Sterigmatocystin (BioDeep_00000002621)

 

Secondary id: BioDeep_00000383539

human metabolite Endogenous Toxin


代谢物信息卡片


15-hydroxy-11-methoxy-6,8,20-trioxapentacyclo[10.8.0.0²,⁹.0³,⁷.0¹⁴,¹⁹]icosa-1(12),2(9),4,10,14,16,18-heptaen-13-one

化学式: C18H12O6 (324.06338519999997)
中文名称: 柄曲霉素
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 0.08%

分子结构信息

SMILES: C12OC3=C(C(O)=CC=C3)C(=O)C=1C(=CC1O[C@@]3([H])OC=C[C@@]3([H])C2=1)OC
InChI: InChI=1S/C18H12O6/c1-21-11-7-12-13(8-5-6-22-18(8)24-12)17-15(11)16(20)14-9(19)3-2-4-10(14)23-17/h2-8,18-19H,1H3

描述信息

Sterigmatocystin is a mycotoxin of Aspergillus versicolor and Chaetomium species Sterigmatocystin is a poison of the type dermatoxin, from the fungi genus Aspergillus. It appears on crusts of cheese with mold. Sterigmatocystin is a toxic metabolite structurally closely related to the aflatoxins (compare general fact sheet number 2), and consists of a xanthone nucleus attached to a bifuran structure. Sterigmatocystin is mainly produced by the fungi Aspergillus nidulans and A. versicolor. It has been reported in mouldy grain, green coffee beans and cheese although information on its occurrence in foods is limited. It appears to occur much less frequently than the aflatoxins, although analytical methods for its determination have not been as sensitive until recently, and so it is possible that small concentrations in food commodities may not always have been detected. Although it is a potent liver carcinogen similar to aflatoxin B1, current knowledge suggests that it is nowhere near as widespread in its occurrence. If this is the true situation it would be justified to consider sterigmatocystin as no more than a risk to consumers in special or unusual circumstances. Sterigmatocystin is a number of closely related compounds such o-methyl sterigmatocystin are known and some may also occur naturally. The IARC-classification of sterigmatocystin is group 2B, which means it is possibly carcinogenic to humans. In practice, the risk is quite low however, because this substance only appears on cheese crusts with mold, and because of that the chance of daily exposure is very low. Sterigmatocystin is a molded crust is best not to be consumed in whole, but after removing the crust, the cheese can still be consumed. Sterigmatocystin is a different kind of mold than that which appears on cheese itself, which can simply be removed before further consumption
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2320

同义名列表

4 个代谢物同义名

15-hydroxy-11-methoxy-6,8,20-trioxapentacyclo[10.8.0.0²,⁹.0³,⁷.0¹⁴,¹⁹]icosa-1(12),2(9),4,10,14,16,18-heptaen-13-one; 3a,12C-Dihydro-8-hydroxy-6-methoxy-7H-furo[3,2:4,5]furo[2,3-c]xanthen-7-one, 9ci; Sterigmatocystine; Sterigmatocystin



