Nortriptyline (BioDeep_00000397504)
Main id: BioDeep_00000000644
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
Nortriptyline
化学式: C19H21N (263.16739060000003)
中文名称: 去甲替林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13
InChI: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
CONFIDENCE standard compound; INTERNAL_ID 1567
D049990 - Membrane Transport Modulators
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N
同义名列表
4 个代谢物同义名
Nortriptyline; Nortryptyline; Desmethylamitriptyline; Desitriptilina
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:7640
- KEGG: C07274
- KEGGdrug: D08288
- PubChem: 4543
- DrugBank: DB00540
- ChEMBL: CHEMBL445
- MeSH: Nortriptyline
- CAS: 72-69-5
- MoNA: WA000741
- MoNA: WA000740
- MoNA: WA000739
- MoNA: WA000738
- MoNA: WA000737
- MoNA: AU156706
- PubChem: 9483
- PDB-CCD: 21B
- NIKKAJI: J5.253A
- RefMet: Nortriptyline
- medchemexpress: HY-118620
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 138013 - Senegalia berlandieri: 10.1016/S0031-9422(97)00240-9
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao. Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation.
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2023 May; 21(1):123. doi:
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2022 10; 350(?):256-270. doi:
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BMC pharmacology & toxicology.
2022 08; 23(1):59. doi:
10.1186/s40360-022-00601-6. [PMID: 35932053] - Nicklas Hasselblad Lundstrøm, Nikolaj K Holgersen, Maija Bruun Haastrup. The effect of smoking on the plasma concentration of tricyclic antidepressants: a systematic review.
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The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2011 Oct; 12(7):528-38. doi:
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Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
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Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2011 Apr; 6(2):89-98. doi:
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The pharmacogenomics journal.
2011 Apr; 11(2):138-45. doi:
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Human psychopharmacology.
2011 Apr; 26(3):252-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Feb; 39(2):312-21. doi:
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Journal of separation science.
2010 Dec; 33(23-24):3774-80. doi:
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Journal of pharmaceutical and biomedical analysis.
2010 Nov; 53(3):735-9. doi:
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Biomedical chromatography : BMC.
2010 Oct; 24(10):1113-9. doi:
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Bioanalysis.
2010 Sep; 2(9):1553-60. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2010 Aug; 34(6):1037-48. doi:
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Psychopharmacology.
2010 Jun; 210(3):331-6. doi:
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Journal of psychopharmacology (Oxford, England).
2010 Apr; 24(4):531-5. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Mar; 878(9-10):841-4. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2010 Mar; 6(1):72-3. doi:
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Analytica chimica acta.
2010 Jan; 658(2):133-40. doi:
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Addiction (Abingdon, England).
2009 Dec; 104(12):2110-7. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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The pharmacogenomics journal.
2009 Aug; 9(4):225-33. doi:
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The British journal of psychiatry : the journal of mental science.
2009 Jul; 195(1):30-8. doi:
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Journal of pharmaceutical sciences.
2009 Apr; 98(4):1587-601. doi:
10.1002/jps.21511. [PMID: 18780336] - Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
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Pharmacoepidemiology and drug safety.
2009 Mar; 18(3):253-7. doi:
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Psychiatria polska.
2008 Nov; 42(6):903-14. doi:
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Journal of separation science.
2008 Jul; 31(12):2288-94. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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Talanta.
2008 Jun; 75(5):1293-9. doi:
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Journal of colloid and interface science.
2008 Mar; 319(1):81-93. doi:
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Clinical pharmacology and therapeutics.
2008 Mar; 83(3):436-42. doi:
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British journal of clinical pharmacology.
2008 Jan; 65(1):134-8. doi:
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Clinical pharmacology and therapeutics.
2007 Nov; 82(5):606-9. doi:
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Journal of forensic sciences.
2007 Nov; 52(6):1396-400. doi:
10.1111/j.1556-4029.2007.00583.x. [PMID: 18093069] - Claudete Alves, Alvaro J Santos-Neto, Christian Fernandes, José C Rodrigues, Fernando M Lanças. Analysis of tricyclic antidepressant drugs in plasma by means of solid-phase microextraction-liquid chromatography-mass spectrometry.
Journal of mass spectrometry : JMS.
2007 Oct; 42(10):1342-7. doi:
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Life sciences.
2007 Sep; 81(15):1205-10. doi:
10.1016/j.lfs.2007.08.020. [PMID: 17889906] - Zheng Zhou, Juan Zhen, Nathan K Karpowich, Regina M Goetz, Christopher J Law, Maarten E A Reith, Da-Neng Wang. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science (New York, N.Y.).
2007 Sep; 317(5843):1390-3. doi:
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Regional anesthesia and pain medicine.
2007 Sep; 32(5):377-81. doi:
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Yao xue xue bao = Acta pharmaceutica Sinica.
2007 Aug; 42(8):843-8. doi:
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The Chinese journal of physiology.
2006 Dec; 49(6):283-9. doi:
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JAMA.
2006 Oct; 296(13):1609-18. doi:
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Analytical and bioanalytical chemistry.
2006 Sep; 386(2):256-63. doi:
10.1007/s00216-006-0629-5. [PMID: 16896629] - Soo-Youn Lee, Kwang Min Sohn, Ji Young Ryu, Young Ran Yoon, Jae Gook Shin, Jong-Won Kim. Sequence-based CYP2D6 genotyping in the Korean population.
Therapeutic drug monitoring.
2006 Jun; 28(3):382-7. doi:
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