Buformin (BioDeep_00000003439)
Secondary id: BioDeep_00001868702
human metabolite blood metabolite
代谢物信息卡片
(E)-2-butyl-1-(diaminomethylidene)guanidine
化学式: C6H15N5 (157.1327)
中文名称: 丁福明
谱图信息:
最多检出来源 Homo sapiens(COVID-19)(not specific) 8.04%
分子结构信息
SMILES: CCCC/N=C(\N)/N=C(N)N
InChI: InChI=1S/C6H15N5/c1-2-3-4-10-6(9)11-5(7)8/h2-4H2,1H3,(H6,7,8,9,10,11)
描述信息
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BA - Biguanides
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98234 - Biguanide Antidiabetic Agent
D007004 - Hypoglycemic Agents > D001645 - Biguanides
KEIO_ID B010
同义名列表
25 个代谢物同义名
(E)-2-butyl-1-(diaminomethylidene)guanidine; Grossmann brand OF buformin hydrochloride; N-Butyl-n-(diaminomethylidene)guanidine; N-Butylimidodicarbonimidic diamide; andromaco Brand OF buformin; Buformin andromaco brand; N(1)-Butylbiguanide; 1 Butylbiguanide; 1-Butylbiguanide; 1-Butyldiguanide; Retard, silubin; Butylbiguanide; Butyldiguanide; Silubin retard; Buforminum; Buformine; Buformina; Butformin; Buformin; Gliporal; Glybigid; Silubin; Adebit; W 37; Buformin
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:3209
- KEGG: C07674
- KEGGdrug: D00595
- PubChem: 2468
- HMDB: HMDB0249431
- Metlin: METLIN66714
- DrugBank: DB04830
- ChEMBL: CHEMBL39736
- Wikipedia: Buformin
- MeSH: Buformin
- chemspider: 2374
- CAS: 1215700-80-3
- CAS: 692-13-7
- MoNA: KO002447
- MoNA: KO002444
- MoNA: KO002446
- MoNA: KO002445
- MoNA: KO002443
- PMhub: MS000009680
- PubChem: 9876
- PDB-CCD: BFR
- NIKKAJI: J9.453F
- RefMet: Buformin
- KNApSAcK: 3209
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Amin Wurita, Koutaro Hasegawa, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki. Postmortem distribution/redistribution of buformin in body fluids and solid tissues in an autopsy case using liquid chromatography-tandem mass spectrometry with QuEChERS extraction method.
Forensic science international.
2020 Sep; 314(?):110376. doi:
10.1016/j.forsciint.2020.110376. [PMID: 32615395] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Takahiro Isono, Tokuhiro Chano, Junji Yonese, Takeshi Yuasa. Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas.
Scientific reports.
2016 05; 6(?):25669. doi:
10.1038/srep25669. [PMID: 27157976] - Zongjian Zhu, Weiqin Jiang, Matthew D Thompson, Dimas Echeverria, John N McGinley, Henry J Thompson. Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat.
Cancer prevention research (Philadelphia, Pa.).
2015 Jun; 8(6):518-27. doi:
10.1158/1940-6207.capr-14-0121. [PMID: 25804611] - Takahiro Isono, Tokuhiro Chano, Asuka Kitamura, Takeshi Yuasa. Glucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells.
PloS one.
2014; 9(5):e96168. doi:
10.1371/journal.pone.0096168. [PMID: 24796485] - Sergei V Jargin. Testing of serum atherogenicity in cell cultures: questionable data published.
German medical science : GMS e-journal.
2012; 10(?):Doc02. doi:
10.3205/000153. [PMID: 22355278] - Weihua Chen, Zhongjun Qin. Development of a gene cloning system in a fast-growing and moderately thermophilic Streptomyces species and heterologous expression of Streptomyces antibiotic biosynthetic gene clusters.
BMC microbiology.
2011 Oct; 11(?):243. doi:
10.1186/1471-2180-11-243. [PMID: 22032628] - Vladimir N Anisimov, Lev M Berstein, Irina G Popovich, Mark A Zabezhinski, Peter A Egormin, Tatiana S Piskunova, Anna V Semenchenko, Margarita L Tyndyk, Maria N Yurova, Irina G Kovalenko, Tatiana E Poroshina. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
Aging.
2011 Feb; 3(2):148-57. doi:
10.18632/aging.100273. [PMID: 21386129] - Zongjian Zhu, Weiqin Jiang, Matthew D Thompson, John N McGinley, Henry J Thompson. Metformin as an energy restriction mimetic agent for breast cancer prevention.
