Tiamulin (BioDeep_00000002708)
代谢物信息卡片
Tiamulin
化学式: C28H47NO4S (493.3226)
中文名称: 泰妙菌素
谱图信息:
最多检出来源 Homo sapiens(COVID-19)(plant) 15.91%
分子结构信息
SMILES: C=CC1(C)CC(OC(=O)CSCCN(CC)CC)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O
InChI: InChI=1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:44137
- KEGG: C12065
- KEGGdrug: D06127
- PubChem: 656958
- PubChem: 4517617
- Metlin: METLIN43351
- DrugBank: DB11468
- ChEMBL: CHEMBL1234521
- CAS: 55297-95-5
- MoNA: AU105511
- MoNA: AU105510
- MoNA: AU105509
- MoNA: AU105508
- MoNA: AU105507
- MoNA: AU105506
- MoNA: AU105505
- MoNA: AU105504
- MoNA: AU105503
- MoNA: AU105502
- MoNA: AU105501
- PMhub: MS000004574
- PubChem: 14218
- PDB-CCD: MUL
- NIKKAJI: J12.323D
- RefMet: Tiamulin
- KNApSAcK: 44137
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emma Stubberfield, Manal AbuOun, Roderick M Card, David Welchman, Muna F Anjum. Molecular characterization of antimicrobial resistance in Brachyspira species isolated from UK chickens: Identification of novel variants of pleuromutilin and beta-lactam resistance genes.
Veterinary microbiology.
2024 Jan; 290(?):109992. doi:
10.1016/j.vetmic.2024.109992. [PMID: 38306769] - Katsivelou Eleni, Perruchon Chiara, Karas A Panagiotis, Sarantidou Apostolia, Pappa Eleni, Katsoula Athanasia, Ligda Panagiota, Sotiraki Smaragda, Martin-Laurent Fabrice, Vasileiadis Sotirios, Karpouzas G Dimitrios. Accelerated dissipation, soil microbial toxicity and dispersal of antimicrobial resistance in soils repeatedly exposed to tiamulin, tilmicosin and sulfamethoxazole.
The Science of the total environment.
2023 Jun; ?(?):164817. doi:
10.1016/j.scitotenv.2023.164817. [PMID: 37329912] - Igor Bosevski, Andreja Žgajnar Gotvajn. Biotreatability Improvement of Antibiotic-Contaminated Waters: High Efficiency of Direct Ozonation in Comparison to Hydroxyl Radical Oxidation.
Acta chimica Slovenica.
2023 Mar; 70(1):65-73. doi:
10.17344/acsi.2022.7793. [PMID: 37005620] - C Perruchon, E Katsivelou, P A Karas, S Vassilakis, A A Lithourgidis, T A Kotsopoulos, S Sotiraki, S Vasileiadis, D G Karpouzas. Following the route of veterinary antibiotics tiamulin and tilmicosin from livestock farms to agricultural soils.
Journal of hazardous materials.
2022 05; 429(?):128293. doi:
10.1016/j.jhazmat.2022.128293. [PMID: 35066227] - Yongtao Liu, Cuiyu Cao, Yi Song, Shun Zhou, Yibin Yang, Ning Xu, Qiuhong Yang, Jing Dong, Xiaohui Ai. Pharmacokinetics, bioavailability, and tissue disposal profiles of Tiamulin fumarate in Nile tilapia (Oreochromis niloticus) following oral and intravenous administrations.
Journal of veterinary pharmacology and therapeutics.
2021 Jul; 44(4):590-602. doi:
10.1111/jvp.12957. [PMID: 33675107] - Yunxing Fu, Chunqing Leng, Yuan Fan, Xia Ma, Xianghui Li, Xuefei Wang, Zhenghuan Guo, Xiujun Wang, Ruofeng Shang. In Vitro and In Vivo Activity of 14-O-[(4,6-Diamino-pyrimidine-2-yl) thioacetyl] Mutilin against Methicillin-Resistant Staphylococcus aureus.
