N-Acetylneuraminic acid (BioDeep_00000260987)

Main id: BioDeep_00000001628

Secondary id: BioDeep_00000014376, BioDeep_00000399867

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


N-Acetyl-alpha-neuraminic acid

化学式: C11H19NO9 (309.106)
中文名称: N-乙酰神经氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 16.35%

分子结构信息

SMILES: CC(=N[C@@H]1[C@H](C[C@](C(=O)O)(O)O[C@H]1[C@@H]([C@@H](CO)O)O)O)O
InChI: InChI=1S/C11H19NO9/c1-4(14)12-8(5(15)2-6(16)11(20)21)10(19)9(18)7(17)3-13/h5,7-10,13,15,17-19H,2-3H2,1H3,(H,12,14)(H,20,21)/t5-,7+,8+,9+,10+/m0/s1

描述信息

An N-acylneuraminic acid where the N-acyl group is specified as acetyl.
N-Acetylneuraminic acid with alpha configuration at the anomeric centre.
N-Acetylneuraminic acid with beta configuration at the anomeric centre.
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; SQVRNKJHWKZAKO-PFQGKNLYSA-N_STSL_0228_N-Acetylneuraminic acid_2000fmol_190114_S2_LC02MS02_081; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
N-Acetylneuraminic acid is a sialic acid monosaccharide ubiquitous on cell membrane glycoproteins and glycolipids of mammalian cell ganglioglycerides, which plays a biological role in neurotransmission, leukocyte vasodilation, and viral or bacterial infection.

同义名列表

9 个代谢物同义名

N-Acetylneuraminic acid; N-Acetyl-alpha-neuraminic acid; N-Acetyl-neuraminic acid; N-Acetyl-beta-neuraminic acid; 5-N-Acetyl-D-neuraminic acid; NANA; Lactaminic acid; N-Acetylneuraminate; (-)-N-Acetylneuraminic acid



