p-Cresol (BioDeep_00000002893)

 

Secondary id: BioDeep_00000405468, BioDeep_00000861763

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs Toxin


代谢物信息卡片


4-(Pentafluorosulfanyl)phenol

化学式: C7H8O (108.0575118)
中文名称: 对甲酚, 4-甲基苯酚, 对甲基苯酚
谱图信息: 最多检出来源 Homo sapiens(blood) 0.14%

Reviewed

Last reviewed on 2024-07-23.

Cite this Page

p-Cresol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/p-cresol (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000002893). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1cc(ccc1C)O
InChI: InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3

描述信息

para-Cresol, also 4-methylphenol, is an organic compound with the formula CH3C6H4(OH). P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. It has a role as a uremic toxin, a human metabolite and an Escherichia coli metabolite. It is a colourless solid that is widely used intermediate in the production of other chemicals. It is a derivative of phenol and is an isomer of o-cresol and m-cresol. It is a partially lipophilic moiety which strongly binds to plasma protein (close to 100\\%) under normal conditions. p-Cresol is metabolized through conjugation, mainly sulphation and glucuronization, but removal of the unconjugated p-cresol is, at least in part, via the urine. Therefore it is not surprising that this compound, together with several other phenoles, is retained when the kidneys fail. P-Cresol is an end-product of protein breakdown, and an increase of the nutritional protein load in healthy individuals results in enhanced generation and urinary excretion. The serum p-cresol concentration in uremic patients can be decreased by changing to a low-protein diet. p-Cresol is one of the metabolites of the amino acid tyrosine, and to a certain extent also of phenylalanine, which are converted to 4-hydroxyphenylacetic acid by intestinal bacteria, before being decarboxylated to p-cresol (putrefaction). The main contributing bacteria are aerobes (mainly enterobacteria), but to a certain extent also anaerobes play a role (mainly Clostridium perfringens). In uremia, modifications in the intestinal flora result in the specific overgrowth of bacteria that are specific p-cresol producers. The administration of antibiotics reduces urinary excretion of p-cresol, as a result of the liquidation of the producing bacteria. Environmental factors might also contribute. The liver cytochrome P450 metabolizes toluene to benzyl alcohol, but also to o-cresol and p-cresol. Toluene is not only used industrially, but it is also the most widely abusively inhaled solvent. Furthermore, p-cresol is a metabolite of menthofuran, one of the metabolites of R-(+)-pulegone, which is found in extracts from the plants Mentha pulegium and Hedeoma pulegioides, commonly known as pennyroyal oil and pennyroyal tea. These extracts are popular as unconventional herbal therapeutic agents and are applied as abortiva, diaphoretics, emmenagogues, and psychedelic drugs. Pennyroyal oil is extensively used for its pleasant mint-like smell in the flavoring industry. The toxicity of pennyroyal oil and menthofuran is well known. Another compound used in traditional medicine, especially in Japan, which is a precursor of p-cresol is wood tar creosote. p-Cresol has been reported to affect several biochemical, biological and physiological functions: (i) it diminishes the oxygen uptake of rat cerebral cortex slices; (ii) it increases the free active drug concentration of warfarin and diazepam; (iii) it has been related to growth retardation in the weanling pig; (iv) it alters cell membrane permeability, at least in bacteria; (v) it induces LDH leakage from rat liver slices; (vi) it induces susceptibility to auditive epileptic crises; and (vii) it blocks cell K+ channels. (PMID:10570076). p-Cresol is a uremic toxin that is at least partially removed by peritoneal dialysis in haemodialysis patients, and has been involved in the progression of renal failure (PMID:11169029). At concentrations encountered during uremia, p-cresol inhibits phagocyte function and decreases leukocyte adhesion to cytokine-stimulated endothelial cells. (PMID:14681860). p-Cresol can be found in Bacteroides, Bifidobacterium, Clostridium, Enterobacter and Lactobacillus (PMID:2394806; PMID:30208103). As a volatile organic compound, it has been identified as a fecal biomarker of Clostridium difficile infection (PMID:30986230).
Present in blackcurrant buds, asparagus, cooked cured pork, black tea, fermented tea, yellow passion fruit juice, malt, peated malt, kumazasa (Sasa albo-marginata), lambs lettuce, squid and cuttlefish. Flavouring ingredient. 4-Methylphenol is found in many foods, some of which are animal foods, cereals and cereal products, tamarind, and tarragon.

