(-)-Gossypol (BioDeep_00000000287)

 

Secondary id: BioDeep_00000872950

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs Antitumor activity Volatile Flavor Compounds natural product


代谢物信息卡片


ethanoic acid;7-[8-methanoyl-3-methyl-1,6,7-tris(oxidanyl)-5-propan-2-yl-naphthalen-2-yl]-6-methyl-2,3,8-tris(oxidanyl)-4-propan-2-yl-naphthalene-1-carbaldehyde

化学式: C30H30O8 (518.194058)
中文名称: (R)-(-)-棉子酚, (-)-棉子素, 棉子醇, 棉籽酚, 棉子酚, 棉酚
谱图信息: 最多检出来源 Viridiplantae(plant) 0.93%

分子结构信息

SMILES: C12C=C(C(C3C(C)=CC4C(C(C)C)=C(C(O)=C(C=O)C=4C=3O)O)=C(O)C=1C(C=O)=C(C(O)=C2C(C)C)O)C
InChI: InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3

描述信息

Gossypol has been used in trials studying the treatment of Non-small Cell Lung Cancer.
(-)-Gossypol or (R)-Gossypol, is the R-isomer of [Gossypol].
Gossypol is a natural product found in Malva pseudolavatera, Hibiscus syriacus, and other organisms with data available.
Gossypol is an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive.
(-)-Gossypol is found in fats and oils. (-)-Gossypol is a constituent of Gossypium hirsutum (cotton).(-)-gossypol has been shown to exhibit anti-tumor, anti-cancer and anti-proliferative functions (A7832, A7833, A7834).
A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Gossypol, also known as gossypol, (+)-isomer or (-)-gossypol, is a member of the class of compounds known as sesquiterpenoids. Sesquiterpenoids are terpenes with three consecutive isoprene units. Thus, gossypol is considered to be an isoprenoid lipid molecule. Gossypol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Gossypol can be found in cottonseed, okra, soy bean, and sunflower, which makes gossypol a potential biomarker for the consumption of these food products. Gossypol is a non-carcinogenic (not listed by IARC) potentially toxic compound. Among other things, it has been tested as a male oral contraceptive in China. In addition to its putative contraceptive properties, gossypol has also long been known to possess antimalarial properties. Other researchers are investigating the anticancer properties of gossypol . Gossypol may cause apoptosis via the regulation of Bax and Bcl-2 proteins. It is also an inhibitor of calcineurin and protein kinases C, and has been shown to bind calmodulin (L1239) (T3DB).
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
(-)-Gossypol is found in fats and oils. (-)-Gossypol is a constituent of Gossypium hirsutum (cotton)
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product
C1907 - Drug, Natural Product
Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

