Acetovanillone (BioDeep_00000002580)

human metabolite PANOMIX_OTCML-2023 blood metabolite

代谢物信息卡片

1-(4-hydroxy-3-methoxyphenyl)ethan-1-one

化学式: C9H10O3 (166.062991)
中文名称: 香草乙酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1=CC(=C(C=C1)O)OC
InChI: InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3

描述信息

Acetovanillone, also known as 4-hydroxy-3-methoxyacetophenone or acetoguaiacon, is a member of the class of compounds known as alkyl-phenylketones. Alkyl-phenylketones are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. Acetovanillone is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Acetovanillone is a faint, sweet, and vanillin tasting compound found in corn and garden onion, which makes acetovanillone a potential biomarker for the consumption of these food products. Acetovanillone may be a unique S.cerevisiae (yeast) metabolite.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D020011 - Protective Agents > D000975 - Antioxidants
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].

同义名列表

18 个代谢物同义名

1-(4-hydroxy-3-methoxyphenyl)ethan-1-one; 4-Hydroxy-3-methoxyphenyl methyl ketone; 1-(4-Hydroxy-3-methoxyphenyl)ethanone; 4’-hydroxy-3’-methoxyacetophenone; 3-Methoxy-4-hydroxyphenylethanone; 3’-methoxy-4’-hydroxyacetophenone; 4-hydroxy-3-methoxyacetophenone; 3-Methoxy-4-hydroxyacetophenone; 2-methoxy-4-acetylphenol; 4-Acetyl-2-methoxyphenol; 4-Acetylguaiacol; Acetovanillone; Acetoguaiacone; Acetoguaiacol; Acetoguaicone; Acetoguaiacon; apocynine; apocynin

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:2781
KEGG: C11380
PubChem: 2214
HMDB: HMDB0247918
Metlin: METLIN69025
DrugBank: DB12618
ChEMBL: CHEMBL346919
Wikipedia: Apocynin
KNApSAcK: C00002689
foodb: FDB012055
chemspider: 21106900
CAS: 16522-48-8
CAS: 498-02-2
PMhub: MS000004025
PubChem: 13554
PDB-CCD: I75
3DMET: B04230
NIKKAJI: J13.670K
medchemexpress: HY-N0088

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

54 个相关的物种来源信息

97171 - Abies nephrolepis: 10.1002/CBDV.201000373
342581 - Abies spectabilis: 10.1248/CPB.58.1646
1475093 - Aglaia foveolata: 10.1002/CHIN.200438214
4679 - Allium cepa: 10.1016/J.PHYTOCHEM.2007.01.021
663965 - Anastatica hierochuntica:
61254 - Apocynum androsaemifolium: 10.1039/CT9099500734
13339 - Apocynum cannabinum: 10.1055/S-0028-1101540
377125 - Apocynum venetum L.: -
2528738 - Baccharis tola:
3589 - Basella alba: 10.1016/0889-1575(91)90017-Z
228709 - Cynanchum wilfordii: 10.1016/S0031-9422(97)00403-2
139932 - Engelhardia roxburghiana: 10.1016/J.PHYTOCHEM.2007.01.018
317934 - Fabiana imbricata: 10.1016/S0031-9422(00)89738-1
2764646 - Gypsophila Licentiana Hand.-Mazz.: -
9606 - Homo sapiens: -
310458 - Hyoscyamus albus: 10.1016/S0031-9422(00)94766-6
80369 - Imperata cylindrica: 10.1021/JF902310J
58944 - Iris domestica: 10.1007/BF02976631
34205 - Iris germanica:
995810 - Iris nigricans: 10.1021/NP50104A001
29817 - Iris pallida: 10.1002/HLCA.19490320426
114617 - Iris tectorum:
292520 - Iris tingitana: 10.1016/S0031-9422(00)83844-3
2039844 - Lagochilus leiacanthus: 10.1248/CPB.59.1535
189220 - Ligularia stenocephala: 10.1007/S11418-006-0008-8
307243 - Mansonia gagei: 10.1248/CPB.55.1332
470706 - Neopicrorhiza scrophulariiflora: 10.1016/S0378-8741(00)00268-3
72228 - Ophiocordyceps sinensis: 10.1021/NP100902F
35924 - Paeonia lactiflora: 10.1271/BBB1961.48.2847
62886 - Paeonia rockii: 10.1021/NP200359V
45171 - Paeonia suffruticosa:
3330 - Picea glauca: 10.1016/S0031-9422(96)00388-3
195120 - Picrorhiza kurrooa: 10.1016/0014-5793(92)80680-F
33090 - Plants: -
904463 - Pojarkovia pojarkovae: 10.1007/S11418-006-0008-8
375122 - Polygala fruticosa: 10.1016/J.PHYMED.2007.09.014
174549 - Polygala senega: 10.1002/FFJ.2730100408
75702 - Populus euphratica: 10.1007/S10600-008-0003-2
