Atractylenolide (BioDeep_00000000341)
Secondary id: BioDeep_00000859328
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
(4aS-trans)- 4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
化学式: C15H18O2 (230.1307)
中文名称: 白术内酯 I, 白术内酯I
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 87.84%
Reviewed
Last reviewed on 2024-07-09.
Cite this Page
Atractylenolide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/atractylenolide (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000000341). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1(=C)[C@H]2[C@@](CCC1)(C=C1C(=C(C(=O)O1)C)C2)C
InChI: InChI=1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1
描述信息
Atractylenolide I is a natural product found in Solanum lyratum, Atractylodes japonica, and other organisms with data available.
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
同义名列表
13 个代谢物同义名
(4aS-trans)- 4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one; (4aS,8aS)-3,8a-dimethyl-5-methylidene-4a,6,7,8-tetrahydro-4H-benzo[f][1]benzofuran-2-one; (4aS,8aS)-3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one; 8,12-EPOXYEUDESMA-4(14),7(11),8-TRIEN-12-ONE; Atractylenolide I, >=98\\% (HPLC); 8,9-dehydroasterolide; Atractylenolide 1; Atractylenolide-1; Atractylenolide I; Atractylenolide-I; AtractylenolideI; Atractylenolide; SCHEMBL18827263
数据库引用编号
9 个数据库交叉引用编号
- KEGG: C17885
- PubChem: 5321018
- ChEMBL: CHEMBL449520
- MeSH: atractylenolide I
- KNApSAcK: C00012889
- chemspider: 4478915
- CAS: 73069-13-3
- medchemexpress: HY-N0201
- PMhub: MS000026178
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
12 个相关的物种来源信息
- 69404 - Atractylodes chinensis: 10.1248/CPB.27.2954
- 2547412 - Atractylodes japonica:
- 2547412 - Atractylodes japonica: -
- 41486 - Atractylodes lancea:
- 41486 - Atractylodes Lancea (Thunb.)Dc.: -
- 265785 - Atractylodes macrocephala:
- 265785 - Atractylodes macrocephala: 10.1248/CPB.27.2954
- 265785 - Atractylodes Macrocephala Koidz.: -
- 33090 - Plants: -
- 230192 - Solanum lyratum: 10.1007/BF02978238
- 33090 - 白术: -
- 33090 - 苍术: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mengwei Wang, Tong-Hua Zhang, Yunjin Li, Xiaofeng Chen, Qiongyin Zhang, Ying Zheng, Denglu Long, Xin Cheng, An Hong, Xuesong Yang, Guang Wang. Atractylenolide-I Alleviates Hyperglycemia-Induced Heart Developmental Malformations through Direct and Indirect Modulation of the STAT3 Pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155698. doi:
10.1016/j.phymed.2024.155698. [PMID: 38728919] - Zhiyi Xie, Minqiu Lin, Xinglishang He, Yingjie Dong, Yigong Chen, Bo Li, Suhong Chen, Guiyuan Lv. Chemical Constitution, Pharmacological Effects and the Underlying Mechanism of Atractylenolides: A Review.
Molecules (Basel, Switzerland).
2023 May; 28(10):. doi:
10.3390/molecules28103987. [PMID: 37241729] - Juan Zou, Yuanyuan Li, Jingyi Cai, Xiaotian Peng, Lincong Zhang, Tian Tian, Tianming Wang, Rong Shi, Jiasheng Wu, Yueming Ma. Identification of Yinchenwuling fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2023 Jan; 1215(?):123570. doi:
10.1016/j.jchromb.2022.123570. [PMID: 36542898] - Meng Fan, Xiaofan Gu, Wanli Zhang, Qiang Shen, Ruiqin Zhang, Qiaoyu Fang, Yueping Wang, Xiaodong Guo, Xiongwen Zhang, Xuan Liu. Atractylenolide I ameliorates cancer cachexia through inhibiting biogenesis of IL-6 and tumour-derived extracellular vesicles.
Journal of cachexia, sarcopenia and muscle.
2022 12; 13(6):2724-2739. doi:
10.1002/jcsm.13079. [PMID: 36085573] - Susan M Britza, Ian F Musgrave, Roger W Byard. Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I.
Toxicology mechanisms and methods.
2022 Oct; 32(8):606-615. doi:
10.1080/15376516.2022.2057267. [PMID: 35354423] - Yue Han, Can Bai, Xi-Meng He, Qing-Ling Ren. P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells.
Purinergic signalling.
