2-Aminobenzimidazole (BioDeep_00000002892)

 

Secondary id: BioDeep_00000397525

human metabolite blood metabolite


代谢物信息卡片


2-Aminobenzimidazole tartrate(2:1), (L)-(+)-isomer

化学式: C7H7N3 (133.064)
中文名称: 2-氨基苯并咪唑
谱图信息: 最多检出来源 Homo sapiens(blood) 42.36%

分子结构信息

SMILES: C1=CC=C2C(=C1)NC(=N2)N
InChI: InChI=1S/C7H7N3/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H3,8,9,10)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2161; ORIGINAL_PRECURSOR_SCAN_NO 2159
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2163; ORIGINAL_PRECURSOR_SCAN_NO 2161
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4547; ORIGINAL_PRECURSOR_SCAN_NO 4545
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4569; ORIGINAL_PRECURSOR_SCAN_NO 4568
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4534; ORIGINAL_PRECURSOR_SCAN_NO 4533
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2155; ORIGINAL_PRECURSOR_SCAN_NO 2153
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4517; ORIGINAL_PRECURSOR_SCAN_NO 4515
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4544; ORIGINAL_PRECURSOR_SCAN_NO 4543
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4549; ORIGINAL_PRECURSOR_SCAN_NO 4547
CONFIDENCE standard compound; INTERNAL_ID 1067; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2165; ORIGINAL_PRECURSOR_SCAN_NO 2163
CONFIDENCE standard compound; EAWAG_UCHEM_ID 138
CONFIDENCE standard compound; INTERNAL_ID 2003
CONFIDENCE standard compound; INTERNAL_ID 4008
KEIO_ID A042

同义名列表

17 个代谢物同义名

2-Aminobenzimidazole tartrate(2:1), (L)-(+)-isomer; 2-Aminobenzimidazole, conjugate monoacid; 2,3-dihydro-1H-1,3-benzodiazol-2-imine; 2-Aminobenzimidazole monohydrochloride; 2-Aminobenzimidazole monoperchlorate; 2-Aminobenzimidazole sulfate (2:1); 2-Aminobenzimidazole hydrochloride; 2-Aminobenzimidazole monobenzoate; 2-Aminobenzimidazole monosulfate; 2-Aminobenzimidazole sulfate; 1H-Benzimidazol-2-amine; Benzimidazol-2-ylamine; 2-Iminobenzimidazoline; 2-AMINOBENZIMIDAZOLE; caswell no. 033AA; 2-Aminobenzimidazole; 2-Aminobenzimidazole



