Ropinirole (BioDeep_00000002547)
Secondary id: BioDeep_00000409842
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1H-indol-2-one
化学式: C16H24N2O (260.18885339999997)
中文名称: 罗匹尼罗
谱图信息:
最多检出来源 Homo sapiens(blood) 0.07%
分子结构信息
SMILES: CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1
InChI: InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
描述信息
Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinsons disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole). [Wikipedia]
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BC - Dopamine agonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
同义名列表
14 个代谢物同义名
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1H-indol-2-one; SmithKline beecham brand OF ropinirole hydrochloride; GlaxoSmithKline brand OF ropinirole hydrochloride; 4-(2-(Di-N-propylamino)ethyl)-2(3H)-indolone; Ropinirole hydrochloride; SK And F-101,468; SK And F 101468; Ropinirolum; ropinirole; Ropinirol; Ropitor; Requip; Ropinirole; Ropinirole
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:8888
- KEGG: C07564
- KEGGdrug: D08489
- PubChem: 5095
- HMDB: HMDB0014413
- Metlin: METLIN2361
- DrugBank: DB00268
- ChEMBL: CHEMBL589
- Wikipedia: Ropinirole
- chemspider: 4916
- CAS: 91374-21-9
- PMhub: MS000003488
- PubChem: 9767
- NIKKAJI: J264.965I
- KNApSAcK: 8888
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohd Akram, Neha, Pinky, Mohd Saqib, Mohd Salman, Suhel Parvez. Neuroprotective effect of ropinirole against Aβ1-42 -induced neurochemical perturbations and cognitive impairments in a rodent model.
The Kaohsiung journal of medical sciences.
2023 Nov; 39(11):1119-1128. doi:
10.1002/kjm2.12770. [PMID: 37902529] - Satoru Morimoto, Shinichi Takahashi, Daisuke Ito, Yugaku Daté, Kensuke Okada, Chris Kato, Shiho Nakamura, Fumiko Ozawa, Chai Muh Chyi, Ayumi Nishiyama, Naoki Suzuki, Koki Fujimori, Tosho Kondo, Masaki Takao, Miwa Hirai, Yasuaki Kabe, Makoto Suematsu, Masahiro Jinzaki, Masashi Aoki, Yuto Fujiki, Yasunori Sato, Norihiro Suzuki, Jin Nakahara, Hideyuki Okano. Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Cell stem cell.
2023 Jun; 30(6):766-780.e9. doi:
10.1016/j.stem.2023.04.017. [PMID: 37267913] - Saman Fatima, Mubashshir Ali, Syed Naved Quadri, Sarwar Beg, M Samim, Suhel Parvez, Malik Zainul Abdin, Prashant Mishra, Farhan Jalees Ahmad. Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach".
Biomaterials.
2022 10; 289(?):121805. doi:
10.1016/j.biomaterials.2022.121805. [PMID: 36162213] - Magdalene Huen-Yin Tang, Hok-Fung Tong, Ka-Chung Wong, Yeow-Kuan Chong. Ropinirole metabolite mimics a new psychoactive substance (4-HO-MET) in LC-MS/MS.
Forensic science international.
2022 Feb; 331(?):111151. doi:
10.1016/j.forsciint.2021.111151. [PMID: 34973484] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Hideki Mochizuki, Nobutaka Hattori, Kazuko Hasegawa, Masahiro Nomoto, Eiji Uchida, Takaaki Terahara, Koji Okawa, Hiroyuki Fukuta. Long-term study of ropinirole patch in Parkinson's disease patients with/without basal l-dopa.
Parkinsonism & related disorders.
2021 02; 83(?):105-109. doi:
10.1016/j.parkreldis.2020.12.023. [PMID: 33497892] - Nida Nehal, Bushra Nabi, Saleha Rehman, Ankita Pathak, Ashif Iqubal, Saif Ahmad Khan, M Shahar Yar, Suhel Parvez, Sanjula Baboota, Javed Ali. Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson's disease: Formulation perspective and In vitro and In vivo assessment.
International journal of biological macromolecules.
2021 Jan; 167(?):605-619. doi:
10.1016/j.ijbiomac.2020.11.207. [PMID: 33278450] - Pi-Kai Chang, Kun-Yi Chien, Jin-Chung Chen. Dopamine transporter is downregulated and its association with chaperone protein Hsc70 is enhanced by activation of dopamine D3 receptor.
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2020 12; 165(?):263-271. doi:
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2020 Jan; 37(1):198-209. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Shinichi Takahashi, Satoru Morimoto, Hideyuki Okano. [Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment].
Brain and nerve = Shinkei kenkyu no shinpo.
2019 Sep; 71(9):943-952. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
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2018 09; 16(3):182-184. doi:
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International journal of biological macromolecules.
2017 Oct; 103(?):347-354. doi:
10.1016/j.ijbiomac.2017.04.059. [PMID: 28457956] - Nobutaka Hattori, Kazuko Hasegawa, Katsuaki Sato, Erika Mitsuyama, Yotaro Numachi. Clinical evaluation of ropinirole controlled-release formulation at 18-24 mg/day in Japanese patients with Parkinson's disease.
Parkinsonism & related disorders.
2017 Jul; 40(?):33-39. doi:
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The Cochrane database of systematic reviews.
2016 11; 11(?):CD010690. doi:
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Bioanalysis.
2016 Sep; 8(17):1823-35. doi:
10.4155/bio-2016-0087. [PMID: 27491846] - Hayley J MacDonald, Cathy M Stinear, April Ren, James P Coxon, Justin Kao, Lorraine Macdonald, Barry Snow, Steven C Cramer, Winston D Byblow. Dopamine Gene Profiling to Predict Impulse Control and Effects of Dopamine Agonist Ropinirole.
Journal of cognitive neuroscience.
2016 Jul; 28(7):909-19. doi:
10.1162/jocn_a_00946. [PMID: 26942320] - Susan Mohamed, Roberto Riva, Manuela Contin. Validated UHPLC-MS/MS method for the simultaneous determination of pramipexole and ropinirole in plasma of patients with Parkinson's disease.
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2016 Apr; 1017-1018(?):114-119. doi:
10.1016/j.jchromb.2016.02.041. [PMID: 26970845] - M Z Zhu, W D Le, G Jin. Ropinirole alters gene expression profiles in SH-SY5Y cells: a whole genome microarray study.
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2016 Feb; 49(2):e4857. doi:
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Materials science & engineering. C, Materials for biological applications.
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10.1016/j.ijpharm.2014.07.025. [PMID: 25062866] - Ryszard Tomasiuk, Stanislaw Szlufik, Andrzej Friedman, Dariusz Koziorowski. Ropinirole treatment in Parkinson's disease associated with higher serum level of inflammatory biomarker NT-proCNP.
Neuroscience letters.
2014 Apr; 566(?):147-50. doi:
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2013 Sep; 24(9):2101-15. doi:
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2012 Oct; 19(7):422-5. doi:
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Clinical interventions in aging.
2012; 7(?):83-8. doi:
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