Perfluorooctanesulfonate (PFOS) (BioDeep_00000003063)

human metabolite Industrial Pollutants Exogenous Chemicals and Drugs

代谢物信息卡片

1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid

化学式: C8HF17O3S (499.9375)
中文名称: 全氟辛烷磺酸, 十七氟辛烷磺酸
谱图信息: 最多检出来源 Homo sapiens(general) 23.13%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Perfluorooctanesulfonate (PFOS). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/perfluorooctanesulfonate_(pfos) (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003063). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(C(C(F)(F)S(=O)(=O)O)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F
InChI: InChI=1S/C8HF17O3S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H,26,27,28)

描述信息

Perfluorooctane-1-sulfonic acid is a perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines. It has a role as an antilipemic drug and a persistent organic pollutant. It is functionally related to an octane-1-sulfonic acid.

Perfluorooctane sulfonate (PFOS) can cause cancer according to an independent committee of scientific and health experts. It can cause developmental toxicity according to The Environmental Protection Agency (EPA).

Perfluorooctanesulfonic acid or perfluorooctane sulfonate (PFOS), is a man-made fluorosurfactant and global pollutant. PFOS was the key ingredient in Scotchgard, a fabric protector made by 3M, and numerous stain repellents. It was added to Annex B of the Stockholm Convention on Persistent Organic Pollutants in May 2009. PFOS can form from the degradation of precursors in addition to industrial production. The PFOS levels that have been detected in wildlife are considered high enough to affect health parameters, and recently higher serum levels of PFOS were found to be associated with increased risk of chronic kidney disease in the general US population, consistent with earlier animal studies. This association was independent of confounders such as age, sex, race/ethnicity, body mass index, diabetes, hypertension, and serum cholesterol level.

同义名列表

5 个代谢物同义名

Perfluorooctanesulfonic acid; Perfluorooctylsulfonic acid; PFOS; PFOS; Perfluorooctanesulfonic acid

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:39421
KEGG: C18142
PubChem: 74483
HMDB: HMDB0059586
Metlin: METLIN72060
ChEMBL: CHEMBL1876554
CAS: 1763-23-1
MoNA: AU240559
MoNA: AU240562
MoNA: AU240560
MoNA: AU240557
MoNA: AU240558
MoNA: SM877253
PMhub: MS000007897
PDB-CCD: P8S
NIKKAJI: J56.090A
PubChem: 96024359
KNApSAcK: 39421

