Santin (BioDeep_00000003830)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2- (4-Methoxyphenyl) -5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one

化学式: C18H16O7 (344.0896)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 37.19%

分子结构信息

SMILES: c(c3OC)(O)cc(O1)c(c3O)C(C(=C1c(c2)ccc(OC)c2)OC)=O
InChI: InChI=1S/C18H16O7/c1-22-10-6-4-9(5-7-10)16-18(24-3)15(21)13-12(25-16)8-11(19)17(23-2)14(13)20/h4-8,19-20H,1-3H3

描述信息

A trimethoxyflavone that is flavone substituted by methoxy groups at positions 3, 6 and 4 and hydroxy groups at positions 5 and 7 respectively.

同义名列表

3 个代谢物同义名

Santin; 2- (4-Methoxyphenyl) -5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one; Santin



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

141 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CASP3, CASP7, CASP8, CASP9, CHUK, IKBKB, IKBKG, MAPK14
Endoplasmic reticulum membrane 1 HSP90B1
Nucleus 10 CASP3, CASP7, CASP8, CASP9, CHUK, HSP90B1, IKBKB, IKBKG, JUND, MAPK14
cytosol 9 CASP3, CASP7, CASP8, CASP9, CHUK, HSP90B1, IKBKB, IKBKG, MAPK14
nucleoplasm 8 CASP3, CASP7, CASP8, CHUK, IKBKG, JUND, MAPK14, PRODH
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 2 TNF, VCAM1
lamellipodium 1 CASP8
cell surface 4 ICAM1, TNF, TNFRSF10B, VCAM1
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 1 VCAM1
Golgi membrane 1 INS
mitochondrial inner membrane 1 PRODH
neuronal cell body 2 CASP3, TNF
sarcolemma 1 VCAM1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 CASP7
plasma membrane 5 ICAM1, IFNLR1, TNF, TNFRSF10B, VCAM1
Membrane 5 HSP90B1, ICAM1, IFNLR1, TNFRSF10B, VCAM1
extracellular exosome 4 HSP90B1, ICAM1, PEPD, VCAM1
endoplasmic reticulum 2 HSP90B1, VCAM1
extracellular space 7 CASP7, CXCL8, ICAM1, IL10, INS, TNF, VCAM1
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 4 CASP8, CASP9, MAPK14, PRODH
protein-containing complex 4 CASP8, CASP9, HSP90B1, IKBKG
intracellular membrane-bounded organelle 1 PRODH
filopodium 1 VCAM1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 ICAM1, IFNLR1, VCAM1
Secreted 3 CXCL8, IL10, INS
extracellular region 6 CXCL8, HSP90B1, IL10, INS, MAPK14, TNF
cytoplasmic side of plasma membrane 2 CHUK, IKBKB
mitochondrial outer membrane 1 CASP8
mitochondrial matrix 1 PRODH
transcription regulator complex 1 JUND
CD40 receptor complex 2 CHUK, IKBKB
external side of plasma membrane 3 ICAM1, TNF, VCAM1
midbody 1 HSP90B1
Early endosome 1 VCAM1
apical part of cell 1 VCAM1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 CASP8
Membrane raft 3 ICAM1, IKBKB, TNF
focal adhesion 2 HSP90B1, ICAM1
collagen-containing extracellular matrix 2 HSP90B1, ICAM1
nuclear speck 1 MAPK14
chromatin 1 JUND
phagocytic cup 1 TNF
mitotic spindle 1 IKBKG
cytoskeleton 1 CASP8
podosome 1 VCAM1
Secreted, extracellular space 1 CASP7
spindle pole 2 IKBKG, MAPK14
serine/threonine protein kinase complex 1 IKBKB
endosome lumen 1 INS
microvillus 1 VCAM1
Melanosome 1 HSP90B1
cell body 1 CASP8
sperm plasma membrane 1 HSP90B1
ubiquitin ligase complex 1 IKBKG
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
transcription repressor complex 1 JUND
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ICAM1
apoptosome 1 CASP9
IkappaB kinase complex 3 CHUK, IKBKB, IKBKG
Sarcoplasmic reticulum lumen 1 HSP90B1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endoplasmic reticulum chaperone complex 1 HSP90B1
[Vascular cell adhesion protein 1]: Cell membrane 1 VCAM1
[Soluble Vascular Cell Adhesion Molecule-1]: Secreted 1 VCAM1
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex 1 VCAM1
caspase complex 1 CASP9
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Lukasz Szoka, Jolanta Nazaruk, Marcin Stocki, Valery Isidorov. Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells. Journal of cellular and molecular medicine. 2021 12; 25(24):11085-11096. doi: 10.1111/jcmm.17031. [PMID: 34755444]
