Cholestan-3-one (BioDeep_00000003861)

Main id: BioDeep_00000636707

Secondary id: BioDeep_00000031806, BioDeep_00000398232, BioDeep_00001868788

natural product PANOMIX_OTCML-2023


代谢物信息卡片


5beta-cholestan-3-one

化学式: C27H46O (386.3548)
中文名称:
谱图信息: 最多检出来源 Mus musculus(plant) 9.55%

分子结构信息

SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4C3(CCC(=O)C4)C)C
InChI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-20,22-25H,6-17H2,1-5H3

描述信息

同义名列表

3 个代谢物同义名

Cholestan-3-one; 5beta-cholestan-3-one; 5beta-Cholestan-3-one



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, BCL2, CASP8, CASP9, CCNE1, HTT, IDI1, PCSK9, PRKX
Peripheral membrane protein 1 COQ10A
Endosome membrane 2 HTT, LDLR
Endoplasmic reticulum membrane 5 BCL2, CYP19A1, CYP51A1, FDFT1, STAR
Nucleus 6 BCL2, CASP8, CASP9, CCNE1, HTT, PRKX
autophagosome 1 HTT
cytosol 7 BCL2, CASP8, CASP9, CCNE1, HTT, IDI1, PRKCQ
dendrite 1 HTT
centrosome 1 CCNE1
nucleoplasm 4 CASP8, CCNE1, HTT, PRKX
Cell membrane 7 ABCB1, ABCG5, ADRB3, HTT, LDLR, NPC1L1, STAR
lamellipodium 1 CASP8
Multi-pass membrane protein 7 ABCB1, ABCG5, ADRB3, CYP19A1, FDFT1, HTT, NPC1L1
Synapse 1 HTT
cell surface 3 ABCB1, LDLR, PCSK9
Golgi apparatus 3 HTT, LDLR, PCSK9
lysosomal membrane 1 PCSK9
mitochondrial inner membrane 1 COQ10A
presynaptic membrane 1 HTT
Lysosome 3 LDLR, NPC2, PCSK9
endosome 1 PCSK9
plasma membrane 9 ABCB1, ABCG5, ADRB3, HTT, LDLR, NPC1L1, PCSK9, PRKCQ, STAR
Membrane 8 ABCB1, ABCG5, BCL2, CYP19A1, CYP51A1, FDFT1, LDLR, NPC1L1
apical plasma membrane 3 ABCB1, ABCG5, NPC1L1
axon 1 HTT
basolateral plasma membrane 1 LDLR
extracellular exosome 2 ABCB1, NPC2
endoplasmic reticulum 6 BCL2, CYP19A1, FDFT1, HTT, NPC2, PCSK9
extracellular space 2 NPC2, PCSK9
lysosomal lumen 1 NPC2
perinuclear region of cytoplasm 2 HTT, PCSK9
mitochondrion 5 BCL2, CASP8, CASP9, COQ10A, STAR
protein-containing complex 4 BCL2, CASP8, CASP9, HTT
intracellular membrane-bounded organelle 1 CYP51A1
Microsome membrane 2 CYP19A1, CYP51A1
Single-pass type I membrane protein 2 LDLR, STAR
Secreted 2 NPC2, PCSK9
extracellular region 2 NPC2, PCSK9
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 3 BCL2, CYP51A1, LDLR
mitochondrial outer membrane 2 BCL2, CASP8
mitochondrial matrix 1 STAR
centriolar satellite 1 PRKCQ
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 LDLR
low-density lipoprotein particle 1 LDLR
Early endosome 3 HTT, LDLR, PCSK9
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
COPII-coated ER to Golgi transport vesicle 1 PCSK9
postsynaptic membrane 1 HTT
Apical cell membrane 3 ABCB1, ABCG5, NPC1L1
Cell projection, lamellipodium 1 CASP8
Mitochondrion inner membrane 1 COQ10A
Matrix side 1 COQ10A
Membrane raft 1 HTT
pore complex 1 BCL2
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
Peroxisome 1 IDI1
mitochondrial intermembrane space 1 STAR
Late endosome 3 HTT, LDLR, PCSK9
receptor complex 3 ABCG5, ADRB3, LDLR
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
cytoskeleton 1 CASP8
centriole 1 HTT
brush border membrane 1 NPC1L1
Endomembrane system 3 HTT, LDLR, NPC1L1
sorting endosome 1 LDLR
Cytoplasmic vesicle membrane 2 HTT, NPC1L1
cell body 1 CASP8
myelin sheath 1 BCL2
endoplasmic reticulum lumen 1 PCSK9
azurophil granule lumen 1 NPC2
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
ATP-binding cassette (ABC) transporter complex 1 ABCG5
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 1 LDLR
external side of apical plasma membrane 1 ABCB1
endolysosome membrane 2 LDLR, PCSK9
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 1 CASP8
ripoptosome 1 CASP8
postsynaptic cytosol 1 HTT
somatodendritic compartment 1 LDLR
extrinsic component of external side of plasma membrane 1 PCSK9
presynaptic cytosol 1 HTT
cyclin E1-CDK2 complex 1 CCNE1
PCSK9-LDLR complex 2 LDLR, PCSK9
inclusion body 1 HTT
PCSK9-AnxA2 complex 1 PCSK9
BAD-BCL-2 complex 1 BCL2
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
caspase complex 1 CASP9


