(-)-Guttiferone E (BioDeep_00000292322)

Main id: BioDeep_00000000617

 

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-[5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione

化学式: C38H50O6 (602.3607)
中文名称: 大蒜素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C
InChI: InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3/b32-31-/t27-,28+,37+,38-/m0/s1

描述信息

(-)-Guttiferone E is found in fruits. (-)-Guttiferone E is a constituent of Garcinia indica (kokam). Camboginol isolated from Garcinia cambogia.
Constituent of Garcinia indica (kokam). Camboginol isolated from Garcinia cambogia. (-)-Guttiferone E is found in fruits.
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity[2].

同义名列表

5 个代谢物同义名

3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-[5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; (-)-Guttiferone E; camboginol; Garcinol; Garcinol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

79 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ANXA5, BCL2, CASP3, CAT, CCND1, EP300, KAT2B, NFKB1, NOS2, PIK3CA, PTGS2, STAT3, VEGFA
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 13 BCL2, CASP3, CCND1, EP300, JUN, KAT2B, NFKB1, NOS2, PARP1, PCNA, PPARGC1A, STAT3, VEGFA
cytosol 13 ANXA5, BCL2, CASP3, CAT, CCND1, EP300, KAT2B, NFKB1, NOS2, PARP1, PIK3CA, PPARGC1A, STAT3
nuclear body 2 PARP1, PCNA
centrosome 3 CCND1, KAT2B, PCNA
nucleoplasm 11 CASP3, CCND1, EP300, JUN, KAT2B, NFKB1, NOS2, PARP1, PCNA, PPARGC1A, STAT3
RNA polymerase II transcription regulator complex 2 JUN, STAT3
Cell membrane 2 ITGAM, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 PIK3CA
Golgi apparatus membrane 1 GORASP1
cell surface 3 ITGAM, TNF, VEGFA
glutamatergic synapse 1 CASP3
Golgi apparatus 2 GORASP1, VEGFA
Golgi membrane 1 GORASP1
neuronal cell body 2 CASP3, TNF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 NOS2, PARP1
plasma membrane 5 ITGAM, NOS2, PIK3CA, STAT3, TNF
Membrane 6 ANXA5, BCL2, CAT, ITGAM, PARP1, VEGFA
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CAT, ITGAM, PCNA
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 3 ITGAM, TNF, VEGFA
perinuclear region of cytoplasm 2 NOS2, PIK3CA
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CAT, NFKB1, PARP1
protein-containing complex 5 BCL2, CAT, KAT2B, PARP1, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ITGAM
Secreted 1 VEGFA
extracellular region 5 ANXA5, CAT, NFKB1, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
transcription regulator complex 5 EP300, JUN, NFKB1, PARP1, STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 KAT2B
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 3 ANXA5, ITGAM, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 PARP1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 2 ITGAM, TNF
pore complex 1 BCL2
focal adhesion 2 ANXA5, CAT
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 1 PPARGC1A
PML body 1 PPARGC1A
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
actomyosin 1 KAT2B
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 7 EP300, JUN, NFKB1, PARP1, PCNA, PPARGC1A, STAT3
phagocytic cup 1 TNF
mitotic spindle 1 KAT2B
Chromosome 2 EP300, PARP1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 2 PARP1, PCNA
chromosome, telomeric region 2 PARP1, PCNA
nuclear chromosome 1 JUN
