Rivastigmine (BioDeep_00000002492)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(S)-N-Ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate

化学式: C14H22N2O2 (250.1681192)
中文名称: 利凡斯的明, 卡巴拉汀
谱图信息: 最多检出来源 Homo sapiens(urine) 5%

分子结构信息

SMILES: CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
InChI: InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1

描述信息

Rivastigmine is only found in individuals that have used or taken this drug. It is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimers type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.Rivastigmine is a carbamate derivative that is structurally related to physostigmine, but not to donepezil and tacrine. The precise mechanism of rivastigmine has not been fully determined, but it is suggested that rivastigmine binds reversibly with and inactivates chlolinesterase (eg. acetylcholinesterase, butyrylcholinesterase), preventing the hydrolysis of acetycholine, and thus leading to an increased concentration of acetylcholine at cholinergic synapses. The anticholinesterase activity of rivastigmine is relatively specific for brain acetylcholinesterase and butyrylcholinesterase compared with those in peripheral tissues.
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
N - Nervous system > N06 - Psychoanaleptics > N06D - Anti-dementia drugs > N06DA - Anticholinesterases
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2844
EAWAG_UCHEM_ID 2844; CONFIDENCE standard compound
D020011 - Protective Agents
D004791 - Enzyme Inhibitors

同义名列表

21 个代谢物同义名

(S)-N-Ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate; 3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate; m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamic acid; (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamic acid; (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate; m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate; 3-[1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate; Tartrate, rivastigmine hydrogen; Hydrogen tartrate, rivastigmine; Rivastigmine hydrogen tartrate; RivastigmineTartrate; Ena 713 free base; 713, SDZ ENA; ENA 713, SDZ; RIVASTIGMINE; SDZ ENA 713; 713, ENA; Prometax; ENA 713; ENA-713; Exelon



