metformin (BioDeep_00000397913)

Main id: BioDeep_00000001376

 

PANOMIX_OTCML-2023


代谢物信息卡片


metformin

化学式: C4H11N5 (129.1014)
中文名称: 1,1-二甲基双胍, 二甲双胍
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)C(=N)N=C(N)N
InChI: InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)

描述信息

A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BA - Biguanides
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98234 - Biguanide Antidiabetic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D007004 - Hypoglycemic Agents > D001645 - Biguanides
C1892 - Chemopreventive Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE Reference Standard (Level 1)
Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy[1].

同义名列表

4 个代谢物同义名

metformin; 1,1-Dimethylbiguanide; Metformin; Metformin



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 BDNF, CTNNB1, GCK, GDF15, IRS1, NOS3, PIK3C3, PTGS2, SLC2A2, SREBF1, TNK1, TP53
Peripheral membrane protein 3 GCK, PTGS2, TNK1
Endosome membrane 1 INSR
Endoplasmic reticulum membrane 3 CYP19A1, PTGS2, SREBF1
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 7 CTNNB1, GCK, GDF15, IRS1, NOS3, SREBF1, TP53
autophagosome 1 PIK3C3
cytosol 7 CTNNB1, GCK, IRS1, NOS3, PIK3C3, SREBF1, TP53
dendrite 1 BDNF
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 2 CTNNB1, TP53
nucleoplasm 6 CTNNB1, GCK, IRS1, NOS3, SREBF1, TP53
Cell membrane 5 CTNNB1, INSR, MGAM, SLC2A2, SLC5A2
lamellipodium 1 CTNNB1
Multi-pass membrane protein 5 CACNA1I, CYP19A1, SLC2A2, SLC5A2, SREBF1
Golgi apparatus membrane 2 GCK, SREBF1
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 2 CTNNB1, PIK3C3
Golgi apparatus 2 GDF15, NOS3
Golgi membrane 3 GCK, NOS3, SREBF1
neuronal cell body 2 GIP, IAPP
presynaptic membrane 1 CTNNB1
synaptic vesicle 1 BDNF
Lysosome 1 INSR
endosome 1 PIK3C3
plasma membrane 10 CACNA1I, CTNNB1, INSR, IRS1, MGAM, NOS3, REN, SLC2A2, SLC5A2, TNK1
Membrane 12 BDNF, CACNA1I, CTNNB1, CYP19A1, INSR, MGAM, PIK3C3, REN, SLC2A2, SLC5A2, TNK1, TP53
apical plasma membrane 3 MGAM, SLC2A2, SLC5A2
axon 2 BDNF, INSR
basolateral plasma membrane 2 CTNNB1, GCK
brush border 1 SLC2A2
caveola 4 INSR, IRS1, NOS3, PTGS2
extracellular exosome 5 CTNNB1, GDF15, INSR, MGAM, SLC5A2
endoplasmic reticulum 4 CYP19A1, PTGS2, SREBF1, TP53
extracellular space 5 BDNF, GDF15, GIP, IAPP, REN
perinuclear region of cytoplasm 3 BDNF, CTNNB1, NOS3
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 2 GCK, TP53
protein-containing complex 4 CTNNB1, PTGS2, SREBF1, TP53
intracellular membrane-bounded organelle 1 IRS1
Microsome membrane 2 CYP19A1, PTGS2
Single-pass type I membrane protein 1 INSR
Secreted 5 BDNF, GDF15, IAPP, MGAM, REN
extracellular region 6 BDNF, GDF15, GIP, IAPP, MGAM, REN
Single-pass membrane protein 1 MGAM
neuronal cell body membrane 1 INSR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 CTNNB1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 1 INSR
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 TP53
Wnt signalosome 1 CTNNB1
midbody 1 PIK3C3
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
apical part of cell 2 CTNNB1, REN
cell-cell junction 2 CTNNB1, SLC2A2
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 SLC5A2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 1 CTNNB1
GABA-ergic synapse 1 PIK3C3
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 PIK3C3
Nucleus, PML body 1 TP53
PML body 1 TP53
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
axoneme 1 PIK3C3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 2 INSR, PIK3C3
receptor complex 1 INSR
neuron projection 1 PTGS2
chromatin 2 SREBF1, TP53
phagocytic vesicle membrane 1 PIK3C3
cell periphery 1 CTNNB1
cytoskeleton 1 NOS3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 GCK
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
nuclear envelope 1 SREBF1
Endomembrane system 1 CTNNB1
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasmic vesicle membrane 1 SREBF1
tertiary granule membrane 1 MGAM
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 CTNNB1
germ cell nucleus 1 TP53
replication fork 1 TP53
secretory granule lumen 1 GIP
endoplasmic reticulum lumen 3 BDNF, GIP, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 1 NOS3
beta-catenin-TCF complex 1 CTNNB1
presynaptic endosome 1 PIK3C3
ER to Golgi transport vesicle membrane 1 SREBF1
presynaptic active zone cytoplasmic component 1 CTNNB1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 CTNNB1
ficolin-1-rich granule membrane 1 MGAM
dendrite membrane 1 INSR
catenin complex 1 CTNNB1
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
postsynaptic endosome 1 PIK3C3
Autolysosome 1 PIK3C3
insulin receptor complex 2 INSR, IRS1
beta-catenin-TCF7L2 complex 1 CTNNB1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1


