Ropinirole (BioDeep_00000002547)
Secondary id: BioDeep_00000409842
human metabolite blood metabolite
代谢物信息卡片
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1H-indol-2-one
化学式: C16H24N2O (260.1889)
中文名称: 罗匹尼罗
谱图信息:
最多检出来源 Homo sapiens(blood) 26.93%
分子结构信息
SMILES: CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1
InChI: InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
描述信息
Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinsons disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole). [Wikipedia]
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BC - Dopamine agonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
同义名列表
14 个代谢物同义名
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1H-indol-2-one; SmithKline beecham brand OF ropinirole hydrochloride; GlaxoSmithKline brand OF ropinirole hydrochloride; 4-(2-(Di-N-propylamino)ethyl)-2(3H)-indolone; Ropinirole hydrochloride; SK And F-101,468; SK And F 101468; Ropinirolum; ropinirole; Ropinirol; Ropitor; Requip; Ropinirole; Ropinirole
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:8888
- KEGG: C07564
- KEGGdrug: D08489
- PubChem: 5095
- HMDB: HMDB0014413
- Metlin: METLIN2361
- DrugBank: DB00268
- ChEMBL: CHEMBL589
- Wikipedia: Ropinirole
- chemspider: 4916
- CAS: 91374-21-9
- PMhub: MS000003488
- PubChem: 9767
- NIKKAJI: J264.965I
- KNApSAcK: 8888
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohd Akram, Neha, Pinky, Mohd Saqib, Mohd Salman, Suhel Parvez. Neuroprotective effect of ropinirole against Aβ1-42 -induced neurochemical perturbations and cognitive impairments in a rodent model.
The Kaohsiung journal of medical sciences.
2023 Nov; 39(11):1119-1128. doi:
10.1002/kjm2.12770. [PMID: 37902529] - Satoru Morimoto, Shinichi Takahashi, Daisuke Ito, Yugaku Daté, Kensuke Okada, Chris Kato, Shiho Nakamura, Fumiko Ozawa, Chai Muh Chyi, Ayumi Nishiyama, Naoki Suzuki, Koki Fujimori, Tosho Kondo, Masaki Takao, Miwa Hirai, Yasuaki Kabe, Makoto Suematsu, Masahiro Jinzaki, Masashi Aoki, Yuto Fujiki, Yasunori Sato, Norihiro Suzuki, Jin Nakahara, Hideyuki Okano. Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Cell stem cell.
2023 Jun; 30(6):766-780.e9. doi:
10.1016/j.stem.2023.04.017. [PMID: 37267913] - Saman Fatima, Mubashshir Ali, Syed Naved Quadri, Sarwar Beg, M Samim, Suhel Parvez, Malik Zainul Abdin, Prashant Mishra, Farhan Jalees Ahmad. Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach".
Biomaterials.
2022 10; 289(?):121805. doi:
10.1016/j.biomaterials.2022.121805. [PMID: 36162213] - Magdalene Huen-Yin Tang, Hok-Fung Tong, Ka-Chung Wong, Yeow-Kuan Chong. Ropinirole metabolite mimics a new psychoactive substance (4-HO-MET) in LC-MS/MS.
Forensic science international.
2022 Feb; 331(?):111151. doi:
10.1016/j.forsciint.2021.111151. [PMID: 34973484] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Hideki Mochizuki, Nobutaka Hattori, Kazuko Hasegawa, Masahiro Nomoto, Eiji Uchida, Takaaki Terahara, Koji Okawa, Hiroyuki Fukuta. Long-term study of ropinirole patch in Parkinson's disease patients with/without basal l-dopa.
Parkinsonism & related disorders.
2021 02; 83(?):105-109. doi:
10.1016/j.parkreldis.2020.12.023. [PMID: 33497892] - Nida Nehal, Bushra Nabi, Saleha Rehman, Ankita Pathak, Ashif Iqubal, Saif Ahmad Khan, M Shahar Yar, Suhel Parvez, Sanjula Baboota, Javed Ali. Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson's disease: Formulation perspective and In vitro and In vivo assessment.
International journal of biological macromolecules.
2021 Jan; 167(?):605-619. doi:
10.1016/j.ijbiomac.2020.11.207. [PMID: 33278450] - Pi-Kai Chang, Kun-Yi Chien, Jin-Chung Chen. Dopamine transporter is downregulated and its association with chaperone protein Hsc70 is enhanced by activation of dopamine D3 receptor.
