Norizalpinin (BioDeep_00000002806)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl- (9CI)

化学式: C15H10O5 (270.052821)
中文名称: 3,5,7-三羟基黄酮, 高良姜精, 高良姜素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O)c1ccccc1)O)O
InChI: InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H

描述信息

Galangin is a 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells. It has a role as an antimicrobial agent, an EC 3.1.1.3 (triacylglycerol lipase) inhibitor and a plant metabolite. It is a trihydroxyflavone and a 7-hydroxyflavonol.
Galangin is a natural product found in Alpinia conchigera, Populus koreana, and other organisms with data available.
Constituent of Galanga root (Alpinia officinarum). Galangin is found in many foods, some of which are apple, garden onion (variety), sweet orange, and grape wine.
A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
Norizalpinin is found in apple. Norizalpinin is a constituent of Galanga root (Alpinia officinarum)
D009676 - Noxae > D009153 - Mutagens
Galangin (Norizalpinin) is?an?agonist/antagonist?of the?arylhydrocarbon?receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.
Galangin (Norizalpinin) is?an?agonist/antagonist?of the?arylhydrocarbon?receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.

同义名列表

31 个代谢物同义名

数据库引用编号

22 个数据库交叉引用编号

ChEBI: CHEBI:5262
KEGG: C10044
PubChem: 5281616
HMDB: HMDB0029521
Metlin: METLIN45739
ChEMBL: CHEMBL309490
Wikipedia: Galangin
LipidMAPS: LMPK12111653
MeSH: galangin
ChemIDplus: 0000548834
MetaCyc: CPD-13502
KNApSAcK: C00004533
foodb: FDB000657
chemspider: 4444935
CAS: 548-83-4
medchemexpress: HY-N0382
PMhub: MS000005574
MetaboLights: MTBLC5262
PubChem: 12230
PDB-CCD: KMC
3DMET: B03487
NIKKAJI: J1.607A

分类词条

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

Flavonoid Biosynthesis: Hydrogen Ion + NADPH + Naringenin ⟶ Apiforol + NADP

PharmGKB(0)

