Laudanosine (BioDeep_00000398001)
Secondary id: BioDeep_00000002519
PANOMIX_OTCML-2023 natural product
代谢物信息卡片
化学式: C21H27NO4 (357.194)
中文名称: 劳丹素
谱图信息:
最多检出来源 Viridiplantae(plant) 59.56%
分子结构信息
SMILES: CN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC
InChI: InChI=1S/C21H27NO4/c1-22-9-8-15-12-20(25-4)21(26-5)13-16(15)17(22)10-14-6-7-18(23-2)19(11-14)24-3/h6-7,11-13,17H,8-10H2,1-5H3
描述信息
D002491 - Central Nervous System Agents
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.628
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.624
Acquisition and generation of the data is financially supported by the Max-Planck-Society
IPB_RECORD: 2441; CONFIDENCE confident structure
DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity[1].
DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity[1].
同义名列表
3 个代谢物同义名
数据库引用编号
34 个数据库交叉引用编号
- ChEBI: CHEBI:91599
- PubChem: 15548
- ChEMBL: CHEMBL1407
- CAS: 20412-65-1
- CAS: 1699-51-0
- MoNA: PR310613
- MoNA: RIKENPlaSMA001026
- MoNA: RIKENPlaSMA001022
- MoNA: RIKENPlaSMA001018
- MoNA: RIKENPlaSMA001014
- MoNA: RIKENPlaSMA001010
- MoNA: RIKENPlaSMA001006
- MoNA: RIKENPlaSMA001002
- MoNA: RIKENPlaSMA000998
- MoNA: RIKENPlaSMA000994
- MoNA: RIKENPlaSMA000990
- MoNA: RIKENPlaSMA000986
- MoNA: RIKENPlaSMA000982
- MoNA: BML81577
- MoNA: BML81575
- MoNA: BML00124
- MoNA: BML00112
- MoNA: BML00100
- MoNA: CE000010
- MoNA: CE000009
- MoNA: CE000008
- MoNA: CE000007
- MoNA: CE000006
- MoNA: PB005882
- MoNA: PB005881
- MoNA: PB005864
- medchemexpress: HY-122489
- LOTUS: LTS0049787
- LOTUS: LTS0094818
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
52 个相关的物种来源信息
- 22140 - Annonaceae: LTS0049787
- 22140 - Annonaceae: LTS0094818
- 41773 - Berberidaceae: LTS0049787
- 41773 - Berberidaceae: LTS0094818
- 22774 - Berberis: LTS0049787
- 22774 - Berberis: LTS0094818
- 1433312 - Berberis heteropoda: 10.1007/BF00631012
- 1433312 - Berberis heteropoda: LTS0049787
- 1433312 - Berberis heteropoda: LTS0094818
- 1439896 - Berberis nummularia: 10.1007/BF00630532
- 1439896 - Berberis nummularia: LTS0049787
- 1439896 - Berberis nummularia: LTS0094818
- 108408 - Cissampelos: LTS0049787
- 108408 - Cissampelos: LTS0094818
- 108409 - Cissampelos pareira: 10.1016/0031-9422(75)80388-8
- 108409 - Cissampelos pareira: LTS0049787
- 108409 - Cissampelos pareira: LTS0094818
- 2759 - Eukaryota: LTS0049787
- 2759 - Eukaryota: LTS0094818
- 56853 - Glaucium flavum: 10.1104/PP.15.01240
- 295145 - Guatteria: LTS0049787
- 295145 - Guatteria: LTS0094818
- 343270 - Guatteria amplifolia: 10.1055/S-2003-41126
- 343270 - Guatteria amplifolia: LTS0049787
- 343270 - Guatteria amplifolia: LTS0094818
- 651330 - Hazomalania: LTS0094818
- 651331 - Hazomalania voyronii: 10.1055/S-2006-957367
- 651331 - Hazomalania voyronii: LTS0094818
- 22009 - Hernandiaceae: LTS0094818
- 3398 - Magnoliopsida: LTS0049787
- 3398 - Magnoliopsida: LTS0094818
- 3455 - Menispermaceae: LTS0049787
- 3455 - Menispermaceae: LTS0094818
- 3468 - Papaver: LTS0049787
- 3468 - Papaver: LTS0094818
- 357472 - Papaver macrostomum: 10.1080/13880200701538948
- 357472 - Papaver macrostomum: LTS0049787
- 357472 - Papaver macrostomum: LTS0094818
- 3469 - Papaver somniferum: 10.1016/S0021-9673(00)94605-3
- 3469 - Papaver somniferum: LTS0049787
- 3469 - Papaver somniferum: LTS0094818
- 215229 - Papaver somniferum subsp. setigerum: 10.1135/CCCC19961047
- 215229 - Papaver somniferum subsp. setigerum: LTS0049787
- 215229 - Papaver somniferum subsp. setigerum: LTS0094818
- 3465 - Papaveraceae: LTS0049787
- 3465 - Papaveraceae: LTS0094818
- 35493 - Streptophyta: LTS0049787
- 35493 - Streptophyta: LTS0094818
- 58023 - Tracheophyta: LTS0049787
- 58023 - Tracheophyta: LTS0094818
- 33090 - Viridiplantae: LTS0049787
- 33090 - Viridiplantae: LTS0094818
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
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Journal of pharmaceutical and biomedical analysis.