数据库引用编号

39 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

35 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Monika Trienens, Joachim Kurtz, Bregje Wertheim. Rapid but narrow - Evolutionary adaptation and transcriptional response of Drosophila melanogaster to toxic mould. Molecular ecology. 2023 06; 32(11):2784-2797. doi: 10.1111/mec.16885. [PMID: 37066754]
  • Jihui Xi, Dongyun Yang, Huali Xue, Zhiguang Liu, Yang Bi, Yuan Zhang, Xi Yang, Suqin Shang. Isolation of the Main Pathogens Causing Postharvest Disease in Fresh Angelica sinensis during Different Storage Stages and Impacts of Ozone Treatment on Disease Development and Mycotoxin Production. Toxins. 2023 Feb; 15(2):. doi: 10.3390/toxins15020154. [PMID: 36828468]
  • Siqi Ma, Donglin Zhao, Xiaobin Han, Yulong Peng, Tingting Ren, Mei Wang, Jun Wan, Jilin Ding, Xiuchun Du, Fubin Zhao, Yiqiang Li, Chengsheng Zhang. New application of Aspergillus versicolor in promoting plant growth after suppressing sterigmatocystin production via genome mining and engineering. Microbial biotechnology. 2023 01; 16(1):139-147. doi: 10.1111/1751-7915.14176. [PMID: 36415948]
  • Christina Rehagel, Ronald Maul, Kim Lara Gützkow, Ömer Akineden. Enzyme immunoassays for the detection of mycotoxins in plant-based milk alternatives: pitfalls and limitations. Mycotoxin research. 2022 Nov; 38(4):265-274. doi: 10.1007/s12550-022-00467-x. [PMID: 36053453]
  • Huanyan Liang, Qianyu Hou, Yakui Zhou, Lei Zhang, Meihua Yang, Xiangsheng Zhao. Centrifugation-Assisted Solid-Phase Extraction Coupled with UPLC-MS/MS for the Determination of Mycotoxins in ARECAE Semen and Its Processed Products. Toxins. 2022 10; 14(11):. doi: 10.3390/toxins14110742. [PMID: 36355992]
  • Qin Li, Aimin Fu, Mengsha Wei, Yang Xiao, Jie Yin, Jianzheng Huang, Xiao-Nian Li, Qingyi Tong, Chunmei Chen, Hucheng Zhu, Yonghui Zhang. Asperemestrins A-D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic Fungus Aspergillus nidulans. Organic letters. 2022 09; 24(37):6800-6804. doi: 10.1021/acs.orglett.2c02701. [PMID: 36074729]
  • Maria Alonso-Jauregui, Elena González-Peñas, Adela López de Cerain, Ariane Vettorazzi. Genotoxicity of 12 Mycotoxins by the SOS/umu Test: Comparison of Liver and Kidney S9 Fraction. Toxins. 2022 06; 14(6):. doi: 10.3390/toxins14060400. [PMID: 35737061]
  • Beatriz Arce-López, Lydia Alvarez-Erviti, Barbara De Santis, María Izco, Silvia López-Calvo, Maria Eugenia Marzo-Sola, Francesca Debegnach, Elena Lizarraga, Adela López de Cerain, Elena González-Peñas, Ariane Vettorazzi. Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease. Toxins. 2021 07; 13(7):. doi: 10.3390/toxins13070477. [PMID: 34357949]
  • Beatriz Arce-López, Elena Lizarraga, Reyes López de Mesa, Elena González-Peñas. Assessment of Exposure to Mycotoxins in Spanish Children through the Analysis of Their Levels in Plasma Samples. Toxins. 2021 02; 13(2):. doi: 10.3390/toxins13020150. [PMID: 33672088]
  • Benjamin Kövesi, Szabina Kulcsár, Zsolt Ancsin, Erika Zándoki, Márta Erdélyi, Miklós Mézes, Krisztián Balogh. Individual and Combined Effects of Aflatoxin B1 and Sterigmatocystin on Lipid Peroxidation and Glutathione Redox System of Common Carp Liver. Toxins. 2021 02; 13(2):. doi: 10.3390/toxins13020109. [PMID: 33540648]
  • Hongmei Zeng, Jingjing Cai, Hidemi Hatabayashi, Hiroyuki Nakagawa, Hiromitsu Nakajima, Kimiko Yabe. verA Gene is Involved in the Step to Make the Xanthone Structure of Demethylsterigmatocystin in Aflatoxin Biosynthesis. International journal of molecular sciences. 2020 Sep; 21(17):. doi: 10.3390/ijms21176389. [PMID: 32887494]
  • Shuo Gao, Wen-Jing Tian, Zu-Jian Liao, Guang-Hui Wang, De-Quan Zeng, Xiang-Zhong Liu, Xiao-Yao Wang, Hu Zhou, Hai-Feng Chen, Ting Lin. Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii. Chemistry & biodiversity. 2020 Sep; 17(9):e2000424. doi: 10.1002/cbdv.202000424. [PMID: 32672903]