文献列表

  • Xiaodan Chen, Faranak Bahramimehr, Nasim Shahhamzehei, Huangjie Fu, Siyi Lin, Hanxiao Wang, Changyu Li, Thomas Efferth, Chunlan Hong. Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155665. doi: 10.1016/j.phymed.2024.155665. [PMID: 38768535]
  • Erin Ussery, Mark McMaster, Vince Palace, Joanne Parrott, Nicholas C Blandford, Richard Frank, Karen Kidd, Oana Birceanu, Joanna Wilson, Mehran Alaee, Jessie Cunningham, Abby Wynia, Thomas Clark, Sheena Campbell, Lauren Timlick, Sonya Michaleski, Stephanie Marshall, Kristin Nielsen. Effects of metformin on wild fathead minnows (Pimephales promelas) using in-lake mesocosms in a boreal lake ecosystem. The Science of the total environment. 2024 Jun; 929(?):172457. doi: 10.1016/j.scitotenv.2024.172457. [PMID: 38649046]
  • Soo Lim, Seung-Hwan Lee, Kyung-Wan Min, Chang Beom Lee, Sang Yong Kim, Hye Jin Yoo, Nan Hee Kim, Jae Hyeon Kim, Seungjoon Oh, Jong Chul Won, Hyuk Sang Kwon, Mi Kyung Kim, Jung Hwan Park, In-Kyung Jeong, Sungrae Kim. A multicentre, double-blind, placebo-controlled, randomized, parallel comparison, phase 3 trial to evaluate the efficacy and safety of pioglitazone add-on therapy in type 2 diabetic patients treated with metformin and dapagliflozin. Diabetes, obesity & metabolism. 2024 Jun; 26(6):2188-2198. doi: 10.1111/dom.15526. [PMID: 38425186]
  • Yaotian Cai, Gao Jun, Xiaojie Zhuang. Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2024 Jun; 35(6):1089-1098. doi: 10.1007/s00198-023-07013-0. [PMID: 38536446]
  • Sriravali Pulipaka, Hridya Chempon, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Sunita Kumari, Rajamannar Thennati, Srigiridhar Kotamraju. Mitochondria-targeted esculetin and metformin delay endothelial senescence by promoting fatty acid β-oxidation: Relevance in age-associated atherosclerosis. Mechanisms of ageing and development. 2024 Jun; 219(?):111931. doi: 10.1016/j.mad.2024.111931. [PMID: 38554949]
  • Qian Yang, Mohammed Abed Jawad, Abdullah Ali Alzahrani, Zahraa F Hassan, Ahmed Elawady, Ahmed Hjazi, Mehran Naghibi. Synergistic effects of Metformin and Forskolin on oxidative stress induced by diabetes and hepatocellular cancer: An animal study. Toxicon : official journal of the International Society on Toxinology. 2024 May; 243(?):107720. doi: 10.1016/j.toxicon.2024.107720. [PMID: 38614244]
  • Diana Belen Onofre-Camarena, Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medina, Marcela Galar-Martínez, José Roberto Jerónimo Juárez, Selene Elizabeth Herrera-Vázquez. Assessing the impact of COVID-19 era drug combinations on hepatic functionality: A thorough investigation in adult Danio rerio. Environmental pollution (Barking, Essex : 1987). 2024 May; 349(?):123997. doi: 10.1016/j.envpol.2024.123997. [PMID: 38636837]
  • Guillem Cuatrecasas, Francisco De Cabo, M José Coves, Ioana Patrascioiu, Gerardo Aguilar, Gabriel Cuatrecasas, Sonia March, Marta Calbo, Olga Rossell, Mariona Balfegó, Camila Benito, Silvana Di Gregorio, Pilar Garcia Lorda, Elena Muñoz. Dapagliflozin added to metformin reduces perirenal fat layer in type 2 diabetic patients with obesity. Scientific reports. 2024 05; 14(1):10832. doi: 10.1038/s41598-024-61590-6. [PMID: 38734755]