同义名列表

122 个代谢物同义名

ethanoic acid;7-[8-methanoyl-3-methyl-1,6,7-tris(oxidanyl)-5-propan-2-yl-naphthalen-2-yl]-6-methyl-2,3,8-tris(oxidanyl)-4-propan-2-yl-naphthalene-1-carbaldehyde; acetic acid;7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-yl-2-naphthalenyl)-2,3,8-trihydroxy-6-methyl-4-propan-2-yl-1-naphthalenecarboxaldehyde; acetic acid;7-(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2-naphthyl)-2,3,8-trihydroxy-4-isopropyl-6-methyl-naphthalene-1-carbaldehyde; 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde; 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde; 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(methylethyl)(2-naphthyl)]-2,3,8-trihy droxy-6-methyl-4-(methylethyl)naphthalenecarbaldehyde; 7-(8-Formyl-1,6,7-trihydroxy-3-methyl-5-(methylethyl)(2-naphthyl))-2,3,8-trihydroxy-6-methyl-4-(methylethyl)naphthalenecarbaldehyde; 7-(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2-naphthyl)-2,3,8-trihydroxy-4-isopropyl-6-methyl-naphthalene-1-carbaldehyde; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde; (2,2-BINAPHTHALENE)-8,8-DICARBOXALDEHYDE, 1,1,6,6,7,7-HEXAHYDROXY-3,3-DIMETHYL-5,5-BIS(1-METHYLETHYL)-, (2S)-; (2,2-BINAPHTHALENE)-8,8-DICARBOXALDEHYDE, 1,1,6,6,7,7-HEXAHYDROXY-3,3-DIMETHYL-5,5-BIS(1-METHYLETHYL)-, (S)-; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-, (-)-; [2,2-Binaphthalene]-8,8-dicarboxaldehyde,1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-, (2R)-; (-)-1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-[2,2-binaphthalene]-8,8-dicarboxaldehyde; (-)-1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)[2,2-binaphthalene]-8,8-dicarboxaldehyde; [2,2-Binaphthalene]-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-; (+)1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)[2,2-binaphthalene]-8,8-dicarboxaldehyde; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-, (+)-; 1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-[2,2-binaphthalene]-8,8-dicarboxaldehyde; 1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)[2,2-binaphthalene]-8,8-dicarboxaldehyde; 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-2,2-binaphthalene-8,8-dicarbaldehyde; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-; [2,8-dicarboxaldehyde, 1,1,6,6,7,7- hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-, (2R)-; 1,1,6,6,7,7-Hexahydroxy-5,5-diisopropyl-3,3-dimethyl-[2,2-binaphthalene]-8,8-dicarbaldehyde; 1,1,6,6,7,7-Hexahydroxy-5,5-diisopropyl-3,3-dimethyl[2,2-binaphthalene]-8,8-dicarbaldehyde; 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-2,2-binaphthyl-8,8-dicarbaldehyde; [2,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1- methylethyl)-; [2,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-; [2,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-; (2,8-dicarboxaldehyde, 1,1,6,67,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-; (-)-2,2-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene); (R)-2,2-BIS(8-FORMYL-1,6,7-TRIHYDROXY-5-ISOPROPYL-3-METHYLNAPHTHALENE); 2,2-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene); 2,2-bi[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]; 8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2,2-bisnaphthalene; 8-Formyl-1,7-trihydroxy-5-isopropyl-3-methyl-2,2-bisnaphthalene; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahyd; ( inverted exclamation markA)-GOSSYPOL FROM COTTON SEEDS; (+/-)-Gossypol from cotton seeds, >=95\\% (HPLC); 4-08-00-03754 (Beilstein Handbook Reference); (+/-)-Gossypol from cotton seeds; QBKSWRVVCFFDOT-UHFFFAOYSA-N; Gossypol from cotton seeds; Dipotassium Salt, Gossypol; Gossypol Dipotassium Salt; Gossypol, (+-)-Isomer; Sodium Salt, Gossypol; Gossypol Sodium Salt; GOSSYPOL S-FORM [MI]; Gossypol, (-)-Isomer; Gossypol, (+)-Isomer; GOSSYPOL R-FORM [MI]; Prestwick0_000677; Prestwick2_000677; Prestwick1_000677; Prestwick3_000677; Spectrum2_001472; Spectrum5_001035; GOSSYPOL [MART.]; Spectrum3_001516; (S)-(+)-Gossypol; Spectrum3_001102; (R)-(-)-Gossypol; Spectrum5_000693; Spectrum2_001624; Spectrum4_001931; GOSSYPOL [VANDF]; racemic-Gossypol; Spectrum4_000846; UNII-KAV15B369O; UNII-8DY2X8LXW4; UNII-XNA7DR63CQ; Gossypol, (S)-; Gissypol, (R)-; (+/-)-Gossypol; Gossypol, (R)-; GOSSYPOL, (+)-; R-(-)-gossypol; Tox21_110434_1; DivK1c_006698; BPBio1_000851; GOSSYPOL [MI]; (+-)-Gossypol; DivK1c_000173; KBio2_000839; KBio2_007137; GOSSYPOL, R-; KBio3_002691; Tox21_500847; (R)-Gossypol; KBio2_003407; KBio1_000173; KBio2_004569; NCI60_004391; KBio1_001642; Tox21_110434; NCI60_001588; (S)-Gossypol; KBio3_002024; (+)-Gossypol; KBio2_005975; KBio2_002001; (-)-Gossypol; SMP2_000170; Gossypol, 4; IDI1_000173; XNA7DR63CQ; KAV15B369O; 8DY2X8LXW4; Thespesin; No Fertil; AI3-22957; C30H30O8; Gossypol; Pogosin; AT-101; ssypol; Tash 1; GO3; BL 193; Gossypol



