Kainic acid (BioDeep_00000396427)

 

Secondary id: BioDeep_00000003872

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


InChI=1/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s

化学式: C10H15NO4 (213.100103)
中文名称: 海藻酸, 卡英酸, 海人草酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 31.25%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Kainic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/kainic_acid (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000396427). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(=C)C1CNC(C1CC(=O)O)C(=O)O
InChI: InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

描述信息

Kainic acid is a dicarboxylic acid, a pyrrolidinecarboxylic acid, a L-proline derivative and a non-proteinogenic L-alpha-amino acid. It has a role as an antinematodal drug and an excitatory amino acid agonist. It is a conjugate acid of a kainate(1-).
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].

同义名列表

54 个代谢物同义名

InChI=1/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2-alpha,3-beta,4-beta))-; (2S-(2.ALPHA.,3.BETA.,4.BETA.))-2-CARBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-; (2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid; (2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid; (2S,3S,4S)-3-(Carboxymethyl)-4-Prop-1-En-2-yl-Pyrrolidine-2-Carboxylicacid; (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-; (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid; L-proline, 3-(carboxymethyl)-4-(1-methylethenyl)-, (3S,4S)-; 2S-CARBOXY-4S-(1-METHYLETHENYL)-3S-PYRROLDINEACETIC ACID; (3S,4R)-3-(carboxymethyl)-4-(prop-1-en-2-yl)-L-proline; rel-(3R,4R)-3-(carboxymethyl)-4-isopropenyl-D-proline; (3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-yl-L-proline; 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl-; 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine; 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic acid; 4-22-00-01523 (Beilstein Handbook Reference); 3-(Carboxymethyl)-4-isopropenylproline; Acide kainique [INN-French]; Acidum kainicum [INN-Latin]; Acido kainico [INN-Spanish]; (-)-(.alpha.)-Kainic Acid; Kainic acid (synthetic); Kainic acid [INN:JAN]; KAINIC ACID [WHO-DD]; L-alpha-Kainic acid; alpha- Kainic acid; KAINIC ACID [INN]; alpha-Kainic acid; KAINIC ACID [MI]; Acidum kainicum; rac Kainic Acid; Acide kainique; Tox21_110905_1; BPBio1_001306; Lopac0_000656; Acid, Digenic; Acido kainico; Tox21_500656; Digenic acid; Acid, Kainic; Tox21_110905; Kainic acid; Digensaeure; kainic-acid; Kainsaeure; C10H15NO4; Helminal; Digenin; Kainate; 1p1n; KAI



