2-AMINOBENZIMIDAZOLE (BioDeep_00000397525)
Main id: BioDeep_00000002892
代谢物信息卡片
1-METHYLBENZOTRIAZOLE
化学式: C7H7N3 (133.064)
中文名称: 2-氨基苯并咪唑, 1-甲基-1H-苯并三唑, 1-甲基苯并三唑
谱图信息:
最多检出来源 Mus musculus(not specific) 9.02%
分子结构信息
SMILES: C1=CC=C2C(=C1)NC(=N2)N
InChI: InChI=1S/C7H7N3/c1-10-7-5-3-2-4-6(7)8-9-10/h2-5H,1H3
描述信息
A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group.
CONFIDENCE standard compound; INTERNAL_ID 2240
CONFIDENCE standard compound; INTERNAL_ID 2003
同义名列表
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:27822
- KEGG: C10901
- PubChem: 13624
- PubChem: 25902
- ChEMBL: CHEMBL305513
- ChEMBL: CHEMBL3086212
- CAS: 162938-41-2
- CAS: 934-32-7
- CAS: 13351-73-0
- MoNA: AU224011
- MoNA: AU224010
- MoNA: AU224009
- MoNA: AU224008
- MoNA: AU224007
- MoNA: AU200311
- MoNA: AU200310
- MoNA: AU200309
- MoNA: AU200308
- MoNA: AU200307
- MoNA: AU200305
- MoNA: AU200302
- MoNA: AU200301
- MetaboLights: MTBLC27822
- PubChem: 13084
- PDB-CCD: AX7
- NIKKAJI: J3.655B
- KNApSAcK: 27822
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Aymun Madni Zubair, Muhammad Nasir Hayat Malik, Waqas Younis, Muhammad Atif Hayat Malik, Shah Jahan, Ishtiaq Ahmed, Alamgeer Yuchi, Muhammad Naveed Mushtaq, Romeeza Tahir, Muhammad Bilal Sarwar, Muhammad Roman, Ayaz Ali Khan, Muhammad Nouman Tahir, Muhammad Tariq Khan, Hafiz Amir Ali Kharl, Gagun Kamran, Abdullah Abdo Albegali, Ali Imran. Novel acetamide derivatives of 2-aminobenzimidazole prevent inflammatory arthritis in rats via suppression of pro-inflammatory mediators.
Inflammopharmacology.
2022 Jun; 30(3):1005-1019. doi:
10.1007/s10787-022-00969-1. [PMID: 35429318] - Peili Jiao, Yuxi Wang, Beibei Mao, Bingding Wang, Yi Zhong, Hongwei Jin, Lihe Zhang, Liangren Zhang, Zhenming Liu. Discovery of 2-(2-aminobenzo[d]thiazol-6-yl) benzo[d]oxazol-5-amine derivatives that regulated HPV relevant cellular pathway and prevented cervical cancer from abnormal proliferation.
European journal of medicinal chemistry.
2020 Oct; 204(?):112556. doi:
10.1016/j.ejmech.2020.112556. [PMID: 32739649] - M S Attia, A O Youssef, Ziya A Khan, M N Abou-Omar. Alpha fetoprotein assessment by using a nano optical sensor thin film binuclear Pt-2-aminobenzimidazole-Bipyridine for early diagnosis of liver cancer.
Talanta.
2018 Aug; 186(?):36-43. doi:
10.1016/j.talanta.2018.04.043. [PMID: 29784373] - Nadia El-wakiel, Mai El-keiy, Mohamed Gaber. Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu(II), Ni(II) and Co(II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Aug; 147(?):117-23. doi:
10.1016/j.saa.2015.03.020. [PMID: 25827773] - Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, Jinbin Tian, Dhananjay P Thakur, Jinmei Zhu, Zixin Deng, Xianming Hu, Meng Wu, Owen B McManus, Min Li, Xuechuan Hong, Michael X Zhu, Huai-Rong Luo. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
British journal of pharmacology.