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	11	BDNF, CASP3, CAT, CCND1, ESR1, HPGDS, MAPK14, NFE2L2, PFAS, PPARG, TP53
Peripheral membrane protein	3	ACHE, CYP1B1, ESR1
Endoplasmic reticulum membrane	1	CYP1B1
Nucleus	9	ACHE, CASP3, CCND1, ESR1, MAPK14, NFE2L2, PPARA, PPARG, TP53
cytosol	13	ACOX1, CASP3, CAT, CCND1, ESR1, GPT, HPGDS, LEP, MAPK14, NFE2L2, PFAS, PPARG, TP53
dendrite	1	BDNF
centrosome	3	CCND1, NFE2L2, TP53
nucleoplasm	9	CASP3, CCND1, ESR1, HPGDS, MAPK14, NFE2L2, PPARA, PPARG, TP53
RNA polymerase II transcription regulator complex	2	NFE2L2, PPARG
Cell membrane	3	ACHE, ESR1, TNF
Cytoplasmic side	1	ESR1
Synapse	1	ACHE
cell surface	2	ACHE, TNF
glutamatergic synapse	2	CASP3, MAPK14
Golgi apparatus	4	ACHE, ATRN, ESR1, NFE2L2
neuromuscular junction	1	ACHE
neuronal cell body	2	CASP3, TNF
synaptic vesicle	1	BDNF
Cytoplasm, cytosol	1	NFE2L2
plasma membrane	5	ACHE, ATRN, ESR1, NFE2L2, TNF
Membrane	7	ACHE, ACOX1, BDNF, CAT, CYP1B1, ESR1, TP53
axon	1	BDNF
extracellular exosome	4	ATRN, CAT, GPT, PFAS
endoplasmic reticulum	1	TP53
extracellular space	6	ACHE, ATRN, BDNF, IL6, LEP, TNF
perinuclear region of cytoplasm	3	ACHE, BDNF, PPARG
bicellular tight junction	1	CCND1
mitochondrion	4	CAT, CYP1B1, MAPK14, TP53
protein-containing complex	3	CAT, ESR1, TP53
intracellular membrane-bounded organelle	4	CAT, CYP1B1, HPGDS, PPARG
Microsome membrane	1	CYP1B1
postsynaptic density	1	CASP3
Single-pass type I membrane protein	1	ATRN
Secreted	4	ACHE, BDNF, IL6, LEP
extracellular region	7	ACHE, BDNF, CAT, IL6, LEP, MAPK14, TNF
[Isoform 2]: Secreted	1	ATRN
Mitochondrion matrix	1	TP53
mitochondrial matrix	2	CAT, TP53
Extracellular side	1	ACHE
transcription regulator complex	2	ESR1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	1	TP53
Nucleus membrane	1	CCND1
nuclear membrane	1	CCND1
external side of plasma membrane	1	TNF
nucleolus	1	TP53
recycling endosome	1	TNF
Single-pass type II membrane protein	1	TNF
Membrane raft	1	TNF
Cytoplasm, cytoskeleton	1	TP53
focal adhesion	1	CAT
Peroxisome	2	ACOX1, CAT
basement membrane	1	ACHE
Peroxisome matrix	1	CAT
peroxisomal matrix	2	ACOX1, CAT
peroxisomal membrane	2	ACOX1, CAT
Nucleus, PML body	1	TP53
PML body	1	TP53
nuclear speck	1	MAPK14
receptor complex	1	PPARG
chromatin	5	ESR1, NFE2L2, PPARA, PPARG, TP53
mediator complex	1	NFE2L2
phagocytic cup	1	TNF
spindle pole	1	MAPK14
Lipid-anchor, GPI-anchor	1	ACHE
site of double-strand break	1	TP53
[Isoform 3]: Secreted	1	ATRN
euchromatin	1	ESR1
side of membrane	1	ACHE
germ cell nucleus	1	TP53
replication fork	1	TP53
ficolin-1-rich granule lumen	2	CAT, MAPK14
secretory granule lumen	2	CAT, MAPK14
endoplasmic reticulum lumen	2	BDNF, IL6
nuclear matrix	1	TP53
transcription repressor complex	2	CCND1, TP53
[Isoform 1]: Nucleus	2	ESR1, TP53
synaptic cleft	1	ACHE
protein-DNA complex	1	NFE2L2
death-inducing signaling complex	1	CASP3
[Isoform 1]: Cell membrane	1	ATRN
cyclin-dependent protein kinase holoenzyme complex	1	CCND1
[Tumor necrosis factor, soluble form]: Secreted	1	TNF
catalase complex	1	CAT
interleukin-6 receptor complex	1	IL6
cyclin D1-CDK4 complex	1	CCND1
[Isoform H]: Cell membrane	1	ACHE
[Neurotrophic factor BDNF precursor form]: Secreted	1	BDNF
cyclin D1-CDK6 complex	1	CCND1
[C-domain 2]: Secreted	1	TNF
[Tumor necrosis factor, membrane form]: Membrane	1	TNF
[C-domain 1]: Secreted	1	TNF