Brain research bulletin.
2020 12; 165(?):263-271. doi:
10.1016/j.brainresbull.2020.10.005. [PMID: 33049353] - Shakshi Sharma, Khadga Raj, Shamsher Singh. Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats.
Neurotoxicity research.
2020 Jan; 37(1):198-209. doi:
10.1007/s12640-019-00120-z. [PMID: 31654381] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Shinichi Takahashi, Satoru Morimoto, Hideyuki Okano. [Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment].
Brain and nerve = Shinkei kenkyu no shinpo.
2019 Sep; 71(9):943-952. doi:
10.11477/mf.1416201386. [PMID: 31506396] - Manuela Contin, Giovanna Lopane, Susan Mohamed, Giovanna Calandra-Buonaura, Sabina Capellari, Patrizia De Massis, Stefania Nassetti, Alessandro Perrone, Roberto Riva, Luisa Sambati, Cesa Scaglione, Pietro Cortelli. Clinical pharmacokinetics of pramipexole, ropinirole and rotigotine in patients with Parkinson's disease.
Parkinsonism & related disorders.
2019 04; 61(?):111-117. doi:
10.1016/j.parkreldis.2018.11.007. [PMID: 30446407] - Chenrong Huang, Ziteng Wang, Linsheng Liu, Xiaoxue Liu, Ji Dong, Qingqing Xu, Bin Zhang, Liyan Miao. Predicting the dopamine D2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic-pharmacodynamic modeling.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Feb; 49(2):143-151. doi:
10.1080/00498254.2018.1428383. [PMID: 29334326] - Peter M Sinclair. Interventions for chronic kidney disease-associated restless legs syndrome.
International journal of evidence-based healthcare.
2018 09; 16(3):182-184. doi:
10.1097/xeb.0000000000000137. [PMID: 29517509] - Tomoo Mano. Camptocormia Induced by a Dopaminergic Agonist.
Clinical neuropharmacology.
2018 Mar; 41(2):70-72. doi:
10.1097/wnf.0000000000000266. [PMID: 29401068] - Somasree Ray, Goutam Roy, Sabyasachi Maiti, Uttam Kumar Bhattacharyya, Ayantika Sil, Ritwika Mitra. Development of smart hydrogels of etherified gum ghatti for sustained oral delivery of ropinirole hydrochloride.
International journal of biological macromolecules.
2017 Oct; 103(?):347-354. doi:
10.1016/j.ijbiomac.2017.04.059. [PMID: 28457956] - Nobutaka Hattori, Kazuko Hasegawa, Katsuaki Sato, Erika Mitsuyama, Yotaro Numachi. Clinical evaluation of ropinirole controlled-release formulation at 18-24 mg/day in Japanese patients with Parkinson's disease.
Parkinsonism & related disorders.
2017 Jul; 40(?):33-39. doi:
10.1016/j.parkreldis.2017.04.005. [PMID: 28442303] - Ravi Kanth Bhamidipati, Ramesh Mullangi, Nuggehally R Srinivas. Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Feb; 47(2):112-118. doi:
10.3109/00498254.2016.1166290. [PMID: 27093131] - Zeyad T Sahli, Jae Jo, Shaker A Mousa, Frank I Tarazi. Clinical management of restless legs syndrome in end-stage renal disease patients.
CNS spectrums.
2017 Feb; 22(1):14-21. doi:
10.1017/s109285291600064x. [PMID: 27702420] - Seerapani Gopaluni, Mohamed Sherif, Naim A Ahmadouk. Interventions for chronic kidney disease-associated restless legs syndrome.
The Cochrane database of systematic reviews.
2016 11; 11(?):CD010690. doi:
10.1002/14651858.cd010690.pub2. [PMID: 27819409] - Xingjin Yan, Shouwei Zhao, Wenwen Zhu, Jing Rao, Li Kang, Jiaqiang Xu, Dan Li, Lixia Qin, Lihui Qiu, Gao Li, Jiangeng Huang, Luqin Si. LC-MS/MS assay of ropinirole in rat biological matrices: elimination of lysoglycerophosphocholines-based matrix effect.
Bioanalysis.
2016 Sep; 8(17):1823-35. doi:
10.4155/bio-2016-0087. [PMID: 27491846] - Hayley J MacDonald, Cathy M Stinear, April Ren, James P Coxon, Justin Kao, Lorraine Macdonald, Barry Snow, Steven C Cramer, Winston D Byblow. Dopamine Gene Profiling to Predict Impulse Control and Effects of Dopamine Agonist Ropinirole.