55489 - Posidonia oceanica: 10.1016/S0031-9422(97)01118-7
93820 - Pyrola americana: 10.1248/CPB.40.2083
642531 - Pyrola incarnata: 10.1248/CPB.40.2083
642532 - Pyrola japonica: 10.1248/CPB.40.2083
13651 - Pyrola rotundifolia: 10.1248/CPB.40.2083
50506 - Sargentodoxa cuneata: 10.3987/COM-03-9777
462527 - Senecio filaginoides: 10.1002/BSCB.19860950903
3562 - Spinacia oleracea: 10.1111/J.0901-9928.2000.870104.X
1826902 - Stellaria dichotoma:
157443 - Vincetoxicum atratum: 10.1021/NP000428B
648865 - Vincetoxicum mongolicum: 10.1021/NP50086A013
159976 - Viscum coloratum: 10.1248/CPB.54.1063
29760 - Vitis vinifera: 10.3389/FMICB.2017.00457
4577 - Zea mays: 10.1248/CPB.55.153
751879 - Ziziphora clinopodioides: 10.1016/J.FITOTE.2011.11.023
569774 - 金线莲: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Xuan Li, Wenyu Wu, Huan He, Lin Guan, Guancheng Chen, Zhijun Lin, Huan Li, Jialin Jiang, Xin Dong, Zhuoji Guan, Pinliang Chen, Zigang Pan, Weiwei Huang, Runjia Yu, Wenxin Song, Lu Lu, Zhongqi Yang, Zixin Chen, Lingjun Wang, Shaoxiang Xian, Jie Chen. Analysis and validation of hub genes in neutrophil extracellular traps for the long-term prognosis of myocardial infarction. Gene. 2024 Jul; 914(?):148369. doi: 10.1016/j.gene.2024.148369. [PMID: 38485036]
Cunxiang Bo, Fang Liu, Zewen Zhang, Zhongjun Du, Haidi Xiu, Zhenling Zhang, Ming Li, Caiqing Zhang, Qiang Jia. Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway. BMC pulmonary medicine. 2024 May; 24(1):224. doi: 10.1186/s12890-024-03014-9. [PMID: 38720270]
Xinglong Zhang, Ran Pang, Kai Zhang, Qian Xu, Chunlei Xu, Wei Shi, Xinyu Liang, Dong Li, Wenhao Cui, Shucai Bai, Zhijun Li, Hui Li, Huafeng Zhang. Apocynin exerts cytoprotective effects on dexamethasone-induced osteoblasts by inhibiting oxidative stress through the Nrf2 signalling pathway. Journal of cellular and molecular medicine. 2023 Sep; ?(?):. doi: 10.1111/jcmm.17974. [PMID: 37749949]
Reham Mokhtar Aman, Randa Ahmed Zaghloul, Wael M Elsaed, Irhan Ibrahim Abu Hashim. In vitro-in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis. Drug delivery and translational research. 2023 Jun; ?(?):. doi: 10.1007/s13346-023-01360-5. [PMID: 37284937]
Yongzhen Du, Tong Xu, Dongliu Luo, Yixuan Wang, Hang Yin, Chengguo Liu, Shu Li. Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol. Environmental toxicology. 2023 Mar; ?(?):. doi: 10.1002/tox.23794. [PMID: 36988283]
Gara N Dexter, Laura E Navas, Jason C Grigg, Harbir Bajwa, David J Levy-Booth, Jie Liu, Nathan A Louie, Seyed A Nasseri, Soo-Kyeong Jang, Scott Renneckar, Lindsay D Eltis, William W Mohn. Bacterial catabolism of acetovanillone, a lignin-derived compound. Proceedings of the National Academy of Sciences of the United States of America. 2022 10; 119(43):e2213450119. doi: 10.1073/pnas.2213450119. [PMID: 36256818]
Joanna Depciuch, Paweł Jakubczyk, Wiesław Paja, Jaromir Sarzyński, Krzysztof Pancerz, Merve Açıkel Elmas, Elif Keskinöz, Özlem Bingöl Özakpınar, Serap Arbak, Gökçe Özgün, Sevde Altuntaş, Zozan Guleken. Apocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Oct; 279(?):121495. doi: 10.1016/j.saa.2022.121495. [PMID: 35700610]
Adriel Ekozin, Chiagoziem A Otuechere, Adewale Adewuyi. Apocynin loaded silver nanoparticles displays potent in vitro biological activities and mitigates pyrogallol-induced hepatotoxicity. Chemico-biological interactions. 2022 Sep; 365(?):110069. doi: 10.1016/j.cbi.2022.110069. [PMID: 35944648]
Bin Li, Yuchun Shi, Yanbin Fu. Apocynin inhibits compressive force-induced apoptosis and autophagy of periodontal ligament stem cells. Oral diseases. 2022 Jun; ?(?):. doi: 10.1111/odi.14296. [PMID: 35770313]