文献列表

Tzu-Hsin Yen, Sheng-Han Lee, Chuan-Ho Tang, Hao-Jan Liang, Ching-Yu Lin. Lipid responses to perfluorooctane sulfonate exposure for multiple rat organs. Ecotoxicology and environmental safety. 2024 Jun; 277(?):116368. doi: 10.1016/j.ecoenv.2024.116368. [PMID: 38669874]
Wenjie Yi, Junwen Shi, Liying Wang, Dongxuan Wang, Yiting Wang, Jingwen Song, Lili Xin, Fei Jiang. Maternal PFOS exposure in mice induces hepatic lipid accumulation and inflammation in adult female offspring: Involvement of microbiome-gut-liver axis and autophagy. Journal of hazardous materials. 2024 May; 470(?):134177. doi: 10.1016/j.jhazmat.2024.134177. [PMID: 38565010]
Qiyu Wang, Xueyan Gu, Limin Mo, Nannan Wan, Liu Wu, Shuai Liu, Miao Zhang, Mingqi Li, Xi Liu, Yu Liu. Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study. Environment international. 2024 May; 187(?):108687. doi: 10.1016/j.envint.2024.108687. [PMID: 38677088]
Mark Annunziato, Narmin Bashirova, Muhamed N H Eeza, Ariel Lawson, Francisco Fernandez-Lima, Lilian V Tose, Jörg Matysik, A Alia, John P Berry. An Integrated Metabolomics-Based Model, and Identification of Potential Biomarkers, of Perfluorooctane Sulfonic Acid Toxicity in Zebrafish Embryos. Environmental toxicology and chemistry. 2024 Apr; 43(4):896-914. doi: 10.1002/etc.5824. [PMID: 38411227]
Nadine Khoury, María Ángeles Martínez, Stephanie K Nishi, Miguel Ángel Martínez-González, Dolores Corella, Olga Castañer, J Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Manuel Santos-Lozano, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A Tur, Sergio Cinza Sanjurjo, Xavier Pintó, José Juan Gaforio, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Carmen Sayon-Orea, Jose V Sorli, Karla-Alejandra Pérez-Vega, Antonio Garcia-Rios, Francisco Ortiz-Díaz, Enrique Gómez-Gracia, M A Zulet, Alice Chaplin, Rosa Casas, Inmaculada Salcedo-Bellido, Lucas Tojal-Sierra, Maria-Rosa Bernal-Lopez, Zenaida Vazquez-Ruiz, Eva M Asensio, Albert Goday, Patricia J Peña-Orihuela, Antonio J Signes-Pastor, Ana Garcia-Arellano, Montse Fitó, Nancy Babio, Jordi Salas-Salvadó. Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population. Environment international. 2024 Apr; 186(?):108565. doi: 10.1016/j.envint.2024.108565. [PMID: 38574403]
Zhen Lin, Wei Zhou, Zhen Ke, Zhonghua Wu. Ecotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate on aquatic plant Vallisneria natans. Environmental science and pollution research international. 2024 Apr; 31(18):26646-26664. doi: 10.1007/s11356-024-32705-3. [PMID: 38451456]
Xiaohan Li, Qian Zhang, Aiqing Wang, Shan Shan, Xueying Wang, Yarong Wang, Jianmei Wan, Ping Ning, Chengjiao Hong, Hailin Tian, Yun Zhao. Hepatotoxicity induced in rats by chronic exposure to F-53B, an emerging replacement of perfluorooctane sulfonate (PFOS). Environmental pollution (Barking, Essex : 1987). 2024 Apr; 346(?):123544. doi: 10.1016/j.envpol.2024.123544. [PMID: 38367689]
Madeline C Tompach, Charlotte K Gridley, Sida Li, John M Clark, Yeonhwa Park, Alicia R Timme-Laragy. Comparing the effects of developmental exposure to alpha lipoic acid (ALA) and perfluorooctanesulfonic acid (PFOS) in zebrafish (Danio rerio). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 Apr; 186(?):114560. doi: 10.1016/j.fct.2024.114560. [PMID: 38432440]