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

296 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aarti Gupta, Manoj Kumar, Baohong Zhang, Maharishi Tomar, Amandeep Kaur Walia, Prince Choyal, Ravi Prakash Saini, Jayashree Potkule, David J Burritt, Vijay Sheri, Pooja Verma, Deepak Chandran, Lam-Son Phan Tran. Improvement of qualitative and quantitative traits in cotton under normal and stressed environments using genomics and biotechnological tools: A review. Plant science : an international journal of experimental plant biology. 2024 Mar; 340(?):111937. doi: 10.1016/j.plantsci.2023.111937. [PMID: 38043729]
  • Zhen-Nan Zhang, Lu Long, Xiao-Tong Zhao, Shen-Zhai Shang, Fu-Chun Xu, Jing-Ruo Zhao, Gai-Yuan Hu, Ling-Yu Mi, Chun-Peng Song, Wei Gao. The dual role of GoPGF reveals that the pigment glands are synthetic sites of gossypol in aerial parts of cotton. The New phytologist. 2024 Jan; 241(1):314-328. doi: 10.1111/nph.19331. [PMID: 37865884]
  • Yi Zhang, Yuxue Wang, Ting Liu, Xincheng Luo, Yi Wang, Longyan Chu, Jianpin Li, Hongliu An, Peng Wan, Dong Xu, Yazhen Yang, Jianmin Zhang. GhMYC1374 regulates the cotton defense response to cotton aphids by mediating the production of flavonoids and free gossypol. Plant physiology and biochemistry : PPB. 2023 Dec; 205(?):108162. doi: 10.1016/j.plaphy.2023.108162. [PMID: 37951101]
  • Jianyi Li, Long Jin, Yuntong Lv, Yaping Ding, Kunpeng Yan, Hang Zhang, Yiou Pan, Qingli Shang. Inducible Cytochrome P450s in the Fat Body and Malpighian Tubules of the Polyphagous Pests of Spodoptera litura Confer Xenobiotic Tolerance. Journal of agricultural and food chemistry. 2023 Oct; 71(40):14517-14526. doi: 10.1021/acs.jafc.3c04865. [PMID: 37773746]
  • Zhonglei Wang, Xian-Qing Song, Wenjing Xu, Shizeng Lei, Hao Zhang, Liyan Yang. Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Nutrients. 2023 Sep; 15(18):. doi: 10.3390/nu15183885. [PMID: 37764669]
  • Xiaohui Shi, Xinwei Lv, Dong Xiao. Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation. Clinical and translational science. 2023 Aug; ?(?):. doi: 10.1111/cts.13618. [PMID: 37626472]
  • Teame Gereziher Mehari, Hui Fang, Wenxiang Feng, Yuanyuan Zhang, Muhammad Jawad Umer, Jinlei Han, Allah Ditta, Muhammad K R Khan, Fang Liu, Kai Wang, Baohua Wang. Genome-wide identification and expression analysis of terpene synthases in Gossypium species in response to gossypol biosynthesis. Functional & integrative genomics. 2023 Jun; 23(2):197. doi: 10.1007/s10142-023-01125-w. [PMID: 37270747]
  • Linglei Kong, Shaoqi Li, Yuyuan Qian, Hailiang Cheng, Youping Zhang, Dongyun Zuo, Limin Lv, Qiaolian Wang, Junlan Li, Guoli Song. Comparative Transcriptome Analysis Revealed Key Genes Regulating Gossypol Synthesis in Tetraploid Cultivated Cotton. Genes. 2023 05; 14(6):. doi: 10.3390/genes14061144. [PMID: 37372323]
  • Yuanli Dai, Shang Liu, Dongyun Zuo, Qiaolian Wang, Limin Lv, Youping Zhang, Hailiang Cheng, John Z Yu, Guoli Song. Identification of MYB gene family and functional analysis of GhMYB4 in cotton (Gossypium spp.). Molecular genetics and genomics : MGG. 2023 May; 298(3):755-766. doi: 10.1007/s00438-023-02005-5. [PMID: 37027022]