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cheng-Wei Lu, Tzu-Yu Lin, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Gypenoside XVII Reduces Synaptic Glutamate Release and Protects against Excitotoxic Injury in Rats. Biomolecules. 2024 May; 14(5):. doi: 10.3390/biom14050589. [PMID: 38785996]
  • Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh, Su-Jane Wang. Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats. European journal of pharmacology. 2024 Jan; 963(?):176280. doi: 10.1016/j.ejphar.2023.176280. [PMID: 38113967]
  • Ming-Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wang. Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats. European journal of pharmacology. 2023 Dec; 961(?):176197. doi: 10.1016/j.ejphar.2023.176197. [PMID: 38000721]
  • Miaomiao Du, Jing Wang, Yuan Jin, Jingfeng Fan, Shuaijun Zan, Zelong Li. Response mechanism of microbial community during anaerobic biotransformation of marine toxin domoic acid. Environmental research. 2022 12; 215(Pt 2):114410. doi: 10.1016/j.envres.2022.114410. [PMID: 36154856]
  • Antoine Kavaye Kandeda, Saleh Nodeina, Symphorien Talom Mabou. An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention. Metabolic brain disease. 2022 10; 37(7):2581-2602. doi: 10.1007/s11011-022-01052-y. [PMID: 35916986]
  • Taiwo G Olubodun-Obadun, Ismail O Ishola, Benneth Ben-Azu, Olasunmbo Afolayan, Ekene Nwose, Ayorinde B James, Abayomi M Ajayi, Solomon Umukoro, Olufunmilayo O Adeyemi. Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures. Journal of food biochemistry. 2022 10; 46(10):e14342. doi: 10.1111/jfbc.14342. [PMID: 35851712]
  • Zhangjin Qin, Jiaqi Song, Aolei Lin, Wei Yang, Wenbo Zhang, Fuxin Zhong, Lihong Huang, Yang Lü, Weihua Yu. GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome. Journal of neuroinflammation. 2022 May; 19(1):121. doi: 10.1186/s12974-022-02482-2. [PMID: 35624482]
  • Wei-Horng Jean, Chih-Ta Huang, Jung-Hsuan Hsu, Kuan-Ming Chiu, Ming-Yi Lee, Jiann-Shing Shieh, Tzu-Yu Lin, Su-Jane Wang. Anticonvulsive and Neuroprotective Effects of Eupafolin in Rats Are Associated with the Inhibition of Glutamate Overexcitation and Upregulation of the Wnt/β-Catenin Signaling Pathway. ACS chemical neuroscience. 2022 05; 13(10):1594-1603. doi: 10.1021/acschemneuro.2c00227. [PMID: 35500294]
  • Edavalath Methal Ramya, Garlapati Phani Kumar, Yadavalli Chandrasekhar, Kandangath Raghavan Anilakumar. Adaptogenic potential of ginsenosides against domoic acid-induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and in silico studies. Journal of food biochemistry. 2022 05; 46(5):e14089. doi: 10.1111/jfbc.14089. [PMID: 35102569]
  • Antoine Kavaye Kandeda, Symphorien Talom Mabou, Clémentine Moutchida. An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation. Epilepsy & behavior : E&B. 2022 04; 129(?):108611. doi: 10.1016/j.yebeh.2022.108611. [PMID: 35193072]
  • Milos Bogdanovic, Hila Asraf, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel. The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 03; 42(13):2824-2834. doi: 10.1523/jneurosci.0908-21.2022. [PMID: 35169020]
  • Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats. International journal of molecular sciences. 2022 Feb; 23(5):. doi: 10.3390/ijms23052641. [PMID: 35269784]
  • Lubing Li, Xiahatai Ayiding, Ran Han. miRNA-Gene Interaction Network Construction Strategy to Discern Promising Traditional Chinese Medicine against Osteoporosis. BioMed research international. 2022; 2022(?):9093614. doi: 10.1155/2022/9093614. [PMID: 35757478]
  • Xiaomao Li, Yan Liu, Siyi Wang, Yikai Jiang, Adnan Mohammed Algradi, Yuanyuan Zhou, Juan Pan, Wei Guan, Haixue Kuang, Bingyou Yang. The Aerial Parts of Bupleurum Chinense DC. Aromatic Oil Attenuate Kainic Acid-Induced Epilepsy-Like Behavior and Its Potential Mechanisms. BioMed research international. 2022; 2022(?):1234612. doi: 10.1155/2022/1234612. [PMID: 35445130]
  • Ali Hasanvand, Azam Hosseinzadeh, Morteza Saeedavi, Mehdi Goudarzi, Zahra Basir, Saeed Mehrzadi. Neuroprotective effects of tannic acid against kainic acid-induced seizures in mice. Human & experimental toxicology. 2022 Jan; 41(?):9603271221093989. doi: 10.1177/09603271221093989. [PMID: 35544363]