  • Rašić Dubravka, Jakšić Daniela, Hulina Tomašković Andrea, Kifer Domagoj, Kopjar Nevenka, Rumora Lada, Želježić Davor, Peraica Maja, Šegvić Klarić Maja. Sterigmatocystin moderately induces oxidative stress in male Wistar rats after short-term oral treatment. Mycotoxin research. 2020 May; 36(2):181-191. doi: 10.1007/s12550-019-00382-8. [PMID: 31836962]
  • Veronica Zingales, Mónica Fernández-Franzón, Maria-José Ruiz. Sterigmatocystin-induced cytotoxicity via oxidative stress induction in human neuroblastoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Feb; 136(?):110956. doi: 10.1016/j.fct.2019.110956. [PMID: 31712107]
  • Taoling Min, Lei Xiong, Yan Liang, Rui Xu, Chenchang Fa, Sheng Yang, Haifeng Hu. Disruption of stcA blocks sterigmatocystin biosynthesis and improves echinocandin B production in Aspergillus delacroxii. World journal of microbiology & biotechnology. 2019 Jul; 35(7):109. doi: 10.1007/s11274-019-2687-9. [PMID: 31280382]
  • Benjamin Kövesi, Csilla Pelyhe, Erika Zándoki, Miklós Mézes, Krisztián Balogh. Effect of short-term sterigmatocystin exposure on lipid peroxidation and glutathione redox system and expression of glutathione redox system regulatory genes in common carp liver. Toxicon : official journal of the International Society on Toxinology. 2019 Apr; 161(?):50-56. doi: 10.1016/j.toxicon.2019.03.001. [PMID: 30849453]
  • Xiaofang Lu, Chaoquan Luo, Jianyong Xing, Zhengzhou Han, Tong Li, Weiwei Wu, Hui Xu, Ruoting Zhan, Weiwen Chen. Optimization of Storage Conditions of the Medicinal Herb Ilex asprella against the Sterigmatocystin Producer Aspergillus versicolor Using Response Surface Methodology. Toxins. 2018 11; 10(12):. doi: 10.3390/toxins10120499. [PMID: 30486344]
  • M Takagi, S Uno, E Kokushi, F Sato, Mmp Wijayagunawardane, J Fink-Gremmels. Measurement of urinary concentrations of the mycotoxins zearalenone and sterigmatocystin as biomarkers of exposure in mares. Reproduction in domestic animals = Zuchthygiene. 2018 Feb; 53(1):68-73. doi: 10.1111/rda.13054. [PMID: 28921680]
  • Victor Sobolev, Renee Arias, Kerestin Goodman, Travis Walk, Valerie Orner, Paola Faustinelli, Alicia Massa. Suppression of Aflatoxin Production in Aspergillus Species by Selected Peanut (Arachis hypogaea) Stilbenoids. Journal of agricultural and food chemistry. 2018 Jan; 66(1):118-126. doi: 10.1021/acs.jafc.7b04542. [PMID: 29207242]
  • Katsuki Toda, Emiko Kokushi, Seiichi Uno, Ayaka Shiiba, Hiroshi Hasunuma, Yasuo Fushimi, Missaka P B Wijayagunawardane, Chunhua Zhang, Osamu Yamato, Masayasu Taniguchi, Johanna Fink-Gremmels, Mitsuhiro Takagi. Gas Chromatography-Mass Spectrometry for Metabolite Profiling of Japanese Black Cattle Naturally Contaminated with Zearalenone and Sterigmatocystin. Toxins. 2017 09; 9(10):. doi: 10.3390/toxins9100294. [PMID: 28934162]
  • Brandon T Pfannenstiel, Xixi Zhao, Jennifer Wortman, Philipp Wiemann, Kurt Throckmorton, Joseph E Spraker, Alexandra A Soukup, Xingyu Luo, Daniel L Lindner, Fang Yun Lim, Benjamin P Knox, Brian Haas, Gregory J Fischer, Tsokyi Choera, Robert A E Butchko, Jin-Woo Bok, Katharyn J Affeldt, Nancy P Keller, Jonathan M Palmer. Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus Aspergillus. mBio. 2017 09; 8(5):. doi: 10.1128/mbio.01246-17. [PMID: 28874473]
  • Rodrigo A Olarte, Carolyn J Worthington, Bruce W Horn, Geromy G Moore, Rakhi Singh, James T Monacell, Joe W Dorner, Eric A Stone, De-Yu Xie, Ignazio Carbone. Enhanced diversity and aflatoxigenicity in interspecific hybrids of Aspergillus flavus and Aspergillus parasiticus. Molecular ecology. 2015 Apr; 24(8):1889-909. doi: 10.1111/mec.13153. [PMID: 25773520]
  • Alberto Biancardi, Chiara Dall'Asta. Determination of sterigmatocystin in feed by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2015; 32(12):2093-100. doi: 10.1080/19440049.2015.1094709. [PMID: 26471726]
  • Yasuo Fushimi, Mitsuhiro Takagi, Seiichi Uno, Emiko Kokushi, Masayuki Nakamura, Hiroshi Hasunuma, Urara Shinya, Eisaburo Deguchi, Johanna Fink-Gremmels. Measurement of sterigmatocystin concentrations in urine for monitoring the contamination of cattle feed. Toxins. 2014 Nov; 6(11):3117-28. doi: 10.3390/toxins6113117. [PMID: 25375815]
