13-HOTE (BioDeep_00000003298)

   

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(9Z,11E,15Z)-(13S)-13-Hydroxyoctadeca-9,11,15-trienoic acid

化学式: C18H30O3 (294.2195)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 21.61%

分子结构信息

SMILES: C(CCCCCCC/C=C\C=C\[C@@H](O)C/C=C\CC)(=O)O
InChI: InChI=1S/C18H30O3/c1-2-3-11-14-17(19)15-12-9-7-5-4-6-8-10-13-16-18(20)21/h3,7,9,11-12,15,17,19H,2,4-6,8,10,13-14,16H2,1H3,(H,20,21)

描述信息

13-HOTE is a biologically active lipid molecule produced due to altered intestinal lipid metabolism indicative of Alox15 activity. (PMID: 18258795) [HMDB]
13-HOTE is a biologically active lipid molecule produced due to altered intestinal lipid metabolism indicative of Alox15 activity. (PMID: 18258795).

同义名列表

17 个代谢物同义名

(9Z,11E,15Z)-(13S)-13-Hydroxyoctadeca-9,11,15-trienoic acid; (9Z,11E,13S,15Z)-13-Hydroxyoctadeca-9,11,15-trienoic acid; (9Z,11E,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid; (9Z,11E,15Z)-(13S)-Hydroxyoctadeca-9,11,15-trienoate; 13S-hydroxy-9Z,11E,15Z-octadecatrienoic acid; 13-Hydroxy-9Z,11E,15Z-octadecatrienoic acid; 13-hydroxy-9,11,15-octadecatrienoic acid; 13-Hydroxy-9Z,11E,15Z-octadecatrienoate; 13-OH-9Z,11E,15Z-octadecatrienoic acid; 13-OH-9Z,11E,15Z-Octadecatrienoate; 13-Hydroxyoctadecatrienic acid; 13(S)-HOTrE; 13S-HOTrE; 13(S)-HOT; FA 18:3;O; 13-HoTrE; 13-HOTE