Abhishek Kumar, Subrata Kumar Ghosh, Rahul Katiyar, Amare Eshetu Gemeda, Rupali Rautela, Amarjeet Bisla, Neeraj Srivastava, Sanjeev Kumar Bhure, Huidrom Lakshmi Devi, Vikash Chandra. Supplementation of Mito TEMPO and acetovanillone in semen extender improves freezability of buffalo spermatozoa. Andrology. 2022 05; 10(4):775-788. doi: 10.1111/andr.13158. [PMID: 35060362]
Venkata Prasuja Nakka, Raghu Gogada, Praveen Kumar Simhadri, Mohammed Abdul Qadeer, Prakash Babu Phanithi. Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke. Brain research bulletin. 2022 05; 182(?):1-11. doi: 10.1016/j.brainresbull.2022.02.003. [PMID: 35143926]
Rüya Kuru Yaşar, Dilruba Kuru, Ali Şen, Göksel Şener, Feriha Ercan, Ayşen Yarat. Effects of Myrtus communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet. Turkish journal of ophthalmology. 2021 Dec; 51(6):344-350. doi: 10.4274/tjo.galenos.2021.27981. [PMID: 34963261]
Cuneyt Tayman, Ufuk Çakır, Hasan Akduman, Şefika Karabulut, Murat Çağlayan. The therapeutic effect of Apocynin against hyperoxy and Inflammation-Induced lung injury. International immunopharmacology. 2021 Dec; 101(Pt A):108190. doi: 10.1016/j.intimp.2021.108190. [PMID: 34607228]
Shreya R Savla, Ankit P Laddha, Yogesh A Kulkarni. Pharmacology of apocynin: a natural acetophenone. Drug metabolism reviews. 2021 11; 53(4):542-562. doi: 10.1080/03602532.2021.1895203. [PMID: 33689526]
Omnia A M Abd El-Ghafar, Emad H M Hassanein, Ahmed M Sayed, Eman K Rashwan, Abdel-Gawad S Shalkami, Ayman M Mahmoud. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytotherapy research : PTR. 2021 Aug; 35(8):4499-4510. doi: 10.1002/ptr.7153. [PMID: 33969557]
Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):462-473. doi: 10.1080/10641963.2021.1901110. [PMID: 33775188]
Ajmal Ahmad, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Ahmed M Abu El-Asrar. Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina. Molecular and cellular biochemistry. 2021 May; 476(5):2099-2109. doi: 10.1007/s11010-021-04071-y. [PMID: 33515385]
T Y Chia, V Murugaiyah, N Ak Khan, M A Sattar, M H Abdulla, E J Johns, A Ahmad, Z Hassan, G Kaur, H Y Mei, F U Ahmad, S Akhtar. Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression. Physiological research. 2021 03; 70(1):13-26. doi: 10.33549/physiolres.934497. [PMID: 33728924]
Shugo Suzuki, Samuel M Cohen, Lora L Arnold, Karen L Pennington, Min Gi, Hiroyuki Kato, Taku Naiki, Aya Naiki-Ito, Hideki Wanibuchi, Satoru Takahashi. Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. Toxicology letters. 2021 Jan; 336(?):32-38. doi: 10.1016/j.toxlet.2020.11.005. [PMID: 33176187]
Sai Bharadwaja, Praveen Kumar Issac, Jocelyn Cleta, Rakesh Jeganathan, Sri Snehaa Chandrakumar, Sujatha Sundaresan. An in vitro mechanistic approach towards understanding the distinct pathways regulating insulin resistance and adipogenesis by apocynin. Journal of biosciences. 2021; 46(?):. doi: . [PMID: 33709960]
T Y Chia, V Murugaiyah, M A Sattar, N A K Khan, A Ahmad, M H Abdulla, E J Johns, H Y Mei, S Akhtar, F U Ahmad. The restorative effect of apocynin and catalase in l-arginine induced hypotension on normotensive subjects - the role of oxidative stress. Physiological research. 2020 12; 69(6):1051-1066. doi: 10.33549/physiolres.934426. [PMID: 33210935]
Fen Zheng, Chao Ye, Guo-Wei Wan, Bing Zhou, Ying Tong, Jian-Zhen Lei, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex. Pflugers Archiv : European journal of physiology. 2020 11; 472(11):1577-1586. doi: 10.1007/s00424-020-02461-7. [PMID: 32915316]
Han Sha, Yanchao Ma, Yuli Tong, Jie Zhao, Fengzhi Qin. Apocynin inhibits placental TLR4/NF-κB signaling pathway and ameliorates preeclampsia-like symptoms in rats. Pregnancy hypertension. 2020 Oct; 22(?):210-215. doi: 10.1016/j.preghy.2020.10.006. [PMID: 33099123]
