4-Chloro-o-phenylenediamine (BioDeep_00000002883)

   


代谢物信息卡片


4-Chloro-ortho-phenylenediamine

化学式: C6H7ClN2 (142.0298)
中文名称: 4-氯邻苯二胺, 4-氯-o-苯二胺
谱图信息: 最多检出来源 Homo sapiens(not specific) 20%

分子结构信息

SMILES: C1=CC(=C(C=C1Cl)N)N
InChI: InChI=1S/C6H7ClN2/c7-4-1-2-5(8)6(9)3-4/h1-3H,8-9H2



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BRIP1, DHFR, HDAC6, RAD51, TKTL1
Nucleus 7 BRIP1, HDAC6, KDR, LIG4, PCNA, RAD51, XRCC5
cytosol 5 DHFR, HDAC6, RAD51, TKTL1, XRCC5
dendrite 1 HDAC6
nuclear body 2 BRIP1, PCNA
centrosome 3 HDAC6, PCNA, RAD51
nucleoplasm 6 BRIP1, HDAC6, LIG4, PCNA, RAD51, XRCC5
Cell membrane 2 KDR, KIT
Cell projection, axon 1 HDAC6
cell junction 1 KDR
Golgi apparatus 1 KDR
mitochondrial inner membrane 1 BRIP1
acrosomal vesicle 1 KIT
endosome 1 KDR
plasma membrane 3 KDR, KIT, XRCC5
Membrane 2 KIT, XRCC5
axon 1 HDAC6
caveola 1 HDAC6
extracellular exosome 1 PCNA
endoplasmic reticulum 1 KDR
extracellular space 1 KIT
perinuclear region of cytoplasm 2 HDAC6, RAD51
mitochondrion 3 BRIP1, DHFR, RAD51
protein-containing complex 2 RAD51, XRCC5
intracellular membrane-bounded organelle 1 LIG4
Single-pass type I membrane protein 1 KIT
extracellular region 2 KDR, XRCC5
cytoplasmic side of plasma membrane 1 KIT
[Isoform 2]: Secreted 1 KDR
Mitochondrion matrix 1 RAD51
mitochondrial matrix 1 RAD51
anchoring junction 1 KDR
Cell projection, cilium 1 HDAC6
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 HDAC6, RAD51
nuclear membrane 1 BRIP1
external side of plasma membrane 2 KDR, KIT
multivesicular body 1 HDAC6
perikaryon 1 HDAC6
nucleolus 2 RAD51, XRCC5
axon cytoplasm 1 HDAC6
Early endosome 1 KDR
cell-cell junction 1 KIT
Membrane raft 1 KDR
Cytoplasm, cytoskeleton 1 HDAC6
microtubule 1 HDAC6
PML body 1 RAD51
receptor complex 2 KDR, KIT
ciliary basal body 1 HDAC6
chromatin 2 PCNA, RAD51
cell leading edge 1 HDAC6
microtubule associated complex 1 HDAC6
Chromosome 2 RAD51, XRCC5
Cytoplasm, cytoskeleton, cilium basal body 1 HDAC6
Nucleus, nucleolus 1 XRCC5
nuclear replication fork 1 PCNA
chromosome, telomeric region 4 LIG4, PCNA, RAD51, XRCC5
nuclear chromosome 1 RAD51
site of double-strand break 1 RAD51
fibrillar center 1 KIT
sorting endosome 1 KDR
lateral element 1 RAD51
Cell projection, dendrite 1 HDAC6
replication fork 2 BRIP1, PCNA
[Isoform 3]: Cytoplasm 1 KIT
secretory granule lumen 1 XRCC5
male germ cell nucleus 2 PCNA, RAD51
histone deacetylase complex 1 HDAC6
small-subunit processome 1 XRCC5
aggresome 1 HDAC6
nuclear telomere cap complex 1 XRCC5
condensed nuclear chromosome 1 RAD51
nuclear lamina 1 PCNA
ribonucleoprotein complex 1 XRCC5
protein-DNA complex 1 XRCC5
condensed chromosome 2 LIG4, RAD51
site of DNA damage 1 XRCC5
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
DNA-dependent protein kinase complex 1 XRCC5
inclusion body 1 HDAC6
presynaptic intermediate filament cytoskeleton 1 RAD51
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
DNA-dependent protein kinase-DNA ligase 4 complex 2 LIG4, XRCC5
Ku70:Ku80 complex 1 XRCC5
nonhomologous end joining complex 2 LIG4, XRCC5
BRCA1-B complex 1 BRIP1
nuclear ubiquitin ligase complex 1 RAD51
DNA ligase IV complex 1 LIG4
mitochondrial large ribosomal subunit 1 BRIP1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Leong Chee Onn, Chen Ssu Ching, Tiong Yee Lian, Loh Veng Foon, Ng Chew Hee, Chye Soi Moi. 4-chloro-1,2-phenylenediamine induces apoptosis in Mardin-Darby canine kidney cells via activation of caspases. Environmental toxicology. 2014 Jun; 29(6):655-64. doi: 10.1002/tox.21792. [PMID: 22778066]
  • Oz Malkesman, Daniel R Austin, Tyson Tragon, Gang Wang, Gregory Rompala, Anahita B Hamidi, Zhenzhong Cui, W Scott Young, Kazu Nakazawa, Carlos A Zarate, Husseini K Manji, Guang Chen. Acute D-serine treatment produces antidepressant-like effects in rodents. The international journal of neuropsychopharmacology. 2012 Sep; 15(8):1135-48. doi: 10.1017/s1461145711001386. [PMID: 21906419]
  • L Soler-Niedziela, X Shi, J Nath, T Ong. Studies on three structurally related phenylenediamines with the mouse micronucleus assay system. Mutation research. 1991 Jan; 259(1):43-8. doi: 10.1016/0165-1218(91)90108-x. [PMID: 1703280]
  • E K Weisburger, A S Murthy, R W Fleischman, M Hagopian. Carcinogenicity of 4-chloro-o-phenylenediamine, 4-chloro-m-phenylenediamine, and 2-chloro-p-phenylenediamine in Fischer 344 rats and B6C3F1 mice. Carcinogenesis. 1980 Jun; 1(6):495-9. doi: 10.1093/carcin/1.6.495. [PMID: 7273282]