Sterigmatocystin (BioDeep_00000002621)

 

Secondary id: BioDeep_00000383539

human metabolite Endogenous Toxin natural product


代谢物信息卡片


15-hydroxy-11-methoxy-6,8,20-trioxapentacyclo[10.8.0.0²,⁹.0³,⁷.0¹⁴,¹⁹]icosa-1(12),2(9),4,10,14,16,18-heptaen-13-one

化学式: C18H12O6 (324.0634)
中文名称: 柄曲霉素
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 8.13%

分子结构信息

SMILES: C12OC3=C(C(O)=CC=C3)C(=O)C=1C(=CC1O[C@@]3([H])OC=C[C@@]3([H])C2=1)OC
InChI: InChI=1S/C18H12O6/c1-21-11-7-12-13(8-5-6-22-18(8)24-12)17-15(11)16(20)14-9(19)3-2-4-10(14)23-17/h2-8,18-19H,1H3

描述信息

Sterigmatocystin is a mycotoxin of Aspergillus versicolor and Chaetomium species Sterigmatocystin is a poison of the type dermatoxin, from the fungi genus Aspergillus. It appears on crusts of cheese with mold. Sterigmatocystin is a toxic metabolite structurally closely related to the aflatoxins (compare general fact sheet number 2), and consists of a xanthone nucleus attached to a bifuran structure. Sterigmatocystin is mainly produced by the fungi Aspergillus nidulans and A. versicolor. It has been reported in mouldy grain, green coffee beans and cheese although information on its occurrence in foods is limited. It appears to occur much less frequently than the aflatoxins, although analytical methods for its determination have not been as sensitive until recently, and so it is possible that small concentrations in food commodities may not always have been detected. Although it is a potent liver carcinogen similar to aflatoxin B1, current knowledge suggests that it is nowhere near as widespread in its occurrence. If this is the true situation it would be justified to consider sterigmatocystin as no more than a risk to consumers in special or unusual circumstances. Sterigmatocystin is a number of closely related compounds such o-methyl sterigmatocystin are known and some may also occur naturally. The IARC-classification of sterigmatocystin is group 2B, which means it is possibly carcinogenic to humans. In practice, the risk is quite low however, because this substance only appears on cheese crusts with mold, and because of that the chance of daily exposure is very low. Sterigmatocystin is a molded crust is best not to be consumed in whole, but after removing the crust, the cheese can still be consumed. Sterigmatocystin is a different kind of mold than that which appears on cheese itself, which can simply be removed before further consumption
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2320

同义名列表

5 个代谢物同义名

15-hydroxy-11-methoxy-6,8,20-trioxapentacyclo[10.8.0.0²,⁹.0³,⁷.0¹⁴,¹⁹]icosa-1(12),2(9),4,10,14,16,18-heptaen-13-one; 3a,12C-Dihydro-8-hydroxy-6-methoxy-7H-furo[3,2:4,5]furo[2,3-c]xanthen-7-one, 9ci; Sterigmatocystine; Sterigmatocystin; Sterigmatocystin



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

101 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AIMP2, ALB, BCL2, CAT, CDKN1A, CHEK2, CYP1A1, FASN, KEAP1, MAPK8, MDM2, TFPT
Peripheral membrane protein 2 CYP1A1, HSD17B6
Endoplasmic reticulum membrane 2 BCL2, CYP1A1
Nucleus 11 AIMP2, ALB, BCL2, CDKN1A, CHEK2, GABPA, KEAP1, MAPK8, MDM2, PCNA, TFPT
cytosol 10 AIMP2, ALB, BCL2, CAT, CDKN1A, FASN, GSS, KEAP1, MAPK8, MDM2
nuclear body 2 CDKN1A, PCNA
centrosome 2 ALB, PCNA
nucleoplasm 8 CDKN1A, CHEK2, GABPA, KEAP1, MAPK8, MDM2, PCNA, TFPT
Cell membrane 2 CD69, TNF
Early endosome membrane 1 HSD17B6
Synapse 1 MAPK8
cell surface 2 TNF, TNR
glutamatergic synapse 2 MDM2, TNR
Golgi apparatus 3 ALB, CHEK2, FASN
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 AIMP2
plasma membrane 4 CD69, FASN, MDM2, TNF
Membrane 4 AIMP2, BCL2, CAT, FASN
axon 1 MAPK8
extracellular exosome 5 ALB, CAT, FASN, GSS, PCNA
Lumenal side 1 HSD17B6
endoplasmic reticulum 4 ALB, BCL2, HSD17B6, KEAP1
extracellular space 4 ALB, IL6, TNF, TNR
perinuclear region of cytoplasm 1 CDKN1A
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 3 BCL2, CAT, CYP1A1
protein-containing complex 6 ALB, BCL2, CAT, CD69, CDKN1A, MDM2
intracellular membrane-bounded organelle 3 CAT, CYP1A1, HSD17B6
Microsome membrane 2 CYP1A1, HSD17B6
postsynaptic density 1 MDM2
Secreted 2 ALB, IL6
extracellular region 5 ALB, CAT, IL6, TNF, TNR
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
centriolar satellite 1 KEAP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 CD69, TNF
Secreted, extracellular space, extracellular matrix 1 TNR
nucleolus 2 CDKN1A, MDM2
midbody 1 KEAP1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 CD69, TNF
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 2 TNF, TNR
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
PML body 1 CHEK2
collagen-containing extracellular matrix 1 TNR
ciliary basal body 1 ALB
chromatin 2 GABPA, PCNA
phagocytic cup 1 TNF
centriole 1 ALB
Nucleus, nucleolus 1 MDM2
spindle pole 1 ALB
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
actin filament 2 KEAP1, TFPT
blood microparticle 1 ALB
Cul3-RING ubiquitin ligase complex 1 KEAP1
Nucleus, nucleoplasm 1 MDM2
Melanosome 1 FASN
replication fork 1 PCNA
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 ALB, IL6
transcription repressor complex 1 MDM2
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 MDM2
perineuronal net 1 TNR
nuclear lamina 1 PCNA
basal dendrite 1 MAPK8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
cyclin-dependent protein kinase holoenzyme complex 2 CDKN1A, PCNA
Ino80 complex 1 TFPT
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
PCNA complex 1 PCNA
PCNA-p21 complex 2 CDKN1A, PCNA
replisome 1 PCNA
tenascin complex 1 TNR
glycogen granule 1 FASN
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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