数据库引用编号

53 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, CD22, CHL1, NANS, NEU4
Peripheral membrane protein 1 COQ10A
Endosome membrane 1 TF
Endoplasmic reticulum membrane 1 NEU4
Mitochondrion membrane 1 NEU4
Nucleus 3 ALB, CHL1, CMAS
cytosol 4 ALB, GNE, NANS, RENBP
dendrite 1 CHL1
centrosome 2 ALB, CHL1
nucleoplasm 3 CHL1, CMAS, SLC3A2
Cell membrane 6 CD22, CHL1, MAG, SELE, SLC3A2, TNF
Golgi apparatus membrane 1 GBGT1
Synapse 1 SLC3A2
cell junction 1 SLC3A2
cell surface 5 CD22, EPO, SLC3A2, TF, TNF
Golgi apparatus 3 ALB, GBGT1, ST6GAL1
Golgi membrane 2 GBGT1, ST6GAL1
lysosomal membrane 1 SLC3A2
mitochondrial inner membrane 2 COQ10A, NEU4
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 GNE
Lysosome 1 NEU4
plasma membrane 9 CD22, CHL1, MAG, NEU4, SELE, SIGLEC1, SLC3A2, TF, TNF
Membrane 9 CD22, CHL1, CMAS, CYB5D2, GBGT1, MAG, NEU4, SIGLEC1, SLC3A2
apical plasma membrane 2 SLC3A2, TF
basolateral plasma membrane 1 SLC3A2
caveola 1 SELE
extracellular exosome 8 ALB, CD22, CHL1, EPO, NANS, RENBP, SLC3A2, TF
Lysosome membrane 1 SLC3A2
endoplasmic reticulum 1 ALB
extracellular space 6 ALB, EPO, IL6, SELE, TF, TNF
lysosomal lumen 1 NEU4
perinuclear region of cytoplasm 2 SELE, TF
mitochondrion 1 COQ10A
protein-containing complex 1 ALB
Microsome membrane 1 NEU4
Single-pass type I membrane protein 5 CD22, CHL1, MAG, SELE, SIGLEC1
Secreted 5 ALB, CYB5D2, EPO, IL6, TF
extracellular region 8 ALB, CYB5D2, EPO, IL6, SIGLEC1, ST6GAL1, TF, TNF
Mitochondrion outer membrane 1 NEU4
Single-pass membrane protein 2 CHL1, MAG
mitochondrial outer membrane 1 NEU4
basal part of cell 1 TF
neuronal cell body membrane 1 CD22
anchoring junction 2 ALB, SLC3A2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CHL1
external side of plasma membrane 3 CD22, SELE, TNF
cytoplasmic vesicle 1 TF
nucleolus 1 CHL1
midbody 1 CHL1
Early endosome 3 CD22, SIGLEC1, TF
apical part of cell 1 CHL1
clathrin-coated pit 2 SELE, TF
recycling endosome 3 CD22, TF, TNF
Single-pass type II membrane protein 4 GBGT1, SLC3A2, ST6GAL1, TNF
vesicle 2 GBGT1, TF
Apical cell membrane 1 SLC3A2
Mitochondrion inner membrane 1 COQ10A
Matrix side 1 COQ10A
Membrane raft 3 MAG, SELE, TNF
Late endosome 2 SIGLEC1, TF
Cell projection, neuron projection 1 NEU4
neuron projection 1 NEU4
ciliary basal body 1 ALB
chromatin 1 CHL1
phagocytic cup 1 TNF
Chromosome 1 CHL1
centriole 1 ALB
Nucleus, nucleolus 1 CHL1
spindle pole 2 ALB, CHL1
blood microparticle 2 ALB, TF
Basolateral cell membrane 1 SLC3A2
Cytoplasm, cytoskeleton, spindle pole 1 CHL1
Endomembrane system 1 CYB5D2
Melanosome 1 SLC3A2
Golgi cisterna membrane 1 ST6GAL1
cell body 1 EPO
myelin sheath 1 MAG
basal plasma membrane 2 SLC3A2, TF
secretory granule lumen 2 EPO, TF
HFE-transferrin receptor complex 1 TF
endoplasmic reticulum lumen 3 ALB, IL6, TF
platelet alpha granule lumen 1 ALB
endocytic vesicle 1 TF
paranode region of axon 1 MAG
Schmidt-Lanterman incisure 1 MAG
[Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix 1 CHL1
Golgi apparatus, Golgi stack membrane 1 ST6GAL1
Lysosome lumen 1 NEU4
clathrin-coated endocytic vesicle membrane 1 TF
[Isoform 1]: Cell membrane 2 NEU4, SIGLEC1
vesicle coat 1 TF
Golgi medial cisterna 1 ST6GAL1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
compact myelin 1 MAG
cortical cytoskeleton 1 SELE
interleukin-6 receptor complex 1 IL6
myelin sheath adaxonal region 1 MAG
amino acid transport complex 1 SLC3A2
apical pole of neuron 1 SLC3A2
Golgi trans cisterna 1 ST6GAL1
mesaxon 1 MAG
ciliary transition fiber 1 ALB
[Isoform 2]: Mitochondrion inner membrane 1 NEU4
dense body 1 TF
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
organelle inner membrane 1 NEU4