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113277. [PMID: 34071703] - Noelia Cambeiro-Pérez, Xiana González-Gómez, Ledicia Rey-Salgueiro, Jesús Simal-Gándara, Elena Martínez-Carballo. Rapid liquid chromatographic method for the control of doxycycline and tiamulin residues and their metabolites in vivo assays with pigs: Treatment and depletion.
Journal of pharmaceutical and biomedical analysis.
2020 Oct; 190(?):113428. doi:
10.1016/j.jpba.2020.113428. [PMID: 32739650] - Zhen Jin, Le Wang, Hong Gao, Ying-Hui Zhou, Ya-Hong Liu, You-Zhi Tang. Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing acetamine phenyl linker.
European journal of medicinal chemistry.
2019 Nov; 181(?):111594. doi:
10.1016/j.ejmech.2019.111594. [PMID: 31419741] - Prabhakaran Vinothini, Srinivasan Ramesh, Venugopalan Sooraj Nair, Srinivasan Palaninathan Preetha, Padmanabhan Sriram. Pharmacokinetics and relative bioavailability of tiamulin in broiler chicken as influenced by different routes of administration.
Journal of veterinary pharmacology and therapeutics.
2019 Jul; 42(4):447-451. doi:
10.1111/jvp.12774. [PMID: 31102285] - Robert T Jacobs, Christopher S Lunde, Yvonne R Freund, Vincent Hernandez, Xianfeng Li, Yi Xia, David S Carter, Pamela W Berry, Jason Halladay, Fernando Rock, Rianna Stefanakis, Eric Easom, Jacob J Plattner, Louise Ford, Kelly L Johnston, Darren A N Cook, Rachel Clare, Andrew Cassidy, Laura Myhill, Hayley Tyrer, Joanne Gamble, Ana F Guimaraes, Andrew Steven, Franziska Lenz, Alexandra Ehrens, Stefan J Frohberger, Marianne Koschel, Achim Hoerauf, Marc P Hübner, Case W McNamara, Malina A Bakowski, Joseph D Turner, Mark J Taylor, Stephen A Ward. Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
Journal of medicinal chemistry.
2019 03; 62(5):2521-2540. doi:
10.1021/acs.jmedchem.8b01854. [PMID: 30730745] - Yanhua Qi, Guoping Sun, Gaiping Zhang, Yumei Chen, Yankai Liu, Jing Zhang, Jingming Zhou, Aiping Wang. [Preparation of tiamulin artificial complete antigen and development of its monoclonal antibody].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2019 Feb; 35(2):174-179. doi:
. [PMID: 30975284] - Caroline Ivanne Le Roy, Martin John Woodward, Richard John Ellis, Roberto Marcello La Ragione, Sandrine Paule Claus. Antibiotic treatment triggers gut dysbiosis and modulates metabolism in a chicken model of gastro-intestinal infection.
BMC veterinary research.
2019 Jan; 15(1):37. doi:
10.1186/s12917-018-1761-0. [PMID: 30683093] - Aimin Tan, Guifen Gu, Xuan Gui, Yanxin Wu, Gordon Bolger, Albert Licollari, John C Fanaras. Improving the selectivity and sensitivity for quantifying 8-α-hydroxy-mutilin in rabbit tissues by using basic mobile phases and negative ionization.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1072(?):142-148. doi:
10.1016/j.jchromb.2017.11.008. [PMID: 29153999] - S Mohana Devi, S I Lee, I H Kim. Effect of phytogenics on growth performance, fecal score, blood profiles, fecal noxious gas emission, digestibility, and intestinal morphology of weanling pigs challenged with Escherichia coli K88.
Polish journal of veterinary sciences.
2015; 18(3):557-64. doi:
10.1515/pjvs-2015-0072. [PMID: 26618588] - B L Wilberts, P H Arruda, H L Warneke, K R Erlandson, J M Hammer, E R Burrough. Cessation of clinical disease and spirochete shedding after tiamulin treatment in pigs experimentally infected with "Brachyspira hampsonii".
Research in veterinary science.