2018 May; 154(?):166-173. doi:
10.1016/j.jpba.2018.02.007
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Plant physiology.
2015 Oct; 169(2):1127-40. doi:
10.1104/pp.15.01240
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Bioorganic & medicinal chemistry.
2012 Aug; 20(15):4646-52. doi:
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Plant physiology.
2012 Jun; 159(2):618-31. doi:
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Journal of analytical toxicology.
2006 Mar; 30(2):120-4. doi:
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Anaesthesia and intensive care.
2002 Aug; 30(4):422-7. doi:
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European journal of anaesthesiology.
2002 Jul; 19(7):466-73. doi:
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Anesthesia and analgesia.
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Journal of clinical pharmacology.
2001 Jan; 41(1):44-50. doi:
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British journal of anaesthesia.
2000 Dec; 85(6):850-5. doi:
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Journal of natural products.
2000 Aug; 63(8):1146-9. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
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Intensive care medicine.
1998 May; 24(5):519-25. doi:
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Critical care medicine.
1998 Jan; 26(1):180-3. doi:
10.1097/00003246-199801000-00037
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Anaesthesia.
1997 Sep; 52(9):833-41. doi:
10.1111/j.1365-2044.1997.195-az0331.x
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Anesthesia and analgesia.
1996 Nov; 83(5):1065-71. doi:
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. [PMID: 8895287] - A M De Wolf, J A Freeman, V L Scott, W Tullock, D A Smith, D F Kisor, S Kerls, D R Cook. Pharmacokinetics and pharmacodynamics of cisatracurium in patients with end-stage liver disease undergoing liver transplantation.
British journal of anaesthesia.
1996 May; 76(5):624-8. doi:
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British journal of anaesthesia.
1996 Mar; 76(3):382-8. doi:
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Anesthesiology.
1996 Feb; 84(2):300-8. doi:
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European journal of clinical pharmacology.
1996; 49(4):325-32. doi:
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. [PMID: 8857080] - N B Eastwood, A H Boyd, C J Parker, J M Hunter. Pharmacokinetics of 1R-cis 1'R-cis atracurium besylate (51W89) and plasma laudanosine concentrations in health and chronic renal failure.
British journal of anaesthesia.
1995 Oct; 75(4):431-5. doi:
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Clinical pharmacology and therapeutics.
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Acta anaesthesiologica Scandinavica. Supplementum.
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British journal of anaesthesia.
1994 Mar; 72(3):324-7. doi:
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1993 Mar; 17(2):117-9. doi:
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Anesthesiology.
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1989 Dec; 63(6):661-6. doi:
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1989 Nov; 63(5):525-30. doi:
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1989 Nov; 63(5):598-600. doi:
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1989 Jul; 63(1):76-80. doi:
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1989 May; 62(5):548-52. doi:
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Anesthesiology.
1989 Jan; 70(1):109-11. doi:
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The American journal of the medical sciences.
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