Kübra Kavram Sarihan, Melda Yardimoğlu Yilmaz, Fatma Ceyla Eraldemir, Yusufhan Yazir, Esra Acar. Protective effects of apocynin on damaged testes of rats exposed to methotrexate. Turkish journal of medical sciences. 2020 08; 50(5):1409-1420. doi: 10.3906/sag-1909-52. [PMID: 32394677]
Fangfei Liu, Lampson M Fan, Nicholas Michael, Jian-Mei Li. In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study. Pharmacology research & perspectives. 2020 08; 8(4):e00635. doi: 10.1002/prp2.635. [PMID: 32761799]
Alejandra Z Vielma, Mauricio P Boric, Daniel R Gonzalez. Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice. International journal of molecular sciences. 2020 Jul; 21(15):. doi: 10.3390/ijms21155415. [PMID: 32751416]
Iñaki Robles-Vera, Néstor De La Visitación, Marta Toral, Manuel Sánchez, Manuel Gómez-Guzmán, Francisco O'valle, Rosario Jiménez, Juan Duarte, Miguel Romero. Toll-like receptor 7-driven lupus autoimmunity induces hypertension and vascular alterations in mice. Journal of hypertension. 2020 07; 38(7):1322-1335. doi: 10.1097/hjh.0000000000002368. [PMID: 32004206]
Sizhe Wan, Fangyun Luo, Chenkai Huang, Cong Liu, Qingtian Luo, Xuan Zhu. Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. Aging. 2020 06; 12(11):10614-10632. doi: 10.18632/aging.103282. [PMID: 32496208]
Xiaojia Yang, Kailiang Zhao, Wenhong Deng, Liang Zhao, Hongzhong Jin, Fangchao Mei, Yu Zhou, Man Li, Weixing Wang. Apocynin Attenuates Acute Kidney Injury and Inflammation in Rats with Acute Hypertriglyceridemic Pancreatitis. Digestive diseases and sciences. 2020 06; 65(6):1735-1747. doi: 10.1007/s10620-019-05892-0. [PMID: 31617131]
Xianwen Peng, Yongqiang Yang, Li Tang, Jingyuan Wan, Jie Dai, Longjiang Li, Jiayi Huang, Yi Shen, Ling Lin, Xianqiong Gong, Li Zhang. Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):110020. doi: 10.1016/j.biopha.2020.110020. [PMID: 32106375]
Yun Qiu, Fen Zheng, Chao Ye, Ai-Dong Chen, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation. Neuroscience bulletin. 2020 May; 36(5):463-474. doi: 10.1007/s12264-019-00460-y. [PMID: 31989424]
Poonam Rana, Kakulavarapu V Rama Rao, Arunreddy Ravula, Richa Trivedi, Maria D'Souza, Ajay K Singh, Raj K Gupta, Namas Chandra. Oxidative stress contributes to cerebral metabolomic profile changes in animal model of blast-induced traumatic brain injury. Metabolomics : Official journal of the Metabolomic Society. 2020 03; 16(3):39. doi: 10.1007/s11306-020-1649-4. [PMID: 32166461]
Viktoria Rungelrath, Sophie Öhlmann, Gottfried Alber, Wieland Schrödl, Maren von Köckritz-Blickwede, Nicole de Buhr, Alexander Martens, Christoph Georg Baums, Nicole Schütze. Survival of Streptococcus suis in Porcine Blood Is Limited by the Antibody- and Complement-Dependent Oxidative Burst Response of Granulocytes. Infection and immunity. 2020 02; 88(3):. doi: 10.1128/iai.00598-19. [PMID: 31843967]
Teng Liu, Wei Zheng, Linlin Wang, Lin Wang, Yanke Zhang. TLR4/NF-κB Signaling Pathway Participates in the Protective Effects of Apocynin on Gestational Diabetes Mellitus Induced Placental Oxidative Stress and Inflammation. Reproductive sciences (Thousand Oaks, Calif.). 2020 02; 27(2):722-730. doi: 10.1007/s43032-019-00078-5. [PMID: 32046403]
Qin Yang, Hai-Yong Chen, Jia-Nan Wang, Huai-Qin Han, Ling Jiang, Wei-Feng Wu, Biao Wei, Li Gao, Qiu-Ying Ma, Xue-Qi Liu, Qi Chen, Jia-Gen Wen, Juan Jin, Yan Huang, Wei-Jian Ni, Tao-Tao Ma, Jun Li, Xiao-Ming Meng. Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7. Clinical science (London, England : 1979). 2020 01; 134(2):103-122. doi: 10.1042/cs20191047. [PMID: 31898747]
Sanjin Kovacevic, Milan Ivanov, Zoran Miloradovic, Predrag Brkic, Una Jovana Vajic, Maja Zivotic, Nevena Mihailovic-Stanojevic, Djurdjica Jovovic, Danijela Karanovic, Rada Jeremic, Jelena Nesovic-Ostojic. Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats. PloS one. 2020; 15(1):e0226974. doi: 10.1371/journal.pone.0226974. [PMID: 31914135]