  • Runsheng Zheng, Hui Xu, Wenli Wang, Ruoting Zhan, Weiwen Chen. Simultaneous determination of aflatoxin B(1), B(2), G(1), G(2), ochratoxin A, and sterigmatocystin in traditional Chinese medicines by LC-MS-MS. Analytical and bioanalytical chemistry. 2014 May; 406(13):3031-9. doi: 10.1007/s00216-014-7750-7. [PMID: 24658469]
  • Xingang Wang, Anne L Robertson, Jingyu Li, Ruth Jinfen Chai, Wang Haishan, Pranvera Sadiku, Nikolay V Ogryzko, Martin Everett, Kanagasundaram Yoganathan, Hongbo Robert Luo, Stephen A Renshaw, Philip W Ingham. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Disease models & mechanisms. 2014 Jan; 7(1):163-9. doi: 10.1242/dmm.012047. [PMID: 24291762]
  • Min Li, Peiwu Li, Hui Wu, Qi Zhang, Fei Ma, Zhaowei Zhang, Xiaoxia Ding, Hengling Wang. An ultra-sensitive monoclonal antibody-based competitive enzyme immunoassay for sterigmatocystin in cereal and oil products. PloS one. 2014; 9(9):e106415. doi: 10.1371/journal.pone.0106415. [PMID: 25184275]
  • Ya-Ming Xu, Patricia Espinosa-Artiles, Mangping X Liu, A Elizabeth Arnold, A A Leslie Gunatilaka. Secoemestrin D, a cytotoxic epitetrathiodioxopiperizine, and emericellenes A-E, five sesterterpenoids from Emericella sp. AST0036, a fungal endophyte of Astragalus lentiginosus1. Journal of natural products. 2013 Dec; 76(12):2330-6. doi: 10.1021/np400762k. [PMID: 24251417]
  • Ying Zhang, Zhi Gang Yao, Juan Wang, Ling Xiao Xing, Yan Xia, Xiang Hong Zhang. Effects of sterigmatocystin on TNF-α, IL-6 and IL-12 expression in murine peripheral blood mononuclear cells and peritoneal macrophages in vivo. Molecular medicine reports. 2012 May; 5(5):1318-22. doi: 10.3892/mmr.2012.788. [PMID: 22344519]
  • Sunčica Kocić-Tanackov, Gordana Dimić, Jelena Lević, Ilija Tanackov, Aleksandra Tepić, Biserka Vujičić, Jelica Gvozdanović-Varga. Effects of onion (Allium cepa L.) and garlic (Allium sativum L.) essential oils on the Aspergillus versicolor growth and sterigmatocystin production. Journal of food science. 2012 May; 77(5):M278-84. doi: 10.1111/j.1750-3841.2012.02662.x. [PMID: 22497489]
  • Wen-Bing Yin, Saori Amaike, Dana J Wohlbach, Audrey P Gasch, Yi-Ming Chiang, Clay C C Wang, Jin Woo Bok, Marko Rohlfs, Nancy P Keller. An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Molecular microbiology. 2012 Mar; 83(5):1024-34. doi: 10.1111/j.1365-2958.2012.07986.x. [PMID: 22283524]
  • Pranav Chettri, Ana M Calvo, Jeffrey W Cary, Sourabh Dhingra, Yanan Guo, Rebecca L McDougal, Rosie E Bradshaw. The veA gene of the pine needle pathogen Dothistroma septosporum regulates sporulation and secondary metabolism. Fungal genetics and biology : FG & B. 2012 Feb; 49(2):141-51. doi: 10.1016/j.fgb.2011.11.009. [PMID: 22227160]
  • Dongliang Wu, Shinichi Oide, Ning Zhang, May Yee Choi, B Gillian Turgeon. ChLae1 and ChVel1 regulate T-toxin production, virulence, oxidative stress response, and development of the maize pathogen Cochliobolus heterostrophus. PLoS pathogens. 2012 Feb; 8(2):e1002542. doi: 10.1371/journal.ppat.1002542. [PMID: 22383877]
  • Jack Dwayne Thrasher, Michael R Gray, Kaye H Kilburn, Donald P Dennis, Archie Yu. A water-damaged home and health of occupants: a case study. Journal of environmental and public health. 2012; 2012(?):312836. doi: 10.1155/2012/312836. [PMID: 22220187]
  • Yazmid Reyes-Dominguez, Stefan Boedi, Michael Sulyok, Gerlinde Wiesenberger, Norbert Stoppacher, Rudolf Krska, Joseph Strauss. Heterochromatin influences the secondary metabolite profile in the plant pathogen Fusarium graminearum. Fungal genetics and biology : FG & B. 2012 Jan; 49(1):39-47. doi: 10.1016/j.fgb.2011.11.002. [PMID: 22100541]