文献列表

  • Wenliang Sun, Chao Han, Ruirui Ge, Xiaotong Jiang, Yu Wang, Yingchao Han, Ning Wang, Yanzhi Song, Mingshi Yang, Guoliang Chen, Yihui Deng. Sialic Acid Conjugate-Modified Cationic Liposomal Paclitaxel for Targeted Therapy of Lung Metastasis in Breast Cancer: What a Difference the Cation Content Makes. Molecular pharmaceutics. 2024 Apr; 21(4):1625-1638. doi: 10.1021/acs.molpharmaceut.3c00767. [PMID: 38403951]
  • Michael J Currie, James S Davies, Mariafrancesca Scalise, Ashutosh Gulati, Joshua D Wright, Michael C Newton-Vesty, Gayan S Abeysekera, Ramaswamy Subramanian, Weixiao Y Wahlgren, Rosmarie Friemann, Jane R Allison, Peter D Mace, Michael D W Griffin, Borries Demeler, Soichi Wakatsuki, David Drew, Cesare Indiveri, Renwick C J Dobson, Rachel A North. Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter. eLife. 2024 Feb; 12(?):. doi: 10.7554/elife.92307. [PMID: 38349818]
  • Tripti Halder, Bijit Saha, Namdev Dhas, Sanjeev Acharya, Niyati Acharya. Development and evaluation of multi-functionalized sialic acid conjugated asiatic acid nanoconstruct to mitigate cognitive deficits in Alzheimer's disease. Drug development research. 2024 Feb; 85(1):e22146. doi: 10.1002/ddr.22146. [PMID: 38349270]
  • Ricardo Zamudio Cañas, María Eugenia Jaramillo Flores, Verónica Vallejo Ruiz, Raúl Jacobo Delgado Macuil, Valentín López Gayou. Detection of Sialic Acid to Differentiate Cervical Cancer Cell Lines Using a Sambucus nigra Lectin Biosensor. Biosensors. 2024 Jan; 14(1):. doi: 10.3390/bios14010034. [PMID: 38248411]
  • Ashok Kumar Jangid, Sungjun Kim, Hee Won Park, Hyun Jin Kim, Kyobum Kim. Ex Vivo Surface Decoration of Phenylboronic Acid onto Natural Killer Cells for Sialic Acid-Mediated Versatile Cancer Cell Targeting. Biomacromolecules. 2024 Jan; 25(1):222-237. doi: 10.1021/acs.biomac.3c00916. [PMID: 38130077]
  • Shunfang Liu, Yaozhen He, Minding Feng, Yongtong Huang, Wenhao Wu, Jiu Wang. Targeted Delivery of Arctigenin Using Sialic Acid Conjugate-Modified Liposomes for the Treatment of Breast Cancer. Molecules (Basel, Switzerland). 2024 Jan; 29(1):. doi: 10.3390/molecules29010278. [PMID: 38202860]
  • Xueying Tang, Jiashuo Zhang, Dezhi Sui, Qiongfen Yang, Tianyu Wang, Zihan Xu, Xiaoya Li, Xin Gao, Xinyang Yan, Xinrong Liu, Yanzhi Song, Yihui Deng. Simultaneous dendritic cells targeting and effective endosomal escape enhance sialic acid-modified mRNA vaccine efficacy and reduce side effects. Journal of controlled release : official journal of the Controlled Release Society. 2023 12; 364(?):529-545. doi: 10.1016/j.jconrel.2023.11.008. [PMID: 37949317]
  • Reo Takeda, Ayaka Tabuchi, Yudai Nonaka, Ryotaro Kano, Mizuki Sudo, Yutaka Kano, Daisuke Hoshino. Cmah deficiency blunts cellular senescence in adipose tissues and improves whole-body glucose metabolism in aged mice. Geriatrics & gerontology international. 2023 Nov; ?(?):. doi: 10.1111/ggi.14732. [PMID: 37968438]
  • Zhangyang Wang, Xiaoqun Nie, Fang Gao, Yanmin Tang, Yuanyuan Ma, Yiying Zhang, Yanqin Gao, Chen Yang, Jing Ding, Xin Wang. Increasing brain N-acetylneuraminic acid alleviates hydrocephalus-induced neurological deficits. CNS neuroscience & therapeutics. 2023 11; 29(11):3183-3198. doi: 10.1111/cns.14253. [PMID: 37222223]
  • Yuna Guo, Pingping Wang, Liangyu Jiang, Chaowen Deng, Lei Zheng, Cong Song, Jianwei Jiao. Multifunctional Proximity Labeling Strategy for Lipid Raft-Specific Sialic Acid Tracking and Engineering. Bioconjugate chemistry. 2023 Sep; ?(?):. doi: 10.1021/acs.bioconjchem.3c00236. [PMID: 37767911]