Nianxin Yang, Agustin Gonzalez-Vicente, Jeffrey L Garvin. Angiotensin II-induced superoxide and decreased glutathione in proximal tubules: effect of dietary fructose. American journal of physiology. Renal physiology. 2020 01; 318(1):F183-F192. doi: 10.1152/ajprenal.00462.2019. [PMID: 31760771]
Yong Chia Tan, Munavvar Abdul Sattar, Ahmad F Ahmeda, Nurzalina Abdul Karim Khan, Vikneswaran Murugaiyah, Ashfaq Ahmad, Zurina Hassan, Gurjeet Kaur, Mohammed Hadi Abdulla, Edward James Johns. Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats. PloS one. 2020; 15(4):e0231472. doi: 10.1371/journal.pone.0231472. [PMID: 32298299]
Emad H M Hassanein, Omnia A M Abd El-Ghafar, Marwa A Ahmed, Ahmed M Sayed, Wail M Gad-Elrab, Jamaan S Ajarem, Ahmed A Allam, Ayman M Mahmoud. Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats. Drug design, development and therapy. 2020; 14(?):5275-5288. doi: 10.2147/dddt.s281854. [PMID: 33299300]
Joanna Wieczfinska, Przemyslaw Sitarek, Ewa Skała, Tomasz Kowalczyk, Rafal Pawliczak. Inhibition of NADPH Oxidase-Derived Reactive Oxygen Species Decreases Expression of Inflammatory Cytokines in A549 Cells. Inflammation. 2019 Dec; 42(6):2205-2214. doi: 10.1007/s10753-019-01084-0. [PMID: 31612365]
A Walkowska, I Vaneckova, J Sadowski, E Kompanowska-Jezierska. Rapid blood pressure increase after renal denervation in anaesthetized rats: interaction of oxidative stress and neuronal nitric oxide synthase. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 Aug; 70(4):. doi: 10.26402/jpp.2019.4.12. [PMID: 31741458]
Matthew Kuriakose, Daniel Younger, Arun Reddy Ravula, Eren Alay, Kakulavarapu V Rama Rao, Namas Chandra. Synergistic Role of Oxidative Stress and Blood-Brain Barrier Permeability as Injury Mechanisms in the Acute Pathophysiology of Blast-induced Neurotrauma. Scientific reports. 2019 05; 9(1):7717. doi: 10.1038/s41598-019-44147-w. [PMID: 31118451]
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Liyan Hou, Ruixue Huang, Fuqiang Sun, Lin Zhang, Qingshan Wang. NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis. Toxicology. 2019 04; 417(?):64-73. doi: 10.1016/j.tox.2019.02.011. [PMID: 30797899]
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Hyo Hee Yang, Kyung-Eon Oh, Yang Hee Jo, Jong Hoon Ahn, Qing Liu, Ayman Turk, Jae Young Jang, Bang Yeon Hwang, Ki Yong Lee, Mi Kyeong Lee. Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay. Bioorganic & medicinal chemistry. 2018 01; 26(2):509-515. doi: 10.1016/j.bmc.2017.12.011. [PMID: 29254897]
Jie Liu, Yuzhang Zhu, Shipiao Chen, Bin Shen, Fang Yu, Yi Zhang, Ruilin Shen. Apocynin Attenuates Cobalt Chloride-Induced Pheochromocytoma Cell Apoptosis by Inhibiting P38-MAPK/Caspase-3 Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 48(1):208-214. doi: 10.1159/000491720. [PMID: 30007963]
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Satvika Sharma, Ankush Parmar, Rishi Bhardwaj, Rakesh Kumar Bijarnia, Tanzeer Kaur. Design and Characterization of Apocynin Loaded PLGA Nanoparticles and their In vivo Efficacy in Hyperoxaluric Rats. Current drug delivery. 2018; 15(7):1020-1027. doi: 10.2174/1567201815666180228163519. [PMID: 29493454]
Xia Li, Hao Guo, Lei Zhao, Bodong Wang, Haixiao Liu, Liang Yue, Hao Bai, Haiyang Jiang, Li Gao, Dayun Feng, Yan Qu. Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2017 12; 1863(12):3265-3276. doi: 10.1016/j.bbadis.2017.08.010. [PMID: 28844957]
Shuxian Zhang, Xiaohua Tan, Yan Chen, Xiuying Zhang. Postconditioning protects renal fibrosis by attenuating oxidative stress-induced mitochondrial injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2017 Oct; 32(10):1628-1636. doi: 10.1093/ndt/gfw469. [PMID: 28339958]