Katarzyna Mokra, Izabela Kaczmarska, Bożena Bukowska. Perfluorooctane sulfonate (PFOS) and its selected analogs induce various cell death types in peripheral blood mononuclear cells. Chemosphere. 2024 Apr; 354(?):141664. doi: 10.1016/j.chemosphere.2024.141664. [PMID: 38485001]
Jun Hyeok Kim, Gretchen Kroh, Hsiu-An Chou, Shih-Hung Yang, Addison Frese, Michael Lynn, Kung-Hui Chu, Libo Shan. Perfluorooctanesulfonic Acid Alters the Plant's Phosphate Transport Gene Network and Exhibits Antagonistic Effects on the Phosphate Uptake. Environmental science & technology. 2024 Mar; 58(12):5405-5418. doi: 10.1021/acs.est.3c10930. [PMID: 38483317]
Si-Si Liu, Sheng-Ming Cheng, Qi-Si Cai, Guang-Guo Ying, Chang-Er Chen. Short-term mass loads of per- and polyfluoroalkyl substances in a wastewater treatment plant from South China. Environmental science and pollution research international. 2024 Mar; 31(11):17417-17425. doi: 10.1007/s11356-024-32204-5. [PMID: 38337116]
Qiaoli Liang, Pritam Mondal, Qi Li, Tahir Maqbool, Chao Zhao, Daqian Jiang, Greg J Szulczewski, Gayan B Wijeratne. Nitro Indole Derivatives as Novel Dual-Polarity Matrices for MALDI Mass Spectrometry and Imaging with Broad Applications. Analytical chemistry. 2024 Jan; 96(4):1668-1677. doi: 10.1021/acs.analchem.3c04684. [PMID: 38226847]
Cyren M Rico, Dane C Wagner, Polycarp C Ofoegbu, Naum J Kirwa, Preston Clubb, Kameron Coates, Jenny E Zenobio, Adeyemi S Adeleye. Toxicity assessment of perfluorooctanesulfonic acid (PFOS) on a spontaneous plant, velvetleaf (Abutilon theophrasti), via metabolomics. The Science of the total environment. 2024 Jan; 907(?):167894. doi: 10.1016/j.scitotenv.2023.167894. [PMID: 37866594]
Amber M Hall, Elvira Fleury, George D Papandonatos, Jessie P Buckley, Kim M Cecil, Aimin Chen, Bruce P Lanphear, Kimberly Yolton, Douglas I Walker, Kurt D Pennell, Joseph M Braun, Katherine E Manz. Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study. Environmental science & technology. 2023 Dec; 57(51):21627-21636. doi: 10.1021/acs.est.3c07515. [PMID: 38091497]
Vladimíra Puklová, Naděžda Čapková, Alena Fialová, Adam Vavrouš, Kristýna Žejglicová, Milena Černá. Association among serum per- and polyfluoroalkyl substances, lipid profile and metabolic syndrome in Czech adults, HBM-EHES survey 2019. Central European journal of public health. 2023 Dec; 31(4):227-234. doi: 10.21101/cejph.a7799. [PMID: 38309699]
Yanhui Ge, Zhan Wang, Xuelu Chen, Wen Wang, Zhenying Liu, Hongwen Sun, Lianying Zhang. Comparative Toxicological Effects of PFOS and its Alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonate on Earthworms. Environmental toxicology and chemistry. 2023 Oct; ?(?):. doi: 10.1002/etc.5774. [PMID: 37861387]
Justin M Conley, Christy S Lambright, Nicola Evans, Aimen K Farraj, Jacob Smoot, Rachel D Grindstaff, Donna Hill, James McCord, Elizabeth Medlock-Kakaley, Aaron Dixon, Erin Hines, L Earl Gray. Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat. The Science of the total environment. 2023 Sep; 892(?):164609. doi: 10.1016/j.scitotenv.2023.164609. [PMID: 37271399]
Zanina Ilieva, Patricia Hania, Roxana Suehring, Kimberley Gilbride, Rania Hamza. Impact of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) on secondary sludge microorganisms: removal, potential toxicity, and their implications on existing wastewater treatment regulations in Canada. Environmental science. Processes & impacts. 2023 Sep; ?(?):. doi: 10.1039/d3em00202k. [PMID: 37674406]