Journal of cognitive neuroscience.
2016 Jul; 28(7):909-19. doi:
10.1162/jocn_a_00946. [PMID: 26942320] - Susan Mohamed, Roberto Riva, Manuela Contin. Validated UHPLC-MS/MS method for the simultaneous determination of pramipexole and ropinirole in plasma of patients with Parkinson's disease.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Apr; 1017-1018(?):114-119. doi:
10.1016/j.jchromb.2016.02.041. [PMID: 26970845] - M Z Zhu, W D Le, G Jin. Ropinirole alters gene expression profiles in SH-SY5Y cells: a whole genome microarray study.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2016 Feb; 49(2):e4857. doi:
10.1590/1414-431x20154857. [PMID: 26785691] - Christina Karavasili, Nikolaos Bouropoulos, Lamprini Sygellou, Elsa P Amanatiadou, Ioannis S Vizirianakis, Dimitrios G Fatouros. PLGA/DPPC/trimethylchitosan spray-dried microparticles for the nasal delivery of ropinirole hydrochloride: in vitro, ex vivo and cytocompatibility assessment.
Materials science & engineering. C, Materials for biological applications.
2016 Feb; 59(?):1053-1062. doi:
10.1016/j.msec.2015.11.028. [PMID: 26652464] - Gulam Mustafa, Alka Ahuja, Abdulmohsen H Al Rohaimi, Shahnawaz Muslim, Allam A Hassan, Sanjula Baboota, Javed Ali. Nano-ropinirole for the management of Parkinsonism: blood-brain pharmacokinetics and carrier localization.
Expert review of neurotherapeutics.
2015 Jun; 15(6):695-710. doi:
10.1586/14737175.2015.1036743. [PMID: 25955028] - Pratikkumar Patel, Anuradha Pol, Sandeep More, Dhaval R Kalaria, Yogeshvar N Kalia, Vandana B Patravale. Colloidal soft nanocarrier for transdermal delivery of dopamine agonist: ex vivo and in vivo evaluation.
Journal of biomedical nanotechnology.
2014 Nov; 10(11):3291-303. doi:
10.1166/jbn.2014.1857. [PMID: 26000388] - Yasmine M Gabal, Amany O Kamel, Omaima A Sammour, Ahmed H Elshafeey. Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route.
International journal of pharmaceutics.
2014 Oct; 473(1-2):442-57. doi:
10.1016/j.ijpharm.2014.07.025. [PMID: 25062866] - Ryszard Tomasiuk, Stanislaw Szlufik, Andrzej Friedman, Dariusz Koziorowski. Ropinirole treatment in Parkinson's disease associated with higher serum level of inflammatory biomarker NT-proCNP.
Neuroscience letters.
2014 Apr; 566(?):147-50. doi:
10.1016/j.neulet.2014.02.053. [PMID: 24602984] - Chandrakantsing V Pardeshi, Veena S Belgamwar, Avinash R Tekade, Sanjay J Surana. Novel surface modified polymer-lipid hybrid nanoparticles as intranasal carriers for ropinirole hydrochloride: in vitro, ex vivo and in vivo pharmacodynamic evaluation.
Journal of materials science. Materials in medicine.
2013 Sep; 24(9):2101-15. doi:
10.1007/s10856-013-4965-7. [PMID: 23728521] - Annika Plate, Jens Benninghoff, Gerald H Jansen, Elisabeth Wlasich, Sabina Eigenbrod, Alexander Drzezga, Nathalie L Jansen, Hans A Kretzschmar, Kai Bötzel, Dan Rujescu, Adrian Danek. Atypical parkinsonism due to a D202N Gerstmann-Sträussler-Scheinker prion protein mutation: first in vivo diagnosed case.
Movement disorders : official journal of the Movement Disorder Society.
2013 Feb; 28(2):241-4. doi:
10.1002/mds.25188. [PMID: 23436635] - Chandrakantsing V Pardeshi, Pravin V Rajput, Veena S Belgamwar, Avinash R Tekade, Sanjay J Surana. Novel surface modified solid lipid nanoparticles as intranasal carriers for ropinirole hydrochloride: application of factorial design approach.
Drug delivery.