  • Tanushree Das, Chaitali Mukhopadhyay. Comparison and Possible Binding Orientations of SARS-CoV-2 Spike N-Terminal Domain for Gangliosides GM3 and GM1. The journal of physical chemistry. B. 2023 08; 127(31):6940-6948. doi: 10.1021/acs.jpcb.3c02286. [PMID: 37523476]
  • Adam Wroński, Izabela Dobrzyńska, Szymon Sękowski, Wojciech Łuczaj, Ewa Olchowik-Grabarek, Elżbieta Skrzydlewska. Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA. International journal of molecular sciences. 2023 Aug; 24(15):. doi: 10.3390/ijms241512424. [PMID: 37569799]
  • Tomoko Kaburagi, Yuko Otsuka, Satoru Oshiro. Antiobesity Effect of N-Acetylneuraminic Acid by Enhancing Antioxidative Capacity in Mice Fed a High-Fat Diet. Journal of medicinal food. 2023 Aug; 26(8):550-559. doi: 10.1089/jmf.2023.k.0016. [PMID: 37335945]
  • Yan Huang, Qiufang Zhang, Zhenzhen Guo, Guanhong Deng, Ruibin Chen, Yanfen Zheng. Potential noninvasive biomarkers for the malignant transformation of oral leukoplakia: A systematic review and meta-analysis. Cancer medicine. 2023 May; ?(?):. doi: 10.1002/cam4.6095. [PMID: 37199052]
  • Geetanjali Negi, Anurag Sharma, Monika Chaudhary, Divya Gupta, Krishnan H Harshan, Nagma Parveen. SARS-CoV-2 Binding to Terminal Sialic Acid of Gangliosides Embedded in Lipid Membranes. ACS infectious diseases. 2023 May; ?(?):. doi: 10.1021/acsinfecdis.3c00106. [PMID: 37145972]
  • Priyanka Bose, Manoj K Jaiswal, Sumit K Singh, Rakesh K Singh, Vinod K Tiwari. Growing impact of sialic acid-containing glycans in future drug discovery. Carbohydrate research. 2023 May; 527(?):108804. doi: 10.1016/j.carres.2023.108804. [PMID: 37031650]
  • Xianmin Meng, Hongxia Zhang, Lingyan Chen, Mingqi Wang, Kaituo Zhang, Xinrong Liu, Yihui Deng, Yanzhi Song. Liposomal Doxorubicin: the Sphingomyelin/Cholesterol System Significantly Enhances the Antitumor Efficacy of Doxorubicin. AAPS PharmSciTech. 2023 Feb; 24(2):64. doi: 10.1208/s12249-022-02489-1. [PMID: 36759405]
  • Petra Kranaster, Jonathan Blum, Jeremias E G A Dold, Valentin Wittmann, Marcel Leist. Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells. Journal of neurochemistry. 2023 Feb; 164(4):481-498. doi: 10.1111/jnc.15737. [PMID: 36504018]
  • Katerina V Djambazova, Martin Dufresne, Lukasz G Migas, Angela R S Kruse, Raf Van de Plas, Richard M Caprioli, Jeffrey M Spraggins. MALDI TIMS IMS of Disialoganglioside Isomers─GD1a and GD1b in Murine Brain Tissue. Analytical chemistry. 2023 01; 95(2):1176-1183. doi: 10.1021/acs.analchem.2c03939. [PMID: 36574465]
  • Erhard Bieberich. Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins. Advances in neurobiology. 2023; 29(?):65-93. doi: 10.1007/978-3-031-12390-0_3. [PMID: 36255672]
  • A V Poznyak, D A Kashirskikh, A Y Postnov, M A Popov, V N Sukhorukov, A N Orekhov. Sialic acid as the potential link between lipid metabolism and inflammation in the pathogenesis of atherosclerosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2023; 56(?):e12972. doi: 10.1590/1414-431x2023e12972. [PMID: 38088673]
  • Roger Sandhoff, Konrad Sandhoff. Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease : Cascades of Secondary Metabolic Errors Can Generate Complex Pathologies (in LSDs). Advances in neurobiology. 2023; 29(?):333-390. doi: 10.1007/978-3-031-12390-0_12. [PMID: 36255681]
  • Bertan Boran Bayrak, Gonul Yenidogan Kulak, Refiye Yanardag, Aysen Yarat. Short term deuterium depletion in drinking water reduced tumor induced oxidative stress in mice liver. Pathology, research and practice. 2022 Dec; 240(?):154186. doi: 10.1016/j.prp.2022.154186. [PMID: 36327814]