Arissa Felipe Borges, Camila Imai Morato, Rodrigo Saar Gomes, Miriam Leandro Dorta, Milton Adriano Pelli de Oliveira, Fátima Ribeiro-Dias. Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis. Pathogens and disease. 2017 09; 75(7):. doi: 10.1093/femspd/ftx082. [PMID: 28830073]
Md Mizanur Rahman, Awale Yousuf Muse, D M Isha Olive Khan, Ismaile Hussein Ahmed, Nusrat Subhan, Hasan Mahmud Reza, Md Ashraful Alam, Lutfun Nahar, Satyajit Dey Sarker. Apocynin prevented inflammation and oxidative stress in carbon tetra chloride induced hepatic dysfunction in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Aug; 92(?):421-428. doi: 10.1016/j.biopha.2017.05.101. [PMID: 28558355]
Bo Hu, Yuhong Wu, Fei Tong, Jie Liu, Xiaohua Shen, Ruilin Shen, Guangtao Xu. Apocynin Alleviates Renal Ischemia/Reperfusion Injury Through Regulating the Level of Zinc and Metallothionen. Biological trace element research. 2017 Jul; 178(1):71-78. doi: 10.1007/s12011-016-0904-z. [PMID: 27909865]
Jiuchun Qiu, Jianping Zhao, Jian Li, Xue Liang, Yajuan Yang, Zhiwei Zhang, Xiaowei Zhang, Huaying Fu, Panagiotis Korantzopoulos, Gary Tse, Tong Liu, Guangping Li. Apocynin attenuates left ventricular remodeling in diabetic rabbits. Oncotarget. 2017 Jun; 8(24):38482-38490. doi: 10.18632/oncotarget.16599. [PMID: 28388570]
Mercedes Muñoz, Maria Elvira López-Oliva, Estéfano Pinilla, María Pilar Martínez, Ana Sánchez, Claudia Rodríguez, Albino García-Sacristán, Medardo Hernández, Luis Rivera, Dolores Prieto. CYP epoxygenase-derived H2O2 is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries. Free radical biology & medicine. 2017 05; 106(?):168-183. doi: 10.1016/j.freeradbiomed.2017.02.031. [PMID: 28212823]
Ho Tsoi, Eagle S H Chu, Xiang Zhang, Jianqiu Sheng, Geicho Nakatsu, Siew C Ng, Anthony W H Chan, Francis K L Chan, Joseph J Y Sung, Jun Yu. Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology. 2017 05; 152(6):1419-1433.e5. doi: 10.1053/j.gastro.2017.01.009. [PMID: 28126350]
Zhu Hui Liu, Dao Peng Dai, Feng Hua Ding, Wen Qi Pan, Yue Hua Fang, Qi Zhang, Man Li, Ping Yang, Xiao Qun Wang, Ying Shen, Ling Jie Wang, Xiao Xiang Yan, Yu Hu He, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Ying Chen, Lin Lu. Association of serum HMGB2 level with MACE at 1 mo of myocardial infarction: Aggravation of myocardial ischemic injury in rats by HMGB2 via ROS. American journal of physiology. Heart and circulatory physiology. 2017 Mar; 312(3):H422-H436. doi: 10.1152/ajpheart.00249.2016. [PMID: 28011583]
Seok Ho Choi, Gil Joon Suh, Woon Yong Kwon, Kyung Su Kim, Min Ji Park, Taegyun Kim, Jeong In Ko. Apocynin suppressed the nuclear factor-κB pathway and attenuated lung injury in a rat hemorrhagic shock model. The journal of trauma and acute care surgery. 2017 03; 82(3):566-574. doi: 10.1097/ta.0000000000001337. [PMID: 28030501]
Shuang Chu, Xiaodong Mao, Hengjiang Guo, Li Wang, Zezheng Li, Yang Zhang, Yunman Wang, Hao Wang, Xuemei Zhang, Wen Peng. Indoxyl sulfate potentiates endothelial dysfunction via reciprocal role for reactive oxygen species and RhoA/ROCK signaling in 5/6 nephrectomized rats. Free radical research. 2017 Mar; 51(3):237-252. doi: 10.1080/10715762.2017.1296575. [PMID: 28277985]
Yuan-Yuan Qin, Mei Li, Xing Feng, Jian Wang, Lijuan Cao, Xi-Kui Shen, Jieyu Chen, Meiling Sun, Rui Sheng, Feng Han, Zheng-Hong Qin. Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke. Free radical biology & medicine. 2017 03; 104(?):333-345. doi: 10.1016/j.freeradbiomed.2017.01.034. [PMID: 28132925]
Sultan Zahiruddin, Washim Khan, Rinki Nehra, Md Javed Alam, Md Nasar Mallick, Rabea Parveen, Sayeed Ahmad. Pharmacokinetics and comparative metabolic profiling of iridoid enriched fraction of Picrorhiza kurroa - An Ayurvedic Herb. Journal of ethnopharmacology. 2017 Feb; 197(?):157-164. doi: 10.1016/j.jep.2016.07.072. [PMID: 27469200]