  • Si Chen, Weishu Zhang, Huiling Zhang, Ying Cui, Feng Wang, Jing Wu, Hongjun Chao, Dazhong Yan. The Complete Genome Sequence of a Gossypol-Degrading Bacterial Strain, Raoultella sp. YL01. Current microbiology. 2023 Apr; 80(5):163. doi: 10.1007/s00284-023-03204-4. [PMID: 37012483]
  • Heping Cao, Kandan Sethumadhavan. Plant Polyphenol Gossypol Induced Cell Death and Its Association with Gene Expression in Mouse Macrophages. Biomolecules. 2023 Mar; 13(4):. doi: 10.3390/biom13040624. [PMID: 37189372]
  • Jia-Ling Lin, Xin Fang, Jian-Xu Li, Zhi-Wen Chen, Wen-Kai Wu, Xiao-Xiang Guo, Ning-Jing Liu, Jia-Fa Huang, Fang-Yan Chen, Ling-Jian Wang, Baofu Xu, Cathie Martin, Xiao-Ya Chen, Jin-Quan Huang. Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds. Nature plants. 2023 Mar; ?(?):. doi: 10.1038/s41477-023-01376-2. [PMID: 36928775]
  • Kun Ye, Teng Teng, Teng Yang, Degang Zhao, Yichen Zhao. Transcriptome analysis reveals the effect of grafting on gossypol biosynthesis and gland formation in cotton. BMC plant biology. 2023 Jan; 23(1):37. doi: 10.1186/s12870-022-04010-z. [PMID: 36642721]
  • Kuang Sheng, Yue Sun, Meng Liu, Yuefen Cao, Yifei Han, Cheng Li, Uzair Muhammad, Muhammad Khan Daud, Wanru Wang, Huazu Li, Samrana Samrana, Yixuan Hui, Shuijin Zhu, Jinhong Chen, Tianlun Zhao. A reference-grade genome assembly for Gossypium bickii and insights into its genome evolution and formation of pigment glands and gossypol. Plant communications. 2023 Jan; 4(1):100421. doi: 10.1016/j.xplc.2022.100421. [PMID: 35949167]
  • Jun Yu, Haiming Yang, Qingyu Sun, Xuean Xu, Zhi Yang, Zhiyue Wang. Effects of cottonseed meal on performance, gossypol residue, liver function, lipid metabolism, and cecal microbiota in geese. Journal of animal science. 2023 Jan; 101(?):. doi: 10.1093/jas/skad020. [PMID: 36634076]
  • Devendra Pandeya, LeAnne M Campbell, Lorraine Puckhaber, Charles Suh, Keerti S Rathore. Gossypol and related compounds are produced and accumulate in the aboveground parts of the cotton plant, independent of roots as the source. Planta. 2022 Dec; 257(1):21. doi: 10.1007/s00425-022-04049-0. [PMID: 36538120]
  • Heping Cao, Kandan Sethumadhavan. Identification of Bcl2 as a Stably Expressed qPCR Reference Gene for Human Colon Cancer Cells Treated with Cottonseed-Derived Gossypol and Bioactive Extracts and Bacteria-Derived Lipopolysaccharides. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217560. [PMID: 36364387]
  • Adam Shepherd, Oliver Brunckhorst, Kamran Ahmed, Qihe Xu. Botanicals in health and disease of the testis and male fertility: A scoping review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154398. doi: 10.1016/j.phymed.2022.154398. [PMID: 36049429]
  • Peng Zhao, Hui Xue, Xiangzhen Zhu, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Lin Niu, Xueke Gao, Junyu Luo, Jinjie Cui. Knockdown of cytochrome P450 gene CYP6AB12 based on nanomaterial technology reduces the detoxification ability of Spodoptera litura to gossypol. Pesticide biochemistry and physiology. 2022 Nov; 188(?):105284. doi: 10.1016/j.pestbp.2022.105284. [PMID: 36464384]