118 个相关的物种来源信息

33090 高良姜: -
29760 Vitis vinifera: 10.1021/JF000661F
3750 Malus domestica: 10.1021/JF000661F
283210 Malus pumila: 10.1021/JF000661F
4043 Petroselinum crispum: 10.1021/JF000661F
180772 Vaccinium vitis-idaea: 10.1021/JF000661F
4442 Camellia sinensis: 10.1021/JF000661F
36774 Brassica oleracea var. italica: 10.1021/JF000661F
4679 Allium cepa: 10.1021/JF000661F
32216 Adenostoma sparsifolium:
1616482 Populus candicans:
73824 Populus balsamifera:
3696 Populus deltoides:
75703 Populus maximowiczii: 10.1515/ZNC-1992-3-424
245546 Populus suaveolens: 10.1515/ZNC-1992-3-424
1085088 Populus koreana: 10.1515/ZNC-1992-3-424
529617 Dennstaedtia scabra: 10.1248/CPB.57.1123
28933 Nothofagus antarctica:
201290 Trichostema lanatum: 10.1515/ZNC-1992-9-1025
688333 Populus cathayana: 10.1515/ZNC-1992-3-423
179740 Populus szechuanica: 10.1515/ZNC-1992-3-423
214225 Callitris columellaris: 10.1016/S0031-9422(00)82391-2
214223 Callitris glaucophylla: 10.1016/S0031-9422(00)82391-2
199623 Alpinia officinarum:
112357 Helichrysum aureum:
7460 Apis mellifera:
489316 Entada phaseoloides: 10.1002/CBDV.201100002
236730 Endosamara racemosa: 10.1016/0031-9422(89)80141-4
113624 Populus laurifolia:
242124 Populus yunnanensis: 10.1515/ZNC-1992-0624
295327 Populus simonii: 10.1515/ZNC-1992-0624
7459 Apis: 10.1021/JF400779W
519526 Vachellia vernicosa: 10.1016/S0031-9422(00)82416-4
3691 Populus nigra:
65409 Scutellaria baicalensis: 10.1111/J.1600-0609.2009.01365.X
3694 Populus trichocarpa: 10.1515/ZNC-1987-9-1004
139307 Pinus morrisonicola: 10.1016/S0031-9422(00)83877-7
45164 Muntingia calabura: 10.1055/S-2005-871223
1108060 Gaga kaulfussii: 10.1021/NP50050A009
594549 Lychnophora ericoides: 10.1002/(SICI)1099-1565(200003/04)11:2<69::AID-PCA499>3.0.CO;2-Y
105671 Alpinia conchigera: 10.1016/S0031-9422(00)90374-1
125667 Xerochrysum viscosum: 10.1016/0031-9422(93)85293-Z
63803 Siparuna: 10.1016/0031-9422(93)85293-Z
542673 Lippia origanoides: 10.1016/J.JFCA.2006.09.005
1986359 Lippia graveolens: 10.1016/J.JFCA.2006.09.005
1498956 Woodsia scopulina: 10.1016/S0031-9422(98)00214-3
191958 Zuccagnia punctata: 10.1021/JF902991T
746492 Achyrocline flaccida: 10.1016/0305-1978(88)90032-4
253221 Alnus sieboldiana: 10.1016/J.PHYMED.2010.10.005
39352 Origanum vulgare: 10.1021/JF00050A028
175237 Ribes viscosissimum: 10.1016/0305-1978(93)90083-4
34296 Datisca cannabina: 10.1007/BF00577183
110723 Hedychium spicatum: 10.1016/J.BMCL.2008.10.121
49827 Glycyrrhiza glabra:
74613 Glycyrrhiza uralensis:
112358 Helichrysum cephaloideum: 10.1016/S0378-8741(97)01514-6
94327 Alpinia galanga: 10.3736/JCIM20111004
454096 Heliotropium filifolium: 10.1016/0305-1978(93)90082-3
29760 Vitis vinifera: 10.1021/JF000661F
3750 Malus domestica: 10.1021/JF000661F
283210 Malus pumila: 10.1021/JF000661F
4043 Petroselinum crispum: 10.1021/JF000661F
180772 Vaccinium vitis-idaea: 10.1021/JF000661F
4442 Camellia sinensis: 10.1021/JF000661F
36774 Brassica oleracea var. italica: 10.1021/JF000661F
4679 Allium cepa: 10.1021/JF000661F
32216 Adenostoma sparsifolium:
1616482 Populus candicans:
73824 Populus balsamifera:
3696 Populus deltoides:
75703 Populus maximowiczii: 10.1515/ZNC-1992-3-424
245546 Populus suaveolens: 10.1515/ZNC-1992-3-424
1085088 Populus koreana: 10.1515/ZNC-1992-3-424
529617 Dennstaedtia scabra: 10.1248/CPB.57.1123
28933 Nothofagus antarctica:
201290 Trichostema lanatum: 10.1515/ZNC-1992-9-1025
688333 Populus cathayana: 10.1515/ZNC-1992-3-423
179740 Populus szechuanica: 10.1515/ZNC-1992-3-423
214225 Callitris columellaris: 10.1016/S0031-9422(00)82391-2
214223 Callitris glaucophylla: 10.1016/S0031-9422(00)82391-2
199623 Alpinia officinarum:
112357 Helichrysum aureum:
7460 Apis mellifera:
489316 Entada phaseoloides: 10.1002/CBDV.201100002
236730 Endosamara racemosa: 10.1016/0031-9422(89)80141-4
113624 Populus laurifolia:
242124 Populus yunnanensis: 10.1515/ZNC-1992-0624
295327 Populus simonii: 10.1515/ZNC-1992-0624
7459 Apis: 10.1021/JF400779W
519526 Vachellia vernicosa: 10.1016/S0031-9422(00)82416-4
3691 Populus nigra:
65409 Scutellaria baicalensis: 10.1111/J.1600-0609.2009.01365.X
3694 Populus trichocarpa: 10.1515/ZNC-1987-9-1004
139307 Pinus morrisonicola: 10.1016/S0031-9422(00)83877-7
45164 Muntingia calabura: 10.1055/S-2005-871223
1108060 Gaga kaulfussii: 10.1021/NP50050A009
594549 Lychnophora ericoides: 10.1002/(SICI)1099-1565(200003/04)11:2<69::AID-PCA499>3.0.CO;2-Y
105671 Alpinia conchigera: 10.1016/S0031-9422(00)90374-1
125667 Xerochrysum viscosum: 10.1016/0031-9422(93)85293-Z
63803 Siparuna: 10.1016/0031-9422(93)85293-Z
542673 Lippia origanoides: 10.1016/J.JFCA.2006.09.005
1986359 Lippia graveolens: 10.1016/J.JFCA.2006.09.005
1498956 Woodsia scopulina: 10.1016/S0031-9422(98)00214-3
191958 Zuccagnia punctata: 10.1021/JF902991T
746492 Achyrocline flaccida: 10.1016/0305-1978(88)90032-4
253221 Alnus sieboldiana: 10.1016/J.PHYMED.2010.10.005
39352 Origanum vulgare: 10.1021/JF00050A028
175237 Ribes viscosissimum: 10.1016/0305-1978(93)90083-4
34296 Datisca cannabina: 10.1007/BF00577183
110723 Hedychium spicatum: 10.1016/J.BMCL.2008.10.121
49827 Glycyrrhiza glabra:
74613 Glycyrrhiza uralensis:
112358 Helichrysum cephaloideum: 10.1016/S0378-8741(97)01514-6
94327 Alpinia galanga: 10.3736/JCIM20111004
454096 Heliotropium filifolium: 10.1016/0305-1978(93)90082-3
9606 Homo sapiens: -
199623 Alpinia officinarum Hance: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Qinghua Lan, Shuanghu Wang, Zhouming Chen, Junyan Hua, Jieru Hu, Songmei Luo, Yanyan Xu. Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma. International journal of pharmaceutics. 2024 Jan; 649(?):123667. doi: 10.1016/j.ijpharm.2023.123667. [PMID: 38048890]
Daibo Wang, Junren Chen, Lin Pu, Lei Yu, Fang Xiong, Luyao Sun, Qian Yu, Xiaoyu Cao, Yan Chen, Fu Peng, Cheng Peng. Galangin: A food-derived flavonoid with therapeutic potential against a wide spectrum of diseases. Phytotherapy research : PTR. 2023 Sep; ?(?):. doi: 10.1002/ptr.8013. [PMID: 37748788]
Tao Yang, Haiqiong Liu, Chaobo Yang, Huaqiang Mo, Xianbao Wang, Xudong Song, Luping Jiang, Ping Deng, Ran Chen, Pengcui Wu, Aihua Chen, Jing Yan. Galangin Attenuates Myocardial Ischemic Reperfusion-Induced Ferroptosis by Targeting Nrf2/Gpx4 Signaling Pathway. Drug design, development and therapy. 2023; 17(?):2495-2511. doi: 10.2147/dddt.s409232. [PMID: 37637264]
Xiaoting Wang, Xinglei Xiao. Galangin inhibits lipopolysaccharide-induced inflammation and stimulates osteogenic differentiation of bone marrow mesenchymal stem cells via regulation of AKT/mTOR signaling. Allergologia et immunopathologia. 2023; 51(1):133-139. doi: 10.15586/aei.v51i1.741. [PMID: 36617832]