2014 Oct; 97(2):341-7. doi:
10.1016/j.rvsc.2014.08.004. [PMID: 25218812] - S Combes, T Gidenne, L Cauquil, O Bouchez, L Fortun-Lamothe. Coprophagous behavior of rabbit pups affects implantation of cecal microbiota and health status.
Journal of animal science.
2014 Feb; 92(2):652-65. doi:
10.2527/jas.2013-6394. [PMID: 24398828] - Eleni Kalogria, Constantinos Pistos, Irene Panderi. Hydrophilic interaction liquid chromatography/positive ion electrospray ionization mass spectrometry method for the quantification of alprazolam and α-hydroxy-alprazolam in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Dec; 942-943(?):158-64. doi:
10.1016/j.jchromb.2013.10.040. [PMID: 24269910] - Andrew Pridmore, David Burch, Peter Lees. Determination of minimum inhibitory and minimum bactericidal concentrations of tiamulin against field isolates of Actinobacillus pleuropneumoniae.
Veterinary microbiology.
2011 Aug; 151(3-4):409-12. doi:
10.1016/j.vetmic.2011.03.016. [PMID: 21497460] - Lei Dai, Cong-Ming Wu, Ming-Gui Wang, Yang Wang, Yu Wang, Si-Yang Huang, Li-Ning Xia, Bei-Bei Li, Jian-Zhong Shen. First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces.
Antimicrobial agents and chemotherapy.
2010 Sep; 54(9):3953-5. doi:
10.1128/aac.00169-10. [PMID: 20585133] - K M S Islam, S Afrin, P M Das, M M Hassan, M Valks, U Klein, D G S Burch, B W Kemppainen. Compatibility of a combination of tiamulin and chlortetracycline with salinomycin in feed during a pulsed medication program coadministration in broilers.
Poultry science.
2008 Dec; 87(12):2528-34. doi:
10.3382/ps.2008-00219. [PMID: 19038809] - M Pringle, A Landén, A Franklin. Tiamulin resistance in porcine Brachyspira pilosicoli isolates.
Research in veterinary science.
2006 Feb; 80(1):1-4. doi:
10.1016/j.rvsc.2005.02.004. [PMID: 16253666] - L Stipkovits, K Lapis, M Hidvégi, E Kósa, R Glávits, A Resetár. Testing the efficacy of fermented wheat germ extract against Mycoplasma gallisepticum infection of chickens.
Poultry science.
2004 Nov; 83(11):1844-8. doi:
10.1093/ps/83.11.1844. [PMID: 15554060] - B Lauritzen, J Lykkesfeldt, M T Skaanild, Ø Angen, J P Nielsen, C Friis. Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection.
Research in veterinary science.
2003 Jun; 74(3):261-70. doi:
10.1016/s0034-5288(03)00028-6. [PMID: 12726745] - C P Stephens, D J Hampson. Evaluation of tiamulin and lincomycin for the treatment of broiler breeders experimentally infected with the intestinal spirochaete Brachyspira pilosicoli.
Avian pathology : journal of the W.V.P.A.
2002 Jun; 31(3):299-304. doi:
10.1080/03079450220136501. [PMID: 12396354] - D J Hampson, S L Oxberry, C P Stephens. Influence of in-feed zinc bacitracin and tiamulin treatment on experimental avian intestinal spirochaetosis caused by Brachyspira intermedia.
Avian pathology : journal of the W.V.P.A.
2002 Jun; 31(3):285-91. doi:
10.1080/03079450220136484. [PMID: 12396352] - C P Stephens, D J Hampson. Intestinal spirochete infections of chickens: a review of disease associations, epidemiology and control.
Animal health research reviews.
2001 Jun; 2(1):83-91. doi:
10.1079/ahrr200116. [PMID: 11708751] - W T Johnston, C E Dewey, R M Friendship, N Smart, B J McEwen, M Stalker, C F de Lange. An investigation of the etiology of a mild diarrhea observed in a group of grower/finisher pigs.
The Canadian veterinary journal = La revue veterinaire canadienne.
