Nortriptyline (BioDeep_00000397504)

Main id: BioDeep_00000000644

 

PANOMIX_OTCML-2023 Antitumor activity Volatile Flavor Compounds natural product


代谢物信息卡片


Nortriptyline

化学式: C19H21N (263.16739060000003)
中文名称: 去甲替林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13
InChI: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
CONFIDENCE standard compound; INTERNAL_ID 1567
D049990 - Membrane Transport Modulators
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N

同义名列表

6 个代谢物同义名

Nortriptyline; Nortryptyline; Desmethylamitriptyline; Desitriptilina; Nortriptyline; Nortriptyline



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao. Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation. Cell communication and signaling : CCS. 2023 May; 21(1):123. doi: 10.1186/s12964-023-01128-x. [PMID: 37231437]
  • Bram Bogaert, Félix Sauvage, Roberta Guagliardo, Cristina Muntean, Van Phuc Nguyen, Eline Pottie, Mike Wels, An-Katrien Minnaert, Riet De Rycke, Qiangbing Yang, Dan Peer, Niek Sanders, Katrien Remaut, Yannis M Paulus, Christophe Stove, Stefaan C De Smedt, Koen Raemdonck. A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs. Journal of controlled release : official journal of the Controlled Release Society. 2022 10; 350(?):256-270. doi: 10.1016/j.jconrel.2022.08.009. [PMID: 35963467]
  • Iraj Yazdani, Raheleh Majdani, Morteza Ghasemnejad-Berenji, Ahmad Reza Dehpour. Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rats: a comparative study. BMC pharmacology & toxicology. 2022 08; 23(1):59. doi: 10.1186/s40360-022-00601-6. [PMID: 35932053]
  • Nicklas Hasselblad Lundstrøm, Nikolaj K Holgersen, Maija Bruun Haastrup. The effect of smoking on the plasma concentration of tricyclic antidepressants: a systematic review. Acta neuropsychiatrica. 2022 Feb; 34(1):1-9. doi: 10.1017/neu.2021.28. [PMID: 34497000]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Naomi T Jessurun, Annemieke Vermeulen Windsant, Oenone Mikes, Eugène P van Puijenbroek, Rob J van Marum, Koen Grootens, Hieronymus J Derijks. Inhibition of CYP2D6 with low dose (5 mg) paroxetine in patients with high 10-hydroxynortriptyline serum levels-A prospective pharmacokinetic study. British journal of clinical pharmacology. 2021 03; 87(3):1529-1532. doi: 10.1111/bcp.14455. [PMID: 32621544]
  • Pansy Elsamadisi, Alyssa Sclafani, Ifeoma Mary Eche. Delayed Cardiotoxicity From a Massive Nortriptyline Overdose Requiring Prolonged Treatment. Journal of pharmacy practice. 2020 Aug; 33(4):543-547. doi: 10.1177/0897190019838700. [PMID: 30983469]
  • Hossein Salar Amoli, Yadollah Yamini, Hossein Darmani. Polyoxomolybdate368 /polyaniline nanocomposite as a novel fiber for solid-phase microextraction of antidepressant drugs in biological samples. Journal of separation science. 2020 Jul; 43(13):2636-2645. doi: 10.1002/jssc.201901152. [PMID: 32277789]
  • Blanka Miková, Miloš Dvořák, Lenka Ryšavá, Pavel Kubáň. Hollow Fiber Liquid-Phase Microextraction At-Line Coupled to Capillary Electrophoresis for Direct Analysis of Human Body Fluids. Analytical chemistry. 2020 05; 92(10):7171-7178. doi: 10.1021/acs.analchem.0c00697. [PMID: 32289222]
  • Fernanda Midori de Oliveira, Guilherme Luiz Scheel, Rodinei Augusti, César Ricardo Teixeira Tarley, Clésia Cristina Nascentes. Supramolecular microextraction combined with paper spray ionization mass spectrometry for sensitive determination of tricyclic antidepressants in urine. Analytica chimica acta. 2020 Apr; 1106(?):52-60. doi: 10.1016/j.aca.2020.01.061. [PMID: 32145855]
