CDP (BioDeep_00000003515)

 

Secondary id: BioDeep_00000400230

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

化学式: C9H15N3O11P2 (403.01818199999997)
中文名称: 胞苷5-二磷酸酯, 胞苷-5'-二磷酸, 胞苷 5'-二磷酸
谱图信息: 最多检出来源 Homo sapiens(blood) 1.09%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
InChI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

描述信息

Cytidine diphosphate, abbreviated CDP, and also known as 5-CDP, belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety. It is a cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. CDP exists in all living species, ranging from bacteria to humans. In humans, CDP is involved in cardiolipin biosynthesis. Outside of the human body, CDP has been detected, but not quantified in several different foods, such as carobs, mexican oregano, evergreen huckleberries, green vegetables, and pepper (Capsicum baccatum).
Cytidine 5-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate. [HMDB]. CDP is found in many foods, some of which are sweet cherry, hard wheat, roman camomile, and ginseng.
Acquisition and generation of the data is financially supported in part by CREST/JST.

同义名列表

18 个代谢物同义名

[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid; Cytidine-5-diphosphate sodium salt hydrate,from yeast; Cytidine, 5-(trihydrogen pyrophosphoric acid); Cytidine, 5-(trihydrogen pyrophosphate); Cytidine 5-pyrophosphoric acid; CYTIDINE-5-diphosphoric acid; Cytidine 5-diphosphoric acid; Cytidine diphosphoric acid; Cytidine diphosphate (CDP); Cytidine 5-pyrophosphate; Cytidine 5-diphosphate; Cytidine-5-diphosphate; Diphosphate, cytidine; Cytidine diphosphate; Cytidine-diphosphate; 5-CDP; CDP; Cytidine 5'-diphosphate(CDP)



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

376 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(11)

WikiPathways(1)

Plant Reactome(0)