2022 Mar; ?(?):. doi:
10.1007/s11302-022-09854-6. [PMID: 35235139] - Zhi-Mei Ma, Shang-Lei Lai, Jin-Yan Zhu, Qin-Chao Ding, Xiao-Bing Dou, Song-Tao Li. [Atractylenolide Ⅰ improves acetaminophen-induced acute liver injury in mice by inhibiting MAPK/NF-κB signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Feb; 47(4):1017-1023. doi:
10.19540/j.cnki.cjcmm.20211008.701. [PMID: 35285202] - Cheng Zheng, Wenting Li, Yao Yao, Ying Zhou. Quality Evaluation of Atractylodis Macrocephalae Rhizoma Based on Combinative Method of HPLC Fingerprint, Quantitative Analysis of Multi-Components and Chemical Pattern Recognition Analysis.
Molecules (Basel, Switzerland).
2021 Nov; 26(23):. doi:
10.3390/molecules26237124. [PMID: 34885706] - Hui Li, Wen Cao, Xun-Bin Zhang, Xi-Xia Zhang, Chao Gu, Li-Mei Gu, Cheng-Yu Pan, Yao-Zhou Tian, Min Lu. Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway.
Molecular medicine reports.
2021 10; 24(4):. doi:
10.3892/mmr.2021.12331. [PMID: 34368880] - Mao Deng, Huijuan Chen, Jiaying Long, Jiawen Song, Long Xie, Xiaofang Li. Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics.
Archives of pharmacal research.
2021 Jul; 44(7):633-654. doi:
10.1007/s12272-021-01342-6. [PMID: 34269984] - Hanchen Xu, Kevin Van der Jeught, Zhuolong Zhou, Lu Zhang, Tao Yu, Yifan Sun, Yujing Li, Changlin Wan, Ka Man So, Degang Liu, Michael Frieden, Yuanzhang Fang, Amber L Mosley, Xiaoming He, Xinna Zhang, George E Sandusky, Yunlong Liu, Samy O Meroueh, Chi Zhang, Aruna B Wijeratne, Cheng Huang, Guang Ji, Xiongbin Lu. Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation.
The Journal of clinical investigation.
2021 05; 131(10):. doi:
10.1172/jci146832. [PMID: 33830945] - Yangyang Guo, Yanyi Xiao, Hengyue Zhu, Hangcheng Guo, Ying Zhou, Yangping Shentu, Chenfei Zheng, Chaosheng Chen, Yongheng Bai. Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.
Biochemical pharmacology.
2021 01; 183(?):114344. doi:
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Theriogenology.
2020 Aug; 152(?):129-138. doi:
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Pakistan journal of pharmaceutical sciences.
2020 May; 33(3):953-960. doi:
". [PMID: 33191218] - Kuilong Wang, Wei Huang, Xianan Sang, Xin Wu, Qiyuan Shan, Dongxin Tang, Xiaofen Xu, Gang Cao. Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Mar; 68(?):153191. doi:
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Acta pharmacologica Sinica.
2020 Feb; 41(2):237-248. doi:
10.1038/s41401-019-0275-z. [PMID: 31341256] - Zi-Xin Mai, Tian-Qi Yu, Ting-Ting Fan. [Atractylenolide I Can Induce Apoptosis of U266 Cells and Enhance Bortezomib Effect].
Zhongguo shi yan xue ye xue za zhi.
2020 Feb; 28(1):177-184. doi:
10.19746/j.cnki.issn.1009-2137.2020.01.030. [PMID: 32027273] - Xiaoyi Chen, Xuefen Sun, Haimin Hua, Yuan Yi, Huiling Li, Chao Chen. Quality evaluation of decoction pieces of Rhizoma Atractylodis Macrocephalae by near infrared spectroscopy coupled with chemometrics.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Oct; 221(?):117169. doi:
10.1016/j.saa.2019.117169. [PMID: 31174137] - Yun Hee Jeong, Wei Li, Younghoon Go, You-Chang Oh. Atractylodis Rhizoma Alba Attenuates Neuroinflammation in BV2 Microglia upon LPS Stimulation by Inducing HO-1 Activity and Inhibiting NF-κB and MAPK.
International journal of molecular sciences.
2019 Aug; 20(16):. doi:
10.3390/ijms20164015. [PMID: 31426492] - Shizhao Xu, Xiaojie Qi, Yuqiang Liu, Yuhan Liu, Xin Lv, Jianzhi Sun, Qian Cai. UPLC-MS/MS of Atractylenolide I, Atractylenolide II, Atractylenolide III, and Atractyloside A in Rat Plasma after Oral Administration of Raw and Wheat Bran-Processed Atractylodis Rhizoma.
Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
10.3390/molecules23123234. [PMID: 30544552] - Wuwen Feng, Hui Ao, Shijun Yue, Cheng Peng. Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs.
Scientific reports.