同义名列表

27 个代谢物同义名

4-(Pentafluorosulfanyl)phenol; 1-Hydroxy-4-methylbenzene; 1-Methyl-4-hydroxybenzene; 4-Cresol, potassium salt; 4-Cresol, aluminum salt; P-Methylhydroxybenzene; 4-Cresol, sodium salt; Paramethyl phenol; 4-Hydroxytoluene; P-Hydroxytoluene; P-Methyl phenol; 4-Methyl phenol; 4-Methyl-phenol; p-Tolyl alcohol; P-Cresylic acid; p-Methylphenol; 4-Methylphenol; P-Oxytoluene; Para-cresol; P-Cresylate; Paracresol; P-CRESOL; 4-Cresol; m-cresol; p-Kresol; P-Toluol; p-Cresol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

11 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(10)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

65 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kimberly C Paul, Keren Zhang, Douglas I Walker, Janet Sinsheimer, Yu Yu, Cynthia Kusters, Irish Del Rosario, Aline Duarte Folle, Adrienne M Keener, Jeff Bronstein, Dean P Jones, Beate Ritz. Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson's disease. Molecular neurodegeneration. 2023 Dec; 18(1):100. doi: 10.1186/s13024-023-00694-5. [PMID: 38115046]
  • Tripti Singh, Dan Bahadur Pal, Ashok Kumar Bhatiya, Pradeep Kumar Mishra, Abeer Hashem, Abdulaziz Abdullah Alqarawi, Elsayed Fathi AbdAllah, Vijai Kumar Gupta, Neha Srivastava. Integrated process approach for degradation of p-cresol pollutant under photocatalytic reactor using activated carbon/TiO2 nanocomposite: application in wastewater treatment. Environmental science and pollution research international. 2022 Sep; 29(41):61811-61820. doi: 10.1007/s11356-021-15454-5. [PMID: 34415523]
  • Kaden K Fujita, Jon A Doering, Eric Stock, Zhe Lu, Tony Montina, Steve Wiseman. Effects of dietary 2-(2H-benzotriazol-2-yl)-4-methylphenol (UV-P) exposure on Japanese medaka (Oryzias latipes) in a short-term reproduction assay. Aquatic toxicology (Amsterdam, Netherlands). 2022 Jul; 248(?):106206. doi: 10.1016/j.aquatox.2022.106206. [PMID: 35635984]
  • Milad Moradi, Jafar Soleymani, Abolghasem Jouyban. A combination of amino-functionalized fibrous silica (KCC-1-NH2)/effectively and efficiently oxidized graphene oxide (EEGO) nanocomposite for dispersive solid-phase extraction, pre-concentration and fluorescence determination of total para-cresol in plasma samples of chronic kidney disease patients. Journal of pharmaceutical and biomedical analysis. 2022 May; 214(?):114746. doi: 10.1016/j.jpba.2022.114746. [PMID: 35378367]
  • Sofía Campillo, Lourdes Bohorquez, Elena Gutiérrez-Calabrés, Diego García-Ayuso, Verónica Miguel, Mercedes Griera, Yolanda Calle, Sergio de Frutos, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Laura Calleros. Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation. Experimental & molecular medicine. 2022 03; 54(3):226-238. doi: 10.1038/s12276-022-00738-8. [PMID: 35246616]
  • F Blachier, M Andriamihaja. Effects of the L-tyrosine-derived bacterial metabolite p-cresol on colonic and peripheral cells. Amino acids. 2022 Mar; 54(3):325-338. doi: 10.1007/s00726-021-03064-x. [PMID: 34468872]
  • Laura Turriziani, Arianna Ricciardello, Francesca Cucinotta, Fabiana Bellomo, Giada Turturo, Maria Boncoddo, Silvestro Mirabelli, Maria Luisa Scattoni, Maddalena Rossi, Antonio M Persico. Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study. Autism research : official journal of the International Society for Autism Research. 2022 01; 15(1):56-69. doi: 10.1002/aur.2639. [PMID: 34813183]
  • Nour Jalaleddine, Mahmood Hachim, Hamza Al-Hroub, Narjes Saheb Sharif-Askari, Abiola Senok, Adel Elmoselhi, Bassam Mahboub, Nimmi Moni Samuel Kurien, Richard K Kandasamy, Mohammad H Semreen, Rabih Halwani, Nelson C Soares, Saba Al Heialy. N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients. Frontiers in immunology. 2022; 13(?):827603. doi: 10.3389/fimmu.2022.827603. [PMID: 35663953]