INOH(3)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(348)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaoman You, Yuese Ning, Guo-Liang Wang. Editing a rice CDP-DAG synthase confers broad-spectrum resistance. Trends in plant science. 2023 Aug; ?(?):. doi: 10.1016/j.tplants.2023.08.011. [PMID: 37648632]
  • Qiyue Zhang, Nikabou Batigma Boundjou, Lijun Jia, Xinliang Wang, Ling Zhou, Helga Peisker, Qing Li, Liang Guo, Peter Dörmann, Dianqiu Lyu, Yonghong Zhou. A Cytidinediphosphate Diacylglycerol Synthase is essential for mitochondrial structure and energy production in Arabidopsis thaliana. The Plant journal : for cell and molecular biology. 2023 Feb; ?(?):. doi: 10.1111/tpj.16139. [PMID: 36789486]
  • Alexandra Polyansky, Oren Shatz, Milana Fraiberg, Eyal Shimoni, Tali Dadosh, Muriel Mari, Fulvio M Reggiori, Chao Qin, Xianlin Han, Zvulun Elazar. Phospholipid imbalance impairs autophagosome completion. The EMBO journal. 2022 12; 41(23):e110771. doi: 10.15252/embj.2022110771. [PMID: 36300838]
  • Lance G A Nunes, Matthew W Pitts, Peter R Hoffmann. Selenoprotein I (selenoi) as a critical enzyme in the central nervous system. Archives of biochemistry and biophysics. 2022 10; 729(?):109376. doi: 10.1016/j.abb.2022.109376. [PMID: 36007576]
  • Lin Zheng, Ting Zhou, Hui Liu, Zuying Zhou, Mingyan Chi, Yueting Li, Zipeng Gong, Yong Huang. Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair (Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium chinense (Lour.) Harms) by UPLC-MS/MS. Molecules (Basel, Switzerland). 2022 Jun; 27(13):. doi: 10.3390/molecules27134025. [PMID: 35807271]
  • Fangzhou Zhu, Zhiqin Dong, Xinfu Li, Qiang Xiong. Microbial Inactivation Property of Pulsed Corona Discharge Plasma and Its Effect on Chilled Pork Preservation. Foodborne pathogens and disease. 2022 02; 19(2):159-167. doi: 10.1089/fpd.2021.0035. [PMID: 34898276]
  • Guotong Fu, Clifford S Guy, Nicole M Chapman, Gustavo Palacios, Jun Wei, Peipei Zhou, Lingyun Long, Yong-Dong Wang, Chenxi Qian, Yogesh Dhungana, Hongling Huang, Anil Kc, Hao Shi, Sherri Rankin, Scott A Brown, Amanda Johnson, Randall Wakefield, Camenzind G Robinson, Xueyan Liu, Anthony Sheyn, Jiyang Yu, Suzanne Jackowski, Hongbo Chi. Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine. Nature. 2021 07; 595(7869):724-729. doi: 10.1038/s41586-021-03692-z. [PMID: 34234346]
  • Haifang Zhao, Tao Wang. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila. PLoS genetics. 2020 10; 16(10):e1009070. doi: 10.1371/journal.pgen.1009070. [PMID: 33064773]
  • Yi Wu, Keshi Chen, Guangsuo Xing, Linpeng Li, Bochao Ma, Zhijuan Hu, Lifan Duan, Xingguo Liu. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science advances. 2019 11; 5(11):eaax7525. doi: 10.1126/sciadv.aax7525. [PMID: 31807705]
  • Elizabeth Calzada, Ouma Onguka, Steven M Claypool. Phosphatidylethanolamine Metabolism in Health and Disease. International review of cell and molecular biology. 2016; 321(?):29-88. doi: 10.1016/bs.ircmb.2015.10.001. [PMID: 26811286]
  • Carla D Jorge, Nuno Borges, Helena Santos. A novel pathway for the synthesis of inositol phospholipids uses cytidine diphosphate (CDP)-inositol as donor of the polar head group. Environmental microbiology. 2015 Jul; 17(7):2492-504. doi: 10.1111/1462-2920.12734. [PMID: 25472423]
  • Ahrathy Selathurai, Greg M Kowalski, Micah L Burch, Patricio Sepulveda, Steve Risis, Robert S Lee-Young, Severine Lamon, Peter J Meikle, Amanda J Genders, Sean L McGee, Matthew J Watt, Aaron P Russell, Matthew Frank, Suzanne Jackowski, Mark A Febbraio, Clinton R Bruce. The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity. Cell metabolism. 2015 May; 21(5):718-30. doi: 10.1016/j.cmet.2015.04.001. [PMID: 25955207]
  • Alison C Lilley, Louise Major, Simon Young, Michael J R Stark, Terry K Smith. The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei. Molecular microbiology. 2014 May; 92(3):453-70. doi: 10.1111/mmi.12553. [PMID: 24533860]
  • Anne Hartmann, Maria Hellmund, Richard Lucius, Dennis R Voelker, Nishith Gupta. Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii. The Journal of biological chemistry. 2014 Mar; 289(10):6809-6824. doi: 10.1074/jbc.m113.509406. [PMID: 24429285]
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  • Marwa A Aboukhatwa, Ashiwel S Undieh. Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition. BMC neuroscience. 2010 Jan; 11(?):10. doi: 10.1186/1471-2202-11-10. [PMID: 20105322]
  • Roberta Leonardi, Matthew W Frank, Pamela D Jackson, Charles O Rock, Suzanne Jackowski. Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis. The Journal of biological chemistry. 2009 Oct; 284(40):27077-89. doi: 10.1074/jbc.m109.031336. [PMID: 19666474]
  • Morgan D Fullerton, Fatima Hakimuddin, Arend Bonen, Marica Bakovic. The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase-deficient mice. The Journal of biological chemistry. 2009 Sep; 284(38):25704-13. doi: 10.1074/jbc.m109.023846. [PMID: 19625253]
  • Yesim Ozarda Ilcol, Zeki Yilmaz, Mehmet Cansev, Ismail H Ulus. Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: involvement of the peripheral nicotinic acetylcholine receptors. Shock (Augusta, Ga.). 2009 Sep; 32(3):286-94. doi: 10.1097/shk.0b013e3181971b02. [PMID: 19060783]
  • Edward W C Sewell, Mark P Pereira, Eric D Brown. The wall teichoic acid polymerase TagF is non-processive in vitro and amenable to study using steady state kinetic analysis. The Journal of biological chemistry. 2009 Aug; 284(32):21132-8. doi: 10.1074/jbc.m109.010215. [PMID: 19520862]
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  • Jean E Vance. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. Journal of lipid research. 2008 Jul; 49(7):1377-87. doi: 10.1194/jlr.r700020-jlr200. [PMID: 18204094]
  • Y O Ilcol, M Cansev, M S Yilmaz, E Hamurtekin, I H Ulus. Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system. Archives of physiology and biochemistry. 2007 Oct; 113(4-5):186-201. doi: 10.1080/13813450701531243. [PMID: 17917852]
  • Pedro Besada, Dae Hong Shin, Stefano Costanzi, Hyojin Ko, Christophe Mathé, Julien Gagneron, Gilles Gosselin, Savitri Maddileti, T Kendall Harden, Kenneth A Jacobson. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. Journal of medicinal chemistry. 2006 Sep; 49(18):5532-43. doi: 10.1021/jm060485n. [PMID: 16942026]
  • Maria José Caballero, Germán Gallardo, Lidia Robaina, Daniel Montero, Antonio Fernández, Marisol Izquierdo. Vegetable lipid sources affect in vitro biosynthesis of triacylglycerols and phospholipids in the intestine of sea bream (Sparus aurata). The British journal of nutrition. 2006 Mar; 95(3):448-54. doi: 10.1079/bjn20051529. [PMID: 16512929]
  • C J R Loewen, M L Gaspar, S A Jesch, C Delon, N T Ktistakis, S A Henry, T P Levine. Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science (New York, N.Y.). 2004 Jun; 304(5677):1644-7. doi: 10.1126/science.1096083. [PMID: 15192221]
  • Wendy M Iwanyshyn, Gil-Soo Han, George M Carman. Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc. The Journal of biological chemistry. 2004 May; 279(21):21976-83. doi: 10.1074/jbc.m402047200. [PMID: 15028711]
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