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALOX12, ALOX5, CASP1, COL1A1, CYP4F2, NLRP3, PTGS1, PTGS2
Peripheral membrane protein 5 ALOX15, ALOX5, CYP4F2, PTGS1, PTGS2
Endoplasmic reticulum membrane 5 CYP19A1, CYP4F2, FADS3, PTGS1, PTGS2
Nucleus 2 MPO, NLRP3
cytosol 5 ALOX12, ALOX15, ALOX5, CASP1, NLRP3
nucleoplasm 2 ALOX5, MPO
Cell membrane 3 ALOX15, CASP1, TNF
Multi-pass membrane protein 2 CYP19A1, FADS3
Golgi apparatus membrane 1 NLRP3
cell surface 1 TNF
Golgi apparatus 1 PTGS1
Golgi membrane 1 NLRP3
neuronal cell body 1 TNF
sarcolemma 1 ALOX12
Cytoplasm, cytosol 3 ALOX15, ALOX5, NLRP3
Lysosome 1 MPO
plasma membrane 3 ALOX15, CASP1, TNF
Membrane 9 ALOX12, ALOX15, COL1A1, COL4A1, COL4A2, CYP19A1, CYP4F2, FADS3, NLRP3
apical plasma membrane 1 CYP4F2
caveola 1 PTGS2
extracellular exosome 5 ALOX12, COL1A2, COL4A2, MPO, PTGS1
endoplasmic reticulum 3 CYP19A1, NLRP3, PTGS2
extracellular space 11 ALOX5, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, CRP, MPO, TNF
perinuclear region of cytoplasm 1 ALOX5
mitochondrion 1 NLRP3
protein-containing complex 2 CASP1, PTGS2
intracellular membrane-bounded organelle 3 CYP4F2, MPO, PTGS1
Microsome membrane 4 CYP19A1, CYP4F2, PTGS1, PTGS2
Secreted 5 COL1A2, COL3A1, COL5A1, CRP, NLRP3
extracellular region 12 ALOX5, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, CRP, MPO, NLRP3, TNF
cytoplasmic side of plasma membrane 1 ALOX15
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 5 COL1A1, COL1A2, COL3A1, COL5A1, COL5A2
nucleolus 1 CASP1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 1 TNF
microtubule 1 CASP1
extracellular matrix 1 COL5A2
basement membrane 3 COL4A1, COL4A2, COL5A1
collagen trimer 7 COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2
collagen-containing extracellular matrix 7 COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2
secretory granule 2 COL1A1, MPO
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
phagocytic cup 1 TNF
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 2 NLRP3, PTGS1
Lipid droplet 1 ALOX15
microtubule organizing center 1 NLRP3
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
endoplasmic reticulum lumen 8 COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, PTGS2
nuclear matrix 1 ALOX5
azurophil granule lumen 1 MPO
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
AIM2 inflammasome complex 1 CASP1
phagocytic vesicle lumen 1 MPO
canonical inflammasome complex 1 CASP1
Secreted, extracellular space, extracellular matrix, basement membrane 2 COL4A1, COL4A2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
collagen type I trimer 2 COL1A1, COL1A2
collagen type XI trimer 1 COL5A2
collagen type III trimer 1 COL3A1
collagen type IV trimer 2 COL4A1, COL4A2
collagen type V trimer 2 COL5A1, COL5A2
Nucleus intermembrane space 1 ALOX5
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Susanna L Lundström, Jun Yang, Henrik J Källberg, Sarah Thunberg, Guro Gafvelin, Jesper Z Haeggström, Reidar Grönneberg, Johan Grunewald, Marianne van Hage, Bruce D Hammock, Anders Eklund, Åsa M Wheelock, Craig E Wheelock. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PloS one. 2012; 7(3):e33780. doi: 10.1371/journal.pone.0033780. [PMID: 22438998]
  • Susanna L Lundström, Bettina Levänen, Malin Nording, Anna Klepczynska-Nyström, Magnus Sköld, Jesper Z Haeggström, Johan Grunewald, Magnus Svartengren, Bruce D Hammock, Britt-Marie Larsson, Anders Eklund, Åsa M Wheelock, Craig E Wheelock. Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. PloS one. 2011; 6(8):e23864. doi: 10.1371/journal.pone.0023864. [PMID: 21897859]
  • Michel Havaux, Brigitte Ksas, Agnieszka Szewczyk, Dominique Rumeau, Fabrice Franck, Stefano Caffarri, Christian Triantaphylidès. Vitamin B6 deficient plants display increased sensitivity to high light and photo-oxidative stress. BMC plant biology. 2009 Nov; 9(?):130. doi: 10.1186/1471-2229-9-130. [PMID: 19903353]
  • James F Collins, Zihua Hu, P N Ranganathan, Dian Feng, Laura M Garrick, Michael D Garrick, Richard W Browne. Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators. American journal of physiology. Gastrointestinal and liver physiology. 2008 Apr; 294(4):G948-62. doi: 10.1152/ajpgi.00274.2007. [PMID: 18258795]
  • Myun-Ho Bang, Jae-Taek Han, Hae Yeong Kim, Young-Doo Park, Chang-Ho Park, Kang-Ro Lee, Nam-In Baek. 13-Hydroxy-9Z,11E,15E-octadecatrienoic acid from the leaves of Cucurbita moschata. Archives of pharmacal research. 2002 Aug; 25(4):438-40. doi: 10.1007/bf02976597. [PMID: 12214851]
  • G Schulze-Tanzil, Souza P de, B Behnke, S Klingelhoefer, A Scheid, M Shakibaei. Effects of the antirheumatic remedy hox alpha--a new stinging nettle leaf extract--on matrix metalloproteinases in human chondrocytes in vitro. Histology and histopathology. 2002 04; 17(2):477-85. doi: 10.14670/hh-17.477. [PMID: 11962753]