Journal of carcinogenesis.
2011; 10(?):17. doi:
10.4103/1477-3163.83043. [PMID: 21799661] - Ompal Singh, Zakia Khanam, Neelam Misra, Manoj Kumar Srivastava. Chamomile (Matricaria chamomilla L.): An overview.
Pharmacognosy reviews.
2011 Jan; 5(9):82-95. doi:
10.4103/0973-7847.79103. [PMID: 22096322] - Julián F Petrulevičius, Torsten Wappler, André Nel, Jes Rust. The diversity of Odonata and their endophytic ovipositions from the Upper Oligocene Fossillagerstätte of Rott (Rhineland, Germany).
ZooKeys.
2011; ?(130):67-89. doi:
10.3897/zookeys.130.1441. [PMID: 22259267] - Junji Kozawa, Hiromi Iwahashi, Kohei Okita, Yukiyoshi Okauchi, Akihisa Imagawa, Iichiro Shimomura. Insulin tolerance test predicts the effectiveness of insulin sensitizers in japanese type 2 diabetic patients.
Diabetes therapy : research, treatment and education of diabetes and related disorders.
2010 Dec; 1(2):121-30. doi:
10.1007/s13300-010-0011-7. [PMID: 22127749] - S Svraka, E Kuijper, E Duizer, D Bakker, M Koopmans. Clostridium difficile is not associated with outbreaks of viral gastroenteritis in the elderly in the Netherlands.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2010 Jun; 29(6):677-82. doi:
10.1007/s10096-010-0913-3. [PMID: 20339889] - Alexander Ihlow, Patrick Schweizer, Udo Seiffert. A high-throughput screening system for barley/powdery mildew interactions based on automated analysis of light micrographs.
BMC plant biology.
2008 Jan; 8(?):6. doi:
10.1186/1471-2229-8-6. [PMID: 18215267] - Kayoko Tahara, Ayumi Yonemoto, Yuji Yoshiyama, Toshiya Nakamura, Masaaki Aizawa, Yoshikuni Fujita, Takashi Nishikawa. Determination of antihyperglycemic biguanides in serum and urine using an ion-pair solid-phase extraction technique followed by HPLC-UV on a pentafluorophenylpropyl column and on an octadecyl column.
Biomedical chromatography : BMC.
2006 Nov; 20(11):1200-5. doi:
10.1002/bmc.685. [PMID: 16799926] - Nicholas Lintzeris, John Strang, Nicola Metrebian, Sarah Byford, Christopher Hallam, Sally Lee, Deborah Zador. Methodology for the Randomised Injecting Opioid Treatment Trial (RIOTT): evaluating injectable methadone and injectable heroin treatment versus optimised oral methadone treatment in the UK.
Harm reduction journal.
2006 Sep; 3(?):28. doi:
10.1186/1477-7517-3-28. [PMID: 17002810] - Mariko Asai, Shouta Higuchi, Masafumi Kubota, Kazuhiro Iguchi, Shigeyuki Usui, Kazuyuki Hirano. Regulators for blood glucose level affect gene expression of aquaporin 3.
Biological & pharmaceutical bulletin.
2006 May; 29(5):991-6. doi:
10.1248/bpb.29.991. [PMID: 16651733] - Aharon Oren, Nuphar Pri-El, Orr Shapiro, Nachshon Siboni. Buoyancy studies in natural communities of square gas-vacuolate archaea in saltern crystallizer ponds.
Saline systems.
2006 Apr; 2(?):4. doi:
10.1186/1746-1448-2-4. [PMID: 16613609] - A Holstein, E-H Egberts. [Traditional contraindications to the use of metformin -- more harmful than beneficial?].
Deutsche medizinische Wochenschrift (1946).
2006 Jan; 131(3):105-10. doi:
10.1055/s-2006-924934. [PMID: 16418951] - A H Banskota, N T Nguyen, Y Tezuka, T Nobukawa, S Kadota. Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2006 Jan; 13(1-2):109-14. doi:
10.1016/j.phymed.2004.01.015. [PMID: 16360940] - Tadashi Kiho, Motohiro Kato, Shigeyuki Usui, Kazuyuki Hirano. Effect of buformin and metformin on formation of advanced glycation end products by methylglyoxal.
Clinica chimica acta; international journal of clinical chemistry.
2005 Aug; 358(1-2):139-45. doi:
10.1016/j.cccn.2005.02.012. [PMID: 15946656] - Daniel L Nickrent, Joshua P Der, Frank E Anderson. Discovery of the photosynthetic relatives of the 'Maltese mushroom' Cynomorium.