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
I band 1 KAT2B
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
euchromatin 1 JUN
replication fork 1 PCNA
myelin sheath 1 BCL2
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, NFKB1
endoplasmic reticulum lumen 1 PTGS2
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
kinetochore 1 KAT2B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
vesicle membrane 1 ANXA5
nuclear lamina 1 PCNA
A band 1 KAT2B
[Isoform 1]: Nucleus 1 PPARGC1A
SAGA complex 1 KAT2B
histone acetyltransferase complex 1 EP300
protein-DNA complex 2 EP300, PARP1
death-inducing signaling complex 1 CASP3
ATAC complex 1 KAT2B
site of DNA damage 1 PARP1
integrin complex 1 ITGAM
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
integrin alphaM-beta2 complex 1 ITGAM
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Tongxin Wang, Lu Huang, Changhong Xia, Yan Zhou, Weilei Yao, Liwen Zhang, Feiruo Huang. Dietary supplementation with garcinol during late gestation alleviates disorders of bile acid metabolism and improves the performance of sows and newborn piglets. Journal of animal science. 2023 Oct; ?(?):. doi: 10.1093/jas/skad352. [PMID: 37819678]
  • Weilei Yao, Enling Wang, Yan Zhou, Yanxu Han, Shimin Li, Xinyi Yin, Xinlei Huang, Feiruo Huang. Effects of garcinol supplementation on the performance, egg quality, and intestinal health of laying hens in the late laying period. Poultry science. 2023 Jul; 102(10):102939. doi: 10.1016/j.psj.2023.102939. [PMID: 37562130]
  • Xueying Wang, Jiling Feng, Rong Wu, Jiaqi Tan, Qing Huang, Yeelin Phang, Li Zhang, Wenwei Fu, Hongxi Xu, Changwu Zheng. Garcinol and its analogues: Synthesis, cytotoxic activity and mechanistic investigation. Bioorganic chemistry. 2023 Jan; 133(?):106389. doi: 10.1016/j.bioorg.2023.106389. [PMID: 36731298]
  • Pathanin Chantree, Pongsakorn Martviset, Nattaya Thongsepee, Kant Sangpairoj, Phornphan Sornchuer. Anti-Inflammatory Effect of Garcinol Extracted from Garcinia dulcis via Modulating NF-κB Signaling Pathway. Nutrients. 2023 Jan; 15(3):. doi: 10.3390/nu15030575. [PMID: 36771283]
  • Brahamacharry Paul, Raghuvir H Gaonkar, Debasmita Dutta, Rajesh Dasi, Biswajit Mukherjee, Shantanu Ganguly, Sujoy K Das. Inhibitory potential of iRGD peptide-conjugated garcinol-loaded biodegradable nanoparticles in rat colorectal carcinoma. Biomaterials advances. 2022 Mar; 134(?):112714. doi: 10.1016/j.msec.2022.112714. [PMID: 35581094]
  • Weilei Yao, Jun Xia, Tongxin Wang, Juan Li, Lu Huang, Feiruo Huang. Garcinol promotes hepatic gluconeogenesis by inhibiting P300/CBP-associated factor in late-pregnant sows. The British journal of nutrition. 2021 07; 126(1):1-8. doi: 10.1017/s000711452000375x. [PMID: 32967737]
  • Dan Zheng, Jia-Ming Jiang, Si-Min Chen, Shi-Jie Wan, Han-Gui Ren, Gan Chen, Gang Xu, Hua Zhou, Hong Zhang, Hong-Xi Xu. Structural Revision of Guttiferone F and 30-epi-Cambogin. Journal of natural products. 2021 04; 84(4):1397-1402. doi: 10.1021/acs.jnatprod.0c01031. [PMID: 33683883]
  • Patrycja Kopytko, Katarzyna Piotrowska, Joanna Janisiak, Maciej Tarnowski. Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22062828. [PMID: 33799504]