Xiaoying Li, Zhan Wang, Yanhui Ge, Hongwen Sun, Lianying Zhang. Comparative stress response assessment of PFOS and its alternatives, F-53B and OBS, in wheat: An insight of toxic mechanisms and relative magnitudes. Ecotoxicology and environmental safety. 2023 Aug; 263(?):115333. doi: 10.1016/j.ecoenv.2023.115333. [PMID: 37586196]
Wang Yang, Xi Ling, Shijun He, Haonan Cui, Zeyu Yang, Huihui An, Lihong Wang, Peng Zou, Qing Chen, Jinyi Liu, Lin Ao, Jia Cao. PPARα/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach. Environment international. 2023 Aug; 178(?):108138. doi: 10.1016/j.envint.2023.108138. [PMID: 37572494]
Liang Yu, Zulin Hua, Xiaodong Liu, Luying Chen, Yuan Zhang, Yixin Ma, Yueyang Dong, Hongqin Xue. The addition of iron-carbon enhances the removal of perfluoroalkyl acids (PFAAs) in constructed wetlands. Environmental pollution (Barking, Essex : 1987). 2023 Jun; 327(?):121534. doi: 10.1016/j.envpol.2023.121534. [PMID: 37001598]
Eun Ki Min, Hyojin Lee, Eun Ji Sung, Seong Woo Seo, Myungha Song, Seungjun Wang, Seong Soon Kim, Myung Ae Bae, Tae-Young Kim, Sangkyu Lee, Ki-Tae Kim. Integrative multi-omics reveals analogous developmental neurotoxicity mechanisms between perfluorobutanesulfonic acid and perfluorooctanesulfonic acid in zebrafish. Journal of hazardous materials. 2023 May; 457(?):131714. doi: 10.1016/j.jhazmat.2023.131714. [PMID: 37263023]
Yaxuan Liu, Tianyue Jin, Lan Wang, Jingchun Tang. Polystyrene micro and nanoplastics attenuated the bioavailability and toxic effects of Perfluorooctane sulfonate (PFOS) on soybean (Glycine max) sprouts. Journal of hazardous materials. 2023 04; 448(?):130911. doi: 10.1016/j.jhazmat.2023.130911. [PMID: 36860033]
Yongzhen Du, Tong Xu, Dongliu Luo, Yixuan Wang, Hang Yin, Chengguo Liu, Shu Li. Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol. Environmental toxicology. 2023 Mar; ?(?):. doi: 10.1002/tox.23794. [PMID: 36988283]
Kailee E Hopkins, Melissa A McKinney, Robert J Letcher, Kim J Fernie. The influence of environmental and ecological factors on the accumulation and distribution of short- and long-chain perfluoroalkyl acids in a mid-trophic avian insectivore. Environmental pollution (Barking, Essex : 1987). 2023 Mar; 321(?):121133. doi: 10.1016/j.envpol.2023.121133. [PMID: 36690292]
Guoqi Yu, Jinguo Wang, Yongjie Liu, Tingyu Luo, Xi Meng, Ruiyuan Zhang, Bo Huang, Yan Sun, Jun Zhang. Metabolic perturbations in pregnant rats exposed to low-dose perfluorooctanesulfonic acid: An integrated multi-omics analysis. Environment international. 2023 Feb; 173(?):107851. doi: 10.1016/j.envint.2023.107851. [PMID: 36863164]
Zhiyi Yang, Lei Fu, Mengxi Cao, Fang Li, Jingguang Li, Zhiyu Chen, Ang Guo, Huifang Zhong, Wenbo Li, Yong Liang, Qian Luo. PFAS-induced lipidomic dysregulations and their associations with developmental toxicity in zebrafish embryos. The Science of the total environment. 2023 Feb; 861(?):160691. doi: 10.1016/j.scitotenv.2022.160691. [PMID: 36473658]
Samuel Thomas, William A Ricke, Lingjun Li. Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases. Chemical research in toxicology. 2023 Feb; 36(2):251-259. doi: 10.1021/acs.chemrestox.2c00328. [PMID: 36749316]
Feng Han, Jiaying Liu, Yuxin Wang, Jingguang Li, Bing Lyu, Yunfeng Zhao, Yongning Wu. Penetration of Perfluorooctanesulfonate Isomers and Their Alternatives from Maternal Blood to Milk and Its Associations with Chemical Properties and Milk Primary Components. Environmental science & technology. 2023 02; 57(6):2457-2463. doi: 10.1021/acs.est.2c07401. [PMID: 36734054]
