, Yu Liu, Xi Chu, Zhenqing Sun, Xue Han. Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger. The Journal of pharmacy and pharmacology. 2022 Aug; 74(8):1133-1139. doi: 10.1093/jpp/rgac029. [PMID: 35511715]
  • Shuwei Zhang, Emily DiMango, Yingdong Zhu, Tarnjot K Saroya, Charles W Emala, Shengmin Sang. Pharmacokinetics of Gingerols, Shogaols, and Their Metabolites in Asthma Patients. Journal of agricultural and food chemistry. 2022 Aug; 70(31):9674-9683. doi: 10.1021/acs.jafc.2c03150. [PMID: 35916113]
  • Priyadharshini Thangavelu, Viswanathan Sundaram, Kaavya Gunasekaran, Bonaventure Mujyambere, Sowndarya Raju, Arya Kannan, Ashok Arasu, Kadirvelu Krishna, Jayaraj Ramamoorthi, Sivasamy Ramasamy, Thirunavukkarasu Velusamy, Suja Samiappan. Development of optimized novel liposome loaded with 6-gingerol and assessment of its therapeutic activity against NSCLC In vitro and In vivo experimental models. Chemistry and physics of lipids. 2022 07; 245(?):105206. doi: 10.1016/j.chemphyslip.2022.105206. [PMID: 35483420]
  • Xiaohong Deng, Dandan Chen, Xianjun Sun, Jingcheng Dong, Jianhua Huang. Effects of ginger extract and its major component 6-gingerol on anti-tumor property through mitochondrial biogenesis in CD8+ T cells. Journal of food science. 2022 Jul; 87(7):3307-3317. doi: 10.1111/1750-3841.16228. [PMID: 35708209]
  • Min Su, Xueqin Wang, Gang Cao, Li Sun, Rodney J Y Ho, Yanquan Han, Yan Hong, Deling Wu. Prediction of the potential mechanism of compound gingerol against liver cancer based on network pharmacology and experimental verification. The Journal of pharmacy and pharmacology. 2022 Jun; 74(6):869-886. doi: 10.1093/jpp/rgac002. [PMID: 35429380]
  • Xue Han, Panpan Liu, Bin Zheng, Muqing Zhang, Yuanyuan Zhang, Yucong Xue, Chenxu Liu, Xi Chu, Xiangting Wang, Shijiang Sun, Li Chu. 6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells. The Journal of nutritional biochemistry. 2022 06; 104(?):108975. doi: 10.1016/j.jnutbio.2022.108975. [PMID: 35245652]
  • Nantaporn Promdam, Pissared Khuituan, Pharkphoom Panichayupakaranant. Effects of standardized [6]-gingerol extracts and [6]-gingerol on isolated ileum and lower esophageal sphincter contractions in mice. Food chemistry. 2022 Jun; 378(?):132077. doi: 10.1016/j.foodchem.2022.132077. [PMID: 35042108]
  • Wanlin Zhong, Jiaqing Zhu, Juanjuan Yi, Changcheng Zhao, Yanling Shi, Qiaozhen Kang, Jinyong Huang, Limin Hao, Jike Lu. Biochemical analysis reveals the systematic response of motion sickness mice to ginger (Zingiber officinale) extract's amelioration effect. Journal of ethnopharmacology. 2022 May; 290(?):115077. doi: 10.1016/j.jep.2022.115077. [PMID: 35131339]
  • Bo Deng, Xiao-Li Jiang, You-Cai Xu, Si Chen, Min Cai, Sui-Hui Deng, Wen-Jun Ding, Hong-Lin Xu, Shuang-Wei Zhang, Zhang-Bin Tan, Rui-Xue Chen, Bin Liu, Jing-Zhi Zhang. 10-Gingerol, a natural AMPK agonist, suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. Food & function. 2022 Mar; 13(6):3234-3246. doi: 10.1039/d1fo03610f. [PMID: 35213678]
  • Li Zhong, Rui Wang, Qin-Hui Wen, Jian Li, Jia-Wei Lin, Xin-An Zeng. The interaction between bovine serum albumin and [6]-,[8]- and [10]-gingerol: An effective strategy to improve the solubility and stability of gingerol. Food chemistry. 2022 Mar; 372(?):131280. doi: 10.1016/j.foodchem.2021.131280. [PMID: 34818732]
  • Quan-Cao Zhan, Yu-Zhe Liu, Yu-Meng Xi, Yan Zeng, Jia-Yu Tian, Li Liu, Dong Li, Yamahara Johji, Jian-Wei Wang. [6-Gingerol ameliorates adipose tissue insulin resistance in aging rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Mar; 47(6):1642-1649. doi: 10.19540/j.cnki.cjcmm.20211008.702. [PMID: 35347963]
  • Chwan-Li Shen, Rui Wang, Guangchen Ji, Moamen M Elmassry, Masoud Zabet-Moghaddam, Heather Vellers, Abdul N Hamood, Xiaoxia Gong, Parvin Mirzaei, Shengmin Sang, Volker Neugebauer. Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation. The Journal of nutritional biochemistry. 2022 02; 100(?):108904. doi: 10.1016/j.jnutbio.2021.108904. [PMID: 34748918]
  • Zhe Cheng, Xinyu Xiong, Yi Zhou, Fan Wu, Qingqing Shao, Ruolan Dong, Qiong Liu, Lingli Li, Guang Chen. 6-gingerol ameliorates metabolic disorders by inhibiting hypertrophy and hyperplasia of adipocytes in high-fat-diet induced obese mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112491. doi: 10.1016/j.biopha.2021.112491. [PMID: 34896967]
  • Xiao-Xuan Guo, Yun-Dan Zhang, Tian-Cai Wang, Xin-Lu Wang, Yan-Yang Xu, Yong Wang, Jing Qiu. Ginger and 6-gingerol prevent lipopolysaccharide-induced intestinal barrier damage and liver injury in mice. Journal of the science of food and agriculture. 2022 Feb; 102(3):1066-1075. doi: 10.1002/jsfa.11442. [PMID: 34309869]
  • Li Liu, Nan Yu, Wei Leng, Yun Lu, Xinxin Xia, Hui Yuan. 6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1. Allergologia et immunopathologia. 2022; 50(2):104-114. doi: 10.15586/aei.v50i2.533. [PMID: 35257553]
  • Babatunde Joseph Oso, Akinwunmi Oluwaseun Adeoye, Ige Francis Olaoye. Pharmacoinformatics and hypothetical studies on allicin, curcumin, and gingerol as potential candidates against COVID-19-associated proteases. Journal of biomolecular structure & dynamics. 2022 Jan; 40(1):389-400. doi: 10.1080/07391102.2020.1813630. [PMID: 32876538]
  • Tamilvelan Manjunathan, Ajay Guru, Jesu Arokiaraj, Pushparathinam Gopinath. 6-Gingerol and Semisynthetic 6-Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish. Chemistry & biodiversity. 2021 Dec; 18(12):e2100650. doi: 10.1002/cbdv.202100650. [PMID: 34599795]
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