(-)-Gossypol (BioDeep_00000000287)

 

Secondary id: BioDeep_00000872950

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs Antitumor activity natural product


代谢物信息卡片


ethanoic acid;7-[8-methanoyl-3-methyl-1,6,7-tris(oxidanyl)-5-propan-2-yl-naphthalen-2-yl]-6-methyl-2,3,8-tris(oxidanyl)-4-propan-2-yl-naphthalene-1-carbaldehyde

化学式: C30H30O8 (518.1941)
中文名称: (R)-(-)-棉子酚, (-)-棉子素, 棉子醇, 棉籽酚, 棉子酚, 棉酚
谱图信息: 最多检出来源 Viridiplantae(plant) 84.2%

分子结构信息

SMILES: C12C=C(C(C3C(C)=CC4C(C(C)C)=C(C(O)=C(C=O)C=4C=3O)O)=C(O)C=1C(C=O)=C(C(O)=C2C(C)C)O)C
InChI: InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3

描述信息

Gossypol has been used in trials studying the treatment of Non-small Cell Lung Cancer.
(-)-Gossypol or (R)-Gossypol, is the R-isomer of [Gossypol].
Gossypol is a natural product found in Malva pseudolavatera, Hibiscus syriacus, and other organisms with data available.
Gossypol is an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive.
(-)-Gossypol is found in fats and oils. (-)-Gossypol is a constituent of Gossypium hirsutum (cotton).(-)-gossypol has been shown to exhibit anti-tumor, anti-cancer and anti-proliferative functions (A7832, A7833, A7834).
A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Gossypol, also known as gossypol, (+)-isomer or (-)-gossypol, is a member of the class of compounds known as sesquiterpenoids. Sesquiterpenoids are terpenes with three consecutive isoprene units. Thus, gossypol is considered to be an isoprenoid lipid molecule. Gossypol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Gossypol can be found in cottonseed, okra, soy bean, and sunflower, which makes gossypol a potential biomarker for the consumption of these food products. Gossypol is a non-carcinogenic (not listed by IARC) potentially toxic compound. Among other things, it has been tested as a male oral contraceptive in China. In addition to its putative contraceptive properties, gossypol has also long been known to possess antimalarial properties. Other researchers are investigating the anticancer properties of gossypol . Gossypol may cause apoptosis via the regulation of Bax and Bcl-2 proteins. It is also an inhibitor of calcineurin and protein kinases C, and has been shown to bind calmodulin (L1239) (T3DB).
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
(-)-Gossypol is found in fats and oils. (-)-Gossypol is a constituent of Gossypium hirsutum (cotton)
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product
C1907 - Drug, Natural Product
Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