  • Zhen Shen, Wei Dong, Zehua Chen, Guoqian Chen, Yan Zhang, Zige Li, Haixiong Lin, Huamei Chen, Minling Huang, Ying Guo, Ziwei Jiang. Total flavonoids of Rhizoma Drynariae enhances CD31hiEmcnhi vessel formation and subsequent bone regeneration in rat models of distraction osteogenesis by activating PDGF‑BB/VEGF/RUNX2/OSX signaling axis. International journal of molecular medicine. 2022 09; 50(3):. doi: 10.3892/ijmm.2022.5167. [PMID: 35795995]
  • Dileknur Topaloglu, Ismet Burcu Turkyilmaz, Refiye Yanardag. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. Journal of biochemical and molecular toxicology. 2022 Sep; 36(9):e23124. doi: 10.1002/jbt.23124. [PMID: 35670011]
  • Martin F Peter, Jan A Ruland, Peer Depping, Niels Schneberger, Emmanuele Severi, Jonas Moecking, Karl Gatterdam, Sarah Tindall, Alexandre Durand, Veronika Heinz, Jan Peter Siebrasse, Paul-Albert Koenig, Matthias Geyer, Christine Ziegler, Ulrich Kubitscheck, Gavin H Thomas, Gregor Hagelueken. Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter. Nature communications. 2022 08; 13(1):4471. doi: 10.1038/s41467-022-31907-y. [PMID: 35927235]
  • Lauren Byrd-Leotis, Nan Jia, Yasuyuki Matsumoto, Dongli Lu, Yoshihiro Kawaoka, David A Steinhauer, Richard D Cummings. Sialylated and sulfated N-Glycans in MDCK and engineered MDCK cells for influenza virus studies. Scientific reports. 2022 07; 12(1):12757. doi: 10.1038/s41598-022-16605-5. [PMID: 35882911]
  • Mengying Liu, Liane Z X Huang, Anthony A Smits, Christian Büll, Yoshiki Narimatsu, Frank J M van Kuppeveld, Henrik Clausen, Cornelis A M de Haan, Erik de Vries. Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions. Nature communications. 2022 07; 13(1):4054. doi: 10.1038/s41467-022-31840-0. [PMID: 35831293]
  • Yaoming Chen, Yuting He, Xiaoxia Zhan, Dubo Chen, Pinning Feng, Yan Yan, Yichong Wang. Sialic Acid as a Suitable Marker of Clinical Disease Activity in Patients with Crohn's Disease. Laboratory medicine. 2022 Jul; 53(4):381-385. doi: 10.1093/labmed/lmac006. [PMID: 35199160]
  • Lieh-Bang Liou, Ting-Yi Wang, I-Ju Liu, Han-Chung Wu, Po-Yuan Ke, Yao-Fan Fang, Yen-Fu Chen. α-2,6-sialic acid/IgG anti-dsDNA ratios correlate with human lupus disease activity and possible mechanisms: A pilot study. Lupus. 2022 Jul; 31(8):927-938. doi: 10.1177/09612033221099766. [PMID: 35531921]
  • Hongbing Liu, Dongdong Liu, Muse Ji, Peifu Xiao, Yi Qin, Jiansong Zhao, Na Wang, Jingxin Gou, Tian Yin, Haibing He, Guoliang Chen, Yu Zhang, Xing Tang. Inflammation-targeted sialic acid-dexamethasone conjugates for reducing the side effects of glucocorticoids. International journal of pharmaceutics. 2022 Jun; 622(?):121900. doi: 10.1016/j.ijpharm.2022.121900. [PMID: 35690305]
  • Kathia Antillon, Patrick A Ross, Mark P Farrell. Directing CAR NK Cells via the Metabolic Incorporation of CAR Ligands into Malignant Cell Glycans. ACS chemical biology. 2022 06; 17(6):1505-1512. doi: 10.1021/acschembio.2c00173. [PMID: 35648806]
  • Junfang Wu, Mingming Zhao, Haoran Wei, Chenze Li, Dong Hu, Lemin Zheng, Dao Wen Wang. Neuraminidase inhibitor treatment is associated with decreased mortality in COVID-19 patients: a retrospective analysis. European heart journal. Cardiovascular pharmacotherapy. 2022 06; 8(4):392-401. doi: 10.1093/ehjcvp/pvac018. [PMID: 35294004]
  • Yuanfei Ge, Jinyong Wu, Min Pang, Dan Hu, Zhongkui Li, Xiangqin Wang, Lijie Sun, Xiangsong Chen, Jianming Yao. Novel carboxymethyl chitosan/N-acetylneuraminic acid hydrogel for the protection of Pediococcus pentosaceus. Food research international (Ottawa, Ont.). 2022 06; 156(?):111355. doi: 10.1016/j.foodres.2022.111355. [PMID: 35650981]
