Octanoylcarnitine (BioDeep_00000003501)
Main id: BioDeep_00000641217
Secondary id: BioDeep_00000405366
human metabolite PANOMIX_OTCML-2023 blood metabolite LipidSearch
代谢物信息卡片
O-octanoyl-R-carnitine
化学式: C15H29NO4 (287.2096474)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 0.78%
分子结构信息
SMILES: CCCCCCCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
InChI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m1/s1
描述信息
CONFIDENCE standard compound; INTERNAL_ID 253
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer[1][2][3].
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:18102
- KEGG: C02838
- PubChem: 11953814
- Metlin: METLIN36665
- Metlin: METLIN960
- LipidMAPS: LMFA07070002
- CAS: 25243-95-2
- MoNA: RP025301
- MoNA: RP025302
- MoNA: RP025303
- PMhub: MS000009795
- PubChem: 5780
- PDB-CCD: OCB
- 3DMET: B00508
- NIKKAJI: J513.375K
- medchemexpress: HY-113161
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yu-Yu Li, Jia Xu, Xue-Cheng Sun, Hong-Yu Li, Kai Mu. Newborn screening and genetic variation of medium chain acyl-CoA dehydrogenase deficiency in the Chinese population.
Journal of pediatric endocrinology & metabolism : JPEM.
2022 Oct; 35(10):1264-1271. doi:
10.1515/jpem-2022-0394. [PMID: 36068006] - Emmalie A Jager, Myrthe M Kuijpers, Annet M Bosch, Margot F Mulder, Estela R Gozalbo, Gepke Visser, Maaike de Vries, Monique Williams, Hans R Waterham, Francjan J van Spronsen, Peter C J I Schielen, Terry G J Derks. A nationwide retrospective observational study of population newborn screening for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in the Netherlands.
Journal of inherited metabolic disease.
2019 09; 42(5):890-897. doi:
10.1002/jimd.12102. [PMID: 31012112] - Yanhan Li, Ruoxin Zhu, Yi Liu, Jinqing Song, Jing Xu, Yanling Yang. Medium-chain acyl-coenzyme A dehydrogenase deficiency: Six cases in the Chinese population.
Pediatrics international : official journal of the Japan Pediatric Society.
2019 Jun; 61(6):551-557. doi:
10.1111/ped.13872. [PMID: 31033143] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Paul E Minkler, Maria S K Stoll, Stephen T Ingalls, Charles L Hoppel. Correcting false positive medium-chain acyl-CoA dehydrogenase deficiency results from newborn screening; synthesis, purification, and standardization of branched-chain C8 acylcarnitines for use in their selective and accurate absolute quantitation by UHPLC-MS/MS.
Molecular genetics and metabolism.
2017 04; 120(4):363-369. doi:
10.1016/j.ymgme.2017.02.006. [PMID: 28190699] - Patricia L Hall, Angela Wittenauer, Arthur Hagar. Newborn screening for medium chain acyl-CoA dehydrogenase deficiency: performance improvement by monitoring a new ratio.
Molecular genetics and metabolism.
2014 Dec; 113(4):274-7. doi:
10.1016/j.ymgme.2014.10.007. [PMID: 25454677] - Anelise M Tonin, Mateus Grings, Lisiane A Knebel, Ângela Zanatta, Alana P Moura, César A J Ribeiro, Guilhian Leipnitz, Moacir Wajner. Disruption of redox homeostasis in cerebral cortex of developing rats by acylcarnitines accumulating in medium-chain acyl-CoA dehydrogenase deficiency.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2012 Aug; 30(5):383-90. doi:
10.1016/j.ijdevneu.2012.03.238. [PMID: 22472139] - S Larsen, N Stride, M Hey-Mogensen, C N Hansen, J L Andersen, S Madsbad, D Worm, J W Helge, F Dela. Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Diabetologia.