  • Tongxin Wang, Juan Li, Yafei Shao, Weilei Yao, Jun Xia, Qiongyu He, Feiruo Huang. The effect of dietary garcinol supplementation on oxidative stability, muscle postmortem glycolysis and meat quality in pigs. Meat science. 2020 Mar; 161(?):107998. doi: 10.1016/j.meatsci.2019.107998. [PMID: 31707156]
  • Weilei Yao, Tongxin Wang, Jun Xia, Juan Li, Xinhong Yu, Feiruo Huang. Dietary Garcinol Attenuates Hepatic Pyruvate and Triglyceride Accumulation by Inhibiting P300/CBP-Associated Factor in Mid-to-Late Pregnant Rats. The Journal of nutrition. 2020 02; 150(2):231-239. doi: 10.1093/jn/nxz238. [PMID: 31579921]
  • Jing Wang, Man Wu, Dan Zheng, Hong Zhang, Yue Lv, Li Zhang, Hong-Sheng Tan, Hua Zhou, Yuan-Zhi Lao, Hong-Xi Xu. Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways. Acta pharmacologica Sinica. 2020 Jan; 41(1):82-92. doi: 10.1038/s41401-019-0271-3. [PMID: 31371781]
  • Ling Ding, Qing Zhu, Feng Zhou, Hongsheng Tan, Wenjia Xu, Chengling Pan, Caixia Zhu, Yuyan Wang, Hong Zhang, Wenwei Fu, Zhikang Qian, Zhenghong Yuan, Hongxi Xu, Fang Wei, Qiliang Cai. Identification of viral SIM-SUMO2-interaction inhibitors for treating primary effusion lymphoma. PLoS pathogens. 2019 12; 15(12):e1008174. doi: 10.1371/journal.ppat.1008174. [PMID: 31830143]
  • H N Fernando, K G U R Kumarasinghe, T D C P Gunasekara, H P S K Wijekoon, E M A K Ekanayaka, S P Rajapaksha, S S N Fernando, P M Jayaweera. Synthesis, Characterization and Antimicrobial Activity of Garcinol Capped Silver Nanoparticles. Journal of microbiology and biotechnology. 2019 Nov; 29(11):1841-1851. doi: 10.4014/jmb.1904.04032. [PMID: 31387343]
  • Tongxin Wang, Weilei Yao, Jun Xia, Juan Li, Yafei Shao, Feiruo Huang. Dietary supplementation with garcinol during late gestation and lactation facilitates acid-base balance and improves the performance of sows and newborn piglets1. Journal of animal science. 2019 Nov; 97(11):4557-4566. doi: 10.1093/jas/skz292. [PMID: 31504564]
  • Rainer Schobert, Bernhard Biersack. Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments. Chemistry & biodiversity. 2019 Sep; 16(9):e1900366. doi: 10.1002/cbdv.201900366. [PMID: 31386266]
  • Satarupa Deb, Banashree Chetia Phukan, Muhammed Khairujjaman Mazumder, Ankumoni Dutta, Rajib Paul, Pallab Bhattacharya, Rajat Sandhir, Anupom Borah. Garcinol, a multifaceted sword for the treatment of Parkinson's disease. Neurochemistry international. 2019 09; 128(?):50-57. doi: 10.1016/j.neuint.2019.04.004. [PMID: 30986504]
  • Sungjin Chung, Soojeong Kim, Mina Son, Minyoung Kim, Eun Sil Koh, Seok Joon Shin, Cheol Whee Park, Ho-Shik Kim. Inhibition of p300/CBP-Associated Factor Attenuates Renal Tubulointerstitial Fibrosis through Modulation of NF-kB and Nrf2. International journal of molecular sciences. 2019 Mar; 20(7):. doi: 10.3390/ijms20071554. [PMID: 30925687]
  • Purnima Warriar, Kalyani Barve, Bala Prabhakar. Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis. Recent patents on inflammation & allergy drug discovery. 2019; 13(1):49-56. doi: 10.2174/1872213x12666181120091528. [PMID: 30457056]
  • Pei-Sheng Lee, Chia-Yi Teng, Nagabhushanam Kalyanam, Chi-Tang Ho, Min-Hsiung Pan. Garcinol Reduces Obesity in High-Fat-Diet-Fed Mice by Modulating Gut Microbiota Composition. Molecular nutrition & food research. 2019 01; 63(2):e1800390. doi: 10.1002/mnfr.201800390. [PMID: 30516329]