文献列表

  • M R Kasimov, G F Zakyrjanova, A R Giniatullin, A L Zefirov, A M Petrov. Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction. Biochimica et biophysica acta. 2016 Jul; 1861(7):606-16. doi: 10.1016/j.bbalip.2016.04.010. [PMID: 27102612]
  • M R Kasimov, A R Giniatullin, A L Zefirov, A M Petrov. Effects of 5α-cholestan-3-one on the synaptic vesicle cycle at the mouse neuromuscular junction. Biochimica et biophysica acta. 2015 May; 1851(5):674-85. doi: 10.1016/j.bbalip.2015.02.012. [PMID: 25725358]
  • Matthew G K Benesch, Ruthven N A H Lewis, David A Mannock, Ronald N McElhaney. A DSC and FTIR spectroscopic study of the effects of the epimeric coprostan-3-ols and coprostan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues. Chemistry and physics of lipids. 2015 May; 188(?):10-26. doi: 10.1016/j.chemphyslip.2015.03.002. [PMID: 25804450]
  • Bianka Ditscheid, Sylvia Keller, Gerhard Jahreis. Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences. European journal of nutrition. 2009 Feb; 48(1):22-30. doi: 10.1007/s00394-008-0755-2. [PMID: 19009227]
  • Gerhard Dongowski, Angelika Lorenz. Intestinal steroids in rats are influenced by the structural parameters of pectin. The Journal of nutritional biochemistry. 2004 Apr; 15(4):196-205. doi: 10.1016/s0955-2863(03)00080-9. [PMID: 15068812]
  • E Kim, S M Jeon, M S Choi. Effects of gamma-irradiated fats on plasma lipid concentrations and hepatic cholesterol metabolism in rats. Annals of nutrition & metabolism. 2001; 45(4):152-8. doi: 10.1159/000046723. [PMID: 11463998]
  • K Suzuki, T Shimizu, T Nakata. The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice. Bioorganic & medicinal chemistry letters. 1998 Aug; 8(16):2133-8. doi: 10.1016/s0960-894x(98)00362-x. [PMID: 9873500]
  • W F Lau, N P Das. In vitro modulation of rat adipocyte ghost membrane fluidity by cholesterol oxysterols. Experientia. 1995 Jul; 51(7):731-7. doi: 10.1007/bf01941271. [PMID: 7628581]
  • A Sziegoleit, D Linder. Studies on the sterol-binding capacity of human pancreatic elastase 1. Gastroenterology. 1991 Mar; 100(3):768-74. doi: 10.1016/0016-5085(91)80024-4. [PMID: 1993499]
  • A K Bhattacharyya, D A Eggen, P Correa, J P Strong. Differences in fecal excretion of cholesterol and bacterial degradation products in high- and low-responding rhesus monkeys: implications in colon cancer. Nutrition and cancer. 1989; 12(1):69-73. doi: 10.1080/01635588909514003. [PMID: 2496397]
  • G V Vahouny, R Khalafi, S Satchithanandam, D W Watkins, J A Story, M M Cassidy, D Kritchevsky. Dietary fiber supplementation and fecal bile acids, neutral steroids and divalent cations in rats. The Journal of nutrition. 1987 Dec; 117(12):2009-15. doi: 10.1093/jn/117.12.2009. [PMID: 2826726]
  • H K Kaul, D B Couch, J D Gingerich, W R Bruce, J A Heddle. Genotoxicity of two fecal steroids in murine colonic epithelium assessed by the sister chromatid exchange technique. Mutagenesis. 1987 Nov; 2(6):441-4. doi: 10.1093/mutage/2.6.441. [PMID: 3328036]
  • P P Nair, N Turjman, G T Goodman, C Guidry, B M Calkins. Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Metabolism of neutral sterols. The American journal of clinical nutrition. 1984 10; 40(4 Suppl):931-6. doi: 10.1093/ajcn/40.4.931. [PMID: 6435444]
  • G E Mott, E M Jackson. Loss of tritium from coprostanone derived from [1,2(n)-3H]cholesterol or [7(n)-3H]cholesterol. Journal of lipid research. 1980 May; 21(4):480-4. doi: . [PMID: 6770018]