  • Anderson Luiz Oenning, Letícia Birk, Sarah Eller, Tiago Franco de Oliveira, Josias Merib, Eduardo Carasek. A green and low-cost method employing switchable hydrophilicity solvent for the simultaneous determination of antidepressants in human urine by gas chromatography - mass spectrometry detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1143(?):122069. doi: 10.1016/j.jchromb.2020.122069. [PMID: 32213465]
  • Maike Scherf-Clavel, Jasper Zebner, Leif Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients. European journal of clinical pharmacology. 2020 Jan; 76(1):73-80. doi: 10.1007/s00228-019-02766-2. [PMID: 31641787]
  • Ioana-Miruna Balmus, Radu Lefter, Alin Ciobica, Sabina Cojocaru, Samson Guenne, Daniel Timofte, Carol Stanciu, Anca Trifan, Luminita Hritcu. Preliminary Biochemical Description of Brain Oxidative Stress Status in Irritable Bowel Syndrome Contention-Stress Rat Model. Medicina (Kaunas, Lithuania). 2019 Dec; 55(12):. doi: 10.3390/medicina55120776. [PMID: 31817740]
  • Luana Mifsud Buhagiar, Carmel Sammut, Yana Chircop, Kersty Axisa, Nicolette Sammut Bartolo, Janis Vella Szijj, Anthony Serracino Inglott, Godfrey LaFerla. Practical liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of amitriptyline, nortriptyline and their hydroxy metabolites in human serum. Biomedical chromatography : BMC. 2019 Dec; 33(12):e4679. doi: 10.1002/bmc.4679. [PMID: 31415098]
  • Mehran Haidari, Sravan Mansani, Dezaray Ponds, Lissett Romero, Christine Cobb, Saad Alsaab. Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs. Clinica chimica acta; international journal of clinical chemistry. 2019 Dec; 499(?):81-86. doi: 10.1016/j.cca.2019.09.001. [PMID: 31491368]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Karen Robijns, Niels W Boone, Rob T P Jansen, Aldy W H M Kuypers, Cees Neef, Daan J Touw. Commutability of proficiency testing material containing amitriptyline and nortriptyline: A study within the framework of the Dutch Calibration 2.000 project. Clinica chimica acta; international journal of clinical chemistry. 2019 Nov; 498(?):6-10. doi: 10.1016/j.cca.2019.07.036. [PMID: 31374190]
  • Abdullah Al Maruf, Alexandra Greenslade, Paul D Arnold, Chad Bousman. Antidepressant pharmacogenetics in children and young adults: A systematic review. Journal of affective disorders. 2019 07; 254(?):98-108. doi: 10.1016/j.jad.2019.05.025. [PMID: 31112844]
  • S N Kondratenko, M I Savelyeva, V G Kukes, E V Shikh, E T Gneushev. Experimental and Clinical Pharmacokinetics of Fluoxetine and Amitriptyline: Comparative Analysis and Possible Methods of Extrapolation. Bulletin of experimental biology and medicine. 2019 Jul; 167(3):356-362. doi: 10.1007/s10517-019-04526-9. [PMID: 31346879]
  • Matthew C Castellana, Andrea Castellar Montes, Jon E Sprague, Tarek M Mahfouz. A high-quality homology model for the human dopamine transporter validated for drug design purposes. Chemical biology & drug design. 2019 05; 93(5):700-711. doi: 10.1111/cbdd.13495. [PMID: 30721576]
  • Ara Koh, Kwan Cheol Pak, Hee Youn Choi, Sunae Ryu, Seung-Eun Choi, Ki Soon Kim, Kyun-Seop Bae, Hyeong-Seok Lim. Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline. Journal of clinical pharmacology. 2019 04; 59(4):532-540. doi: 10.1002/jcph.1344. [PMID: 30452773]
  • Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2. International clinical psychopharmacology. 2019 03; 34(2):93-100. doi: 10.1097/yic.0000000000000250. [PMID: 30557209]
  • Rhian Alice Ceredig, Florian Pierre, Stéphane Doridot, Unai Alduntzin, Eric Salvat, Ipek Yalcin, Claire Gaveriaux-Ruff, Michel Barrot, Dominique Massotte. Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain. The European journal of neuroscience. 2018 09; 48(5):2231-2246. doi: 10.1111/ejn.14093. [PMID: 30059180]