2018 11; 8(1):16160. doi:
10.1038/s41598-018-34509-1. [PMID: 30385774] - Xiu-Qiong Fu, Ji-Yao Chou, Ting Li, Pei-Li Zhu, Jun-Kui Li, Cheng-Le Yin, Tao Su, Hui Guo, Kin-Wah Lee, Muhammad Jahangir Hossen, Gui-Xin Chou, Zhi-Ling Yu. The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I.
Experimental dermatology.
2018 02; 27(2):201-204. doi:
10.1111/exd.13454. [PMID: 29078004] - Rui-Feng Liang, Wen-Jing Ge, Zheng Wei, Xue-Xia Zhang, Wei-Feng Cui, Xue Liu, Geng-Sheng Li. [Effect of Saposhnikoviae Radix on pharmacokinetics and tissue distributions of active components in Tongxie Yaofang in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Oct; 42(19):3802-3808. doi:
10.19540/j.cnki.cjcmm.20170901.005. [PMID: 29235298] - Weifeng Li, Wenbing Zhi, Fang Liu, Zehong He, Xiuei Wang, Xiaofeng Niu. Atractylenolide I restores HO-1 expression and inhibits Ox-LDL-induced VSMCs proliferation, migration and inflammatory responses in vitro.
Experimental cell research.
2017 04; 353(1):26-34. doi:
10.1016/j.yexcr.2017.02.040. [PMID: 28274716] - Yu-Jiao Zhao, Wen-Hui Xu, Xiao-Li Shen, Jun-Sheng Tian, Xue-Mei Qin. [Study on TLC identification and UPLC determination method of atractylenolide in Atractylodes macrocephala].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Feb; 42(3):531-535. doi:
10.19540/j.cnki.cjcmm.20161222.074. [PMID: 28952260] - Qian Xiao, Fang Zheng, JingJing Wu, Qing Tang, Wei Wang, Swei Sunny Hann. Activation of ERK and Mutual Regulation of Stat3 and SP1 Contribute to Inhibition of PDK1 Expression by Atractylenolide-1 in Human Lung Cancer Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 43(6):2353-2366. doi:
10.1159/000484387. [PMID: 29073620] - Na Zhang, Chao Liu, Tie-Min Sun, Xiao-Ku Ran, Ting-Guo Kang, De-Qiang Dou. Two new compounds from Atractylodes macrocephala with neuroprotective activity.
Journal of Asian natural products research.
2017 Jan; 19(1):35-41. doi:
10.1080/10286020.2016.1247351. [PMID: 28027699] - Huey-Lan Huang, Tzu-Wen Lin, Yu-Ling Huang, Ray-Ling Huang. Induction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells.
Bioorganic & medicinal chemistry letters.
2016 Apr; 26(8):1905-9. doi:
10.1016/j.bmcl.2016.03.021. [PMID: 26988300] - Aimin Wang, Zhiming Xiao, Liping Zhou, Juan Zhang, Xiangmin Li, Qingchun He. The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture.
Pharmaceutical biology.
2016; 54(1):146-50. doi:
10.3109/13880209.2015.1024330. [PMID: 25853971] - Chien-Liang Chao, Hui-Chi Huang, Hang-Ching Lin, Tsu-Chung Chang, Wen-Liang Chang. Sesquiterpenes from Baizhu Stimulate Glucose Uptake by Activating AMPK and PI3K.
The American journal of Chinese medicine.
2016; 44(5):963-79. doi:
10.1142/s0192415x16500531. [PMID: 27430917] - Qian Zhang, Yun-Feng Cao, Rui-Xue Ran, Rong-Shan Li, Xue Wu, Pei-Pei Dong, Yan-Yan Zhang, Cui-Min Hu, Wei-Ming Wang. Strong Specific Inhibition of UDP-glucuronosyltransferase 2B7 by Atractylenolide I and III.
Phytotherapy research : PTR.
2016 Jan; 30(1):25-30. doi:
10.1002/ptr.5496. [PMID: 26536846] - Yao Gao, Li Gao, Xiao-xia Gao, Yu-zhi Zhou, Xue-mei Qin, Jun-sheng Tian. [An exploration in the action targets for antidepressant bioactive components of Xiaoyaosan based on network pharmacology].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Dec; 50(12):1589-95. doi:
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Oncology reports.
2015 Sep; 34(3):1543-8. doi:
10.3892/or.2015.4111. [PMID: 26151480] - Han Yan, Yuanyuan Sun, Qili Zhang, Mingjing Yang, Xiaorui Wang, Yang Wang, Zhiguo Yu, Yunli Zhao. Simultaneous determination and pharmacokinetic study of Atractylenolide I, II and III in rat plasma after intragastric administration of Baizhufuling extract and Atractylodis extract by UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jul; 993-994(?):86-92. doi:
10.1016/j.jchromb.2015.05.006. [PMID: 26001909] - Guo-Shun Shan, Liang-Xiao Zhang, Qi-Miao Zhao, Hong-Bin Xiao, Rong-Jie Zhuo, Gang Xu, Hong Jiang, Xian-Min You, Tian-Zhu Jia. Metabolomic study of raw and processed Atractylodes macrocephala Koidz by LC-MS.