同义名列表

122 个代谢物同义名

ethanoic acid;7-[8-methanoyl-3-methyl-1,6,7-tris(oxidanyl)-5-propan-2-yl-naphthalen-2-yl]-6-methyl-2,3,8-tris(oxidanyl)-4-propan-2-yl-naphthalene-1-carbaldehyde; acetic acid;7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-yl-2-naphthalenyl)-2,3,8-trihydroxy-6-methyl-4-propan-2-yl-1-naphthalenecarboxaldehyde; acetic acid;7-(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2-naphthyl)-2,3,8-trihydroxy-4-isopropyl-6-methyl-naphthalene-1-carbaldehyde; 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde; 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde; 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(methylethyl)(2-naphthyl)]-2,3,8-trihy droxy-6-methyl-4-(methylethyl)naphthalenecarbaldehyde; 7-(8-Formyl-1,6,7-trihydroxy-3-methyl-5-(methylethyl)(2-naphthyl))-2,3,8-trihydroxy-6-methyl-4-(methylethyl)naphthalenecarbaldehyde; 7-(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2-naphthyl)-2,3,8-trihydroxy-4-isopropyl-6-methyl-naphthalene-1-carbaldehyde; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde; (2,2-BINAPHTHALENE)-8,8-DICARBOXALDEHYDE, 1,1,6,6,7,7-HEXAHYDROXY-3,3-DIMETHYL-5,5-BIS(1-METHYLETHYL)-, (2S)-; (2,2-BINAPHTHALENE)-8,8-DICARBOXALDEHYDE, 1,1,6,6,7,7-HEXAHYDROXY-3,3-DIMETHYL-5,5-BIS(1-METHYLETHYL)-, (S)-; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-, (-)-; [2,2-Binaphthalene]-8,8-dicarboxaldehyde,1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-, (2R)-; (-)-1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-[2,2-binaphthalene]-8,8-dicarboxaldehyde; (-)-1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)[2,2-binaphthalene]-8,8-dicarboxaldehyde; [2,2-Binaphthalene]-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-; (+)1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)[2,2-binaphthalene]-8,8-dicarboxaldehyde; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-, (+)-; 1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-[2,2-binaphthalene]-8,8-dicarboxaldehyde; 1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)[2,2-binaphthalene]-8,8-dicarboxaldehyde; 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-2,2-binaphthalene-8,8-dicarbaldehyde; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-; [2,8-dicarboxaldehyde, 1,1,6,6,7,7- hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-, (2R)-; 1,1,6,6,7,7-Hexahydroxy-5,5-diisopropyl-3,3-dimethyl-[2,2-binaphthalene]-8,8-dicarbaldehyde; 1,1,6,6,7,7-Hexahydroxy-5,5-diisopropyl-3,3-dimethyl[2,2-binaphthalene]-8,8-dicarbaldehyde; 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-2,2-binaphthyl-8,8-dicarbaldehyde; [2,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1- methylethyl)-; [2,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-; [2,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-; (2,8-dicarboxaldehyde, 1,1,6,67,7-hexahydroxy-5,5-diisopropyl-3,3-dimethyl-; (-)-2,2-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene); (R)-2,2-BIS(8-FORMYL-1,6,7-TRIHYDROXY-5-ISOPROPYL-3-METHYLNAPHTHALENE); 2,2-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene); 2,2-bi[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]; 8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2,2-bisnaphthalene; 8-Formyl-1,7-trihydroxy-5-isopropyl-3-methyl-2,2-bisnaphthalene; (2,2-Binaphthalene)-8,8-dicarboxaldehyde, 1,1,6,6,7,7-hexahyd; ( inverted exclamation markA)-GOSSYPOL FROM COTTON SEEDS; (+/-)-Gossypol from cotton seeds, >=95\\% (HPLC); 4-08-00-03754 (Beilstein Handbook Reference); (+/-)-Gossypol from cotton seeds; QBKSWRVVCFFDOT-UHFFFAOYSA-N; Gossypol from cotton seeds; Dipotassium Salt, Gossypol; Gossypol Dipotassium Salt; Gossypol, (+-)-Isomer; Sodium Salt, Gossypol; Gossypol Sodium Salt; GOSSYPOL S-FORM [MI]; Gossypol, (-)-Isomer; Gossypol, (+)-Isomer; GOSSYPOL R-FORM [MI]; Prestwick0_000677; Prestwick2_000677; Prestwick1_000677; Prestwick3_000677; Spectrum2_001472; Spectrum5_001035; GOSSYPOL [MART.]; Spectrum3_001516; (S)-(+)-Gossypol; Spectrum3_001102; (R)-(-)-Gossypol; Spectrum5_000693; Spectrum2_001624; Spectrum4_001931; GOSSYPOL [VANDF]; racemic-Gossypol; Spectrum4_000846; UNII-KAV15B369O; UNII-8DY2X8LXW4; UNII-XNA7DR63CQ; Gossypol, (S)-; Gissypol, (R)-; (+/-)-Gossypol; Gossypol, (R)-; GOSSYPOL, (+)-; R-(-)-gossypol; Tox21_110434_1; DivK1c_006698; BPBio1_000851; GOSSYPOL [MI]; (+-)-Gossypol; DivK1c_000173; KBio2_000839; KBio2_007137; GOSSYPOL, R-; KBio3_002691; Tox21_500847; (R)-Gossypol; KBio2_003407; KBio1_000173; KBio2_004569; NCI60_004391; KBio1_001642; Tox21_110434; NCI60_001588; (S)-Gossypol; KBio3_002024; (+)-Gossypol; KBio2_005975; KBio2_002001; (-)-Gossypol; SMP2_000170; Gossypol, 4; IDI1_000173; XNA7DR63CQ; KAV15B369O; 8DY2X8LXW4; Thespesin; No Fertil; AI3-22957; C30H30O8; Gossypol; Pogosin; AT-101; ssypol; Tash 1; GO3; BL 193; Gossypol