  • Seok Kim, Seung Un Seo, Kyoung-Jin Min, Seon Min Woo, Ju-Ock Nam, Peter Kubatka, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon. Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression. Molecules (Basel, Switzerland). 2018 Jul; 23(7):. doi: 10.3390/molecules23071614. [PMID: 30004456]
  • Yue Lu, Na-Mi Kim, Yi-Wen Jiang, Hong Zhang, Dan Zheng, Fu-Xiang Zhu, Rui Liang, Bin Li, Hong-Xi Xu. Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. British journal of pharmacology. 2018 04; 175(7):1085-1099. doi: 10.1111/bph.14150. [PMID: 29352742]
  • Kodikonda Madhuri, Prakash Ramachandra Naik. Modulatory effect of garcinol in streptozotocin-induced diabetic Wistar rats. Archives of physiology and biochemistry. 2017 Dec; 123(5):322-329. doi: 10.1080/13813455.2017.1336632. [PMID: 28598692]
  • Shih-Hsin Tu, Yi-Shiou Chiou, Nagabhushanam Kalyanam, Chi-Tang Ho, Li-Ching Chen, Min-Hsiung Pan. Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model. Food & function. 2017 Mar; 8(3):1067-1079. doi: 10.1039/c6fo01588c. [PMID: 28145547]
  • Chi-Cheng Huang, Chien-Min Lin, Yan-Jiun Huang, Li Wei, Lei-Li Ting, Chia-Chun Kuo, Cheyu Hsu, Jeng-Fong Chiou, Alexander T H Wu, Wei-Hwa Lee. Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. Biotechnology and applied biochemistry. 2017 Mar; 64(2):165-173. doi: 10.1002/bab.1446. [PMID: 26400206]
  • Mengqi Wang, Yufei Xie, Youxiu Zhong, Juren Cen, Lei Wang, Yuanyuan Liu, Ying Zhu, Li Tong, Qun Wei. Amelioration of Experimental Autoimmune Encephalomyelitis by Isogarcinol Extracted from Garcinia mangostana L. Mangosteen. Journal of agricultural and food chemistry. 2016 Nov; 64(47):9012-9021. doi: 10.1021/acs.jafc.6b04145. [PMID: 27933873]
  • Fang Hao, Li-Hua Jia, Xiao-Wan Li, Ying-Rui Zhang, Xue-Wu Liu. Garcinol Upregulates GABAA and GAD65 Expression, Modulates BDNF-TrkB Pathway to Reduce Seizures in Pentylenetetrazole (PTZ)-Induced Epilepsy. Medical science monitor : international medical journal of experimental and clinical research. 2016 Nov; 22(?):4415-4425. doi: 10.12659/msm.897579. [PMID: 27855137]
  • Kaikai Shen, Fangfang Lu, Jianling Xie, Minfeng Wu, Bo Cai, Yurong Liu, Hong Zhang, Hongsheng Tan, Yingyi Pan, Hongxi Xu. Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics. Oncotarget. 2016 Aug; 7(31):50596-50611. doi: 10.18632/oncotarget.10585. [PMID: 27418140]
  • Sadhna Aggarwal, Satya N Das. Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016 Jun; 37(6):7175-84. doi: 10.1007/s13277-015-4583-8. [PMID: 26662963]
  • Bin Wang, Ling Lin, Qing Ai, Tao Zeng, Pu Ge, Li Zhang. HAT inhibitor, garcinol, exacerbates lipopolysaccharide‑induced inflammation in vitro and in vivo. Molecular medicine reports. 2016 Jun; 13(6):5290-6. doi: 10.3892/mmr.2016.5189. [PMID: 27122221]
  • Amit K Behera, Mahadeva M Swamy, Nagashayana Natesh, Tapas K Kundu. Garcinol and Its Role in Chronic Diseases. Advances in experimental medicine and biology. 2016; 928(?):435-452. doi: 10.1007/978-3-319-41334-1_18. [PMID: 27671827]
  • A P Anu Aravind, K R T Asha, K B Rameshkumar. Phytochemical analysis and antioxidant potential of the leaves of Garcinia travancorica Bedd. Natural product research. 2016; 30(2):232-6. doi: 10.1080/14786419.2015.1043551. [PMID: 25982126]
