3-Aminopropanenitrile (BioDeep_00000269473)

Main id: BioDeep_00000003430

 

PANOMIX_OTCML-2023


代谢物信息卡片


3-Aminopropanenitrile

化学式: C3H6N2 (70.05309559999999)
中文名称: 3-氨基丙腈
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CN)C#N
InChI: InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2

描述信息

C471 - Enzyme Inhibitor
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].

同义名列表

4 个代谢物同义名

3-Aminopropanenitrile; Z2CN; BAPN; β-Aminopropionitrile



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Kang-Ni Chen, Qi-Lin Peng, Dan-Feng Cao, Zhao-Jun Wang, Kai Zhang, Xin-Yu Zhou, Dong-Yu Min, Bo-Ting Zhou, Xiao-Yuan Mao. Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder. Brain research bulletin. 2024 May; 210(?):110928. doi: 10.1016/j.brainresbull.2024.110928. [PMID: 38493836]
  • Mohd Aslam Saifi, Arbaz Sujat Shaikh, Venkata Rao Kaki, Chandraiah Godugu. Disulfiram prevents collagen crosslinking and inhibits renal fibrosis by inhibiting lysyl oxidase enzymes. Journal of cellular physiology. 2022 05; 237(5):2516-2527. doi: 10.1002/jcp.30717. [PMID: 35285015]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Hannah A Cooper, Stephanie Cicalese, Kyle J Preston, Tatsuo Kawai, Keisuke Okuno, Eric T Choi, Shingo Kasahara, Haruhito A Uchida, Nozomu Otaka, Rosario Scalia, Victor Rizzo, Satoru Eguchi. Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm. Cardiovascular research. 2021 02; 117(3):971-982. doi: 10.1093/cvr/cvaa133. [PMID: 32384150]
  • Shao-Wei Chen, Shing-Hsien Chou, Ying-Chang Tung, Fu-Chih Hsiao, Chien-Te Ho, Yi-Hsin Chan, Victor Chien-Chia Wu, An-Hsun Chou, Ming-En Hsu, Pyng-Jing Lin, Winston W Y Kao, Pao-Hsien Chu. Expression and role of lumican in acute aortic dissection: A human and mouse study. PloS one. 2021; 16(7):e0255238. doi: 10.1371/journal.pone.0255238. [PMID: 34310653]
  • Mohd Aslam Saifi, Chandraiah Godugu. Inhibition of lysyl oxidase ameliorates renal injury by inhibiting CD44-mediated pericyte detachment and loss of peritubular capillaries. Life sciences. 2020 Feb; 243(?):117294. doi: 10.1016/j.lfs.2020.117294. [PMID: 31927047]
  • Wei Ren, Zhiwei Wang, Jiahui Wang, Zhiyong Wu, Quan Ren, Anfeng Yu, Yongle Ruan. IL-5 overexpression attenuates aortic dissection by reducing inflammation and smooth muscle cell apoptosis. Life sciences. 2020 Jan; 241(?):117144. doi: 10.1016/j.lfs.2019.117144. [PMID: 31830482]
  • Yanxiang Gao, Zhizhi Wang, Jianqiao Zhao, Weiliang Sun, Jing Guo, Zufang Yang, Yimin Tu, Changan Yu, Lin Pan, Jingang Zheng. Involvement of B cells in the pathophysiology of β-aminopropionitrile-induced thoracic aortic dissection in mice. Experimental animals. 2019 Aug; 68(3):331-339. doi: 10.1538/expanim.18-0170. [PMID: 30930402]
  • Lu Han, Lu Dai, Yuan-Fei Zhao, Hai-Yang Li, Ou Liu, Feng Lan, Wen-Jian Jiang, Hong-Jia Zhang. CD40L promotes development of acute aortic dissection via induction of inflammation and impairment of endothelial cell function. Aging. 2018 03; 10(3):371-385. doi: 10.18632/aging.101394. [PMID: 29514135]
  • María Miana, María Galán, Ernesto Martínez-Martínez, Saray Varona, Raquel Jurado-López, Belén Bausa-Miranda, Alfonso Antequera, María Luaces, José Martínez-González, Cristina Rodríguez, Victoria Cachofeiro. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Disease models & mechanisms. 2015 Jun; 8(6):543-51. doi: 10.1242/dmm.020107. [PMID: 26035864]