数据库引用编号

68 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AFP, ANG, ASIC3, EGFR, IRAK1, NFKB1, PTGS2, VEGFA
Peripheral membrane protein 1 PTGS2
Endosome membrane 2 EGFR, IRAK1
Endoplasmic reticulum membrane 4 EGFR, PTGDS, PTGES, PTGS2
Nucleus 6 ANG, EGFR, IRAK1, KDR, NFKB1, VEGFA
cytosol 3 ANG, IRAK1, NFKB1
dendrite 1 TRPC5
nucleoplasm 3 ATP2B1, IRAK1, NFKB1
Cell membrane 10 ASIC2, ASIC3, ATP2B1, EGFR, KCNH2, KDR, PROKR2, TNF, TRPA1, TRPC5
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 8 ASIC2, ASIC3, ATP2B1, KCNH2, PROKR2, PTGES, TRPA1, TRPC5
Synapse 1 ATP2B1
cell junction 2 EGFR, KDR
cell surface 5 EGFR, IRAK1, KCNH2, TNF, VEGFA
glutamatergic synapse 2 ATP2B1, EGFR
Golgi apparatus 3 KDR, PTGDS, VEGFA
Golgi membrane 1 EGFR
growth cone 2 ANG, TRPC5
neuronal cell body 4 ANG, ASIC2, TNF, TRPC5
presynaptic membrane 1 ATP2B1
Presynapse 1 TRPC5
endosome 2 EGFR, KDR
plasma membrane 11 ASIC2, ASIC3, ATP2B1, EGFR, IRAK1, KCNH2, KDR, PROKR2, TNF, TRPA1, TRPC5
synaptic vesicle membrane 1 ATP2B1
Membrane 9 ASIC3, ATP2B1, EGFR, IRAK1, KCNH2, PTGES, TRPA1, VEGFA, VEGFC
apical plasma membrane 1 EGFR
basolateral plasma membrane 2 ATP2B1, EGFR
caveola 1 PTGS2
extracellular exosome 2 ATP2B1, PTGDS
endoplasmic reticulum 3 KDR, PTGS2, VEGFA
extracellular space 8 AFP, ANG, EGFR, MMP1, PTGDS, TNF, VEGFA, VEGFC
perinuclear region of cytoplasm 5 ASIC3, EGFR, KCNH2, PTGDS, PTGES
adherens junction 1 VEGFA
mitochondrion 1 NFKB1
protein-containing complex 3 EGFR, IRAK1, PTGS2
intracellular membrane-bounded organelle 1 ATP2B1
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 EGFR
Secreted 5 AFP, ANG, PTGDS, VEGFA, VEGFC
extracellular region 8 ANG, KDR, MMP1, NFKB1, PTGDS, TNF, VEGFA, VEGFC
[Isoform 2]: Secreted 1 KDR
anchoring junction 1 KDR
transcription regulator complex 1 NFKB1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 PTGDS
nuclear membrane 2 EGFR, PTGDS
external side of plasma membrane 2 KDR, TNF
Secreted, extracellular space, extracellular matrix 2 MMP1, VEGFA
actin cytoskeleton 1 ANG
dendritic spine 1 ASIC2
nucleolus 1 ANG
Early endosome 1 KDR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 2 PTGDS, PTGES
Membrane raft 3 EGFR, KDR, TNF
focal adhesion 1 EGFR
extracellular matrix 2 MMP1, VEGFA
basement membrane 1 ANG
intracellular vesicle 1 EGFR
secretory granule 1 VEGFA
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 EGFR, KDR
neuron projection 1 PTGS2
chromatin 1 NFKB1
stereocilium bundle 1 TRPA1
cell projection 1 ATP2B1
phagocytic cup 1 TNF
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
Basolateral cell membrane 1 ATP2B1
sorting endosome 1 KDR
Lipid droplet 1 IRAK1
monoatomic ion channel complex 1 KCNH2
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 EGFR
inward rectifier potassium channel complex 1 KCNH2
synaptic membrane 1 EGFR
voltage-gated potassium channel complex 1 KCNH2
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 2 AFP, PTGS2
platelet alpha granule lumen 2 VEGFA, VEGFC
specific granule lumen 1 NFKB1
endocytic vesicle 1 ANG
postsynaptic density membrane 1 ASIC2
immunological synapse 1 ATP2B1
nuclear envelope lumen 1 PTGES
clathrin-coated endocytic vesicle membrane 1 EGFR
calcium channel complex 1 TRPC5
Rough endoplasmic reticulum 1 PTGDS
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
photoreceptor ribbon synapse 1 ATP2B1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
cation channel complex 1 TRPC5
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Aymun Madni Zubair, Muhammad Nasir Hayat Malik, Waqas Younis, Muhammad Atif Hayat Malik, Shah Jahan, Ishtiaq Ahmed, Alamgeer Yuchi, Muhammad Naveed Mushtaq, Romeeza Tahir, Muhammad Bilal Sarwar, Muhammad Roman, Ayaz Ali Khan, Muhammad Nouman Tahir, Muhammad Tariq Khan, Hafiz Amir Ali Kharl, Gagun Kamran, Abdullah Abdo Albegali, Ali Imran. Novel acetamide derivatives of 2-aminobenzimidazole prevent inflammatory arthritis in rats via suppression of pro-inflammatory mediators. Inflammopharmacology. 2022 Jun; 30(3):1005-1019. doi: 10.1007/s10787-022-00969-1. [PMID: 35429318]