2013; 20(1):47-56. doi:
10.3109/10717544.2012.752421. [PMID: 23311653] - N Hattori, K Hasegawa, T Sakamoto. Pharmacokinetics and effect of food after oral administration of prolonged-release tablets of ropinirole hydrochloride in Japanese patients with Parkinson's disease.
Journal of clinical pharmacy and therapeutics.
2012 Oct; 37(5):571-7. doi:
10.1111/j.1365-2710.2012.01336.x. [PMID: 22390368] - Stefano de Biase, Giovanni Merlino, Simone Lorenzut, Mariarosaria Valente, Gian Luigi Gigli. ADMET considerations for restless leg syndrome drug treatments.
Expert opinion on drug metabolism & toxicology.
2012 Oct; 8(10):1247-61. doi:
10.1517/17425255.2012.708023. [PMID: 22808933] - Sébastien Duband, Carolyne Bidat, Yvan Gaillard, Max Rochet, Jean-Philippe Camdessanche, Michel Péoc'h. A fatal intoxication case involving ropinirole.
Journal of forensic and legal medicine.
2012 Oct; 19(7):422-5. doi:
10.1016/j.jflm.2012.04.013. [PMID: 22920767] - Mark P DeAndrade, Russell L Johnson, Erica L Unger, Li Zhang, Thomas van Groen, Karen L Gamble, Yuqing Li. Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in Btbd9 mutant mice.
Human molecular genetics.
2012 Sep; 21(18):3984-92. doi:
10.1093/hmg/dds221. [PMID: 22678064] - V De Caro, G Giandalia, M G Siragusa, F M Sutera, L I Giannola. New prospective in treatment of Parkinson's disease: studies on permeation of ropinirole through buccal mucosa.
International journal of pharmaceutics.
2012 Jun; 429(1-2):78-83. doi:
10.1016/j.ijpharm.2012.03.022. [PMID: 22465630] - Adnan Azeem, Sushama Talegaonkar, Lalit M Negi, Farhan J Ahmad, Roop K Khar, Zeenat Iqbal. Oil based nanocarrier system for transdermal delivery of ropinirole: a mechanistic, pharmacokinetic and biochemical investigation.
International journal of pharmaceutics.
2012 Jan; 422(1-2):436-44. doi:
10.1016/j.ijpharm.2011.10.039. [PMID: 22057087] - Eva-Maria Hametner, Klaus Seppi, Werner Poewe. Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease.
Clinical interventions in aging.
2012; 7(?):83-8. doi:
10.2147/cia.s11829. [PMID: 22500116] - Motomi Arai. Ropinirole does not affect plasma arginine vasopressin levels in patients with advanced Parkinson's disease.
Neuro endocrinology letters.
2012; 33(7):680-3. doi:
. [PMID: 23391874] - Y Baba, M-A Higuchi, K Fukuyama, H Abe, Y Uehara, T Inoue, T Yamada. Effect of chronic kidney disease on excessive daytime sleepiness in Parkinson disease.
European journal of neurology.
2011 Nov; 18(11):1299-303. doi:
10.1111/j.1468-1331.2011.03391.x. [PMID: 21435111] - Ioannis U Isaias, Giorgio Marotta, Gianni Pezzoli, Osama Sabri, Johannes Schwarz, Paolo Crenna, Joseph Classen, Paolo Cavallari. Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease.
BMC neurology.
2011 Jul; 11(?):88. doi:
10.1186/1471-2377-11-88. [PMID: 21777421] - Manju A Kurian, Yan Li, Juan Zhen, Esther Meyer, Nebula Hai, Hans-Jürgen Christen, Georg F Hoffmann, Philip Jardine, Arpad von Moers, Santosh R Mordekar, Finbar O'Callaghan, Evangeline Wassmer, Elizabeth Wraige, Christa Dietrich, Timothy Lewis, Keith Hyland, Simon Heales, Terence Sanger, Paul Gissen, Birgit E Assmann, Maarten E A Reith, Eamonn R Maher. Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study.
The Lancet. Neurology.
2011 Jan; 10(1):54-62. doi:
10.1016/s1474-4422(10)70269-6. [PMID: 21112253] - Alessandra Fanciulli, Roberta Misasi, Dario Campanelli, Francesca R Buttarelli, Francesco R Pontieri. Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease.
Pharmacological reports : PR.
2011; 63(4):1056-60. doi:
10.1016/s1734-1140(11)70622-3. [PMID: 22001994] - Angelo Antonini, Daniela Calandrella. Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson's disease: implications for patients.