  • Ming Zhong, Hui-Qiang Wang, Hai-Yan Yan, Shuo Wu, Zheng-Yi Gu, Yu-Huan Li. Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways. Journal of Asian natural products research. 2019 Dec; 21(12):1205-1214. doi: 10.1080/10286020.2018.1520221. [PMID: 30417663]
  • Chien-Chang Shen, Wen-Chi Wei, Lie-Chwen Lin. Diterpenoids and Bisnorditerpenoids from Blumea aromatica. Journal of natural products. 2019 11; 82(11):3181-3185. doi: 10.1021/acs.jnatprod.9b00674. [PMID: 31646857]
  • Linh H Mai, Guy G Chabot, Philippe Grellier, Lionel Quentin, Vincent Dumontet, Cyril Poulain, Laila S Espindola, Sylvie Michel, Hue T B Vo, Brigitte Deguin, Raphaël Grougnet. Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). European journal of medicinal chemistry. 2015 Mar; 93(?):93-100. doi: 10.1016/j.ejmech.2015.01.012. [PMID: 25659770]
  • Akhtar Muhammad, Itrat Anis, Zulfiqar Ali, Sufyan Awadelkarim, Ajmal Khan, Asaad Khalid, Muhammad Raza Shah, M Galal, Ikhlas A Khan, M Iqbal Choudhary. Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase. Bioorganic & medicinal chemistry letters. 2012 Jan; 22(1):610-2. doi: 10.1016/j.bmcl.2011.10.072. [PMID: 22082562]
  • Anil Pareek, Manish Suthar, Garvendra S Rathore, Vijay Bansal. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacognosy reviews. 2011 Jan; 5(9):103-10. doi: 10.4103/0973-7847.79105. [PMID: 22096324]
  • K El-Sahwi, S Bellone, E Cocco, M Cargnelutti, F Casagrande, M Bellone, M Abu-Khalaf, N Buza, F A Tavassoli, P Hui, D-A Silasi, M Azodi, P E Schwartz, T J Rutherford, S Pecorelli, A D Santin. In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma. British journal of cancer. 2010 Jan; 102(1):134-43. doi: 10.1038/sj.bjc.6605448. [PMID: 19920829]
  • Carlo Ignazio Giovanni Tuberoso, Paola Montoro, Sonia Piacente, Giulia Corona, Monica Deiana, Maria Assunta Dessì, Cosimo Pizza, Paolo Cabras. Flavonoid characterization and antioxidant activity of hydroalcoholic extracts from Achillea ligustica All. Journal of pharmaceutical and biomedical analysis. 2009 Oct; 50(3):440-8. doi: 10.1016/j.jpba.2009.05.032. [PMID: 19570644]
  • José Antonio Guerra, María Francisca Molina, María José Abad, Angel María Villar, Bermejo Paulina. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum. International immunopharmacology. 2006 Nov; 6(11):1723-8. doi: 10.1016/j.intimp.2006.07.012. [PMID: 16979127]
  • Jian-Qiao Gu, Yuehong Wang, Scott G Franzblau, Gloria Montenegro, Danzhou Yang, Barbara N Timmermann. Antitubercular constituents of Valeriana laxiflora. Planta medica. 2004 Jun; 70(6):509-14. doi: 10.1055/s-2004-827149. [PMID: 15229801]
  • María José Abad, Paulina Bermejo, María Alvarez, José Antonio Guerra, Ana María Silván, Angel Maria Villar. Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages. Planta medica. 2004 Jan; 70(1):34-8. doi: 10.1055/s-2004-815452. [PMID: 14765290]
  • Christophe Long, Pierre Sauleau, Bruno David, Catherine Lavaud, Valérie Cassabois, Frédéric Ausseil, Georges Massiot. Bioactive flavonoids of Tanacetum parthenium revisited. Phytochemistry. 2003 Sep; 64(2):567-9. doi: 10.1016/s0031-9422(03)00208-5. [PMID: 12943776]
  • J C Meng, Y F Hu, J H Chen, R X Tan. Antifungal highly oxygenated guaianolides and other constituents from Ajania fruticulosa. Phytochemistry. 2001 Dec; 58(7):1141-5. doi: 10.1016/s0031-9422(01)00389-2. [PMID: 11730880]
  • Li, Meng, Cheng, Higa, Tanaka, Tan. New guaianolides and xanthine oxidase inhibitory flavonols from ajania fruticulosa. Journal of natural products. 1999 Jul; 62(7):1053-5. doi: 10.1021/np990009i. [PMID: 10425142]
  • I Aljancić, V Vajs, N Menković, I Karadzić, N Juranić, S Milosavljević, S Macura. Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity. Journal of natural products. 1999 Jun; 62(6):909-11. doi: 10.1021/np980536m. [PMID: 10395518]