  • Dianne E van der Wal, Laura M Rey Gomez, Thomas Hueneburg, Claire Linnane, Denese C Marks. Changes in glycans on platelet microparticles released during storage of apheresis platelets are associated with phosphatidylserine externalization and phagocytosis. Transfusion. 2022 06; 62(6):1289-1301. doi: 10.1111/trf.16891. [PMID: 35467785]
  • Mbateudi Danjuma Ika, Mohammed Auwal Ibrahim, Abdullahi Balarabe Sallau, Abdulmalik Abdullahi Salman, Abubakar Muhammad Sani, Murtala Bindawa Isah. Variations in the Serum Sialic Acid Profiles of Malaria Patients in Zaria, Nigeria: A Cross-Sectional Study. Acta parasitologica. 2022 Jun; 67(2):1010-1014. doi: 10.1007/s11686-021-00503-3. [PMID: 35000113]
  • Davide Ret, Linda Stefenatti, Alessio Gentile, Johanna Rohrhofer, Simone Knaus, Eva Untersmayr. DMTMM-mediated methylamidation for MALDI mass spectrometry analysis of N-glycans with structurally conserved sialic acid residues in biological fluids "via direttissima". Talanta. 2022 May; 242(?):123326. doi: 10.1016/j.talanta.2022.123326. [PMID: 35193013]
  • Simon J L Petitjean, Wenzhang Chen, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L Stanifer, Steeve Boulant, Stéphane P Vincent, David Alsteens. Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection. Nature communications. 2022 05; 13(1):2564. doi: 10.1038/s41467-022-30313-8. [PMID: 35538121]
  • Alan B Moran, Richard A Gardner, Manfred Wuhrer, Guinevere S M Lageveen-Kammeijer, Daniel I R Spencer. Sialic Acid Derivatization of Fluorescently Labeled N-Glycans Allows Linkage Differentiation by Reversed-Phase Liquid Chromatography-Fluorescence Detection-Mass Spectrometry. Analytical chemistry. 2022 05; 94(18):6639-6648. doi: 10.1021/acs.analchem.1c02610. [PMID: 35482581]
  • Weiqi Hong, Jingyun Yang, Jun Zou, Zhenfei Bi, Cai He, Hong Lei, Xuemei He, Xue Li, Aqu Alu, Wenyan Ren, Zeng Wang, Xiaohua Jiang, Kunhong Zhong, Guowen Jia, Yun Yang, Wenhai Yu, Qing Huang, Mengli Yang, Yanan Zhou, Yuan Zhao, Dexuan Kuang, Junbin Wang, Haixuan Wang, Siyuan Chen, Min Luo, Ziqi Zhang, Tianqi Lu, Li Chen, Haiying Que, Zhiyao He, Qiu Sun, Wei Wang, Guobo Shen, Guangwen Lu, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Jiong Li, Xiangrong Song, Lunzhi Dai, Chong Chen, Jia Geng, Maling Gou, Lu Chen, Haohao Dong, Yong Peng, Canhua Huang, Zhiyong Qian, Wei Cheng, Changfa Fan, Yuquan Wei, Zhaoming Su, Aiping Tong, Shuaiyao Lu, Xiaozhong Peng, Xiawei Wei. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells. Cellular & molecular immunology. 2022 May; 19(5):577-587. doi: 10.1038/s41423-022-00845-6. [PMID: 35273357]
  • Naazneen Khan, Aniruddha Sasmal, Zahra Khedri, Patrick Secrest, Andrea Verhagen, Saurabh Srivastava, Nissi Varki, Xi Chen, Hai Yu, Travis Beddoe, Adrienne W Paton, James C Paton, Ajit Varki. Sialoglycan-binding patterns of bacterial AB5 toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits. The Journal of biological chemistry. 2022 05; 298(5):101900. doi: 10.1016/j.jbc.2022.101900. [PMID: 35398357]
  • Luca Unione, María J Moure, Maria Pia Lenza, Iker Oyenarte, June Ereño-Orbea, Ana Ardá, Jesús Jiménez-Barbero. The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View. Angewandte Chemie (International ed. in English). 2022 04; 61(18):e202201432. doi: 10.1002/anie.202201432. [PMID: 35191576]
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