  • Fatima Guerrero, Andres Carmona, Maria Jose Jimenez, Teresa Obrero, Victoria Pulido, Juan Antonio Moreno, Sagrario Soriano, Alejandro Martín-Malo, Pedro Aljama. Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins. Toxins. 2021 10; 13(10):. doi: 10.3390/toxins13100738. [PMID: 34679030]
  • Md Moshfekus Saleh-E-In, Paromik Bhattacharyya, Johannes Van Staden. Chemical Composition and Cytotoxic Activity of the Essential Oil and Oleoresins of In Vitro Micropropagated Ansellia africana Lindl: A Vulnerable Medicinal Orchid of Africa. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154556. [PMID: 34361724]
  • Patricia Bermudez-Martin, Jérôme A J Becker, Nicolas Caramello, Sebastian P Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurélia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joëlle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic. The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome. 2021 07; 9(1):157. doi: 10.1186/s40168-021-01103-z. [PMID: 34238386]
  • Yu Wang, Guo Zhu, Muyang Li, Ragini Singh, Carlos Marques, Rui Min, Brajesh Kumar Kaushik, Bingyuan Zhang, Rajan Jha, Santosh Kumar. Water Pollutants p-Cresol Detection Based on Au-ZnO Nanoparticles Modified Tapered Optical Fiber. IEEE transactions on nanobioscience. 2021 07; 20(3):377-384. doi: 10.1109/tnb.2021.3082856. [PMID: 34018936]
  • Lee D Chaves, Sham Abyad, Amanda M Honan, Mark A Bryniarski, Daniel I McSkimming, Corrine M Stahura, Steven C Wells, Donna M Ruszaj, Marilyn E Morris, Richard J Quigg, Rabi Yacoub. Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake. JCI insight. 2021 06; 6(11):. doi: 10.1172/jci.insight.144410. [PMID: 33914709]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Marine P M Letertre, Antonis Myridakis, Luke Whiley, Stéphane Camuzeaux, Matthew R Lewis, Katie E Chappell, Annie Thaikkatil, Marc-Emmanuel Dumas, Jeremy K Nicholson, Jonathan R Swann, Ian D Wilson. A targeted ultra performance liquid chromatography - Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Feb; 1164(?):122511. doi: 10.1016/j.jchromb.2020.122511. [PMID: 33460909]
  • S J Kim, X Zhang, S B Cho, C H Kim, H C Park, S J Moon. Uremic solutes of indoxyl sulfate and p-cresol enhance protease-activated receptor-2 expression in vitro and in vivo in keratinocytes. Human & experimental toxicology. 2021 Jan; 40(1):113-123. doi: 10.1177/0960327120945758. [PMID: 32757783]
  • Witchayapon Kamprom, Tulyapruek Tawonsawatruk, Sumana Mas-Oodi, Korrarit Anansilp, Manoch Rattanasompattikul, Aungkura Supokawej. P-cresol and Indoxyl Sulfate Impair Osteogenic Differentiation by Triggering Mesenchymal Stem Cell Senescence. International journal of medical sciences. 2021; 18(3):744-755. doi: 10.7150/ijms.48492. [PMID: 33437209]
  • Muthu Vijayasarathy, Gopikrishnan Kalarikkal Kiran, Sivaraman Balaji, Jayamanohar Jabastin, Palanisamy Bruntha Devi, Venkatesan Brindha Priyadarisini. In Vitro Detoxification Studies of p-Cresol by Intestinal Bacteria Isolated from Human Feces. Current microbiology. 2020 Oct; 77(10):3000-3012. doi: 10.1007/s00284-020-02124-x. [PMID: 32683469]
  • Federica Gevi, Antonio Belardo, Lello Zolla. A metabolomics approach to investigate urine levels of neurotransmitters and related metabolites in autistic children. Biochimica et biophysica acta. Molecular basis of disease. 2020 10; 1866(10):165859. doi: 10.1016/j.bbadis.2020.165859. [PMID: 32512190]
  • Susane Oshiro, Marta Ramalho, Paloma Cristina Durães, Raissa Andrade, Karolina Silva, Flaviano Silvério, Gevany Pinho. p-Cresol in cheese: Is it a flavouring compound or chemical contaminant?. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1510-1519. doi: 10.1080/19440049.2020.1778190. [PMID: 32679005]