Bing Wu, Changwu Xu, Hua-Sheng Ding, Liqiang Qiu, Ji-Xian Gao, Ming Li, Yuanguo Xiong, Hao Xia, Xiaoxiong Liu. Galangin inhibits neointima formation induced by vascular injury via regulating the PI3K/AKT/mTOR pathway. Food & function. 2022 Nov; 13(23):12077-12092. doi: 10.1039/d2fo02441a. [PMID: 36367287]
Ke Chen, Ran Xue, Yaping Geng, Shenshen Zhang. Galangin inhibited ferroptosis through activation of the PI3K/AKT pathway in vitro and in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 11; 36(11):e22569. doi: 10.1096/fj.202200935r. [PMID: 36183339]
Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Siwayu Rattanakanokchai, Prapassorn Potue, Juthamas Khamseekaew, Sarawoot Bunbupha, Poungrat Pakdeechote. Cardiorenal dysfunction and hypertrophy induced by renal artery occlusion are normalized by galangin treatment in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113231. doi: 10.1016/j.biopha.2022.113231. [PMID: 35687907]
Samir A Salama, Gamil M Abd-Allah, Hesham S Gad, Ahmed M Kabel. Galangin attenuates cadmium-evoked nephrotoxicity: Targeting nucleotide-binding domain-like receptor pyrin domain containing 3 inflammasome, nuclear factor erythroid 2-related factor 2, and nuclear factor kappa B signaling. Journal of biochemical and molecular toxicology. 2022 Jul; 36(7):e23059. doi: 10.1002/jbt.23059. [PMID: 35384154]
Thamizharasi Erusappan, Sivasakthi Paramasivam, Sanmuga Priya Ekambaram. Identification of galangin as the bioactive compound from Alpinia calcarata (Haw.) Roscoe rhizomes to inhibit IRAK-1/ MAPK/ NF-κB p65 and JAK-1 signaling in LPS stimulated RAW 264.7 cells. Journal of ethnopharmacology. 2022 Apr; 288(?):114975. doi: 10.1016/j.jep.2022.114975. [PMID: 35026343]
Anand Kumar Sahu, Ashok Kumar Mishra. Photophysical Behavior of Plant Flavonols Galangin, Kaempferol, Quercetin, and Myricetin in Homogeneous Media and the DMPC Model Membrane: Unveiling the Influence of the B-Ring Hydroxylation of Flavonols. The journal of physical chemistry. B. 2022 04; 126(15):2863-2875. doi: 10.1021/acs.jpcb.2c00929. [PMID: 35404618]
Xiongwei Deng, Hailang Le, Taohong Wan, Meizhi Weng, Yongzhen Tan. Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway. Bioengineered. 2022 04; 13(4):11192-11201. doi: 10.1080/21655979.2022.2062969. [PMID: 35485325]
Xichuan Li, Ce Wang, Jinqian Chen, Xia Hu, Hao Zhang, Zhiying Li, Bei Lan, Wei Zhang, Yanjun Su, Chunze Zhang. Potential interactions among myricetin and dietary flavonols through the inhibition of human UDP-glucuronosyltransferase in vitro. Toxicology letters. 2022 Apr; 358(?):40-47. doi: 10.1016/j.toxlet.2022.01.007. [PMID: 35063619]
Manal A Alfwuaires. Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity. Environmental science and pollution research international. 2022 Mar; 29(14):20279-20288. doi: 10.1007/s11356-021-16804-z. [PMID: 34729716]
Hany H Arab, Ahmed M Ashour, Ahmed H Eid, El-Shaimaa A Arafa, Hana J Al Khabbaz, Sarah A Abd El-Aal. Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways. Life sciences. 2022 Feb; 291(?):120300. doi: 10.1016/j.lfs.2021.120300. [PMID: 34999115]
Yingli Jin, Panpan Yang, Li Wang, Zeyuan Gao, Jia Lv, Zheyu Cui, Tiedong Wang, Dacheng Wang, Lin Wang. Galangin as a direct inhibitor of vWbp protects mice from Staphylococcus aureus-induced pneumonia. Journal of cellular and molecular medicine. 2022 02; 26(3):828-839. doi: 10.1111/jcmm.17129. [PMID: 34931454]
