Ergokryptine (BioDeep_00000003722)

 

Secondary id: BioDeep_00000398700, BioDeep_00000403133

PANOMIX_OTCML-2023


代谢物信息卡片


alpha-Ergocryptine

化学式: C32H41N5O5 (575.3108)
中文名称: 麦角克碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 52.21%

分子结构信息

SMILES: CC(C)CC1C(=O)N2CCCC2C2(O)OC(NC(=O)C3C=C4c5cccc6[nH]cc(c56)CC4N(C)C3)(C(C)C)C(=O)N12
InChI: InChI=1S/C32H41N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,13,15,17-18,20,24-26,33,41H,7,10-12,14,16H2,1-5H3,(H,34,38)

描述信息

D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists

同义名列表

4 个代谢物同义名

alpha-Ergocryptine; Ergokryptine; alpha-Ergocryptine; (6aS,9R)-N-[(1R,2R,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ADRA1A, ANXA5, DDC, HTT, PKHD1, POMC, PRL
Peripheral membrane protein 2 ANXA5, LPL
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 1 DRD1
Nucleus 5 ADRA1A, DRD1, HTT, PKHD1, PRL
autophagosome 1 HTT
cytosol 5 ADRA1A, ANXA5, DDC, HTT, SST
dendrite 2 DRD2, HTT
centrosome 1 PKHD1
nucleoplasm 3 ADRA1A, HTT, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 8 ADRA1A, ADRB3, DRD1, DRD2, HTT, LHCGR, LPL, PKHD1
Multi-pass membrane protein 6 ADRA1A, ADRB3, DRD1, DRD2, HTT, LHCGR
Golgi apparatus membrane 1 DRD2
Synapse 3 CRH, DRD2, HTT
cell surface 2 LPL, PRLR
glutamatergic synapse 2 DRD1, DRD2
Golgi apparatus 2 HTT, PKHD1
Golgi membrane 2 DRD2, INS
neuronal cell body 1 SST
presynaptic membrane 3 DRD1, DRD2, HTT
sarcolemma 1 ANXA5
acrosomal vesicle 1 DRD2
endosome 1 LHCGR
plasma membrane 9 ADRA1A, ADRB3, DRD1, DRD2, GCG, HTT, LHCGR, LPL, PRLR
synaptic vesicle membrane 1 DRD2
Membrane 2 ANXA5, PRLR
apical plasma membrane 1 PKHD1
axon 2 DRD2, HTT
caveola 1 ADRA1A
extracellular exosome 3 ANXA5, DDC, PKHD1
endoplasmic reticulum 3 CSH1, HTT, PKHD1
extracellular space 9 CRH, CSH1, GCG, INS, LHCGR, LPL, POMC, PRL, SST
perinuclear region of cytoplasm 2 HTT, PKHD1
protein-containing complex 1 HTT
intracellular membrane-bounded organelle 1 ADRA1A
Single-pass type I membrane protein 2 PKHD1, PRLR
Secreted 11 CRH, CSH1, GCG, INS, LPL, PKHD1, POMC, PRL, SST, TRH, VIP
extracellular region 12 ANXA5, CRH, CSH1, GCG, INS, LPL, POMC, PRL, PRLR, SST, TRH, VIP
Extracellular side 1 LPL
Cell projection, cilium 1 PKHD1
centriolar satellite 1 LHCGR
ciliary membrane 2 DRD1, DRD2
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
external side of plasma membrane 3 ANXA5, PKHD1, PRLR
varicosity 1 CRH
Secreted, extracellular space, extracellular matrix 1 LPL
chylomicron 1 LPL
very-low-density lipoprotein particle 1 LPL
dendritic spine 2 DRD1, DRD2
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, DRD2
Early endosome 1 HTT
vesicle 1 CSH1
postsynaptic membrane 3 DRD1, DRD2, HTT
Apical cell membrane 1 PKHD1
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
Cytoplasm, cytoskeleton, spindle 1 PKHD1
focal adhesion 2 ANXA5, HTT
GABA-ergic synapse 3 DRD1, DRD2, SST
Cell projection, dendritic spine 1 DRD1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 2 POMC, TRH
lateral plasma membrane 1 DRD2
Late endosome 1 HTT
receptor complex 3 ADRB3, LHCGR, PRLR
Cell projection, neuron projection 1 HTT
Zymogen granule membrane 1 ANXA5
neuron projection 2 HTT, VIP
ciliary basal body 1 PKHD1
cilium 3 DRD1, DRD2, PKHD1
chromatin 1 PRL
mitotic spindle 1 PKHD1
Cytoplasm, cytoskeleton, cilium basal body 1 PKHD1
centriole 1 HTT
non-motile cilium 2 DRD1, DRD2
sperm flagellum 1 DRD2
Endomembrane system 1 HTT
endosome lumen 4 CSH1, INS, PRL, PRLR
Membrane, caveola 1 ADRA1A
Chromosome, centromere 1 PKHD1
Cytoplasmic vesicle membrane 1 HTT
Cell projection, dendrite 1 DRD1
secretory granule lumen 3 GCG, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GCG, INS
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Secreted, extracellular exosome 1 PKHD1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 SST
chromosome, centromeric region 1 PKHD1
9+0 non-motile cilium 1 PKHD1
vesicle membrane 1 ANXA5
dopaminergic synapse 1 DRD2
postsynaptic cytosol 1 HTT
Cell projection, cilium membrane 1 DRD1
presynaptic cytosol 1 HTT
[Glucagon-like peptide 1]: Secreted 1 GCG
inclusion body 1 HTT
catalytic complex 1 LPL
endothelial microparticle 1 ANXA5
G protein-coupled receptor complex 2 DRD1, DRD2
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT


文献列表

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  • Matevž Likar, Marjana Grandič, Breda Jakovac Strajn, Katarina Kos, Franci Aco Celar. Links Between Genetic Groups, Host Specificity, and Ergot-Alkaloid Profiles within Claviceps purpurea (Fr.) Tul. on Slovenian Grasses. Plant disease. 2018 Jul; 102(7):1334-1340. doi: 10.1094/pdis-08-17-1179-re. [PMID: 30673578]
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