2011 Jun; 54(6):1427-36. doi:
10.1007/s00125-011-2098-4. [PMID: 21424396] - Emily H Smith, Cheryl Thomas, David McHugh, Dimitar Gavrilov, Kimiyo Raymond, Piero Rinaldo, Silvia Tortorelli, Dietrich Matern, W Edward Highsmith, Devin Oglesbee. Allelic diversity in MCAD deficiency: the biochemical classification of 54 variants identified during 5 years of ACADM sequencing.
Molecular genetics and metabolism.
2010 Jul; 100(3):241-50. doi:
10.1016/j.ymgme.2010.04.001. [PMID: 20434380] - E M Maier, J Pongratz, A C Muntau, B Liebl, U Nennstiel-Ratzel, U Busch, R Fingerhut, B Olgemöller, A A Roscher, W Röschinger. Dissection of biochemical borderline phenotypes in carriers and genetic variants of medium-chain acyl-CoA dehyrogenase deficiency: implications for newborn screening [corrected].
Clinical genetics.
2009 Aug; 76(2):179-87. doi:
10.1111/j.1399-0004.2009.01217.x. [PMID: 19780764] - William J Rhead. Newborn screening for medium-chain acyl-CoA dehydrogenase deficiency: a global perspective.
Journal of inherited metabolic disease.
2006 Apr; 29(2-3):370-7. doi:
10.1007/s10545-006-0292-1. [PMID: 16763904] - D R de Assis, R C Maria, G C Ferreira, P F Schuck, A Latini, C S Dutra-Filho, C M D Wannmacher, A T S Wyse, M Wajner. Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats.
Experimental neurology.
2006 Jan; 197(1):143-9. doi:
10.1016/j.expneurol.2005.09.002. [PMID: 16203000] - E Schmidt-Sommerfeld, D Penn, M Duran, M J Bennett, R Santer, C A Stanley. Detection of inborn errors of fatty acid oxidation from acylcarnitine analysis of plasma and blood spots with the radioisotopic exchange-high-performance liquid chromatographic method.
The Journal of pediatrics.
1993 May; 122(5 Pt 1):708-14. doi:
10.1016/s0022-3476(06)80009-0. [PMID: 8496747] - J L Van Hove, W Zhang, S G Kahler, C R Roe, Y T Chen, N Terada, D H Chace, A K Iafolla, J H Ding, D S Millington. Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood.
American journal of human genetics.
1993 May; 52(5):958-66. doi:
NULL. [PMID: 8488845] - E Schmidt-Sommerfeld, D Penn, P Rinaldo, D Kossak, B U Li, Z H Huang, D A Gage. Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method.
Pediatric research.
1992 Jun; 31(6):545-51. doi:
10.1203/00006450-199206000-00002. [PMID: 1635814] - M R Muci, G V Gnoni. Short-term effects of triiodothyronine on exogenous and de novo synthesized fatty acids in rat hepatocytes.
Biochemistry international.
1991 Dec; 25(5):807-13. doi:
. [PMID: 1804101] - M Duran, D Ketting, R van Vossen, T E Beckeringh, L Dorland, L Bruinvis, S K Wadman. Octanoylglucuronide excretion in patients with a defective oxidation of medium-chain fatty acids.
Clinica chimica acta; international journal of clinical chemistry.
1985 Nov; 152(3):253-60. doi:
10.1016/0009-8981(85)90100-7. [PMID: 4064333] - M Duran, G Mitchell, J B de Klerk, J P de Jager, M Hofkamp, L Bruinvis, D Ketting, J M Saudubray, S K Wadman. Octanoic acidemia and octanoylcarnitine excretion with dicarboxylic aciduria due to defective oxidation of medium-chain fatty acids.
The Journal of pediatrics.
1985 Sep; 107(3):397-404. doi:
10.1016/s0022-3476(85)80514-x. [PMID: 4032135] - J M Amatruda, D H Lockwood, S Margolis, L A Kiesow. [14C]palmitate uptake in isolated rat liver mitochondria: effects of fasting, diabetes mellitus, and inhibitors of carnitine acyltransferase.
Journal of lipid research.
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