  • Peng Zheng, Yongliang Xia, Guohua Xiao, Chenghui Xiong, Xiao Hu, Siwei Zhang, Huajun Zheng, Yin Huang, Yan Zhou, Shengyue Wang, Guo-Ping Zhao, Xingzhong Liu, Raymond J St Leger, Chengshu Wang. Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional Chinese medicine. Genome biology. 2011 Nov; 12(11):R116. doi: 10.1186/gb-2011-12-11-r116. [PMID: 22112802]
  • Charles G Nasmith, Sean Walkowiak, Li Wang, Winnie W Y Leung, Yunchen Gong, Anne Johnston, Linda J Harris, David S Guttman, Rajagopal Subramaniam. Tri6 is a global transcription regulator in the phytopathogen Fusarium graminearum. PLoS pathogens. 2011 Sep; 7(9):e1002266. doi: 10.1371/journal.ppat.1002266. [PMID: 21980289]
  • Marike J Boenisch, Wilhelm Schäfer. Fusarium graminearum forms mycotoxin producing infection structures on wheat. BMC plant biology. 2011 Jul; 11(?):110. doi: 10.1186/1471-2229-11-110. [PMID: 21798058]
  • Josphat C Matasyoh, Birger Dittrich, Anja Schueffler, Hartmut Laatsch. Larvicidal activity of metabolites from the endophytic Podospora sp. against the malaria vector Anopheles gambiae. Parasitology research. 2011 Mar; 108(3):561-6. doi: 10.1007/s00436-010-2098-1. [PMID: 20922412]
  • Sandra M Mathioni, André Beló, Christopher J Rizzo, Ralph A Dean, Nicole M Donofrio. Transcriptome profiling of the rice blast fungus during invasive plant infection and in vitro stresses. BMC genomics. 2011 Jan; 12(?):49. doi: 10.1186/1471-2164-12-49. [PMID: 21247492]
  • C Huţanaşu, C Sfarti, Anca Trifan, Camelia Cojocariu, Ana Maria Sîngeap, Adrian Spac, C Stanciu. [High levels of sterigmatocystin in patients with chronic liver diseases]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 2011 Jan; 115(1):33-7. doi: . [PMID: 21688557]
  • Jinhua Jiang, Xin Liu, Yanni Yin, Zhonghua Ma. Involvement of a velvet protein FgVeA in the regulation of asexual development, lipid and secondary metabolisms and virulence in Fusarium graminearum. PloS one. 2011; 6(11):e28291. doi: 10.1371/journal.pone.0028291. [PMID: 22140571]
  • T Ramasamy, C Varshneya, V C Katoch. Immunoprotective Effect of Seabuckthorn (Hippophae rhamnoides) and Glucomannan on T-2 Toxin-Induced Immunodepression in Poultry. Veterinary medicine international. 2010 Dec; 2010(?):149373. doi: 10.4061/2010/149373. [PMID: 21151701]
  • Jonathan M Palmer, Sandeep Mallaredy, Dustin W Perry, James F Sanchez, Jeffrey M Theisen, Edyta Szewczyk, Berl R Oakley, Clay C C Wang, Nancy P Keller, Peter M Mirabito. Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans. Microbiology (Reading, England). 2010 Dec; 156(Pt 12):3522-3531. doi: 10.1099/mic.0.039255-0. [PMID: 20724388]
  • Arne Schwelm, Rosie E Bradshaw. Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update. Toxins. 2010 11; 2(11):2680-98. doi: 10.3390/toxins2112680. [PMID: 22069571]
  • Cheng-Hua He, Yan-Hong Fan, Ying Wang, Chao-Ying Huang, Xi-Chun Wang, Hai-Bin Zhang. The individual and combined effects of deoxynivalenol and aflatoxin B₁on primary hepatocytes of Cyprinus carpio. International journal of molecular sciences. 2010 Sep; 11(10):3760-8. doi: 10.3390/ijms11103760. [PMID: 21152299]
  • Pavlina Sobrova, Vojtech Adam, Anna Vasatkova, Miroslava Beklova, Ladislav Zeman, Rene Kizek. Deoxynivalenol and its toxicity. Interdisciplinary toxicology. 2010 Sep; 3(3):94-9. doi: 10.2478/v10102-010-0019-x. [PMID: 21217881]
  • Ludmila V Roze, Anindya Chanda, Maris Laivenieks, Randolph M Beaudry, Katherine A Artymovich, Anna V Koptina, Deena W Awad, Dina Valeeva, Arthur D Jones, John E Linz. Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism. BMC biochemistry. 2010 Aug; 11(?):33. doi: 10.1186/1471-2091-11-33. [PMID: 20735852]
  • André el Khoury, Ali Atoui. Ochratoxin a: general overview and actual molecular status. Toxins. 2010 04; 2(4):461-93. doi: 10.3390/toxins2040461. [PMID: 22069596]
  • Eliana N C Tessari, Estela Kobashigawa, Ana Lúcia S P Cardoso, David R Ledoux, George E Rottinghaus, Carlos A F Oliveira. Effects of aflatoxin B(1) and fumonisin B(1) on blood biochemical parameters in broilers. Toxins. 2010 04; 2(4):453-60. doi: 10.3390/toxins2040453. [PMID: 22069595]