  • Peili Jiao, Yuxi Wang, Beibei Mao, Bingding Wang, Yi Zhong, Hongwei Jin, Lihe Zhang, Liangren Zhang, Zhenming Liu. Discovery of 2-(2-aminobenzo[d]thiazol-6-yl) benzo[d]oxazol-5-amine derivatives that regulated HPV relevant cellular pathway and prevented cervical cancer from abnormal proliferation. European journal of medicinal chemistry. 2020 Oct; 204(?):112556. doi: 10.1016/j.ejmech.2020.112556. [PMID: 32739649]
  • M S Attia, A O Youssef, Ziya A Khan, M N Abou-Omar. Alpha fetoprotein assessment by using a nano optical sensor thin film binuclear Pt-2-aminobenzimidazole-Bipyridine for early diagnosis of liver cancer. Talanta. 2018 Aug; 186(?):36-43. doi: 10.1016/j.talanta.2018.04.043. [PMID: 29784373]
  • Nadia El-wakiel, Mai El-keiy, Mohamed Gaber. Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu(II), Ni(II) and Co(II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Aug; 147(?):117-23. doi: 10.1016/j.saa.2015.03.020. [PMID: 25827773]
  • Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, Jinbin Tian, Dhananjay P Thakur, Jinmei Zhu, Zixin Deng, Xianming Hu, Meng Wu, Owen B McManus, Min Li, Xuechuan Hong, Michael X Zhu, Huai-Rong Luo. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. British journal of pharmacology. 2015 Jul; 172(14):3495-509. doi: 10.1111/bph.13140. [PMID: 25816897]
  • Rangasamy Loganathan, Sethu Ramakrishnan, Eringathodi Suresh, Anvarbatcha Riyasdeen, Mohamad Abdulkadhar Akbarsha, Mallayan Palaniandavar. Mixed ligand copper(II) complexes of N,N-bis(benzimidazol-2-ylmethyl)amine (BBA) with diimine co-ligands: efficient chemical nuclease and protease activities and cytotoxicity. Inorganic chemistry. 2012 May; 51(10):5512-32. doi: 10.1021/ic2017177. [PMID: 22559171]
  • Ghassan Abu Sheikha, Buthina Hussin, Yusuf Al-Hiari, Tariq Al-Qirim, Ghassan Shattat. Synthesis of benzothiophene carboxamide derivatives and their pharmacological evaluation as potent antihypertriglyceridemic agents in rats. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2011 Mar; 66(3-4):93-103. doi: . [PMID: 21630582]
  • Constantinos G Neochoritis, Tryfon Zarganes-Tzitzikas, Constantinos A Tsoleridis, Julia Stephanidou-Stephanatou, Christos A Kontogiorgis, Dimitra J Hadjipavlou-Litina, Theodora Choli-Papadopoulou. One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones. European journal of medicinal chemistry. 2011 Jan; 46(1):297-306. doi: 10.1016/j.ejmech.2010.11.018. [PMID: 21146903]
  • Sweta Singh, Himanshu Ojha, Anjani K Tiwari, Nitin Kumar, Bachcha Singh, Anil Kumar Mishra. Design, synthesis, and in vitro antiproliferative activity of benzimidazole analogues for radiopharmaceutical efficacy. Cancer biotherapy & radiopharmaceuticals. 2010 Apr; 25(2):245-50. doi: 10.1089/cbr.2009.0663. [PMID: 20423239]
  • Minoru Moriya, Hiroyuki Kishino, Shunji Sakuraba, Toshihiro Sakamoto, Takuya Suga, Hidekazu Takahashi, Takao Suzuki, Masahiko Ito, Junko Ito, Ryuichi Moriya, Norihiro Takenaga, Hisashi Iwaasa, Akane Ishihara, Akio Kanatani, Takehiro Fukami. Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists. Bioorganic & medicinal chemistry letters. 2009 Jul; 19(13):3568-72. doi: 10.1016/j.bmcl.2009.04.147. [PMID: 19457661]
  • Liansheng Tian, Fei Chen. [Characterization of a carbendazim-degrading Trichoderma sp. T2-2 and its application in bioremediation]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2009 Jul; 49(7):925-30. doi: ". [PMID: 19873757]
  • Olcay Bekircan, Murat Küxük, Bahittin Kahveci, Sevgi Kolayli. Convenient synthesis of fused heterocyclic 1,3,5-triazines from some N-acyl imidates and heterocyclic amines as anticancer and antioxidant agents. Archiv der Pharmazie. 2005 Aug; 338(8):365-72. doi: 10.1002/ardp.200400964. [PMID: 16041836]
  • Lee Jia, Hong Wong, Yao Wang, Mark Garza, Steve D Weitman. Carbendazim: disposition, cellular permeability, metabolite identification, and pharmacokinetic comparison with its nanoparticle. Journal of pharmaceutical sciences. 2003 Jan; 92(1):161-72. doi: 10.1002/jps.10272. [PMID: 12486692]
  • W Nawrocka, M Zimecki. Synthesis and immunotropic activity of some 2-aminobenzimidazoles, Part 4. Archiv der Pharmazie. 1998 Jul; 331(7-8):249-53. doi: 10.1002/(sici)1521-4184(199807)331:7/8<249::aid-ardp249>3.0.co;2-b. [PMID: 9747181]