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

296 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 AKT1, ALB, ATG5, BCL2, BCL2L1, BECN1, CASP8, CASP9, CAT, CCND1, HPGDS, MAPK14, MAPK8, MCL1, MSMP, VEGFA
Golgi apparatus, trans-Golgi network membrane 1 BECN1
Peripheral membrane protein 3 ATG5, BECN1, CYP1B1
Endosome membrane 1 BECN1
Endoplasmic reticulum membrane 3 BCL2, BECN1, CYP1B1
Mitochondrion membrane 2 BCL2L1, BECN1
Cytoplasmic vesicle, autophagosome 1 BECN1
Nucleus 11 AKT1, ALB, BCL2, BECN1, CASP8, CASP9, CCND1, MAPK14, MAPK8, MCL1, VEGFA
autophagosome 2 ATG5, BECN1
cytosol 15 AKT1, ALB, ATG5, BCL2, BCL2L1, BECN1, CASP8, CASP9, CAT, CCND1, GPT, HPGDS, MAPK14, MAPK8, MCL1
dendrite 1 BECN1
mitochondrial membrane 1 BECN1
nuclear body 1 BECN1
phagocytic vesicle 1 BECN1
phosphatidylinositol 3-kinase complex, class III 1 BECN1
trans-Golgi network 1 BECN1
centrosome 3 ALB, BCL2L1, CCND1
nucleoplasm 7 AKT1, CASP8, CCND1, HPGDS, MAPK14, MAPK8, MCL1
Cell membrane 2 AKT1, TNF
Cytoplasmic side 1 BCL2L1
lamellipodium 2 AKT1, CASP8
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 TNF, VEGFA
glutamatergic synapse 3 AKT1, ATG5, MAPK14
Golgi apparatus 2 ALB, VEGFA
Golgi membrane 1 INS
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 1 TNF
postsynapse 2 AKT1, ATG5
Cytoplasm, cytosol 1 BCL2L1
endosome 1 BECN1
plasma membrane 2 AKT1, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 7 AKT1, ATG5, BCL2, CAT, CYP1B1, MCL1, VEGFA
axon 2 ATG5, MAPK8
extracellular exosome 3 ALB, CAT, GPT
endoplasmic reticulum 5 ALB, BCL2, BCL2L1, BECN1, VEGFA
extracellular space 5 ALB, INS, MSMP, TNF, VEGFA
Schaffer collateral - CA1 synapse 1 ATG5
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 8 BCL2, BCL2L1, CASP8, CASP9, CAT, CYP1B1, MAPK14, MCL1
protein-containing complex 7 AKT1, ALB, ATG5, BCL2, CASP8, CASP9, CAT
intracellular membrane-bounded organelle 3 CAT, CYP1B1, HPGDS
Microsome membrane 1 CYP1B1
Secreted 4 ALB, INS, MSMP, VEGFA
extracellular region 6 ALB, CAT, INS, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 3 BCL2, BCL2L1, MCL1
mitochondrial outer membrane 4 BCL2, BCL2L1, CASP8, MCL1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 2 BCL2L1, CAT
anchoring junction 1 ALB
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CCND1
Bcl-2 family protein complex 3 BCL2, BCL2L1, MCL1
nuclear membrane 3 BCL2, BCL2L1, CCND1
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
axoneme 1 ATG5
nuclear speck 1 MAPK14
ciliary basal body 2 AKT1, ALB
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 ATG5
cytoskeleton 1 CASP8
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
endosome lumen 1 INS
phagophore assembly site 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type I 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type II 1 BECN1
Preautophagosomal structure membrane 1 ATG5
Atg12-Atg5-Atg16 complex 1 ATG5
mitochondria-associated endoplasmic reticulum membrane contact site 1 ATG5
phagophore assembly site membrane 1 ATG5
myosin complex 1 MCL1
Nucleus, nucleoplasm 1 MCL1
cell body 1 CASP8
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
transcription repressor complex 1 CCND1
platelet alpha granule lumen 2 ALB, VEGFA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 1 CASP8
ripoptosome 1 CASP8
transferase complex 1 ATG5
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
cytoplasmic side of mitochondrial outer membrane 1 BECN1
ciliary transition fiber 1 ALB
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[Beclin-1-C 35 kDa]: Mitochondrion 1 BECN1
[Beclin-1-C 37 kDa]: Mitochondrion 1 BECN1
phagophore 1 ATG5