Neuropsychiatric disease and treatment.
2011; 7(?):297-302. doi:
10.2147/ndt.s10097. [PMID: 21654875] - M Meini, M Moncini, D Cecconi, V Cellesi, L Biasci, G Simoni, M Ameglio, M Pellegrini, R N Forgione, P Rucci. Aripiprazole and ropinirole treatment for cocaine dependence: evidence from a pilot study.
Current pharmaceutical design.
2011; 17(14):1376-83. doi:
10.2174/138161211796150783. [PMID: 21524261] - Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard. Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys.
PloS one.
2010 Nov; 5(11):e14053. doi:
10.1371/journal.pone.0014053. [PMID: 21124922] - Santiago Perez-Lloret, Olivier Rascol. Dopamine receptor agonists for the treatment of early or advanced Parkinson's disease.
CNS drugs.
2010 Nov; 24(11):941-68. doi:
10.2165/11537810-000000000-00000. [PMID: 20932066] - Paolo Solla, Antonino Cannas, Francesco Marrosu, Maria Giovanna Marrosu. Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo).
Neuropsychiatric disease and treatment.
2010 Sep; 6(?):483-90. doi:
10.2147/ndt.s5190. [PMID: 20856911] - Petr Dusek, Jitka Busková, Evzen Růzicka, Veronika Majerová, Antonín Srp, Robert Jech, Jan Roth, Karel Sonka. Effects of ropinirole prolonged-release on sleep disturbances and daytime sleepiness in Parkinson disease.
Clinical neuropharmacology.
2010 Jul; 33(4):186-90. doi:
10.1097/wnf.0b013e3181e71166. [PMID: 20661025] - Juan Zhen, Tamara Antonio, Aloke K Dutta, Maarten E A Reith. Concentration of receptor and ligand revisited in a modified receptor binding protocol for high-affinity radioligands: [3H]Spiperone binding to D2 and D3 dopamine receptors.
Journal of neuroscience methods.
2010 Apr; 188(1):32-8. doi:
10.1016/j.jneumeth.2010.01.031. [PMID: 20122961] - W H Jost, L Bergmann. [Clinical data of the prolonged-release formulation of ropinirole].
Fortschritte der Neurologie-Psychiatrie.
2010 Mar; 78 Suppl 1(?):S20-4. doi:
10.1055/s-0029-1245178. [PMID: 20195937] - Eva Maria Hodel, Abdunoor Mulokozi Kabanywanyi, Aggrey Malila, Boris Zanolari, Thomas Mercier, Hans-Peter Beck, Thierry Buclin, Piero Olliaro, Laurent Arthur Decosterd, Blaise Genton. Residual antimalarials in malaria patients from Tanzania--implications on drug efficacy assessment and spread of parasite resistance.
PloS one.
2009 Dec; 4(12):e8184. doi:
10.1371/journal.pone.0008184. [PMID: 20011529] - Jack J Chen, David M Swope, Khashayar Dashtipour, Kelly E Lyons. Transdermal rotigotine: a clinically innovative dopamine-receptor agonist for the management of Parkinson's disease.
Pharmacotherapy.
2009 Dec; 29(12):1452-67. doi:
10.1592/phco.29.12.1452. [PMID: 19947805] - D Vijaya Bharathi, B Jagadeesh, S Sirish Kumar, Revathi Naga Lakshmi, Kishore Kumar Hotha, A Naidu, Ramesh Mullangi. Highly sensitive method for the determination of ropinirole with a lower limit of quantitation of 3.45 pg/mL in human plasma by LC-ESI-MS/MS: application to a clinical pharmacokinetic study.
Biomedical chromatography : BMC.
2009 May; 23(5):557-62. doi:
10.1002/bmc.1144. [PMID: 19101918] - Narong Simakajornboon, Leila Kheirandish-Gozal, David Gozal. Diagnosis and management of restless legs syndrome in children.
Sleep medicine reviews.
2009 Apr; 13(2):149-56. doi:
10.1016/j.smrv.2008.12.002. [PMID: 19186083] - Jeung Hee Lee, Chan Wook Son, Mi Yeon Kim, Min Hee Kim, Hye Ran Kim, Eun Shil Kwak, Sena Kim, Mee Ree Kim. Red beet (Beta vulgaris L.) leaf supplementation improves antioxidant status in C57BL/6J mice fed high fat high cholesterol diet.