  • Tomoya Sano, Yasushi Masuda, Hironobu Yasuno, Tadahiro Shinozawa, Takeshi Watanabe, Masaaki Kakehi. Blood Neurofilament Light Chain as a Potential Biomarker for Central and Peripheral Nervous Toxicity in Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2021 12; 185(1):10-18. doi: 10.1093/toxsci/kfab122. [PMID: 34677616]
  • Emmanuel S Ojo, Ismail O Ishola, Olasunmbo Afolayan, Ayorinde B James, Benneth Ben-Azu, Olufunmilayo O Adeyemi. Cnestis ferruginea Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice. Drug metabolism and personalized therapy. 2021 12; 37(2):191-200. doi: 10.1515/dmpt-2021-0145. [PMID: 34881530]
  • Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang. Chlorogenic Acid Decreases Glutamate Release from Rat Cortical Nerve Terminals by P/Q-Type Ca2+ Channel Suppression: A Possible Neuroprotective Mechanism. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111447. [PMID: 34768876]
  • Wei Lin, Xiao Qian, Li-Kun Yang, Jie Zhu, Dan Wang, Chun-Hua Hang, Yuhai Wang, Tao Chen. Inhibition of miR-134-5p protects against kainic acid-induced excitotoxicity through Sirt3-mediated preservation of mitochondrial function. Epilepsy research. 2021 10; 176(?):106722. doi: 10.1016/j.eplepsyres.2021.106722. [PMID: 34273723]
  • Cara L Field, Sophie T Whoriskey, Xianguo Zhao, Mark G Papich. PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2021 Sep; 52(3):872-879. doi: 10.1638/2020-0223. [PMID: 34687502]
  • Yingchun Xiang, Yumiao Niu, Yacong Xie, Shishuo Chen, Feng Zhu, Weida Shen, Ling-Hui Zeng. Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid-induced neurite injury. Brain and behavior. 2021 08; 11(8):e2266. doi: 10.1002/brb3.2266. [PMID: 34156163]
  • Shaunik Sharma, Steven Carlson, Adriana Gregory-Flores, Andy Hinojo-Perez, Ashley Olson, Thimmasettappa Thippeswamy. Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy. Neurobiology of disease. 2021 08; 156(?):105410. doi: 10.1016/j.nbd.2021.105410. [PMID: 34087381]
  • Emily K Bowers, Raphaela Stimmelmayr, Kathi A Lefebvre. Stability of Domoic Acid in 50\% Methanol Extracts and Raw Fecal Material from Bowhead Whales (Balaena mysticetus). Marine drugs. 2021 Jul; 19(8):. doi: 10.3390/md19080423. [PMID: 34436262]
  • Zhou Wu, Tushar Deshpande, Lukas Henning, Peter Bedner, Gerald Seifert, Christian Steinhäuser. Cell death of hippocampal CA1 astrocytes during early epileptogenesis. Epilepsia. 2021 07; 62(7):1569-1583. doi: 10.1111/epi.16910. [PMID: 33955001]
  • Elva Martin-Batista, Laura E Maglio, Natalia Armas-Capote, Guadalberto Hernández, Diego Alvarez de la Rosa, Teresa Giraldez. SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms. Neurobiology of disease. 2021 06; 153(?):105317. doi: 10.1016/j.nbd.2021.105317. [PMID: 33639207]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Corinne M Gibble, Raphael M Kudela, Susan Knowles, Barbara Bodenstein, Kathi A Lefebvre. Domoic acid and saxitoxin in seabirds in the United States between 2007 and 2018. Harmful algae. 2021 03; 103(?):101981. doi: 10.1016/j.hal.2021.101981. [PMID: 33980431]
  • Antoine Kavaye Kandeda, Fleur Clarisse Okomolo Moto, Jean Pierre Omam Omam, Rigobert Espoir Mbomo Ayissi, Lucie Ojong, Elisabeth Ngo Bum. Pergularia daemia alters epileptogenesis and attenuates cognitive impairment in kainate-treated mice: Insight into anti-inflammatory mechanisms. Epilepsy & behavior : E&B. 2021 02; 115(?):107707. doi: 10.1016/j.yebeh.2020.107707. [PMID: 33429138]
  • Spencer E Fire, Andrea Bogomolni, Robert A DiGiovanni, Greg Early, Tod A Leighfield, Keith Matassa, Glenn A Miller, Kathleen M T Moore, Michael Moore, Misty Niemeyer, Katie Pugliares, Zhihong Wang, Frederick W Wenzel. An assessment of temporal, spatial and taxonomic trends in harmful algal toxin exposure in stranded marine mammals from the U.S. New England coast. PloS one. 2021; 16(1):e0243570. doi: 10.1371/journal.pone.0243570. [PMID: 33406141]
  • Szu Kai Hsu, Chi Feng Hung, Hsiao Ching Yang, Jing Ru Weng, Su Jane Wang. TCD, a triterpenoid isolated from wild bitter gourd, reduces synaptosomal release of glutamate and protects against kainic acid-induced neuronal death. Food & function. 2020 Nov; 11(11):9858-9867. doi: 10.1039/d0fo02039g. [PMID: 33089839]