Ke Hu, Yuxian Li, Ling Jin, Yuefu Chen, Lijun Chen, Yingjun Zhang, Minjiang Huang, Yan Ding, Huiming Yin, Minghua Liang, Bifeng Tan. Protective Effect of Galangin Methylation Modification Based on Cell Imaging on Inflammatory Lung Injury and Its Molecular Mechanism. Contrast media & molecular imaging. 2022; 2022(?):7511345. doi: 10.1155/2022/7511345. [PMID: 36072628]
Francesco Caruso, Molly Berinato, Melissa Hernandez, Stuart Belli, Christopher Smart, Miriam Rossi. Antioxidant properties of bee propolis and an important component, galangin, described by X-ray crystal structure, DFT-D and hydrodynamic voltammetry. PloS one. 2022; 17(5):e0267624. doi: 10.1371/journal.pone.0267624. [PMID: 35584109]
Hamed Hajipour, Mohammad Nouri, Marjan Ghorbani, Ali Bahramifar, Reza Zolfaghari Emameh, Ramezan Ali Taheri. Targeted nanostructured lipid carrier containing galangin as a promising adjuvant for improving cytotoxic effects of chemotherapeutic agents. Naunyn-Schmiedeberg's archives of pharmacology. 2021 12; 394(12):2353-2362. doi: 10.1007/s00210-021-02152-9. [PMID: 34522984]
Hyun-Kyung Song, Sun Haeng Park, Hye Jin Kim, Seol Jang, Taesoo Kim. Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Dec; 144(?):112322. doi: 10.1016/j.biopha.2021.112322. [PMID: 34656059]
Yao-Dong Song, Yan-Yan Liu, De-Jian Li, Shu-Jun Yang, Qiao-Fang Wang, Yan-Na Liu, Meng-Ke Li, Chao-Peng Mei, Hu-Ning Cui, San-Yang Chen, Chang-Ju Zhu. Galangin ameliorates severe acute pancreatitis in mice by activating the nuclear factor E2-related factor 2/heme oxygenase 1 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Dec; 144(?):112293. doi: 10.1016/j.biopha.2021.112293. [PMID: 34634559]
Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Prapassorn Potue, Sarawoot Bunbupha, Poungrat Pakdeechote. Galangin alleviates vascular dysfunction and remodelling through modulation of the TNF-R1, p-NF-κB and VCAM-1 pathways in hypertensive rats. Life sciences. 2021 Nov; 285(?):119965. doi: 10.1016/j.lfs.2021.119965. [PMID: 34543638]
A Madeswaran, S Brahmasundari, P G Midhuna. In silico molecular docking studies of certain commercially available flavonoids as effective antiviral agents against spike glycoprotein of SARS-CoV-2. European review for medical and pharmacological sciences. 2021 Nov; 25(21):6741-6744. doi: 10.26355/eurrev_202111_27119. [PMID: 34787879]
Samir A Salama, Mostafa M Elshafey. Galangin mitigates iron overload-triggered liver injury: Up-regulation of PPARγ and Nrf2 signaling, and abrogation of the inflammatory responses. Life sciences. 2021 Oct; 283(?):119856. doi: 10.1016/j.lfs.2021.119856. [PMID: 34329667]
Rajashri R Naik, Ashok K Shakya, Ghaleb A Oriquat, Shankar Katekhaye, Anant Paradkar, Hugo Fearnley, James Fearnley. Fatty Acid Analysis, Chemical Constituents, Biological Activity and Pesticide Residues Screening in Jordanian Propolis. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26165076. [PMID: 34443664]
Halil Ibrahim Guler, Gizem Tatar, Oktay Yildiz, Ali Osman Belduz, Sevgi Kolayli. Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study. Archives of microbiology. 2021 Aug; 203(6):3557-3564. doi: 10.1007/s00203-021-02351-1. [PMID: 33950349]