Nutrition research and practice.
2009; 3(2):114-21. doi:
10.4162/nrp.2009.3.2.114. [PMID: 20016711] - Muhammad M Nashatizadeh, Kelly E Lyons, Rajesh Pahwa. A review of ropinirole prolonged release in Parkinson's disease.
Clinical interventions in aging.
2009; 4(?):179-86. doi:
10.2147/cia.s3358. [PMID: 19503779] - Juliane Weber, Gillian M Keating. Ropinirole prolonged release: in advanced Parkinson's disease.
CNS drugs.
2009; 23(1):81-90. doi:
10.2165/0023210-200923010-00006. [PMID: 19062777] - Motomi Arai, Masayasu Iwabuchi. Pramipexole as a possible cause of the syndrome of inappropriate antidiuresis.
BMJ case reports.
2009; 2009(?):. doi:
10.1136/bcr.01.2009.1484. [PMID: 21687007] - Wolfgang H Jost, Carsten Buhmann, Gerd Fuchs, Wolfgang Greulich, Sibylla Hummel, Alexei Korchounov, Martina Müngersdorf, Michael Schwarz, Mechthild Spiegel-Meixensberger. Initial experience with ropinirole PR (prolonged release).
Journal of neurology.
2008 Sep; 255 Suppl 5(?):60-3. doi:
10.1007/s00415-008-5008-z. [PMID: 18787884] - Irena Rektorova, Marek Balaz, Jindra Svatova, Katerina Zarubova, Igor Honig, Vaclav Dostal, Silvie Sedlackova, Igor Nestrasil, Jiri Mastik, Martin Bares, Jana Veliskova, Ladislav Dusek. Effects of ropinirole on nonmotor symptoms of Parkinson disease: a prospective multicenter study.
Clinical neuropharmacology.
2008 Sep; 31(5):261-6. doi:
10.1097/wnf.0b013e31815d25ce. [PMID: 18836343] - Mohan L Noone, V G Pradeep Kumar, K Ummer, Laila Achambat, K A Salam. Cirrhosis presenting as Parkinsonism.
Annals of Indian Academy of Neurology.
2008 Jul; 11(3):179-81. doi:
10.4103/0972-2327.42938. [PMID: 19893665] - K A Stockwell, D J Virley, M Perren, M M Iravani, M J Jackson, S Rose, P Jenner. Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets.
Experimental neurology.
2008 May; 211(1):172-9. doi:
10.1016/j.expneurol.2008.01.019. [PMID: 18321484] - Angelo Antonini, Giovanni Abbruzzese, Paolo Barone, Ubaldo Bonuccelli, Leonardo Lopiano, Marco Onofrj, Mario Zappia, Aldo Quattrone. COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson's disease (PD): relevance for motor and non-motor features.
Neuropsychiatric disease and treatment.
2008 Feb; 4(1):1-9. doi:
10.2147/ndt.s2404. [PMID: 18728767] - David J Brooks. Optimizing levodopa therapy for Parkinson's disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective.
Neuropsychiatric disease and treatment.
2008 Feb; 4(1):39-47. doi:
10.2147/ndt.s1660. [PMID: 18728816] - Debra J Tompson, Deborah Vearer. Steady-state pharmacokinetic properties of a 24-hour prolonged-release formulation of ropinirole: results of two randomized studies in patients with Parkinson's disease.
Clinical therapeutics.
2007 Dec; 29(12):2654-66. doi:
10.1016/j.clinthera.2007.12.010. [PMID: 18201581] - Shen Qu, Weidong Le, Xiong Zhang, Wenjie Xie, Aijun Zhang, William G Ondo. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome.
Journal of neuropathology and experimental neurology.
2007 May; 66(5):383-8. doi:
10.1097/nen.0b013e3180517b5f. [PMID: 17483695] - Andrzej Bogucki, Agata Gajos. [Choosing a dopamine agonist in Parkinson's disease].
Neurologia i neurochirurgia polska.
2007 Mar; 41(2 Suppl 1):S14-21. doi:
. [PMID: 17941454] - Ai-Dong Wen, Yan-Yan Jia, Xiao-Xing Luo, Lin-Lin Bi, Xiao-Yan Chen, Da-Fang Zhong. The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers.
Journal of pharmaceutical and biomedical analysis.
2007 Jan; 43(2):774-8. doi:
10.1016/j.jpba.2006.08.001. [PMID: 17055209] - Joseph Jankovic, Mark Stacy. Medical management of levodopa-associated motor complications in patients with Parkinson's disease.