Janaina A Simplicio, Gabriel T do Vale, Natália A Gonzaga, Letícia N Leite, Ulisses V Hipólito, Camila A Pereira, Rita C Tostes, Carlos R Tirapelli. Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries. Journal of physiology and biochemistry. 2017 Feb; 73(1):5-16. doi: 10.1007/s13105-016-0519-z. [PMID: 27722988]
Chun-Lei Zhang, Guo-Ru Shi, Yan-Fei Liu, Yan Wang, Ruo-Yun Chen, De-Quan Yu. Apocynin derivatives from Iris tectorum. Journal of Asian natural products research. 2017 Feb; 19(2):128-133. doi: 10.1080/10286020.2016.1268128. [PMID: 28081623]
Gökçe Şeker Karatoprak, Gamze Aydin, Berrak Altinsoy, Cevahir Altinkaynak, Müberra Koşar, Ismail Ocsoy. The Effect of Pelargonium endlicherianum Fenzl. root extracts on formation of nanoparticles and their antimicrobial activities. Enzyme and microbial technology. 2017 Feb; 97(?):21-26. doi: 10.1016/j.enzmictec.2016.10.019. [PMID: 28010769]
Leonardo Sandrini, Alessandro Ieraci, Patrizia Amadio, Maurizio Popoli, Elena Tremoli, Silvia S Barbieri. Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress. Oxidative medicine and cellular longevity. 2017; 2017(?):9258937. doi: 10.1155/2017/9258937. [PMID: 29317986]
Xingsheng Ren, Feng Zhang, Mingxia Zhao, Zhenzhen Zhao, Shuo Sun, Dustin R Fraidenburg, Haiyang Tang, Ying Han. Angiotensin-(1-7) in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 42(6):2523-2539. doi: 10.1159/000480214. [PMID: 28848201]
Wenhong Deng, Ablikim Abliz, Sheng Xu, Rongze Sun, Wenyi Guo, Qiao Shi, Jia Yu, Weixing Wang. Severity of pancreatitis‑associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocynin. Molecular medicine reports. 2016 Oct; 14(4):3525-34. doi: 10.3892/mmr.2016.5678. [PMID: 27573037]
C M Rosa, R Gimenes, D H S Campos, G N Guirado, C Gimenes, A A H Fernandes, A C Cicogna, R M Queiroz, I Falcão-Pires, D Miranda-Silva, P Rodrigues, F R Laurindo, D C Fernandes, C R Correa, M P Okoshi, K Okoshi. Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus. Cardiovascular diabetology. 2016 09; 15(1):126. doi: 10.1186/s12933-016-0442-1. [PMID: 27585437]
Minu Sharma, Amit Sud, Tanzeer Kaur, Chanderdeep Tandon, S K Singla. N-acetylcysteine with apocynin prevents hyperoxaluria-induced mitochondrial protein perturbations in nephrolithiasis. Free radical research. 2016 Sep; 50(9):1032-44. doi: 10.1080/10715762.2016.1221507. [PMID: 27494339]
Katia Colombo Marchi, Carla Speroni Ceron, Jaqueline J Muniz, Bruno S De Martinis, José E Tanus-Santos, Carlos Renato Tirapelli. NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature. Alcohol and alcoholism (Oxford, Oxfordshire). 2016 Sep; 51(5):522-34. doi: 10.1093/alcalc/agw043. [PMID: 27382085]
Qinbo Yang, Jingang Cui, Peiwei Wang, Xiaoye Du, Wenjian Wang, Teng Zhang, Yu Chen. Changes in interconnected pathways implicating microRNAs are associated with the activity of apocynin in attenuating myocardial fibrogenesis. European journal of pharmacology. 2016 Aug; 784(?):22-32. doi: 10.1016/j.ejphar.2016.05.007. [PMID: 27174579]
Xi Cheng, Xizi Zheng, Yi Song, Lei Qu, Jiawei Tang, Liqiang Meng, Yu Wang. Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats. Free radical research. 2016 Aug; 50(8):840-52. doi: 10.1080/10715762.2016.1181757. [PMID: 27109518]
Neha Sharma, Bimla Nehru. Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model. Molecular neurobiology. 2016 07; 53(5):3326-3337. doi: 10.1007/s12035-015-9267-2. [PMID: 26081143]
Roberta Francesca Capogrosso, Anna Cozzoli, Paola Mantuano, Giulia Maria Camerino, Ada Maria Massari, Valeriana Teresa Sblendorio, Michela De Bellis, Roberto Tamma, Arcangela Giustino, Beatrice Nico, Monica Montagnani, Annamaria De Luca. Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone. Pharmacological research. 2016 Apr; 106(?):101-113. doi: 10.1016/j.phrs.2016.02.016. [PMID: 26930420]