  • Simone A G Mossini, Carla C Arrotéia, Carlos Kemmelmeier. Effect of neem leaf extract and neem oil on Penicillium growth, sporulation, morphology and ochratoxin A production. Toxins. 2009 09; 1(1):3-13. doi: 10.3390/toxins1010003. [PMID: 22069528]
  • D Ryan Georgianna, Gary A Payne. Genetic regulation of aflatoxin biosynthesis: from gene to genome. Fungal genetics and biology : FG & B. 2009 Feb; 46(2):113-25. doi: 10.1016/j.fgb.2008.10.011. [PMID: 19010433]
  • Xiquan Gao, Marion Brodhagen, Tom Isakeit, Sigal Horowitz Brown, Cornelia Göbel, Javier Betran, Ivo Feussner, Nancy P Keller, Michael V Kolomiets. Inactivation of the lipoxygenase ZmLOX3 increases susceptibility of maize to Aspergillus spp. Molecular plant-microbe interactions : MPMI. 2009 Feb; 22(2):222-31. doi: 10.1094/mpmi-22-2-0222. [PMID: 19132874]
  • C Huţanaşu, C Sfarti, Anca Trifan, Camelia Cojocariu, A Spac, M Apostu, L Miron, V Dorneanu, C Stanciu. [High blood and urine concentration of hepatotoxic mycotoxins (aflatoxin B1, sterigmatocystin) in patients with liver cirrhosis]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 2009 Jan; 113(1):59-63. doi: . [PMID: 21495297]
  • Sofie Monbaliu, Christof Van Poucke, Carlos Van Peteghem, Kris Van Poucke, Kurt Heungens, Sarah De Saeger. Development of a multi-mycotoxin liquid chromatography/tandem mass spectrometry method for sweet pepper analysis. Rapid communications in mass spectrometry : RCM. 2009 Jan; 23(1):3-11. doi: 10.1002/rcm.3833. [PMID: 19051227]
  • Glória M Direito, Adriana P Almeida, Simone Aquino, Tatiana Alves dos Reis, Claudia Rodrigues Pozzi, Benedito Corrêa. Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin b₁. International journal of molecular sciences. 2009 Jan; 10(1):50-61. doi: 10.3390/ijms10010050. [PMID: 19333435]
  • Hye-Young Yu, Jeong-Ah Seo, Jung-Eun Kim, Kap-Hoon Han, Won-Bo Shim, Sung-Hwan Yun, Yin-Won Lee. Functional analyses of heterotrimeric G protein G alpha and G beta subunits in Gibberella zeae. Microbiology (Reading, England). 2008 Feb; 154(Pt 2):392-401. doi: 10.1099/mic.0.2007/012260-0. [PMID: 18227243]
  • Marion Brodhagen, Dimitrios I Tsitsigiannis, Ellen Hornung, Cornelia Goebel, Ivo Feussner, Nancy P Keller. Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem. Molecular microbiology. 2008 Jan; 67(2):378-91. doi: 10.1111/j.1365-2958.2007.06045.x. [PMID: 18181962]
  • Nicola J Patron, Ross F Waller, Anton J Cozijnsen, David C Straney, Donald M Gardiner, William C Nierman, Barbara J Howlett. Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes. BMC evolutionary biology. 2007 Sep; 7(?):174. doi: 10.1186/1471-2148-7-174. [PMID: 17897469]
  • Ignazio Carbone, Jorge H Ramirez-Prado, Judy L Jakobek, Bruce W Horn. Gene duplication, modularity and adaptation in the evolution of the aflatoxin gene cluster. BMC evolutionary biology. 2007 Jul; 7(?):111. doi: 10.1186/1471-2148-7-111. [PMID: 17620135]
  • D M Geiser, M A Klich, J C Frisvad, S W Peterson, J Varga, R A Samson. The current status of species recognition and identification in Aspergillus. Studies in mycology. 2007; 59(?):1-10. doi: 10.3114/sim.2007.59.01. [PMID: 18490947]
  • G Perrone, A Susca, G Cozzi, K Ehrlich, J Varga, J C Frisvad, M Meijer, P Noonim, W Mahakarnchanakul, R A Samson. Biodiversity of Aspergillus species in some important agricultural products. Studies in mycology. 2007; 59(?):53-66. doi: 10.3114/sim.2007.59.07. [PMID: 18490950]
  • Rosie E Bradshaw, Shuguang Zhang. Biosynthesis of dothistromin. Mycopathologia. 2006 Sep; 162(3):201-13. doi: 10.1007/s11046-006-0054-5. [PMID: 16944287]
  • Jin Woo Bok, Daan Noordermeer, Shubha P Kale, Nancy P Keller. Secondary metabolic gene cluster silencing in Aspergillus nidulans. Molecular microbiology. 2006 Sep; 61(6):1636-45. doi: 10.1111/j.1365-2958.2006.05330.x. [PMID: 16968230]
  • Dimitrios I Tsitsigiannis, Nancy P Keller. Oxylipins act as determinants of natural product biosynthesis and seed colonization in Aspergillus nidulans. Molecular microbiology. 2006 Feb; 59(3):882-92. doi: 10.1111/j.1365-2958.2005.05000.x. [PMID: 16420358]