CNS drugs.
2007; 21(8):677-92. doi:
10.2165/00023210-200721080-00005. [PMID: 17630819] - Jignesh Bhatt, Arvind Jangid, Raghavendra Shetty, Bhavin Shah, Sandeep Kambli, Gunta Subbaiah, Sadhana Singh. Rapid and sensitive liquid chromatography-mass spectrometry method for determination of ropinirole in human plasma.
Journal of pharmaceutical and biomedical analysis.
2006 Mar; 40(5):1202-8. doi:
10.1016/j.jpba.2005.09.024. [PMID: 16289706] - Stephen J Humphrey, Chauncey N Turman, James T Curry, Gracella J Wheeler. Cardiovascular and electrocardiographic effects of the dopamine receptor agonists ropinirole, apomorphine, and PNU-142774E in conscious beagle dogs.
Journal of cardiovascular pharmacology.
2006 Mar; 47(3):337-47. doi:
10.1097/01.fjc.0000205983.05771.f5. [PMID: 16633074] - Dag Nyholm. Pharmacokinetic optimisation in the treatment of Parkinson's disease : an update.
Clinical pharmacokinetics.
2006; 45(2):109-36. doi:
10.2165/00003088-200645020-00001. [PMID: 16485914] - Miklos Z Molnar, Marta Novak, Istvan Mucsi. Management of restless legs syndrome in patients on dialysis.
Drugs.
2006; 66(5):607-24. doi:
10.2165/00003495-200666050-00003. [PMID: 16620140] - Jeffery Hackett. Evaluation of solid-phase sorbents for the analysis of ropinirole in whole blood.
Journal of analytical toxicology.
2006 Jan; 30(1):44-9. doi:
10.1093/jat/30.1.44. [PMID: 16620531] - Christian Peiser, Marcello Trevisani, David A Groneberg, Q Thai Dinh, Doerthe Lencer, Silvia Amadesi, Barbara Maggiore, Selena Harrison, Pierangelo Geppetti, Axel Fischer. Dopamine type 2 receptor expression and function in rodent sensory neurons projecting to the airways.
American journal of physiology. Lung cellular and molecular physiology.
2005 Jul; 289(1):L153-8. doi:
10.1152/ajplung.00222.2004. [PMID: 15792966] - Jeffrey N Joyce, Cheryl Woolsey, Han Ryoo, Sabine Borwege, Diane Hagner. Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.
BMC biology.
2004 Oct; 2(?):22. doi:
10.1186/1741-7007-2-22. [PMID: 15473914] - William Bara-Jimenez, Tzvetelina Dimitrova, Abdulah Sherzai, Antonella Favit, M M Mouradian, Thomas N Chase. Effect of monoamine reuptake inhibitor NS 2330 in advanced Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society.
2004 Oct; 19(10):1183-6. doi:
10.1002/mds.20124. [PMID: 15390018] - Tianhong Pan, Weidong Le, Joseph Jankovic. Slowing Parkinson's disease progression: recent dopamine agonist trials.
Neurology.
2004 Jan; 62(2):343; author reply 343-4. doi:
NULL. [PMID: 14750218] - Asteria Luzardo-Alvarez, M Begoña Delgado-Charro, José Blanco-Méndez. In vivo iontophoretic administration of ropinirole hydrochloride.
Journal of pharmaceutical sciences.
2003 Dec; 92(12):2441-8. doi:
10.1002/jps.10502. [PMID: 14603489] - Mathias Jähnel. [Pseudopheochromocytoma in Parkinson disease and depression].
Psychiatrische Praxis.
2003 May; 30 Suppl 2(?):S64-5. doi:
. [PMID: 14509040] - J Eric Ahlskog. Slowing Parkinson's disease progression: recent dopamine agonist trials.
Neurology.
2003 Feb; 60(3):381-9. doi:
10.1212/01.wnl.0000044047.58984.2f. [PMID: 12580184] - K Marek, D Jennings, J Seibyl. Do dopamine agonists or levodopa modify Parkinson's disease progression?.
European journal of neurology.
2002 Nov; 9 Suppl 3(?):15-22. doi:
10.1046/j.1468-1331.9.s3.2.x. [PMID: 12464117] - Marie-Paule Muriel, Gaël Orieux, Etienne C Hirsch. Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats.