BMC evolutionary biology.
2005 Jun; 5(?):38. doi:
10.1186/1471-2148-5-38. [PMID: 15969755] - Takahiko Matsuura, Mariko Miyao, Yuzo Mizuno. [A case of lactic acidosis caused by buformin in an oldest elderly diabetic patient].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
2005 Mar; 42(2):235-40. doi:
10.3143/geriatrics.42.235. [PMID: 15852659] - Naoko Kimura, Masahiro Okuda, Ken-ichi Inui. Metformin transport by renal basolateral organic cation transporter hOCT2.
Pharmaceutical research.
2005 Feb; 22(2):255-9. doi:
10.1007/s11095-004-1193-3. [PMID: 15783073] - S Ohara, R Komatsu, T Matsuyama. Short-term effect of buformin, a biguanide, on insulin sensitivity, soluble fraction of tumor necrosis factor receptor and serum lipids in overweight patients with type 2 diabetes mellitus.
Diabetes research and clinical practice.
2004 Nov; 66(2):133-8. doi:
10.1016/j.diabres.2004.03.007. [PMID: 15533580] - Chen-Hsi Chou, Ching-Ling Cheng, Chien-Chen Huang. A validated HPLC method with ultraviolet detection for the determination of buformin in plasma.
Biomedical chromatography : BMC.
2004 May; 18(4):254-8. doi:
10.1002/bmc.312. [PMID: 15162388] - Kazuto Yamazaki, Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazunobu Kira, Takao Saeki, Isao Tanaka. The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight.
European journal of pharmacology.
2004 Mar; 488(1-3):213-8. doi:
10.1016/j.ejphar.2004.02.019. [PMID: 15044053] - Susumu Ogawa, Kazuhisa Takeuchi, Sadayoshi Ito. Plasma BNP levels in the treatment of type 2 diabetes with pioglitazone.
The Journal of clinical endocrinology and metabolism.
2003 Aug; 88(8):3993-6. doi:
10.1210/jc.2002-021765. [PMID: 12915698] - De-Sheng Wang, Hiroyuki Kusuhara, Yukio Kato, Johan W Jonker, Alfred H Schinkel, Yuichi Sugiyama. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Molecular pharmacology.
2003 Apr; 63(4):844-8. doi:
10.1124/mol.63.4.844. [PMID: 12644585] - Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki, Isao Tanaka. Enhanced secretion of glucagon-like peptide 1 by biguanide compounds.
Biochemical and biophysical research communications.
2002 Nov; 298(5):779-84. doi:
10.1016/s0006-291x(02)02565-2. [PMID: 12419322] - Takehito Yamamoto, Makiko Kusama, Kumi Matsuno, Erika Sugiyama, Yasuhiko Yamada, Tatsuji Iga. A new method for determination of buformin in plasma and urine by ion-paired reversed-phase HPLC with ultraviolet detection.
Biomedical chromatography : BMC.
2002 Oct; 16(7):453-4. doi:
10.1002/bmc.182. [PMID: 12378556] - De-Sheng Wang, Johan W Jonker, Yukio Kato, Hiroyuki Kusuhara, Alfred H Schinkel, Yuichi Sugiyama. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
The Journal of pharmacology and experimental therapeutics.
2002 Aug; 302(2):510-5. doi:
10.1124/jpet.102.034140. [PMID: 12130709] - Mei Zhang, Grant A Moore, Michael Lever, Sharon J Gardiner, Carl M J Kirkpatrick, Evan J Begg. Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Jan; 766(1):175-9. doi:
10.1016/s0378-4347(01)00430-3. [PMID: 11824394] - K Mori, J Nakamura, N Koh, F Sakakibara, Y Hamada, T Hara, T Komori, E Nakashima, K Naruse, N Takeuchi, N Hotta. Increased alanine uptake and lipid synthesis from alanine in isolated hepatocytes of Wistar-Kyoto fatty rats: an inhibitory effect of biguanides.
Canadian journal of physiology and pharmacology.
1997 Mar; 75(3):179-84. doi:
10.1139/y97-016. [PMID: 9164699] - H Ogawa, Y Kunoh, T Sugiura, M Nagasaka. Hypoglycemic activities of MTP-3631, a novel thiopyranopyrimidine derivative.
Life sciences.
1992; 50(5):375-81. doi:
10.1016/0024-3205(92)90439-v. [PMID: 1732707] - M A Tashmukhamedova, O A Mukhina, V N Syrov, Z A Khushbaktova, S P Katkova, M I Kosovskiĭ. [Hypoglycemic activity of bicyclic diterpenoids of the clerodane series as compared to adebit and maninil].