Bianhe Lu, Jin Qian, Jing Hu, Yuanyuan Huang, Peifang Wang, Junwei Shen, Yuxuan He, Sijing Tang, Yin Liu, Yuhang Zhang. Plant rhizosphere defense system respond differently to emerging polyfluoroalkyl substances F-53B and PFOS stress. Journal of hazardous materials. 2023 Feb; 443(Pt A):130119. doi: 10.1016/j.jhazmat.2022.130119. [PMID: 36265386]
Paula Pierozan, Marissa Kosnik, Oskar Karlsson. High-content analysis shows synergistic effects of low perfluorooctanoic acid (PFOS) and perfluorooctane sulfonic acid (PFOA) mixture concentrations on human breast epithelial cell carcinogenesis. Environment international. 2023 Feb; 172(?):107746. doi: 10.1016/j.envint.2023.107746. [PMID: 36731186]
Weilan Zhang, Tamia E Wellington, Yanna Liang. Effect of two sorbents on the distribution and transformation of N-ethyl perfluorooctane sulfonamido acetic acid (N-EtFOSAA) in soil-soybean systems. Environmental pollution (Barking, Essex : 1987). 2023 Feb; 318(?):120941. doi: 10.1016/j.envpol.2022.120941. [PMID: 36566675]
Junyi Ling, Lu Hua, Yi Qin, Tianye Gu, Shengyang Jiang, Jianya Zhao. Perfluorooctane sulfonate promotes hepatic lipid accumulation and steatosis in high-fat diet mice through AMP-activated protein kinase/acetyl-CoA carboxylase (AMPK/ACC) pathway. Journal of applied toxicology : JAT. 2023 Feb; 43(2):312-322. doi: 10.1002/jat.4383. [PMID: 35999056]
Ying-Lin Wu, Qian Xiong, Ben Wang, You-Sheng Liu, Pei-Liang Zhou, Li-Xin Hu, Fang Liu, Guang-Guo Ying. Screening of structural and functional alterations in duckweed (Lemna minor) induced by per- and polyfluoroalkyl substances (PFASs) with FTIR spectroscopy. Environmental pollution (Barking, Essex : 1987). 2023 Jan; 317(?):120671. doi: 10.1016/j.envpol.2022.120671. [PMID: 36436661]
Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu. Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes. Ecotoxicology and environmental safety. 2023 Jan; 249(?):114361. doi: 10.1016/j.ecoenv.2022.114361. [PMID: 36508832]
Hua-Ming Xiao, Shuai Zhao, Dilshad Hussain, Jian-Li Chen, Dan Luo, Fang Wei, Xian Wang. Fluoro-cotton assisted non-targeted screening of organic fluorine compounds from rice (Oryza sativa L.) grown in perfluoroalkyl substance polluted soil. Environmental research. 2023 01; 216(Pt 4):114801. doi: 10.1016/j.envres.2022.114801. [PMID: 36375504]
Ling Chen, Yafeng Liu, Hongxin Mu, Huan Li, Su Liu, Mengyuan Zhu, Yuanqing Bu, Bing Wu. Effects of perfluorobutane sulfonate and perfluorooctane sulfonate on lipid homeostasis in mouse liver. Environmental pollution (Barking, Essex : 1987). 2022 Dec; 315(?):120403. doi: 10.1016/j.envpol.2022.120403. [PMID: 36228861]
Ping Zhang, Liangliang Sun, Fei Liu, Qingqing Gao, Ruting Wang, Qiong Ju, Jin Xu. Perfluorooctanoic acid and perfluorooctane sulfonic acid inhibit plant growth through the modulation of phytohormone signalling pathways: Evidence from molecular and genetic analysis in Arabidopsis. The Science of the total environment. 2022 Dec; 851(Pt 2):158287. doi: 10.1016/j.scitotenv.2022.158287. [PMID: 36030856]
Xu Cheng, Yue Wei, Zefang Zhang, Fei Wang, Jia He, Ruixin Wang, Yali Xu, Mulatibieke Keerman, Shiyang Zhang, Ying Zhang, Jiao Bi, Jinqiu Yao, Meian He. Plasma PFOA and PFOS Levels, DNA Methylation, and Blood Lipid Levels: A Pilot Study. Environmental science & technology. 2022 12; 56(23):17039-17051. doi: 10.1021/acs.est.2c04107. [PMID: 36374530]