Movement disorders : official journal of the Movement Disorder Society.
2002 Nov; 17(6):1174-9. doi:
10.1002/mds.10256. [PMID: 12465054] - Mark A Birrell, Natascia Crispino, David J Hele, Hema J Patel, Magdi H Yacoub, Peter J Barnes, Maria G Belvisi. Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD.
British journal of pharmacology.
2002 Jun; 136(4):620-8. doi:
10.1038/sj.bjp.0704758. [PMID: 12055141] - C M Kaye, B Nicholls. Clinical pharmacokinetics of ropinirole.
Clinical pharmacokinetics.
2000 Oct; 39(4):243-54. doi:
10.2165/00003088-200039040-00001. [PMID: 11069211] - M Iida, I Miyazaki, K Tanaka, H Kabuto, E Iwata-Ichikawa, N Ogawa. Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist.
Brain research.
1999 Aug; 838(1-2):51-9. doi:
10.1016/s0006-8993(99)01688-1. [PMID: 10446316] - J V Ramji, J P Keogh, T J Blake, C Broom, R J Chenery, D R Citerone, V A Lewis, A C Taylor, S E Yeulet. Disposition of ropinirole in animals and man.
Xenobiotica; the fate of foreign compounds in biological systems.
1999 Mar; 29(3):311-25. doi:
10.1080/004982599238696. [PMID: 10219970] - A Taylor, A Beerahee, D Citerone, M Davy, K Fitzpatrick, A Lopez-Gil, F Stocchi. The effect of steady-state ropinirole on plasma concentrations of digoxin in patients with Parkinson's disease.
British journal of clinical pharmacology.
1999 Feb; 47(2):219-22. doi:
10.1046/j.1365-2125.1999.00867.x. [PMID: 10190658] - S G Parker, P Raval, S Yeulet, R J Eden. Tolerance to peripheral, but not central, effects of ropinirole, a selective dopamine D2-like receptor agonist.
European journal of pharmacology.
1994 Nov; 265(1-2):17-26. doi:
10.1016/0014-2999(94)90218-6. [PMID: 7883025] - C de Mey, D Enterling, I Meineke, S Yeulet. Interactions between domperidone and ropinirole, a novel dopamine D2-receptor agonist.
British journal of clinical pharmacology.
1991 Oct; 32(4):483-8. doi:
10.1111/j.1365-2125.1991.tb03935.x. [PMID: 1683559] - C de Mey, D Enterling, I Meineke, E Brendel. Effects of the novel D2-dopaminergic agonist ropinirol on supine resting and stimulated circulatory and neuroendocrine variables in healthy volunteers.
Arzneimittel-Forschung.
1990 Jan; 40(1):7-13. doi:
. [PMID: 1971170] - G Acton, C Broom. A dose rising study of the safety and effects on serum prolactin of SK&F 101468, a novel dopamine D2-receptor agonist.
British journal of clinical pharmacology.
1989 Oct; 28(4):435-41. doi:
10.1111/j.1365-2125.1989.tb03524.x. [PMID: 2574051] - I G Beattie, T J Blake. Application of thermospray liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry for the identification of cynomolgus monkey and human metabolites of SK & F 101468, a dopamine D2 receptor agonist.
Journal of chromatography.
1989 Jul; 474(1):123-38. doi:
10.1016/s0021-9673(01)93907-x. [PMID: 2570079] - B A Mico, J E Swagzdis, D A Federowicz, K Straub. Functional group metabolism of dopamine-2 agonists: conversion of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone to 4-(2-di-n-propylaminoethyl)-7-hydroxy-2-(3H)-indolone.
Journal of pharmaceutical sciences.
1986 Oct; 75(10):929-33. doi:
10.1002/jps.2600751003. [PMID: 3795021] - J E Swagzdis, R W Wittendorf, R M DeMarinis, B A Mico. Pharmacokinetics of dopamine-2 agonists in rats and dogs.
Journal of pharmaceutical sciences.
1986 Oct; 75(10):925-8. doi:
10.1002/jps.2600751002. [PMID: 3795020] - J E Swagzdis, B A Mico. Liquid chromatographic determination of 4-(2-di-N,N-propylaminoethyl)-2-(3H)-indolone in rat, dog, and human plasma with ultraviolet detection.
Journal of pharmaceutical sciences.
1986 Jan; 75(1):90-1. doi:
10.1002/jps.2600750122. [PMID: 3958914]