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Aarti Gupta, Manoj Kumar, Baohong Zhang, Maharishi Tomar, Amandeep Kaur Walia, Prince Choyal, Ravi Prakash Saini, Jayashree Potkule, David J Burritt, Vijay Sheri, Pooja Verma, Deepak Chandran, Lam-Son Phan Tran. Improvement of qualitative and quantitative traits in cotton under normal and stressed environments using genomics and biotechnological tools: A review. Plant science : an international journal of experimental plant biology. 2024 Mar; 340(?):111937. doi: 10.1016/j.plantsci.2023.111937. [PMID: 38043729]
  • Zhen-Nan Zhang, Lu Long, Xiao-Tong Zhao, Shen-Zhai Shang, Fu-Chun Xu, Jing-Ruo Zhao, Gai-Yuan Hu, Ling-Yu Mi, Chun-Peng Song, Wei Gao. The dual role of GoPGF reveals that the pigment glands are synthetic sites of gossypol in aerial parts of cotton. The New phytologist. 2024 Jan; 241(1):314-328. doi: 10.1111/nph.19331. [PMID: 37865884]
  • Yi Zhang, Yuxue Wang, Ting Liu, Xincheng Luo, Yi Wang, Longyan Chu, Jianpin Li, Hongliu An, Peng Wan, Dong Xu, Yazhen Yang, Jianmin Zhang. GhMYC1374 regulates the cotton defense response to cotton aphids by mediating the production of flavonoids and free gossypol. Plant physiology and biochemistry : PPB. 2023 Dec; 205(?):108162. doi: 10.1016/j.plaphy.2023.108162. [PMID: 37951101]
  • Jianyi Li, Long Jin, Yuntong Lv, Yaping Ding, Kunpeng Yan, Hang Zhang, Yiou Pan, Qingli Shang. Inducible Cytochrome P450s in the Fat Body and Malpighian Tubules of the Polyphagous Pests of Spodoptera litura Confer Xenobiotic Tolerance. Journal of agricultural and food chemistry. 2023 Oct; 71(40):14517-14526. doi: 10.1021/acs.jafc.3c04865. [PMID: 37773746]
  • Zhonglei Wang, Xian-Qing Song, Wenjing Xu, Shizeng Lei, Hao Zhang, Liyan Yang. Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Nutrients. 2023 Sep; 15(18):. doi: 10.3390/nu15183885. [PMID: 37764669]
  • Xiaohui Shi, Xinwei Lv, Dong Xiao. Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation. Clinical and translational science. 2023 Aug; ?(?):. doi: 10.1111/cts.13618. [PMID: 37626472]
  • Teame Gereziher Mehari, Hui Fang, Wenxiang Feng, Yuanyuan Zhang, Muhammad Jawad Umer, Jinlei Han, Allah Ditta, Muhammad K R Khan, Fang Liu, Kai Wang, Baohua Wang. Genome-wide identification and expression analysis of terpene synthases in Gossypium species in response to gossypol biosynthesis. Functional & integrative genomics. 2023 Jun; 23(2):197. doi: 10.1007/s10142-023-01125-w. [PMID: 37270747]
  • Linglei Kong, Shaoqi Li, Yuyuan Qian, Hailiang Cheng, Youping Zhang, Dongyun Zuo, Limin Lv, Qiaolian Wang, Junlan Li, Guoli Song. Comparative Transcriptome Analysis Revealed Key Genes Regulating Gossypol Synthesis in Tetraploid Cultivated Cotton. Genes. 2023 05; 14(6):. doi: 10.3390/genes14061144. [PMID: 37372323]
  • Yuanli Dai, Shang Liu, Dongyun Zuo, Qiaolian Wang, Limin Lv, Youping Zhang, Hailiang Cheng, John Z Yu, Guoli Song. Identification of MYB gene family and functional analysis of GhMYB4 in cotton (Gossypium spp.). Molecular genetics and genomics : MGG. 2023 May; 298(3):755-766. doi: 10.1007/s00438-023-02005-5. [PMID: 37027022]
  • Si Chen, Weishu Zhang, Huiling Zhang, Ying Cui, Feng Wang, Jing Wu, Hongjun Chao, Dazhong Yan. The Complete Genome Sequence of a Gossypol-Degrading Bacterial Strain, Raoultella sp. YL01. Current microbiology. 2023 Apr; 80(5):163. doi: 10.1007/s00284-023-03204-4. [PMID: 37012483]
  • Heping Cao, Kandan Sethumadhavan. Plant Polyphenol Gossypol Induced Cell Death and Its Association with Gene Expression in Mouse Macrophages. Biomolecules. 2023 Mar; 13(4):. doi: 10.3390/biom13040624. [PMID: 37189372]
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