  • Constant Anatole Pieme, Pathaleon Ambassa, Emmanuel Yankep, Ajit Kumar Saxena. Epigarcinol and isogarcinol isolated from the root of Garcinia ovalifolia induce apoptosis of human promyelocytic leukemia (HL-60 cells). BMC research notes. 2015 Nov; 8(?):700. doi: 10.1186/s13104-015-1596-8. [PMID: 26592743]
  • Desmond N Jackson, Lin Yang, ShiBiao Wu, Edward J Kennelly, Peter N Lipke. Garcinia xanthochymus Benzophenones Promote Hyphal Apoptosis and Potentiate Activity of Fluconazole against Candida albicans Biofilms. Antimicrobial agents and chemotherapy. 2015 Oct; 59(10):6032-8. doi: 10.1128/aac.00820-15. [PMID: 26195512]
  • Wei Li, Hu Li, Mu Zhang, Youxiu Zhong, Mengqi Wang, Juren Cen, Hezhen Wu, Yanfang Yang, Qun Wei. Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Systemic Lupus Erythematosus-like Disease in a Murine Model. Journal of agricultural and food chemistry. 2015 Sep; 63(38):8452-9. doi: 10.1021/acs.jafc.5b03425. [PMID: 26330173]
  • Kaikai Shen, Jianling Xie, Hua Wang, Hong Zhang, Mengyuan Yu, Fangfang Lu, Hongsheng Tan, Hongxi Xu. Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells. Molecular cancer therapeutics. 2015 Jul; 14(7):1738-49. doi: 10.1158/1535-7163.mct-14-1048. [PMID: 25976678]
  • Feng Li, Muthu K Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H Ong, Ser Yue Loo, Mahadeva M M Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui, Gautam Sethi. Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. Oncotarget. 2015 Mar; 6(7):5147-63. doi: 10.18632/oncotarget.2881. [PMID: 25762616]
  • Timo D Stark, Mathias Salger, Oliver Frank, Onesmo B Balemba, Junichiro Wakamatsu, Thomas Hofmann. Antioxidative compounds from Garcinia buchananii stem bark. Journal of natural products. 2015 Feb; 78(2):234-40. doi: 10.1021/np5007873. [PMID: 25625705]
  • Mei-Ling Tsai, Yi-Shiou Chiou, Li-Yu Chiou, Chi-Tang Ho, Min-Hsiung Pan. Garcinol suppresses inflammation-associated colon carcinogenesis in mice. Molecular nutrition & food research. 2014 Sep; 58(9):1820-9. doi: 10.1002/mnfr.201400149. [PMID: 24981158]
  • Jaideep Bibishan Bharate, Ram Ashrey Vishwakarma, Sandip Bibishan Bharate, Manoj Kushwaha, Ajai Prakash Gupta. Quantification of the Polyisoprenylated Benzophenones Garcinol and Isogarcinol Using Multiple Reaction Monitoring LC/Electrospray Ionization-MS/MS Analysis of Ultrasound-Assisted Extracts of Garcinia indica Fruits. Journal of AOAC International. 2014 Sep; 97(5):1317-22. doi: 10.5740/jaoacint.13-137. [PMID: 25902981]
  • Yuping Jing, Qing Ai, Ling Lin, Jie Dai, Mengying Jia, Dan Zhou, Qian Che, Jingyuan Wan, Rong Jiang, Li Zhang. Protective effects of garcinol in mice with lipopolysaccharide/D-galactosamine-induced apoptotic liver injury. International immunopharmacology. 2014 Apr; 19(2):373-80. doi: 10.1016/j.intimp.2014.02.012. [PMID: 24560905]
  • Sheng-Yung Yu, Chiung-Ho Liao, Ming-Hsien Chien, Tsung-Yu Tsai, Jen-Kun Lin, Meng-Shih Weng. Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer. Journal of agricultural and food chemistry. 2014 Mar; 62(9):2085-95. doi: 10.1021/jf4037722. [PMID: 24533688]
  • Guillermo Mariño, Federico Pietrocola, Frank Madeo, Guido Kroemer. Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers. Autophagy. 2014; 10(11):1879-82. doi: 10.4161/auto.36413. [PMID: 25484097]