  • Yan Rong, Tony K L Kiang. Characterizations of Human UDP-Glucuronosyltransferase Enzymes in the Conjugation of p-Cresol. Toxicological sciences : an official journal of the Society of Toxicology. 2020 08; 176(2):285-296. doi: 10.1093/toxsci/kfaa072. [PMID: 32421801]
  • Fatima Guerrero, Andres Carmona, Teresa Obrero, Maria Jose Jiménez, Sagrario Soriano, Juan Antonio Moreno, Alejandro Martín-Malo, Pedro Aljama. Role of endothelial microvesicles released by p-cresol on endothelial dysfunction. Scientific reports. 2020 06; 10(1):10657. doi: 10.1038/s41598-020-67574-6. [PMID: 32606426]
  • Shanshan Li, Yintang Zhang, Shuai Mu, Minrui Ma, Xiaoyan Liu, Haixia Zhang. Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC. Mikrochimica acta. 2020 06; 187(7):388. doi: 10.1007/s00604-020-04362-z. [PMID: 32542460]
  • Emiko Sato, Koji Hosomi, Akiyo Sekimoto, Eikan Mishima, Yuji Oe, Daisuke Saigusa, Sadayoshi Ito, Takaaki Abe, Hiroshi Sato, Jun Kunisawa, Toshimitsu Niwa, Nobuyuki Takahashi. Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition. Biochemical and biophysical research communications. 2020 05; 525(3):773-779. doi: 10.1016/j.bbrc.2020.02.141. [PMID: 32147096]
  • Yan Rong, Tony K L Kiang. Mechanisms of Metabolism Interaction Between p-Cresol and Mycophenolic Acid. Toxicological sciences : an official journal of the Society of Toxicology. 2020 02; 173(2):267-279. doi: 10.1093/toxsci/kfz231. [PMID: 31742356]
  • Yeo Min Yoon, Gyeongyun Go, Chul Won Yun, Ji Ho Lim, Sang Hun Lee. Knockdown of CK2α reduces P-cresol-induced fibrosis in human renal proximal tubule epithelial cells via the downregulation of profilin-1. International journal of medical sciences. 2020; 17(17):2850-2860. doi: 10.7150/ijms.48429. [PMID: 33162813]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Natalia Korytowska, Aleksandra Wyczałkowska-Tomasik, Agnieszka Wiśniewska, Leszek Pączek, Joanna Giebułtowicz. Development of the LC-MS/MS method for determining the p-cresol level in plasma. Journal of pharmaceutical and biomedical analysis. 2019 Apr; 167(?):149-154. doi: 10.1016/j.jpba.2019.01.041. [PMID: 30772758]
  • Marc Vila Cuenca, Jan van Bezu, Rob H J Beelen, Marc G Vervloet, Peter L Hordijk. Stabilization of cell-cell junctions by active vitamin D ameliorates uraemia-induced loss of human endothelial barrier function. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2019 02; 34(2):252-264. doi: 10.1093/ndt/gfy111. [PMID: 29718431]
  • Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee. TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model. International journal of molecular sciences. 2019 Jan; 20(3):. doi: 10.3390/ijms20030613. [PMID: 30708974]
  • Amber Crowley-Gall, Mary Shaw, Stephanie M Rollmann. Host Preference and Olfaction in Drosophila mojavensis. The Journal of heredity. 2019 01; 110(1):68-79. doi: 10.1093/jhered/esy052. [PMID: 30299456]
  • Yi Shi, Jingyi Zhang, Jia He, Donghao Liu, Xiaoyan Meng, Tao Huang, Hua He. A method of detecting two tumor markers (p-hydroxybenzoic acid and p-cresol) in human urine using a porous magnetic -cyclodextrine polymer as solid phase extractant, an alternative for early gastric cancer diagnosis. Talanta. 2019 Jan; 191(?):133-140. doi: 10.1016/j.talanta.2018.08.036. [PMID: 30262042]
  • Natsuki Ikematsu, Masayuki Kashiwagi, Kenji Hara, Brian Waters, Aya Matsusue, Mio Takayama, Shin-Ichi Kubo. Organ distribution of endogenous p-cresol in hemodialysis patients. The journal of medical investigation : JMI. 2019; 66(1.2):81-85. doi: 10.2152/jmi.66.81. [PMID: 31064961]
  • Eiman Abdulla Al Hinai, Piyarach Kullamethee, Ian R Rowland, Jonathan Swann, Gemma E Walton, Daniel M Commane. Modelling the role of microbial p-cresol in colorectal genotoxicity. Gut microbes. 2019; 10(3):398-411. doi: 10.1080/19490976.2018.1534514. [PMID: 30359553]