  • Gary P Brennan, Sebastian Bauer, Tobias Engel, Eva M Jimenez-Mateos, Federico Del Gallo, Thomas D M Hill, Niamh M C Connolly, Lara S Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R Reschke, Norman Delanty, Jochen H M Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C Henshall. Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy. Neurobiology of disease. 2020 10; 144(?):105048. doi: 10.1016/j.nbd.2020.105048. [PMID: 32800995]
  • Santosh Rijal, Dong Hyu Cho, Seon-Ah Park, Seon Hui Jang, István M Ábrahám, Seong Kyu Han. Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21175991. [PMID: 32825350]
  • Jianwen Cao, Cheng Tang, Manman Gao, Yanggang Rui, Jie Zhang, Li Wang, Yang Wang, Bo Xu, Bing Chun Yan. Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy. Journal of ethnopharmacology. 2020 Jul; 257(?):112884. doi: 10.1016/j.jep.2020.112884. [PMID: 32311482]
  • Sara Shum, Jing Jing, Rebekah Petroff, Brenda Crouthamel, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen. Maternal-fetal disposition of domoic acid following repeated oral dosing during pregnancy in nonhuman primate. Toxicology and applied pharmacology. 2020 07; 398(?):115027. doi: 10.1016/j.taap.2020.115027. [PMID: 32360744]
  • Natalia Armas-Capote, Laura E Maglio, Leonel Pérez-Atencio, Elva Martin-Batista, Antonio Reboreda, Juan A Barios, Guadalberto Hernandez, Diego Alvarez de la Rosa, José Antonio Lamas, Luis C Barrio, Teresa Giraldez. SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures. Cerebral cortex (New York, N.Y. : 1991). 2020 05; 30(5):3184-3197. doi: 10.1093/cercor/bhz302. [PMID: 31819941]
  • Cheng Wei Lu, Tzu Yu Lin, Su Jane Wang. 11-Keto-β-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus. Planta medica. 2020 Apr; 86(6):434-441. doi: 10.1055/a-1107-9337. [PMID: 32097973]
  • Ning Weng, Jingbo Sun, Shixiang Kuang, Hai Lan, Qiansong He, Hui Yang, Lin Zhang, Hong Xue. MicroRNA-451 Aggravates Kainic Acid-induced Seizure and Neuronal Apoptosis by Targeting GDNF. Current neurovascular research. 2020; 17(1):50-57. doi: 10.2174/1567202617666191223150510. [PMID: 31870266]
  • Shun Nagashima, Keisuke Takeda, Isshin Shiiba, Mizuho Higashi, Toshifumi Fukuda, Takeshi Tokuyama, Nobuko Matsushita, Seiichi Nagano, Toshiyuki Araki, Mari Kaneko, Go Shioi, Ryoko Inatome, Shigeru Yanagi. Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies. Scientific reports. 2019 12; 9(1):20107. doi: 10.1038/s41598-019-56559-9. [PMID: 31882856]
  • Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis. Molecular neurobiology. 2019 Dec; 56(12):8451-8474. doi: 10.1007/s12035-019-01669-8. [PMID: 31257558]
  • Houria Manouze, Otmane Bouchatta, Mohamed Bennis, Zahra Sokar, Saâdia Ba-M'hamed. Anticonvulsive and neuroprotective effects of aqueous and methanolic extracts of Anacyclus pyrethrum root in kainic acid-induced-status epilepticus in mice. Epilepsy research. 2019 12; 158(?):106225. doi: 10.1016/j.eplepsyres.2019.106225. [PMID: 31710948]
  • Haiyan Yang, Rui Zhang, Chen Jia, Mengyu Chen, Wen Yin, Liming Wei, Haisheng Jiao. Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats. Pharmaceutical biology. 2019 Dec; 57(1):22-28. doi: 10.1080/13880209.2018.1563619. [PMID: 30724642]
  • Kuan-Ho Lin, Chien-Yu Li, Yuan-Man Hsu, Chang-Hai Tsai, Fuu-Jen Tsai, Chih-Hsin Tang, Jai-Sing Yang, Zhi-Hong Wang, Mei-Chin Yin. Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Nov; 133(?):110765. doi: 10.1016/j.fct.2019.110765. [PMID: 31430510]
  • Caitlyn E Bowman, Ebru S Selen Alpergin, Jessica M Ellis, Michael J Wolfgang. Loss of ACOT7 potentiates seizures and metabolic dysfunction. American journal of physiology. Endocrinology and metabolism. 2019 11; 317(5):E941-E951. doi: 10.1152/ajpendo.00537.2018. [PMID: 31039008]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Emmanuel S Ojo, Ismail O Ishola, Benneth Ben-Azu, Olasunmbo O Afolayan, Ayorinde B James, Abayomi M Ajayi, Solomon Umukoro, Olufunmilayo O Adeyemi. Ameliorative influence of Cnestis ferruginea vahl ex DC (Connaraceae) root extract on kainic acid-induced temporal lobe epilepsy in mice: Role of oxidative stress and neuroinflammation. Journal of ethnopharmacology. 2019 Oct; 243(?):112117. doi: 10.1016/j.jep.2019.112117. [PMID: 31351192]
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