  • Iris Usach, José-Maria Ferrer, José-Esteban Peris. In vitro assessment of competitive and time-dependent inhibition of the nevirapine metabolism by nortriptyline in rats. Biochemical pharmacology. 2018 08; 154(?):1-9. doi: 10.1016/j.bcp.2018.04.016. [PMID: 29674001]
  • Iris Usach, Pablo Compañ, José-Esteban Peris. Sex-dependent metabolism of nevirapine in rats: impact on plasma levels, pharmacokinetics and interaction with nortriptyline. International journal of antimicrobial agents. 2018 May; 51(5):707-713. doi: 10.1016/j.ijantimicag.2017.12.026. [PMID: 29309900]
  • Pratik Kumar Jagtap, Kavita Tapadia. Pharmacokinetic determination and analysis of nortriptyline based on GC-MS coupled with hollow-fiber drop-to-drop solvent microextraction technique. Bioanalysis. 2018 Feb; 10(3):143-152. doi: 10.4155/bio-2017-0207. [PMID: 29333862]
  • Andrea Šlampová, Pavel Kubáň. Direct Analysis of Free Aqueous and Organic Operational Solutions as a Tool for Understanding Fundamental Principles of Electromembrane Extraction. Analytical chemistry. 2017 12; 89(23):12960-12967. doi: 10.1021/acs.analchem.7b03829. [PMID: 29083873]
  • Adriana S F S J Ayres, Wilton B Santos, Décio D Junqueira-Ayres, Geison M Costa, Freddy A Ramos, Leonardo Castellanos, Jovelina S F Alves, Laila Asth, Iris U de Medeiros, Silvana M Zucolotto, Elaine C Gavioli. Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis. Neuroscience letters. 2017 Nov; 660(?):79-85. doi: 10.1016/j.neulet.2017.09.010. [PMID: 28893593]
  • Akiko Mikami, Satoko Hori, Hisakazu Ohtani, Yasufumi Sawada. Analysis of the Mechanism of Prolonged Persistence of Drug Interaction between Terbinafine and Amitriptyline or Nortriptyline. Biological & pharmaceutical bulletin. 2017; 40(7):1010-1020. doi: 10.1248/bpb.b16-01004. [PMID: 28674244]
  • Virginia Melis, Iris Usach, Patricia Gandía, José-Esteban Peris. Inhibition of Efavirenz Metabolism by Sertraline and Nortriptyline and Their Effect on Efavirenz Plasma Concentrations. Antimicrobial agents and chemotherapy. 2016 Feb; 60(2):1022-8. doi: 10.1128/aac.02129-15. [PMID: 26643342]
  • Christopher A Crutchfield, Autumn R Breaud, William A Clarke. Quantification of Tricyclic Antidepressants in Serum Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS). Methods in molecular biology (Clifton, N.J.). 2016; 1383(?):265-70. doi: 10.1007/978-1-4939-3252-8_27. [PMID: 26660194]
  • C Norkus, D Rankin, B KuKanich. Evaluation of the pharmacokinetics of oral amitriptyline and its active metabolite nortriptyline in fed and fasted Greyhound dogs. Journal of veterinary pharmacology and therapeutics. 2015 Dec; 38(6):619-22. doi: 10.1111/jvp.12237. [PMID: 25989225]
  • Yousef Abdossalami Asl, Yadollah Yamini, Shahram Seidi, Hatam Amanzadeh. Dynamic electromembrane extraction: Automated movement of donor and acceptor phases to improve extraction efficiency. Journal of chromatography. A. 2015 Nov; 1419(?):10-8. doi: 10.1016/j.chroma.2015.09.077. [PMID: 26455283]
  • Christopher Norkus, David Rankin, Butch KuKanich. Pharmacokinetics of intravenous and oral amitriptyline and its active metabolite nortriptyline in Greyhound dogs. Veterinary anaesthesia and analgesia. 2015 Nov; 42(6):580-9. doi: 10.1111/vaa.12248. [PMID: 25683584]
  • Henriette N Buttenschøn, Leslie Foldager, Betina Elfving, Pia H P Poulsen, Rudolf Uher, Ole Mors. Neurotrophic factors in depression in response to treatment. Journal of affective disorders. 2015 Sep; 183(?):287-94. doi: 10.1016/j.jad.2015.05.027. [PMID: 26047306]