Xiao-Hui Liang, Ming-Zhu Yu, Hai-Lian Shi, Xiao-Jun Wu. [Galangin enhances autophagy by inhibiting NF-κB pathway in gastric cancer MGC-803 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Aug; 46(16):4167-4174. doi: 10.19540/j.cnki.cjcmm.20210406.401. [PMID: 34467729]
Rajendra Sangaraju, Sateesh Alavala, Nasiruddin Nalban, Mahesh Kumar Jerald, Ramakrishna Sistla. Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways. International immunopharmacology. 2021 Jul; 96(?):107754. doi: 10.1016/j.intimp.2021.107754. [PMID: 34162135]
Mohammad H Abukhalil, Osama Y Althunibat, Saleem H Aladaileh, Wesam Al-Amarat, Heba M Obeidat, Alayn' Al-Marddyah A Al-Khawalde, Omnia E Hussein, Manal A Alfwuaires, Abdulmohsen I Algefare, Khalid M Alanazi, Farhan K Al-Swailmi, Hany H Arab, Ayman M Mahmoud. Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111410. doi: 10.1016/j.biopha.2021.111410. [PMID: 33752930]
Xiucheng Li, Jiawei Jiang, Zhifan Yang, Songtao Jin, Xuanyuan Lu, Yu Qian. Galangin suppresses RANKL-induced osteoclastogenesis via inhibiting MAPK and NF-κB signalling pathways. Journal of cellular and molecular medicine. 2021 06; 25(11):4988-5000. doi: 10.1111/jcmm.16430. [PMID: 33939240]
Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
S H Aladaileh, F K Al-Swailmi, M H Abukhalil, M H Shalayel. Galangin protects against oxidative damage and attenuates inflammation and apoptosis via modulation of NF-κB p65 and caspase-3 signaling molecules in a rat model of diabetic nephropathy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2021 Feb; 72(1):. doi: 10.26402/jpp.2021.1.04. [PMID: 34099583]
Thamizharasi Erusappan, Sree Karani Kondapuram, Sanmuga Priya Ekambaram, Mohane Selvaraj Coumar. Investigation of Alpinia calcarata constituent interactions with molecular targets of rheumatoid arthritis: docking, molecular dynamics, and network approach. Journal of molecular modeling. 2021 Jan; 27(1):14. doi: 10.1007/s00894-020-04651-7. [PMID: 33403456]
Jing Fan, Xin-Huai Zhao, Tie-Jing Li. Heat treatment of galangin and kaempferol inhibits their benefits to improve barrier function in rat intestinal epithelial cells. The Journal of nutritional biochemistry. 2021 01; 87(?):108517. doi: 10.1016/j.jnutbio.2020.108517. [PMID: 33011286]
Xue Guan, Zhonghua Li, Shu Zhu, Meijia Cheng, Yetao Ju, Lu Ren, Guanlin Yang, Dongyu Min. Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils. Life sciences. 2021 Jan; 264(?):118660. doi: 10.1016/j.lfs.2020.118660. [PMID: 33127512]
María Fernanda García-Bustos, Agustín Moya Álvarez, Cecilia Pérez Brandan, Cecilia Parodi, Andrea Mabel Sosa, Valeria Carolina Buttazzoni Zuñiga, Oscar Marcelo Pastrana, Paula Manghera, Pablo Alejandro Peñalva, Jorge Diego Marco, Paola Andrea Barroso. Development of a Fluorescent Assay to Search New Drugs Using Stable tdTomato-Leishmania, and the Selection of Galangin as a Candidate With Anti-Leishmanial Activity. Frontiers in cellular and infection microbiology. 2021; 11(?):666746. doi: 10.3389/fcimb.2021.666746. [PMID: 34150675]
Rongrong Ou, Lianzhu Lin, Mouming Zhao, Zhiqing Xie. Action mechanisms and interaction of two key xanthine oxidase inhibitors in galangal: Combination of in vitro and in silico molecular docking studies. International journal of biological macromolecules. 2020 Nov; 162(?):1526-1535. doi: 10.1016/j.ijbiomac.2020.07.297. [PMID: 32777423]
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