Journal of pharmaceutical and biomedical analysis.
2014 Sep; 98(?):74-84. doi:
10.1016/j.jpba.2014.05.010. [PMID: 24893211] - Jue Song, Shi-rui Zheng, Yong Jin, Jun Li. Pharmacokinetic Interaction of astragaloside IV with atractylenolide I and prim-O-glucosylcimifugin in male Sprague Dawley rats.
Planta medica.
2014 Feb; 80(2-3):187-92. doi:
10.1055/s-0033-1360261. [PMID: 24452462] - Qing-Song Shao, Ai-lian Zhang, Wen-Wen Ye, Hai-Peng Guo, Run-Huai Hu. Fast determination of two atractylenolides in Rhizoma Atractylodis Macrocephalae by Fourier transform near-infrared spectroscopy with partial least squares.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014; 120(?):499-504. doi:
10.1016/j.saa.2013.10.035. [PMID: 24211810] - Wen-Long Zhao, Hui Wiu, Guo-Shun Shan, Tian-Zhu Jia. [Verification of processing theory of "reducing ketone and dryness, and increasing ester and effect" for bran-fried atractylodes].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Oct; 38(20):3493-7. doi:
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Biomedical chromatography : BMC.
2013 Jun; 27(6):699-707. doi:
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Journal of pharmaceutical and biomedical analysis.
2013 Apr; 77(?):88-93. doi:
10.1016/j.jpba.2013.01.020. [PMID: 23411001] - Hyun Lim, Je Hyeong Lee, Jinwoong Kim, Yeong Shik Kim, Hyun Pyo Kim. Effects of the rhizomes of Atractylodes japonica and atractylenolide I on allergic response and experimental atopic dermatitis.
Archives of pharmacal research.
2012 Nov; 35(11):2007-12. doi:
10.1007/s12272-012-1118-3. [PMID: 23212643] - Changhe Wang, Qingguang Geng, Yuxuan Wang. [Protective effect of atractylenolide I on immunological liver injury].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Jun; 37(12):1809-13. doi:
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Journal of ethnopharmacology.
2012 May; 141(1):187-92. doi:
10.1016/j.jep.2012.02.018. [PMID: 22366681] - Chia-Jui Tsai, Jui-Wei Liang, Hsiang-Ru Lin. Sesquiterpenoids from Atractylodes macrocephala act as farnesoid X receptor and progesterone receptor modulators.
Bioorganic & medicinal chemistry letters.
2012 Mar; 22(6):2326-9. doi:
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Journal of pharmaceutical and biomedical analysis.
2012 Jan; 58(?):172-6. doi:
10.1016/j.jpba.2011.09.023. [PMID: 22014654] - Xican Li, Gang Wei, Xiaozhen Wang, Dong-Hui Liu, Ru-Dong Deng, Hui Li, Jian-Hong Zhou, Yi-Wei Li, He-Ping Zeng, Dong-Feng Chen. Targeting of the Sonic Hedgehog pathway by atractylenolides promotes chondrogenic differentiation of mesenchymal stem cells.
Biological & pharmaceutical bulletin.
2012; 35(8):1328-35. doi:
10.1248/bpb.b12-00265. [PMID: 22863933] - Hyun Young Park, Hyun Lim, Hyun Pyo Kim, Yong Soo Kwon. Downregulation of matrix metalloproteinase-13 by the root extract of Cyathula officinalis Kuan and its constituents in IL-1β-treated chondrocytes.
Planta medica.
2011 Sep; 77(13):1528-30. doi:
10.1055/s-0030-1270834. [PMID: 21347999] - Suihar Rong, Hai Lin, Ni Gao. [Study on processing technology and processing principles of atractrylodis macrocephalae rhizoma].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 Apr; 36(8):1001-3. doi:
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Integrative cancer therapies.
2011 Mar; 10(1):92-100. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Oct; 877(27):3019-24. doi:
10.1016/j.jchromb.2009.07.022. [PMID: 19664972] - Dan Shou, Shiwen Dai, Jianmin Zhang, Hongyu Li, Zhongming Yu. [Simultaneous determination of atractylenolide III, atractylenolide I and atractylon in Artactylodis macrocephala using microbore liquid chromatography].
Se pu = Chinese journal of chromatography.
2008 Sep; 26(5):637-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Mar; 863(2):215-22. doi:
10.1016/j.jchromb.2008.01.004. [PMID: 18258498] - Wei Li, Hong-Mei Wen, Xiao-Bing Cui, Ke-Wei Zhang. [Process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes].
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