Minu Sharma, Tanzeer Kaur, S K Singla. Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: therapeutic intervention with combinatorial therapy of N-acetyl cysteine and Apocynin. Mitochondrion. 2016 Mar; 27(?):15-24. doi: 10.1016/j.mito.2016.01.002. [PMID: 26779823]
Li-Na Chen, Gang Zhou, le Wu, Shao-Hua Hou. [Effect of NADPH oxidase inhibitor apocynin on the exercise induced proteinuria in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2016 Feb; 32(2):116-120. doi: 10.13459/j.cnki.cjap.2016.02.006. [PMID: 29931860]
Jinlong Yang, Yichao Cheng, Yuanyuan Zhu, Junjun Zhu, Tingting Chen, Yong Xu, Qiang Yong, Shiyuan Yu. [Effect of phenolic ketones on ethanol fermentation and cellular lipid composition of Pichia stipitis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2016 Feb; 32(2):185-94. doi: . [PMID: 27382768]
Ya J Jing, Jing W Ni, Feng H Ding, Yue H Fang, Xiao Q Wang, Hai B Wang, Xiao N Chen, Nan Chen, Wei W Zhan, Lin Lu, Rui Y Zhang. p-Cresyl sulfate is associated with carotid arteriosclerosis in hemodialysis patients and promotes atherogenesis in apoE-/- mice. Kidney international. 2016 Feb; 89(2):439-49. doi: 10.1038/ki.2015.287. [PMID: 26466319]
Valéria Nunes-Souza, Cheila Juliana César-Gomes, Lucas José Sá Da Fonseca, Glaucevane Da Silva Guedes, Salete Smaniotto, Luíza Antas Rabelo. Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. Oxidative medicine and cellular longevity. 2016; 2016(?):1987960. doi: 10.1155/2016/1987960. [PMID: 27057272]
Dong-dong Tang, Hong-xin Niu, Fen-fen Peng, Hai-bo Long, Zong-rui Liu, Hao Zhao, Yi-hua Chen. Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK-NF-κB Signaling Cascade: Protective Effects of Apocynin. Oxidative medicine and cellular longevity. 2016; 2016(?):1852340. doi: 10.1155/2016/1852340. [PMID: 26881015]
Yasir Furkan Cagin, Mehmet Ali Erdogan, Nurhan Sahin, Hakan Parlakpinar, Yahya Atayan, Alaadin Polat, Nigar Vardi, Azibe Yildiz, Kevser Tanbek. Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats. Archives of medical research. 2015 Oct; 46(7):517-26. doi: 10.1016/j.arcmed.2015.08.005. [PMID: 26319609]
Kun Zhang, Yu Liu, Xiaoqiang Liu, Jie Chen, Qingqing Cai, Jingfeng Wang, Hui Huang. Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids. Oncotarget. 2015 Sep; 6(28):24699-708. doi: 10.18632/oncotarget.5084. [PMID: 26322503]
Johanna Abrigo, María Gabriela Morales, Felipe Simon, Daniel Cabrera, Gabriella Di Capua, Claudio Cabello-Verrugio. Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Sep; 22(10):885-93. doi: 10.1016/j.phymed.2015.06.011. [PMID: 26321737]
Yimin Wang, Xiao Luo, Hao Pan, Wei Huang, Xueping Wang, Huali Wen, Kezhen Shen, Baiye Jin. Pharmacological inhibition of NADPH oxidase protects against cisplatin induced nephrotoxicity in mice by two step mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2015 Sep; 83(?):251-60. doi: 10.1016/j.fct.2015.05.007. [PMID: 26032634]
Izabella Z A Pawluczyk, Maryam G Najafabadi, Jeremy R Brown, Alan Bevington, Peter S Topham. Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats. Laboratory investigation; a journal of technical methods and pathology. 2015 Sep; 95(9):1019-28. doi: 10.1038/labinvest.2015.78. [PMID: 26121320]
Roberto Ciarcia, Sara Damiano, Alessia Florio, Manuela Spagnuolo, Enza Zacchia, Caterina Squillacioti, Nicola Mirabella, Salvatore Florio, Ugo Pagnini, Tiziana Garofano, Maria Sole Polito, Giovambattista Capasso, Antonio Giordano. The Protective Effect of Apocynin on Cyclosporine A-Induced Hypertension and Nephrotoxicity in Rats. Journal of cellular biochemistry. 2015 Sep; 116(9):1848-56. doi: 10.1002/jcb.25140. [PMID: 25704923]