  • Grace Scheidemantle, Likun Duan, Mareca Lodge, Magdalina J Cummings, Dalton Hilovsky, Eva Pham, Xiaoqiu Wang, Arion Kennedy, Xiaojing Liu. Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism. Metabolomics : Official journal of the Metabolomic Society. 2024 May; 20(3):53. doi: 10.1007/s11306-024-02113-2. [PMID: 38722395]
  • Yangchen Tang, Mengli Yan, Zemin Fang, Song Jin, Tingjuan Xu. Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice. BMJ open diabetes research & care. 2024 May; 12(3):. doi: 10.1136/bmjdrc-2023-003837. [PMID: 38719505]
  • Nesma A Ghazal, Yara T Agamia, Basant K Meky, Nagwa M Assem, Wafaa M Abdel-Rehim, Sara A Shaker. Cinnamaldehyde ameliorates STZ-induced diabetes through modulation of autophagic process in adipocyte and hepatic tissues on rats. Scientific reports. 2024 05; 14(1):10053. doi: 10.1038/s41598-024-60150-2. [PMID: 38698047]
  • Anthony J Basile, Avin Kreisler, Ryan Hassen, Kavita Singh, Maggie Symes, Gale Larson, Milena Figueiredo de Sousa, Karen L Sweazea. Acute metformin induces hyperglycemia in healthy adult mourning doves, Zenaida macroura. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2024 05; 291(?):111594. doi: 10.1016/j.cbpa.2024.111594. [PMID: 38311294]
  • Jiao Liu, Lixia Shen, Long Nguyen-Hoang, Qiongjie Zhou, Chi Chiu Wang, Xiaohong Lu, Daljit Sahota, Ka Chun Chong, Hao Ying, Weirong Gu, Rong Zhou, Huixia Yang, Yanmin Jiang, Dunjin Chen, Xiaotian Li, Liona Poon. Aspirin versus metformin in pregnancies at high risk of preterm pre-eclampsia in China (AVERT): protocol for a multicentre, double-blind, 3-arm randomised controlled trial. BMJ open. 2024 Apr; 14(4):e074493. doi: 10.1136/bmjopen-2023-074493. [PMID: 38631826]
  • Saif Alnuaimi, Tea Reljic, Fatima S Abdulla, Hamda Memon, Sarah Al-Ali, Teagen Smith, Fadila Serdarevic, Zelija Velija Asimi, Ambuj Kumar, Sabina Semiz. PPAR agonists as add-on treatment with metformin in management of type 2 diabetes: a systematic review and meta-analysis. Scientific reports. 2024 04; 14(1):8809. doi: 10.1038/s41598-024-59390-z. [PMID: 38627464]
  • Lei Dong, Shuai Li, Jie Huang, Wen-Jun Li, Mukhtiar Ali. Co-occurrence, toxicity, and biotransformation pathways of metformin and its intermediate product guanylurea: Current state and future prospects for enhanced biodegradation strategy. The Science of the total environment. 2024 Apr; 921(?):171108. doi: 10.1016/j.scitotenv.2024.171108. [PMID: 38395159]
  • Manuel Adrían Velazquez-Cervantes, Orestes López-Ortega, Victor Javier Cruz-Holguín, Luis Herrera Moro-Huitron, Arturo Flores-Pliego, Ignacio Lara-Hernandez, Mauricio Comas-García, Oscar Villavicencio-Carrisoza, Addy Cecilia Helguera-Reppeto, Haruki Arévalo-Romero, Edgar Ricardo Vázquez-Martínez, Moises León-Juárez. Metformin Inhibits Zika Virus Infection in Trophoblast Cell Line. Current microbiology. 2024 Apr; 81(5):133. doi: 10.1007/s00284-024-03651-7. [PMID: 38592489]
  • Asmaa Badawy Darwish, Amira Mohamed Mohsen, Shaimaa ElShebiney, Rania Elgohary, Mostafa Mohamed Younis. Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats. Scientific reports. 2024 04; 14(1):8247. doi: 10.1038/s41598-024-58601-x. [PMID: 38589438]