  • Cuiping Zhang, Xiuyan Liu, Yin Song, Zhengran Sun, Jinli Zhang, Hao Wu, Yuzhen Yang, Zhenkai Wang, Daohua He. Comparative Transcriptome Analysis Reveals Genes Associated with the Gossypol Synthesis and Gland Morphogenesis in Gossypium hirsutum. Genes. 2022 08; 13(8):. doi: 10.3390/genes13081452. [PMID: 36011363]
  • Chun-Yan Chang, Xiao-Wan Sun, Pan-Pan Tian, Ning-Hui Miao, Yu-Lin Zhang, Xiang-Dong Liu. Plant secondary metabolite and temperature determine the prevalence of Arsenophonus endosymbionts in aphid populations. Environmental microbiology. 2022 08; 24(8):3764-3776. doi: 10.1111/1462-2920.15929. [PMID: 35129273]
  • Mengying Lv, Lei Wang, Yujuan Guo, Jun Yao. NMR-based metabolomics reveals tissue metabolic responses to tetramethoxy gossypol in cottonseed oil. Journal of the science of food and agriculture. 2022 Jul; ?(?):. doi: 10.1002/jsfa.12115. [PMID: 35808803]
  • Cui-Ping Zhang, Jin-Li Zhang, Zheng-Ran Sun, Xiu-Yan Liu, Li-Zhe Shu, Hao Wu, Yin Song, Dao-Hua He. Genome-wide identification and characterization of terpene synthase genes in Gossypium hirsutum. Gene. 2022 Jun; 828(?):146462. doi: 10.1016/j.gene.2022.146462. [PMID: 35413394]
  • Yaning Gao, Wanbo Tai, Xinyi Wang, Shibo Jiang, Asim K Debnath, Lanying Du, Shizhong Chen. A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity. BMC biology. 2022 06; 20(1):143. doi: 10.1186/s12915-022-01344-w. [PMID: 35706035]
  • Shuaichao Zheng, Weijiao Liu, Junyu Luo, Lisha Wang, Xiangzhen Zhu, Xueke Gao, Hongxia Hua, Jinjie Cui. Helicoverpa armigera herbivory negatively impacts Aphis gossypii populations via inducible metabolic changes. Pest management science. 2022 Jun; 78(6):2357-2369. doi: 10.1002/ps.6865. [PMID: 35254729]
  • Hira Maryam, Zulfiqar Ali, Muhammad Abu Bakar Saddique, Fahim Nawaz. GhCDNC and GhCYP706B1 genes mediate gossypol biosynthesis in upland cotton. Molecular biology reports. 2022 Jun; 49(6):4919-4928. doi: 10.1007/s11033-022-07355-8. [PMID: 35338438]
  • Masood Jan, Zhixin Liu, Chenxi Guo, Yaping Zhou, Xuwu Sun. An Overview of Cotton Gland Development and Its Transcriptional Regulation. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094892. [PMID: 35563290]
  • Bicheng Cai, Liang Gong, Yiying Zhu, Lingmei Kong, Xiaoman Ju, Xue Li, Xiaodong Yang, Hongyu Zhou, Yan Li. Identification of Gossypol Acetate as an Autophagy Modulator with Potent Anti-tumor Effect against Cancer Cells. Journal of agricultural and food chemistry. 2022 Mar; 70(8):2589-2599. doi: 10.1021/acs.jafc.1c06399. [PMID: 35180345]
  • Shuaichao Zheng, Junyu Luo, Xiangzhen Zhu, Xueke Gao, Hongxia Hua, Jinjie Cui. Transcriptomic analysis of salivary gland and proteomic analysis of oral secretion in Helicoverpa armigera under cotton plant leaves, gossypol, and tannin stresses. Genomics. 2022 03; 114(2):110267. doi: 10.1016/j.ygeno.2022.01.004. [PMID: 35032617]
  • Zhongqi He, Sunghyun Nam, Hailin Zhang, Ocen Modesto Olanya. Chemical Composition and Thermogravimetric Behaviors of Glanded and Glandless Cottonseed Kernels. Molecules (Basel, Switzerland). 2022 Jan; 27(1):. doi: 10.3390/molecules27010316. [PMID: 35011547]
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