  • Christelle Machon, Benjamin Le Calve, Sylvie Coste, Mirella Riviere, Léa Payen, David Bernard, Jérôme Guitton. Quantification of β-aminopropionitrile, an inhibitor of lysyl oxidase activity, in plasma and tumor of mice by liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2014 Jul; 28(7):1017-23. doi: 10.1002/bmc.3110. [PMID: 24424787]
  • Christiane Beerlage, Jessica Greb, Dorothee Kretschmer, Mohammad Assaggaf, Philip C Trackman, Martin-Leo Hansmann, Michael Bonin, Johannes A Eble, Andreas Peschel, Bernhard Brüne, Volkhard A J Kempf. Hypoxia-inducible factor 1-regulated lysyl oxidase is involved in Staphylococcus aureus abscess formation. Infection and immunity. 2013 Jul; 81(7):2562-73. doi: 10.1128/iai.00302-13. [PMID: 23649089]
  • Devashish Kothapalli, Shu-Lin Liu, Yong Ho Bae, James Monslow, Tina Xu, Elizabeth A Hawthorne, Fitzroy J Byfield, Paola Castagnino, Shilpa Rao, Daniel J Rader, Ellen Puré, Michael C Phillips, Sissel Lund-Katz, Paul A Janmey, Richard K Assoian. Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell reports. 2012 Nov; 2(5):1259-71. doi: 10.1016/j.celrep.2012.09.018. [PMID: 23103162]
  • Roman Thaler, Silvia Spitzer, Monika Rumpler, Nadja Fratzl-Zelman, Klaus Klaushofer, Eleftherios P Paschalis, Franz Varga. Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells. Bone. 2010 Mar; 46(3):703-9. doi: 10.1016/j.bone.2009.10.038. [PMID: 19895920]
  • Héctor A Lucero, Katya Ravid, Jessica L Grimsby, Celeste B Rich, Sandra J DiCamillo, Joni M Mäki, Johanna Myllyharju, Herbert M Kagan. Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells. The Journal of biological chemistry. 2008 Aug; 283(35):24103-17. doi: 10.1074/jbc.m709897200. [PMID: 18586678]
  • A Asanbaeva, K Masuda, E J-M A Thonar, S M Klisch, R L Sah. Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile. Osteoarthritis and cartilage. 2008 Jan; 16(1):1-11. doi: 10.1016/j.joca.2007.05.019. [PMID: 17631390]
  • Gonca Keles, Tarik Basoglu, Oktay Yapici, Burcu Ozkan Cetinkaya, Gokhan Acikgoz, Erhan Firatli. Periodontal & systemic bone changes in rats with experimental lathyrism. The Indian journal of medical research. 2006 Apr; 123(4):541-6. doi: NULL. [PMID: 16783045]
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  • J Farjanel, S Sève, A Borel, P Sommer, D J S Hulmes. Inhibition of lysyl oxidase activity can delay phenotypic modulation of chondrocytes in two-dimensional culture. Osteoarthritis and cartilage. 2005 Feb; 13(2):120-8. doi: 10.1016/j.joca.2004.06.015. [PMID: 15694573]
  • Paul Lijnen, Victor Petrov, Guillermo Diaz-Araya, Robert Fagard. Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2004 Dec; 5(4):183-8. doi: 10.3317/jraas.2004.038. [PMID: 15803436]
  • N Senturk, G C Keles, F F Kaymaz, L Yildiz, G Acikgoz, A Y Turanli. The role of ascorbic acid on collagen structure and levels of serum interleukin-6 and tumour necrosis factor-alpha in experimental lathyrism. Clinical and experimental dermatology. 2004 Mar; 29(2):168-75. doi: 10.1111/j.1365-2230.2004.01473.x. [PMID: 14987276]
  • Paul J Lijnen, Victor V Petrov, Robert H Fagard. Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases. Journal of hypertension. 2004 Jan; 22(1):209-16. doi: 10.1097/00004872-200401000-00031. [PMID: 15106813]
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  • Kyoko Omori, Yoshito Fujiseki, Koichiro Omori, Junko Suzukawa, Chiyoko Inagaki. Regulation of the expression of lysyl oxidase mRNA in cultured rabbit retinal pigment epithelium cells. Matrix biology : journal of the International Society for Matrix Biology. 2002 Jun; 21(4):337-48. doi: 10.1016/s0945-053x(02)00013-6. [PMID: 12128071]
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