Problemy endokrinologii.
1992 Jan; 38(1):48-50. doi:
. [PMID: 1308597] - O V Korkushko, L N Bogatskaia, A N Kovalenko, S N Novikova, D N Kotko. [Correction of dyslipoproteinemia in middle-aged and elderly patients with atherosclerosis using Essentiale in combination with adebit].
Vrachebnoe delo.
1989 Aug; ?(8):19-22. doi:
. [PMID: 2588515] - K Kawaji, Y Fujita, Y Yajima, M Shirataka, H Kubo. Usefulness of anaerobic threshold in estimating intensity of exercise for diabetics.
Diabetes research and clinical practice.
1989 May; 6(4):303-9. doi:
10.1016/0168-8227(89)90070-3. [PMID: 2502368] - Y Kobayashi, H Kubo, T Kinoshita, T Nishikawa. Fluorometric determination of biguanides in serum by high-performance liquid chromatography with reagent-containing mobile phase.
Journal of chromatography.
1988 Aug; 430(1):65-71. doi:
10.1016/s0378-4347(00)83134-5. [PMID: 3215962] - J Schulze, U Julius, W Leonhardt, H Haller. [Metabolism kinetic characterization of hypertriglyceridemias in drug therapy variations].
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1987 Sep; 42(18):506-11. doi:
". [PMID: 3687141] - N Kaniwa, N Aoyagi, H Ogata. Use of PKM-MULTI program for fitting discontinuous absorption profiles using a microcomputer.
Journal of pharmacobio-dynamics.
1984 Dec; 7(12):900-9. doi:
10.1248/bpb1978.7.900. [PMID: 6549471] - R Neubert, W Fürst, W Böhm, S Dabow. [Drug permeation through artificial lipid membranes. 17. The mechanism of ion pair transport].
Die Pharmazie.
1984 Jun; 39(6):401-3. doi:
". [PMID: 6091156] - T Mothes, R Neubert, W Fürst. [Drug permeability through artificial lipid membranes. 15: Effect of anions on the transport of buformin in model membranes and isolated, lumen- and vessel-perfused small intestine].
Die Pharmazie.
1983 Jan; 38(1):46-7. doi:
". [PMID: 6844381] - P Müller, H Fischer, D Sorger. [Vitamin B12-level in serum of diabetics receiving long-term buformin therapy].
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1981 Mar; 36(6):226-8. doi:
NULL. [PMID: 7257460] - L F Verdonck, B Sangster, A N van Heijst, G de Groot, R A Maes. Buformin concentrations in a case of fatal lactic acidosis.
Diabetologia.
1981; 20(1):45-6. doi:
10.1007/bf00253815. [PMID: 7202882] - V N Anisimov, V A Aleksandrov, N M Belous, I A Vasil'eva, V B Matson. [Inhibition of the transplacental blastomogenic effect of N-nitrosomethylurea in rats by buformin].
Biulleten' eksperimental'noi biologii i meditsiny.
1980 Jul; 89(7):88-90. doi:
. [PMID: 6996759] - V A Alexandrov, V N Anisimov, N M Belous, I A Vasilyeva, V B Mazon. The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats.
Carcinogenesis.
1980; 1(12):975-8. doi:
10.1093/carcin/1.12.975. [PMID: 11272113] - W Fürst, R Neubert, B Förster, L Reppel. [Drug permeation through synthetic lipid membranes. Part 13: The effects of tensides on the permeation of ionized drugs (author's transl)].
Die Pharmazie.
1980; 34(5-6):315-6. doi:
". [PMID: 7413708] - K D Kolenda, W Grille, K Johnsen. [Drug interaction during therapy with tolbutamide. The influence of some commonly used drugs on plasma level and half life in diabetic out-patients (author's transl)].
Medizinische Klinik.
1979 Dec; 74(50):1914-22. doi:
. [PMID: 542176] - M Quartarone, A Saitta, G Caruso, U Monacciani, G Perdichizzi, G Squadrito. [Behavior of IRI and some blood lipid indices after buformin administration].
Minerva medica.
1979 May; 70(22):1623-8. doi:
". [PMID: 450301] - E G Berger, V Brunner, H R Meier, P Moehr. [The effect of oral butyl-biguanide on oral glucose tolerance and renal glucose reabsorption in normal human subjects in vivo (author's transl)].
Klinische Wochenschrift.