  • Subramanian Muthukumar, Samuthirapandi Muniasamy, Mahalingam Srinivasan, Andivelu Ilangovan, Soundarapandian Satheshkumar, Thangavel Rajagopal, Velusamy Ramesh Saravana Kumar, Karuppusamy Sivakumar, Govindaraju Archunan. Evaluation of pheromone-based kit: A noninvasive approach of estrus detection in buffalo. Reproduction in domestic animals = Zuchthygiene. 2018 Dec; 53(6):1466-1472. doi: 10.1111/rda.13281. [PMID: 30043999]
  • Yeo Min Yoon, Yong-Seok Han, Chul Won Yun, Jun Hee Lee, Rang Kim, Sang Hun Lee. Pioglitazone Protects Mesenchymal Stem Cells against P-Cresol-Induced Mitochondrial Dysfunction via Up-Regulation of PINK-1. International journal of molecular sciences. 2018 Sep; 19(10):. doi: 10.3390/ijms19102898. [PMID: 30250007]
  • David E Bartlett, Richard B Miller, Scott Thiesfeldt, Hari Vishal Lakhani, Tilak Khanal, Rebecca D Pratt, Cameron L Cottrill, Rebecca L Klug, Nathaniel Seth Adkins, Paul C Bown, D Blaine Nease, Joseph I Shapiro, Komal Sodhi. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092685. [PMID: 30201874]
  • Natsuki Ikematsu, Masayuki Kashiwagi, Kenji Hara, Brian Waters, Aya Matsusue, Mio Takayama, Shin-Ichi Kubo. Diagnostic meaning of blood p-cresol concentration in forensic autopsy cases. Legal medicine (Tokyo, Japan). 2018 Sep; 34(?):27-35. doi: 10.1016/j.legalmed.2018.08.003. [PMID: 30103078]
  • Eleonora Riccio, Massimo Sabbatini, Dario Bruzzese, Lucia Grumetto, Cristina Marchetiello, Maria Amicone, Michele Andreucci, Bruna Guida, Davide Passaretti, Giacomo Russo, Antonio Pisani. Plasma p-cresol lowering effect of sevelamer in non-dialysis CKD patients: evidence from a randomized controlled trial. Clinical and experimental nephrology. 2018 Jun; 22(3):529-538. doi: 10.1007/s10157-017-1504-8. [PMID: 29159529]
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  • Sruthi P Usha, Banshi D Gupta. Urinary p-cresol diagnosis using nanocomposite of ZnO/MoS2 and molecular imprinted polymer on optical fiber based lossy mode resonance sensor. Biosensors & bioelectronics. 2018 Mar; 101(?):135-145. doi: 10.1016/j.bios.2017.10.029. [PMID: 29055196]
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  • Seung Pil Yun, Yeo Min Yoon, Jun Hee Lee, Minjee Kook, Yong-Seok Han, Seo Kyung Jung, Sang Hun Lee. Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein. International journal of molecular sciences. 2018 Jan; 19(2):. doi: 10.3390/ijms19020352. [PMID: 29370069]
  • Gao Chen, Wei-Chang Gong, Jia Ge, Johann Schinnerl, Bin Wang, Wei-Bang Sun. Variation in floral characters, particularly floral scent, in sapromyophilous Stemona species. Journal of integrative plant biology. 2017 Nov; 59(11):825-839. doi: 10.1111/jipb.12580. [PMID: 28836349]
  • Enrique Almanza-Aguilera, Mireia Urpi-Sarda, Rafael Llorach, Rosa Vázquez-Fresno, Mar Garcia-Aloy, Francesc Carmona, Alex Sanchez, Francisco Madrid-Gambin, Ramon Estruch, Dolores Corella, Cristina Andres-Lacueva. Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1H-NMR-based untargeted metabolomics approach. The Journal of nutritional biochemistry. 2017 10; 48(?):36-43. doi: 10.1016/j.jnutbio.2017.06.001. [PMID: 28692847]
  • Bruna Guida, Mauro Cataldi, Andrea Memoli, Rossella Trio, Martina di Maro, Lucia Grumetto, Ivana Capuano, Stefano Federico, Antonio Pisani, Massimo Sabbatini. Effect of a Short-Course Treatment with Synbiotics on Plasma p-Cresol Concentration in Kidney Transplant Recipients. Journal of the American College of Nutrition. 2017 Sep; 36(7):586-591. doi: 10.1080/07315724.2017.1334602. [PMID: 28895794]
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