  • Runan Hu, Yanjing Huang, Yuli Geng, Zhuo Liu, Fan Li, Zhuo Zhang, Wenwen Ma, Kunkun Song, Haoxu Dong, Yufan Song, Mingmin Zhang. Jiawei Buzhong Yiqi decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication. Journal of ethnopharmacology. 2024 Apr; 323(?):117654. doi: 10.1016/j.jep.2023.117654. [PMID: 38158097]
  • Jinhui Dong, Xiaohui Tong, Jing Xu, Min Pan, Lei Wang, Fei Xu, Yajuan Wang, Li Li, Tongsheng Wang. Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice. European journal of pharmacology. 2024 Apr; 968(?):176388. doi: 10.1016/j.ejphar.2024.176388. [PMID: 38367685]
  • Shuying Jiang, Ruiqian Wang, Jian Liao. The Role of Metformin in Overactive Bladder: More Studies Are Warranted. Urology. 2024 04; 186(?):144-145. doi: 10.1016/j.urology.2023.11.038. [PMID: 38369200]
  • Yang Shu, Fujie Yang, Weidong Li, Lisha Li, Qiongying Hu, Daqian Xiong. Changes and Significance of Central Carbon Metabolism before and after Metformin Treatment of Type 2 Diabetes Based on Mass Spectrometry. Discovery medicine. 2024 Apr; 36(183):678-689. doi: 10.24976/discov.med.202436183.64. [PMID: 38665017]
  • Shahinaz Ahmed Helmy, Nashwa Fathy Sayed Morsy, Shahenda Mohamed Elaby, Mohammed Abdel Hameed Awad Ghaly. Antidiabetic Effect of Combined Leaf Extracts of Portulaca oleracea L., Beta vulgaris L., and Cichorium intybus L. in Streptozotocin-Induced Diabetic Rats. Journal of medicinal food. 2024 Apr; 27(4):339-347. doi: 10.1089/jmf.2022.0119. [PMID: 37801671]
  • Teng Zhang, Meng-Yan Wang, Guo-Dong Wang, Qiu-Yue Lv, Yu-Qian Huang, Peng Zhang, Wen Wang, Yan Zhang, Ya-Ping Bai, Li-Qun Guo. Metformin improves nonalcoholic fatty liver disease in db/db mice by inhibiting ferroptosis. European journal of pharmacology. 2024 Mar; 966(?):176341. doi: 10.1016/j.ejphar.2024.176341. [PMID: 38244761]
  • Saja Majeed Shareef, Raghad Abdulsalam Khaleel, Taif M Maryoosh. Nephroprotective effect of cranberry (Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice. Drug metabolism and personalized therapy. 2024 Mar; 39(1):35-45. doi: 10.1515/dmpt-2023-0092. [PMID: 38469711]
  • Seung-Ju Hwang, Yu-Jin Choi, Jing-Hua Wang, Chang-Gue Son. Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116250. doi: 10.1016/j.biopha.2024.116250. [PMID: 38320334]
  • Anna Evelin Juhász, Márton Péter Stubnya, Brigitta Teutsch, Noémi Gede, Péter Hegyi, Péter Nyirády, Ferenc Bánhidy, Nándor Ács, Réka Juhász. Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis. Reproductive health. 2024 Feb; 21(1):28. doi: 10.1186/s12978-024-01758-5. [PMID: 38388374]
  • Arash Bahramzadeh, Sadra Samavarchi Tehrani, Golnaz Goodarzi, ShadiSadat Seyyedebrahimi, Reza Meshkani. Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high-fat diet-fed mice. Phytotherapy research : PTR. 2024 Feb; 38(2):912-924. doi: 10.1002/ptr.8086. [PMID: 38091524]
  • Debasish Hota, Biswa M Padhy, Rituparna Maiti, Debasis Bisoi, Jyoti Prakash Sahoo, Binod K Patro, Pawan Kumar, Apurva Goel, Samudra P Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Debasis Bagchi. A Placebo-Controlled, Double-Blind Clinical Investigation to Evaluate the Efficacy of a Patented Trigonella foenum-graecum Seed Extract 'Fenfuro®' in Type 2 Diabetics. Journal of the American Nutrition Association. 2024 Feb; 43(2):147-156. doi: 10.1080/27697061.2023.2233008. [PMID: 37459747]