  • Lori A Maggio-Hall, Richard A Wilson, Nancy P Keller. Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta. Molecular plant-microbe interactions : MPMI. 2005 Aug; 18(8):783-93. doi: 10.1094/mpmi-18-0783. [PMID: 16134890]
  • Mosaad A Abdel-Wahhab, Aziza M Hasan, Soher E Aly, Karima F Mahrous. Adsorption of sterigmatocystin by montmorillonite and inhibition of its genotoxicity in the Nile tilapia fish (Oreachromis nilaticus). Mutation research. 2005 Apr; 582(1-2):20-7. doi: 10.1016/j.mrgentox.2004.12.009. [PMID: 15781206]
  • Heather H Wilkinson, Anitha Ramaswamy, Sung Chur Sim, Nancy P Keller. Increased conidiation associated with progression along the sterigmatocystin biosynthetic pathway. Mycologia. 2004 Nov; 96(6):1190-8. doi: ". [PMID: 21148941]
  • Yong-Qiang Zhang, Matthias Brock, Nancy P Keller. Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. Genetics. 2004 Oct; 168(2):785-94. doi: 10.1534/genetics.104.027540. [PMID: 15514053]
  • Jin Woo Bok, Nancy P Keller. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryotic cell. 2004 Apr; 3(2):527-35. doi: 10.1128/ec.3.2.527-535.2004. [PMID: 15075281]
  • Yong-Qiang Zhang, Nancy P Keller. Blockage of methylcitrate cycle inhibits polyketide production in Aspergillus nidulans. Molecular microbiology. 2004 Apr; 52(2):541-50. doi: 10.1111/j.1365-2958.2004.03994.x. [PMID: 15066039]
  • F Ma, J Misumi, W Zhao, K Aoki, M Kudo. Long-term treatment with sterigmatocystin, a fungus toxin, enhances the development of intestinal metaplasia of gastric mucosa in Helicobacter pylori-infected Mongolian gerbils. Scandinavian journal of gastroenterology. 2003 Apr; 38(4):360-9. doi: . [PMID: 12739707]
  • G P Kononenko, A A Burkin, N A Soboleva. [Specific features of albumin interactions with hemiacetals of aflatoxins and sterigmatocystin]. Prikladnaia biokhimiia i mikrobiologiia. 2003 Jan; 39(1):116-21. doi: . [PMID: 12625053]
  • Yuan Jin, Jin Woo Bok, Doralinda Guzman-de-Peña, Nancy P Keller. Requirement of spermidine for developmental transitions in Aspergillus nidulans. Molecular microbiology. 2002 Nov; 46(3):801-12. doi: 10.1046/j.1365-2958.2002.03201.x. [PMID: 12410837]
  • David M Wilson, Wellington Mubatanhema, Zeljko Jurjevic. Biology and ecology of mycotoxigenic Aspergillus species as related to economic and health concerns. Advances in experimental medicine and biology. 2002; 504(?):3-17. doi: 10.1007/978-1-4615-0629-4_2. [PMID: 11922097]
  • V Sivakumar, J Thanislass, S Niranjali, H Devaraj. Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity. Human & experimental toxicology. 2001 Aug; 20(8):398-403. doi: 10.1191/096032701682692955. [PMID: 11727790]
  • J Hicks, R A Lockington, J Strauss, D Dieringer, C P Kubicek, J Kelly, N Keller. RcoA has pleiotropic effects on Aspergillus nidulans cellular development. Molecular microbiology. 2001 Mar; 39(6):1482-93. doi: 10.1046/j.1365-2958.2001.02332.x. [PMID: 11260466]
  • K Shimizu, N P Keller. Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics. 2001 Feb; 157(2):591-600. doi: 10.1093/genetics/157.2.591. [PMID: 11156981]
  • N P Keller, C M Watanabe, H S Kelkar, T H Adams, C A Townsend. Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Applied and environmental microbiology. 2000 Jan; 66(1):359-62. doi: 10.1128/aem.66.1.359-362.2000. [PMID: 10618248]
  • R A Butchko, T H Adams, N P Keller. Aspergillus nidulans mutants defective in stc gene cluster regulation. Genetics. 1999 Oct; 153(2):715-20. doi: 10.1093/genetics/153.2.715. [PMID: 10511551]
  • M Fernandes, N P Keller, T H Adams. Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Molecular microbiology. 1998 Jun; 28(6):1355-65. doi: 10.1046/j.1365-2958.1998.00907.x. [PMID: 9680223]
  • C P Woloshuk, R Prieto. Genetic organization and function of the aflatoxin B1 biosynthetic genes. FEMS microbiology letters. 1998 Mar; 160(2):169-76. doi: 10.1111/j.1574-6968.1998.tb12907.x. [PMID: 9532734]