  • Xia Ye, Lei Yuan, Li Zhang, Jing Zhao, Chun-Mei Zhang, Hua-Yu Deng. Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol. Asian Pacific journal of cancer prevention : APJCP. 2014; 15(12):5001-7. doi: 10.7314/apjcp.2014.15.12.5001. [PMID: 24998578]
  • Feng Li, Muthu K Shanmugam, Luxi Chen, Snehajyoti Chatterjee, Jeelan Basha, Alan Prem Kumar, Tapas K Kundu, Gautam Sethi. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer prevention research (Philadelphia, Pa.). 2013 Aug; 6(8):843-54. doi: 10.1158/1940-6207.capr-13-0070. [PMID: 23803415]
  • Takahiro Oike, Hideaki Ogiwara, Kohta Torikai, Takashi Nakano, Jun Yokota, Takashi Kohno. Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining. International journal of radiation oncology, biology, physics. 2012 Nov; 84(3):815-21. doi: 10.1016/j.ijrobp.2012.01.017. [PMID: 22417805]
  • Zaorui Zhao, Lu Fan, Ashley M Fortress, Marissa I Boulware, Karyn M Frick. Hippocampal histone acetylation regulates object recognition and the estradiol-induced enhancement of object recognition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Feb; 32(7):2344-51. doi: 10.1523/jneurosci.5819-11.2012. [PMID: 22396409]
  • Xin Chen, Xinyan Zhang, Ye Lu, Joong-Youn Shim, Shengmin Sang, Zheng Sun, Xiaoxin Chen. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol. Nutrition and cancer. 2012; 64(8):1211-1218. doi: 10.1080/01635581.2012.718032. [PMID: 23137051]
  • Chin-Lin Hsu, Yu-Jyun Lin, Chi-Tang Ho, Gow-Chin Yen. Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food & function. 2012 Jan; 3(1):49-57. doi: 10.1039/c1fo10209e. [PMID: 22094440]
  • Meng-Shih Weng, Chiung-Ho Liao, Sheng-Yung Yu, Jen-Kun Lin. Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. Journal of agricultural and food chemistry. 2011 Feb; 59(3):1031-40. doi: 10.1021/jf104263s. [PMID: 21214247]
  • Ze Tian, Jie Shen, Fengfei Wang, Peigen Xiao, Junshan Yang, Hetian Lei, Andrius Kazlauskas, Isaac S Kohane, Erxi Wu. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PloS one. 2011; 6(6):e21370. doi: 10.1371/journal.pone.0021370. [PMID: 21712951]
  • Taito Nishino, Changshan Wang, Makiko Mochizuki-Kashio, Mitsujiro Osawa, Hiromitsu Nakauchi, Atsushi Iwama. Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PloS one. 2011; 6(9):e24298. doi: 10.1371/journal.pone.0024298. [PMID: 21931675]
  • An-Chin Cheng, Mei-Ling Tsai, Chi-Mei Liu, Ming-Fen Lee, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan. Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food & function. 2010 Dec; 1(3):301-7. doi: 10.1039/c0fo00134a. [PMID: 21776480]
  • Sang-Je Park, Jae-Won Huh, Dae-Soo Kim, Hong-Seok Ha, Yi-Deun Jung, Kung Ahn, Keon Bong Oh, Eung-Woo Park, Kyu-Tae Chang, Heui-Soo Kim. Analysis of the molecular and regulatory properties of active porcine endogenous retrovirus gamma-1 long terminal repeats in kidney tissues of the NIH-Miniature pig. Molecules and cells. 2010 Oct; 30(4):319-25. doi: 10.1007/s10059-010-0121-0. [PMID: 20811814]
  • Joanna Kolodziejczyk, Milena Masullo, Beata Olas, Sonia Piacente, Barbara Wachowicz. Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma. Platelets. 2009 Nov; 20(7):487-92. doi: 10.3109/09537100903165182. [PMID: 19852687]