1978 Mar; 53(16):275-8. doi:
. [PMID: 682523] - E Brunová, Z Slabochová, F Hrubá, V Nováková, O Bejblová, K Vondra. [Follow-up study on the effects of buformin on the serum vitamin B-12 level and on the motility of the stomach and small intestine in diabetics].
Vnitrni lekarstvi.
1978 Mar; 24(3):277-81. doi:
NULL. [PMID: 644896] - P Lefebvre, A Luyckx, F Mosora, M Lacroix, F Pirnay. Oxidation of an exogenous glucose load using naturally labelled 13C-glucose. Effect of butylbiguanide therapy in obese mildly diabetic subjects.
Diabetologia.
1978 Jan; 14(1):39-45. doi:
10.1007/bf00429706. [PMID: 627331] - P H Althoff, W Fassbinder, M Neubauer, K M Koch, K Schöffling. [Haemodialysis in the treatment of biguanide-induced lactate acidosis (author's transl)].
Deutsche medizinische Wochenschrift (1946).
1978 Jan; 103(2):61-8. doi:
10.1055/s-0028-1104382. [PMID: 627171] - F Ritzl, L E Feinendegen, W Lintz, U Tisljar. [Distribution and excretion of 14c-butylbiguanide in man (author's transl)].
Arzneimittel-Forschung.
1978; 28(7):1184-6. doi:
. [PMID: 582707] - T Koschinsky, F A Gries, P Schwandt, P Weisweiler, W Hansen, J Nijssen, R Beckmann. [Treatment of primary hyperlipoproteinemias of type IIB and IV with butylbiguanide and clofibrate (author's transl)].
MMW, Munchener medizinische Wochenschrift.
1977 May; 119(20):701-4. doi:
. [PMID: 195201] - W F Caspary, I Zavada, W Reimold, U Deuticke, D Emrich, B Willms. Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides.
Diabetologia.
1977 May; 13(3):187-93. doi:
10.1007/bf01219698. [PMID: 873086] - H Butt, J Reitinger. [Lactic acidosis after administration of guanidine derivatives (buformine, phenformine) (author's transl)].
Medizinische Klinik.
1977 Apr; 72(16):708-11. doi:
. [PMID: 857140] - H Förster. [The importance of lactate acidosis as a side effect of biguanide therapy].
Fortschritte der Medizin.
1976 Dec; 94(35-36):2065-71. doi:
NULL. [PMID: 1010516] - M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm.
Biochimica et biophysica acta.
1976 Apr; 428(2):525-31. doi:
10.1016/0304-4165(76)90061-1. [PMID: 6049] - P Weisweiler, P Schwandt. [Treatment of primary hyperlipoproteinemias type IV with different biguanides (author's transl)].
Klinische Wochenschrift.
1976 Mar; 54(6):283-5. doi:
10.1007/bf01468924. [PMID: 177803] - H Gutsche, L Blumenbach, W Losert, H Wiemann. [Concentration of 14C-1-butylbiguanide in plasma of diabetic patients and its elimination after administration of a new Galenical formulation (author's transl)].
Arzneimittel-Forschung.
1976; 26(6):1227-9. doi:
NULL. [PMID: 989423] - P Schräpler, E Schulz, J Adlung. [Effect of Buformin retard in adipose patients with impaired glucose tolerance].
Die Medizinische Welt.
1975 Oct; 26(42):1919-21. doi:
". [PMID: 1186481] - V R Beckmann. [Reduction of serum triglycerides with a combined application of butylbiguanide and clofibrate in animal experiments].
Arzneimittel-Forschung.
1975 May; 25(5):775-6. doi:
NULL. [PMID: 1242321] - V M Dil'man, L M Bershteĭn, E V Tsyrlina, Iu F Bobrov, I G Kovaleva. [Correction of endocrine-metabolic disorders in oncologic patients. The effect of biguanides (phenformin and adebita), miskleron and diphenin].
Voprosy onkologii.
1975; 21(11):33-9. doi:
NULL. [PMID: 1210118] - E LUEDTKE. [ON THE EFFECT OF N1,N-BUTYLBIGUANIDE ON RENAL FUNCTION. II. CHANGES IN INULIN- AND PAH-CLEARANCE].
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1964 Jul; 19(?):551-2. doi:
NULL. [PMID: 14231856] - E LUEDTKE. [INFLUENCING RENAL FUNCTION BY N 1,N-BUTYLBIGUANIDE. I. THE EFFECT ON THE MAXIMAL TUBULAR GLUCOSE RE-ABSORPTION].
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1963 Oct; 18(?):923-5. doi:
NULL. [PMID: 14093641]