  • Karen Hodgson, Katherine E Tansey, Rudolf Uher, Mojca Zvezdana Dernovšek, Ole Mors, Joanna Hauser, Daniel Souery, Wolfgang Maier, Neven Henigsberg, Marcella Rietschel, Anna Placentino, Ian W Craig, Katherine J Aitchison, Anne E Farmer, Richard J B Dobson, Peter McGuffin. Exploring the role of drug-metabolising enzymes in antidepressant side effects. Psychopharmacology. 2015 Jul; 232(14):2609-17. doi: 10.1007/s00213-015-3898-x. [PMID: 25761838]
  • Unaiza Qamar, Nisar Ahmad, Saima Farhan. Per Oral Bleeding: Rare Presentation of Gardner-Diamond Syndrome. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2015 Jun; 25(6):465-6. doi: 06.2015/jcpsp.465466. [PMID: 26101006]
  • Stine B Vogensen, Lars Jørgensen, Karsten K Madsen, Andreas Jurik, Nrupa Borkar, Emiliano Rosatelli, Birgitte Nielsen, Gerhard F Ecker, Arne Schousboe, Rasmus P Clausen. Structure activity relationship of selective GABA uptake inhibitors. Bioorganic & medicinal chemistry. 2015 May; 23(10):2480-8. doi: 10.1016/j.bmc.2015.03.060. [PMID: 25882526]
  • E J J Berm, J Paardekooper, E Brummel-Mulder, E Hak, B Wilffert, J G Maring. A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS. Talanta. 2015 Mar; 134(?):165-172. doi: 10.1016/j.talanta.2014.10.041. [PMID: 25618654]
  • T V Maksimova, T V Pleteneva, E M Salomatin, E A Kozina, S S Barsegjan. [The determination of amitriptyline and its metabolite, nortriptyline, in the biological objects of the corpse by the high-performance liquid chromatography technique]. Sudebno-meditsinskaia ekspertiza. 2015 Jan; 58(1):31-34. doi: 10.17116/sudmed201558131-34. [PMID: 25874316]
  • Iris Usach, Virginia Melis, Patricia Gandía, José-Esteban Peris. Pharmacokinetic interaction between nevirapine and nortriptyline in rats: inhibition of nevirapine metabolism by nortriptyline. Antimicrobial agents and chemotherapy. 2014 Dec; 58(12):7041-8. doi: 10.1128/aac.03312-14. [PMID: 25224004]
  • Mariola Sliwińska-Mossoń, Iwona Zieleń, Halina Milnerowicz. New trends in the treatment of nicotine addiction. Acta poloniae pharmaceutica. 2014 Jul; 71(4):525-30. doi: . [PMID: 25272878]
  • Serena Cuboni, Felix Hausch. Snapshot of antidepressants at work: the structure of neurotransmitter transporter proteins. Angewandte Chemie (International ed. in English). 2014 May; 53(20):5008-9. doi: 10.1002/anie.201310567. [PMID: 24729171]
  • Harumasa Takano, Ryosuke Arakawa, Tsuyoshi Nogami, Masayuki Suzuki, Tomohisa Nagashima, Hironobu Fujiwara, Yasuyuki Kimura, Fumitoshi Kodaka, Keisuke Takahata, Hitoshi Shimada, Yoshitaka Murakami, Amane Tateno, Makiko Yamada, Hiroshi Ito, Kazunori Kawamura, Ming-Rong Zhang, Hidehiko Takahashi, Motoichiro Kato, Yoshiro Okubo, Tetsuya Suhara. Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[¹⁸F]FMeNER-D₂. The international journal of neuropsychopharmacology. 2014 Apr; 17(4):553-60. doi: 10.1017/s1461145713001521. [PMID: 24345533]
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  • Sophie J Bordson, Rabia S Atayee, Joseph D Ma, Brookie M Best. Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. Pain medicine (Malden, Mass.). 2014 Mar; 15(3):355-63. doi: 10.1111/pme.12300. [PMID: 24308804]
  • Karen Hodgson, Katherine Tansey, Mojca Zvezdana Dernovsek, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietschel, Daniel Souery, Rebecca Smith, Ian W Craig, Anne E Farmer, Katherine J Aitchison, Sarah Belsey, Sarah Belsy, Oliver S P Davis, Rudolf Uher, Peter McGuffin. Genetic differences in cytochrome P450 enzymes and antidepressant treatment response. Journal of psychopharmacology (Oxford, England). 2014 Feb; 28(2):133-41. doi: 10.1177/0269881113512041. [PMID: 24257813]
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