2015 Jul; 172(14):3495-509. doi:
10.1111/bph.13140. [PMID: 25816897] - Rangasamy Loganathan, Sethu Ramakrishnan, Eringathodi Suresh, Anvarbatcha Riyasdeen, Mohamad Abdulkadhar Akbarsha, Mallayan Palaniandavar. Mixed ligand copper(II) complexes of N,N-bis(benzimidazol-2-ylmethyl)amine (BBA) with diimine co-ligands: efficient chemical nuclease and protease activities and cytotoxicity.
Inorganic chemistry.
2012 May; 51(10):5512-32. doi:
10.1021/ic2017177. [PMID: 22559171] - Ghassan Abu Sheikha, Buthina Hussin, Yusuf Al-Hiari, Tariq Al-Qirim, Ghassan Shattat. Synthesis of benzothiophene carboxamide derivatives and their pharmacological evaluation as potent antihypertriglyceridemic agents in rats.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2011 Mar; 66(3-4):93-103. doi:
. [PMID: 21630582] - Constantinos G Neochoritis, Tryfon Zarganes-Tzitzikas, Constantinos A Tsoleridis, Julia Stephanidou-Stephanatou, Christos A Kontogiorgis, Dimitra J Hadjipavlou-Litina, Theodora Choli-Papadopoulou. One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones.
European journal of medicinal chemistry.
2011 Jan; 46(1):297-306. doi:
10.1016/j.ejmech.2010.11.018. [PMID: 21146903] - Sweta Singh, Himanshu Ojha, Anjani K Tiwari, Nitin Kumar, Bachcha Singh, Anil Kumar Mishra. Design, synthesis, and in vitro antiproliferative activity of benzimidazole analogues for radiopharmaceutical efficacy.
Cancer biotherapy & radiopharmaceuticals.
2010 Apr; 25(2):245-50. doi:
10.1089/cbr.2009.0663. [PMID: 20423239] - Minoru Moriya, Hiroyuki Kishino, Shunji Sakuraba, Toshihiro Sakamoto, Takuya Suga, Hidekazu Takahashi, Takao Suzuki, Masahiko Ito, Junko Ito, Ryuichi Moriya, Norihiro Takenaga, Hisashi Iwaasa, Akane Ishihara, Akio Kanatani, Takehiro Fukami. Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.
Bioorganic & medicinal chemistry letters.
2009 Jul; 19(13):3568-72. doi:
10.1016/j.bmcl.2009.04.147. [PMID: 19457661] - Liansheng Tian, Fei Chen. [Characterization of a carbendazim-degrading Trichoderma sp. T2-2 and its application in bioremediation].
Wei sheng wu xue bao = Acta microbiologica Sinica.
2009 Jul; 49(7):925-30. doi:
". [PMID: 19873757] - Olcay Bekircan, Murat Küxük, Bahittin Kahveci, Sevgi Kolayli. Convenient synthesis of fused heterocyclic 1,3,5-triazines from some N-acyl imidates and heterocyclic amines as anticancer and antioxidant agents.
Archiv der Pharmazie.
2005 Aug; 338(8):365-72. doi:
10.1002/ardp.200400964. [PMID: 16041836] - Lee Jia, Hong Wong, Yao Wang, Mark Garza, Steve D Weitman. Carbendazim: disposition, cellular permeability, metabolite identification, and pharmacokinetic comparison with its nanoparticle.
Journal of pharmaceutical sciences.
2003 Jan; 92(1):161-72. doi:
10.1002/jps.10272. [PMID: 12486692] - W Nawrocka, M Zimecki. Synthesis and immunotropic activity of some 2-aminobenzimidazoles, Part 4.
Archiv der Pharmazie.
1998 Jul; 331(7-8):249-53. doi:
10.1002/(sici)1521-4184(199807)331:7/8<249::aid-ardp249>3.0.co;2-b. [PMID: 9747181]