  • J K Hicks, J H Yu, N P Keller, T H Adams. Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway. The EMBO journal. 1997 Aug; 16(16):4916-23. doi: 10.1093/emboj/16.16.4916. [PMID: 9305634]
  • R Prieto, C P Woloshuk. ord1, an oxidoreductase gene responsible for conversion of O-methylsterigmatocystin to aflatoxin in Aspergillus flavus. Applied and environmental microbiology. 1997 May; 63(5):1661-6. doi: 10.1128/aem.63.5.1661-1666.1997. [PMID: 9143099]
  • H S Kelkar, N P Keller, T H Adams. Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis. Applied and environmental microbiology. 1996 Nov; 62(11):4296-8. doi: 10.1128/aem.62.11.4296-4298.1996. [PMID: 8900026]
  • R Prieto, G L Yousibova, C P Woloshuk. Identification of aflatoxin biosynthesis genes by genetic complementation in an Aspergillus flavus mutant lacking the aflatoxin gene cluster. Applied and environmental microbiology. 1996 Oct; 62(10):3567-71. doi: 10.1128/aem.62.10.3567-3571.1996. [PMID: 8967772]
  • J L Lou, Z Q Guo, Z H Meng. Production and characterization of a monoclonal antibody against sterigmatocystin. Biomedical and environmental sciences : BES. 1996 Mar; 9(1):17-25. doi: . [PMID: 8721623]
  • D W Brown, J H Yu, H S Kelkar, M Fernandes, T C Nesbitt, N P Keller, T H Adams, T J Leonard. Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proceedings of the National Academy of Sciences of the United States of America. 1996 Feb; 93(4):1418-22. doi: 10.1073/pnas.93.4.1418. [PMID: 8643646]
  • N P Keller, S Segner, D Bhatnagar, T H Adams. stcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans. Applied and environmental microbiology. 1995 Oct; 61(10):3628-32. doi: 10.1128/aem.61.10.3628-3632.1995. [PMID: 7486998]
  • H Tian, J Lou, C Du. [Determination of sterigmatocystin in cancerous tissues, blood and urine in patients with liver and stomach cancer]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 1995 Sep; 29(5):276-8. doi: . [PMID: 8556937]
  • J Lou, Z Guo, Z Meng. [Preparation and identification of monoclonal antibody against sterigmatocystin]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 1995 Mar; 29(2):92-5. doi: . [PMID: 7796690]
  • N P Keller, T H Adams. Analysis of a mycotoxin gene cluster in Aspergillus nidulans. SAAS bulletin, biochemistry and biotechnology. 1995; 8(?):14-21. doi: ". [PMID: 7546572]
  • N P Keller, N J Kantz, T H Adams. Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin. Applied and environmental microbiology. 1994 May; 60(5):1444-50. doi: 10.1128/aem.60.5.1444-1450.1994. [PMID: 8017929]
  • D P Hsieh, D N Atkinson. Bisfuranoid mycotoxins: their genotoxicity and carcinogenicity. Advances in experimental medicine and biology. 1991; 283(?):525-32. doi: 10.1007/978-1-4684-5877-0_69. [PMID: 1906226]
  • D S Wang, H L Sun, F Y Xiao, X H Ji, Y X Liang, F G Han. Distribution and excretion of 3H-sterigmatocystin in rats. IARC scientific publications. 1991; ?(105):424-6. doi: NULL. [PMID: 1855893]
  • W R Brian, M A Sari, M Iwasaki, T Shimada, L S Kaminsky, F P Guengerich. Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. Biochemistry. 1990 Dec; 29(51):11280-92. doi: 10.1021/bi00503a018. [PMID: 2271712]
  • D P Hsieh. Biological reactive intermediates of bisfuranoid mycotoxins. The Journal of toxicological sciences. 1990 Dec; 15 Suppl 4(?):152-8. doi: 10.2131/jts.15.supplementiv_152. [PMID: 2129232]
  • D H Chung, M M Abouzied, J J Pestka. Immunochemical assay applied to mycotoxin biosynthesis: ELISA comparison of sterigmatocystin production by Aspergillus versicolor and Aspergillus nidulans. Mycopathologia. 1989 Sep; 107(2-3):93-100. doi: 10.1007/bf00707544. [PMID: 2693965]
  • D L Orti, J Grainger, D L Ashley, R H Hill. Chromatographic and spectroscopic properties of hemiacetals of aflatoxin and sterigmatocystin metabolites. Journal of chromatography. 1989 Jan; 462(?):269-79. doi: 10.1016/s0021-9673(00)91353-0. [PMID: 2738124]