  • Basmah N Aldosari, Ahmed A H Abdellatif, Alanood Sunhat Almurshedi, Iman Mohammed Alfagih, Bushra Tawfeeq AlQuadeib, Asmaa Youssef A Abbas, Yasser A Hassan, Ahmed Abdelfattah, Hesham M Tawfeek. Development of oral formulation of Lepidium seeds significantly decreases the high blood glucose levels in diabetic rats: in vitro formulation and in vivo antidiabetic performance. Drug development and industrial pharmacy. 2024 Feb; 50(2):112-123. doi: 10.1080/03639045.2023.2300649. [PMID: 38156891]
  • Yanling Dai, Chen Qiu, Diandian Zhang, Mianli Li, Weinan Liu. Yam Gruel alone and in combination with metformin regulates hepatic lipid metabolism disorders in a diabetic rat model by activating the AMPK/ACC/CPT-1 pathway. Lipids in health and disease. 2024 Jan; 23(1):28. doi: 10.1186/s12944-024-02014-2. [PMID: 38273354]
  • Ai Mi, Qinxue Hu, Ying Liu, Yanna Zhao, Fenglin Shen, Jinjian Lan, Keren Lv, Bolin Wang, Ruilan Gao, Xiaoling Yu. Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice. Food & function. 2024 Jan; 15(2):794-808. doi: 10.1039/d3fo03572g. [PMID: 38131276]
  • Raditya Dewangga, Kevin Winston, Lazuardi Gayu Ilhami, Suci Indriani, Taofan Siddiq, Suko Adiarto. Association of metformin use with abdominal aortic aneurysm: A systematic review and meta-analysis. Asian cardiovascular & thoracic annals. 2024 Jan; ?(?):2184923231225794. doi: 10.1177/02184923231225794. [PMID: 38239055]
  • Paula Gallardo-Villanueva, Tamara Fernández-Marcelo, Laura Villamayor, Angela M Valverde, Sonia Ramos, Elisa Fernández-Millán, María Angeles Martín. Synergistic Effect of a Flavonoid-Rich Cocoa-Carob Blend and Metformin in Preserving Pancreatic Beta Cells in Zucker Diabetic Fatty Rats. Nutrients. 2024 Jan; 16(2):. doi: 10.3390/nu16020273. [PMID: 38257166]
  • Dan Liang, Lu Liu, Yulin Qi, Feng Nan, Ju Huang, Shiyun Tang, Jianyuan Tang, Nianzhi Chen. Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II. Journal of ethnopharmacology. 2024 Jan; 324(?):117745. doi: 10.1016/j.jep.2024.117745. [PMID: 38228231]
  • Roberto Citarrella, Roberta Chianetta, Simona Amodeo, Luigi Mirarchi, Anna Licata, Maurizio Soresi, Nicola Veronese, Mario Barbagallo, Lydia Giannitrapani. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Cinnamomum zeylanicum Blume and Inulin in Patients with Metabolic Syndrome. Nutrients. 2024 Jan; 16(2):. doi: 10.3390/nu16020249. [PMID: 38257142]
  • Yassmin Raafat Hassan, Riham A El-Shiekh, Hala M El Hefnawy, Osama G Mohamed, Karema Abu-Elfotuh, Ahmed M Hamdan, Alshaymaa Darwish, Ayah M H Gowifel, Ashootosh Tripathi, Camilia George Michael. A mechanistic exploration of the metabolome of African mango seeds and its potential to alleviate cognitive impairment induced by high-fat/high-carbohydrate diets: Involvement of PI3K/AKT/GSK-3β/CREB, PERK/CHOP/Bcl-2, and AMPK/SIRT-1/mTOR Axes. Journal of ethnopharmacology. 2024 Jan; 324(?):117747. doi: 10.1016/j.jep.2024.117747. [PMID: 38218500]
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