  • Satyanshu Kumar, Shelly Sharma, Sunil K Chattopadhyay. High-performance liquid chromatography and LC-ESI-MS method for identification and quantification of two isomeric polyisoprenylated benzophenones isoxanthochymol and camboginol in different extracts of Garcinia species. Biomedical chromatography : BMC. 2009 Aug; 23(8):888-907. doi: 10.1002/bmc.1202. [PMID: 19353725]
  • Milena Masullo, Carla Bassarello, Hisanori Suzuki, Cosimo Pizza, Sonia Piacente. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia. Journal of agricultural and food chemistry. 2008 Jul; 56(13):5205-10. doi: 10.1021/jf800416j. [PMID: 18533663]
  • Sunil K Chattopadhyay, Satyanshu Kumar. Liquid chromatography-tandem mass spectrometry method for identification and quantification of two biologically active polyisoprenylated benzophenones, isoxanthochymol and camboginol, in Garcinia species. Biomedical chromatography : BMC. 2007 Nov; 21(11):1159-65. doi: 10.1002/bmc.868. [PMID: 17583544]
  • Jungil Hong, Seok Joo Kwon, Shengmin Sang, Jihyeung Ju, Jian-nian Zhou, Chi-Tang Ho, Mou-Tuan Huang, Chung S Yang. Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects. Free radical biology & medicine. 2007 Apr; 42(8):1211-21. doi: 10.1016/j.freeradbiomed.2007.01.016. [PMID: 17382202]
  • Sunil K Chattopadhyay, Satyanshu Kumar. A rapid liquid chromatography-tandem mass spectrometry method for quantification of a biologically active molecule camboginol in the extract of Garcinia cambogia. Biomedical chromatography : BMC. 2007 Jan; 21(1):55-66. doi: 10.1002/bmc.719. [PMID: 17080506]
  • Wafaa Hamed, Solenn Brajeul, Florence Mahuteau-Betzer, Odile Thoison, Stéphane Mons, Bernard Delpech, Van Hung Nguyen, Thierry Sévenet, Christian Marazano. Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia. Journal of natural products. 2006 May; 69(5):774-7. doi: 10.1021/np050543s. [PMID: 16724839]
  • Jungil Hong, Shengmin Sang, Hye-Jin Park, Seok Joo Kwon, Nanjoo Suh, Mou-Tuan Huang, Chi-Tang Ho, Chung S Yang. Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives. Carcinogenesis. 2006 Feb; 27(2):278-86. doi: 10.1093/carcin/bgi208. [PMID: 16093250]
  • Chiung-Ho Liao, Shengmin Sang, Chi-Tang Ho, Jen-Kun Lin. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. Journal of cellular biochemistry. 2005 Sep; 96(1):155-69. doi: 10.1002/jcb.20540. [PMID: 16052481]
  • Chiung-Ho Liao, Shengmin Sang, Yu-Chih Liang, Chi-Tang Ho, Jen-Kun Lin. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol. Molecular carcinogenesis. 2004 Nov; 41(3):140-9. doi: 10.1002/mc.20050. [PMID: 15390082]
  • Karanam Balasubramanyam, M Altaf, Radhika A Varier, V Swaminathan, Aarti Ravindran, Parag P Sadhale, Tapas K Kundu. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of biological chemistry. 2004 Aug; 279(32):33716-26. doi: 10.1074/jbc.m402839200. [PMID: 15155757]
  • F Yamaguchi, T Ariga, Y Yoshimura, H Nakazawa. Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. Journal of agricultural and food chemistry. 2000 Feb; 48(2):180-5. doi: 10.1021/jf990845y. [PMID: 10691613]
  • P Bakana, M Claeys, J Totté, L A Pieters, L Van Hoof, Tamba-Vemba, D A Van den Berghe, A J Vlietinck. Structure and chemotherapeutical activity of a polyisoprenylated benzophenone from the stem bark of Garcinia huillensis. Journal of ethnopharmacology. 1987 Sep; 21(1):75-84. doi: 10.1016/0378-8741(87)90096-1. [PMID: 3695558]