2001 Jan; 42(1):33-7. doi:
10.4141/cjas62-005. [PMID: 11195519] - P Wallgren, T Segall, A Pedersen Mörner, A Gunnarsson. Experimental infections with Actinobacillus pleuropneumoniae in pigs--II. Comparison of antibiotics for oral strategic treatment.
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B.
1999 May; 46(4):261-9. doi:
NULL. [PMID: 10379236] - S McOrist, S H Smith, T Klein. Monitored control programme for proliferative enteropathy on British pig farms.
The Veterinary record.
1999 Feb; 144(8):202-4. doi:
10.1136/vr.144.8.202. [PMID: 10097342] - L G Baggetto, M Dong, J Bernaud, L Espinosa, D Rigal, R Bonvallet, E Marthinet. In vitro and in vivo reversal of cancer cell multidrug resistance by the semi-synthetic antibiotic tiamulin.
Biochemical pharmacology.
1998 Nov; 56(9):1219-28. doi:
10.1016/s0006-2952(98)00229-9. [PMID: 9802334] - J L Riond, F Schreiber, M Wanner. Influence of tiamulin concentration in feed on its bioavailability in piglets.
Veterinary research.
1993; 24(6):494-502. doi:
NULL. [PMID: 8111433] - M Mézes, G Sályi, G Bánhidi, S Szeberényi. Effect of acute salinomycin-tiamulin toxicity on the lipid peroxide and antioxidant status of broiler chicken.
Acta veterinaria Hungarica.
1992; 40(4):251-7. doi:
. [PMID: 1305793] - M M Chengappa, L W Pace, J A Williams, C H Herren, S E Ascher. Efficacy of tiamulin against experimentally induced Streptococcus suis type-2 infection in swine.
Journal of the American Veterinary Medical Association.
1990 Dec; 197(11):1467-70. doi:
. [PMID: 2272877] - P Laczay, F Simon, J Lehel. [The effect of monensin, tiamulin and the simultaneous administration of both substances on the microsomal mixed function oxidases and on the peroxide formation in broilers].
DTW. Deutsche tierarztliche Wochenschrift.
1990 Sep; 97(9):354-7. doi:
". [PMID: 2242730] - T Hayashi, I Suenaga, N Narukawa, T Yamazaki. In vitro and in vivo activities of sedecamycin against Treponema hyodysenteriae.
Antimicrobial agents and chemotherapy.
1988 Apr; 32(4):458-61. doi:
10.1128/aac.32.4.458. [PMID: 3377458] - G Laber. Investigation of pharmacokinetic parameters of tiamulin after intramuscular and subcutaneous administration in normal dogs.
Journal of veterinary pharmacology and therapeutics.
1988 Mar; 11(1):45-9. doi:
10.1111/j.1365-2885.1988.tb00119.x. [PMID: 3379663] - L D Olson. Tiamulin in drinking water for treatment and development of immunity to swine dysentery.
Journal of the American Veterinary Medical Association.
1986 May; 188(10):1165-70. doi:
. [PMID: 3721965] - G Ziv, S L Levisohn, B Bar-Moshe, A Bor, S Soback. Clinical pharmacology of tiamulin in ruminants.
Journal of veterinary pharmacology and therapeutics.
1983 Mar; 6(1):23-32. doi:
10.1111/j.1365-2885.1983.tb00451.x. [PMID: 6854730] - G Ziv. Preliminary clinical pharmacological investigations of tylosin and tiamulin in chickens.
Tijdschrift voor diergeneeskunde.
1980 Oct; 105(20):206-10. doi:
. [PMID: 7444918] - J Dreyfuss, S M Singhvi, J M Shaw, P Egli, J J Ross, R Czok, M Nefzger-Biessels, F Battig, I Schuster, F Schmook. Metabolism of tritium- and carbon-14-labeled tiamulin in dogs, rats, and pigs.
The Journal of antibiotics.
1979 May; 32(5):496-503. doi:
10.7164/antibiotics.32.496. [PMID: 528395]