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Damaskini Valvi, Kurt Højlund, Brent A Coull, Flemming Nielsen, Pal Weihe, Philippe Grandjean. Life-course Exposure to Perfluoroalkyl Substances in Relation to Markers of Glucose Homeostasis in Early Adulthood. The Journal of clinical endocrinology and metabolism. 2021 07; 106(8):2495-2504. doi: 10.1210/clinem/dgab267. [PMID: 33890111]
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Mengjing Wang, Qianqian Li, Meifang Hou, Louisa L Y Chan, Meng Liu, Soo Kai Ter, Ting Dong, Yun Xia, Sanjay H Chotirmall, Mingliang Fang. Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 2021 06; 118(24):. doi: 10.1073/pnas.2011957118. [PMID: 34099560]
Eulalia María Beltrán, Carlos Fernández-Torija, María Victoria Pablos, Miguel Ángel Porcel, Pilar García-Hortigüela, Miguel González-Doncel. The effect of PFOs on the uptake and translocation of emerging contaminants by crops cultivated under soil and soilless conditions. Ecotoxicology and environmental safety. 2021 Jun; 215(?):112103. doi: 10.1016/j.ecoenv.2021.112103. [PMID: 33740485]
Yulong Li, Liuyang He, Lixin Lv, Jianming Xue, Li Wu, Zulin Zhang, Lie Yang. Review on plant uptake of PFOS and PFOA for environmental cleanup: potential and implications. Environmental science and pollution research international. 2021 Jun; 28(24):30459-30470. doi: 10.1007/s11356-021-14069-0. [PMID: 33893912]
Matthew C Hamilton, Melissa M Heintz, Marisa Pfohl, Emily Marques, Lucie Ford, Angela L Slitt, William S Baldwin. Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Jun; 152(?):112175. doi: 10.1016/j.fct.2021.112175. [PMID: 33838175]
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Andrea Rowan-Carroll, Anthony Reardon, Karen Leingartner, Remi Gagné, Andrew Williams, Matthew J Meier, Byron Kuo, Julie Bourdon-Lacombe, Ivy Moffat, Richard Carrier, Andy Nong, Luigi Lorusso, Stephen S Ferguson, Ella Atlas, Carole Yauk. High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization. Toxicological sciences : an official journal of the Society of Toxicology. 2021 05; 181(2):199-214. doi: 10.1093/toxsci/kfab039. [PMID: 33772556]
Sumitaka Kobayashi, Fumihiro Sata, Houman Goudarzi, Atsuko Araki, Chihiro Miyashita, Seiko Sasaki, Emiko Okada, Yusuke Iwasaki, Tamie Nakajima, Reiko Kishi. Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study. Scientific reports. 2021 05; 11(1):9994. doi: 10.1038/s41598-021-89285-2. [PMID: 33976266]
Deuk-Yeong Lee, Geun-Hyoung Choi, David Megson, Kyeong-Yeol Oh, Ik-Won Choi, Dong-Cheol Seo, Jin-Hyo Kim. Effect of soil organic matter on the plant uptake of perfluorooctanoic acid (PFOA) and perfluorooctanesulphonic acid (PFOS) in lettuce on granular activated carbon-applied soil. Environmental geochemistry and health. 2021 May; 43(5):2193-2202. doi: 10.1007/s10653-020-00793-y. [PMID: 33411166]
Mo Yang, Li-Yue Li, Xiao-Di Qin, Xiao-Yan Ye, Shu Yu, Qing Bao, Lin Sun, Zhi-Bin Wang, Michael S Bloom, Pasi Jalava, Li-Wen Hu, Hong-Yao Yu, Xiao-Wen Zeng, Bo-Yi Yang, Guang-Hui Dong, Chun-Wei Li. Perfluorooctanesulfonate and perfluorooctanoate exacerbate airway inflammation in asthmatic mice and in vitro. The Science of the total environment. 2021 Apr; 766(?):142365. doi: 10.1016/j.scitotenv.2020.142365. [PMID: 33601665]