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yi Zhou, Ying He, Xue Teng, Jing Mi, Jing Yang, Rongrui Wei, Wenmin Liu, Qinge Ma, Zhenghuai Tan, Zhipei Sang. Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. 2023 Dec; 38(1):2231661. doi: 10.1080/14756366.2023.2231661. [PMID: 37414563]
  • Nikita Subhash Hinge, Himanshu Kathuria, Murali Monohar Pandey. Rivastigmine-DHA ion-pair complex improved loading in hybrid nanoparticles for better amyloid inhibition and nose-to-brain targeting in Alzheimer's. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023 Sep; 190(?):131-149. doi: 10.1016/j.ejpb.2023.06.007. [PMID: 37330117]
  • Hammad Ismail, Dania Khalid, Durdana Waseem, Muhammad Umar Ijaz, Erum Dilshad, Ihsan-Ul Haq, Muhammad Zeeshan Bhatti, Sadaf Anwaar, Madiha Ahmed, Samreen Saleem. Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer's disease combined with insilico molecular docking. PloS one. 2023; 18(11):e0286349. doi: 10.1371/journal.pone.0286349. [PMID: 37910530]
  • Luis Fernando Valladales-Restrepo, Andrés Gaviria-Mendoza, María José Londoño-Serna, Juan Alberto Ospina-Cano, Claudia Giraldo-Giraldo, Manuel Enrique Machado-Duque, Jorge Enrique Machado-Alba. Prescription of transdermal patches in Colombia: A real-world evidence study. The International journal of risk & safety in medicine. 2023; 34(4):325-335. doi: 10.3233/jrs-220027. [PMID: 36776078]
  • Zhipei Sang, Ping Bai, Yujuan Ban, Keren Wang, Anguo Wu, Jing Mi, Jiaqi Hu, Rui Xu, Gaofeng Zhu, Jianta Wang, Jiquan Zhang, Changning Wang, Zhenghuai Tan, Lei Tang. Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies. Bioorganic chemistry. 2022 10; 127(?):106007. doi: 10.1016/j.bioorg.2022.106007. [PMID: 35849893]
  • Nasser A Hassan, Asma K Alshamari, Allam A Hassan, Mohamed G Elharrif, Abdullah M Alhajri, Mohammed Sattam, Reham R Khattab. Advances on Therapeutic Strategies for Alzheimer's Disease: From Medicinal Plant to Nanotechnology. Molecules (Basel, Switzerland). 2022 Jul; 27(15):. doi: 10.3390/molecules27154839. [PMID: 35956796]
  • Reza Aameri, Hossein Ghorbani, Hamid Reza Bazrafshan, Fatemeh Zahra Gharib, Bahareh Korani. Iranian thyme honey plays behavioral, cellular and molecular important roles as an amazing preventive and therapeutic agent in the brain of Alzheimer's rat model. Neuroscience letters. 2022 07; 783(?):136702. doi: 10.1016/j.neulet.2022.136702. [PMID: 35660648]
  • Adelaida Morte, Anna Vaqué, Marc Iniesta, Barbara Schug, Cornelius Koch, Rafael De la Torre, Bjoern Schurad. Bioavailability Study of a Transdermal Patch Formulation of Rivastigmine Compared with Exelon in Healthy Subjects. European journal of drug metabolism and pharmacokinetics. 2022 Jul; 47(4):567-578. doi: 10.1007/s13318-022-00778-5. [PMID: 35696054]
  • S Cunha, M Swedrowska, Y Bellahnid, Z Xu, J M Sousa Lobo, Ben Forbes, A C Silva. Thermosensitive in situ hydrogels of rivastigmine-loaded lipid-based nanosystems for nose-to-brain delivery: characterisation, biocompatibility, and drug deposition studies. International journal of pharmaceutics. 2022 May; 620(?):121720. doi: 10.1016/j.ijpharm.2022.121720. [PMID: 35413397]
  • Samaneh Fateh Basharzad, Mehrdad Hamidi, Aziz Maleki, Zahra Karami, Hamed Mohamadpour, Mohammad Reza Saghatchi Zanjani. Polysorbate-coated mesoporous silica nanoparticles as an efficient carrier for improved rivastigmine brain delivery. Brain research. 2022 04; 1781(?):147786. doi: 10.1016/j.brainres.2022.147786. [PMID: 35041841]
  • Chien-Ting Liu, Chuan-Chi Yang, Wu-Chien Chien, Chi-Hsiang Chung, Chien-Sung Tsai, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Chang Lin, Yi-Shi Chen, Nian-Sheng Tzeng. Association between long-term usage of acetylcholinesterase inhibitors and lung cancer in the elderly: a nationwide cohort study. Scientific reports. 2022 03; 12(1):3531. doi: 10.1038/s41598-022-06377-3. [PMID: 35241672]
  • Yichun Shi, Heng Zhang, Qing Song, Guangjun Yu, Zhuoling Liu, Feng Zhong, Zhenghuai Tan, Xiuxiu Liu, Yong Deng. Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry. 2022 Feb; 230(?):114098. doi: 10.1016/j.ejmech.2021.114098. [PMID: 35026532]
  • Xue Han, Jingchuan Liu, Xiaoyue Hu, Wei Wang, Qing Wang. Design of a Long-Acting Rivastigmine Transdermal Delivery System: Based on Computational Simulation. AAPS PharmSciTech. 2022 Jan; 23(1):54. doi: 10.1208/s12249-021-02207-3. [PMID: 35028813]
  • Fangcheng Fan, Hua Liu, Xiaojie Shi, Yangwen Ai, Qingshan Liu, Yong Cheng. The Efficacy and Safety of Alzheimer's Disease Therapies: An Updated Umbrella Review. Journal of Alzheimer's disease : JAD. 2022; 85(3):1195-1204. doi: 10.3233/jad-215423. [PMID: 34924395]
  • Anayatollah Salimi, Hanna Gobadian, Behzad Sharif Makhmalzadeh. Dermal pharmacokinetics of rivastigmine-loaded liposomes: an ex vivo-in vivo correlation study. Journal of liposome research. 2021 Sep; 31(3):246-254. doi: 10.1080/08982104.2020.1787440. [PMID: 32594811]
  • Yu Cai, Qi Tian, Chao Liu, Liang Fang. Development of long-acting rivastigmine drug-in-adhesive patch utilizing ion-pair strategy and characterization of controlled release mechanism. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Jun; 161(?):105774. doi: 10.1016/j.ejps.2021.105774. [PMID: 33640502]
  • Zhongcheng Cao, Qing Song, Guangjun Yu, Zhuoling Liu, Shiqing Cong, Zhenghuai Tan, Yong Deng. Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2021 04; 35(?):116074. doi: 10.1016/j.bmc.2021.116074. [PMID: 33640707]
  • M A Mora-Navarro, A R Rincón-Sánchez, F P Pacheco-Moisés, M A Mireles-Ramírez, D L C Delgado-Lara, B M Torres-Mendoza, I E Velázquez-Brizuela, G Gabriel Ortiz. Nutritional Status in Patients with Probable Alzheimer's Disease: Effect of Rivastigmine. The journal of nutrition, health & aging. 2021; 25(3):340-346. doi: 10.1007/s12603-020-1519-9. [PMID: 33575726]
  • Sara Hassan Omar, Rihab Osman, Wael Mamdouh, Hend Mohamed Abdel-Bar, Gehanne A S Awad. Bioinspired lipid-polysaccharide modified hybrid nanoparticles as a brain-targeted highly loaded carrier for a hydrophilic drug. International journal of biological macromolecules. 2020 Dec; 165(Pt A):483-494. doi: 10.1016/j.ijbiomac.2020.09.170. [PMID: 32987085]
  • Zhipei Sang, Keren Wang, Ping Bai, Anguo Wu, Jian Shi, Wenmin Liu, Gaofeng Zhu, Yiling Wang, Yu Lan, Zude Chen, Yiyang Zhao, Zhanpin Qiao, Changning Wang, Zhenghuai Tan. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2020 May; 194(?):112265. doi: 10.1016/j.ejmech.2020.112265. [PMID: 32240904]
  • Zhipei Sang, Keren Wang, Jian Shi, Wenmin Liu, Xinfeng Cheng, Gaofeng Zhu, Yiling Wang, Yiyang Zhao, Zhanpin Qiao, Anguo Wu, Zhenghuai Tan. The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2020 Apr; 192(?):112180. doi: 10.1016/j.ejmech.2020.112180. [PMID: 32131034]
  • Anas Shamsi, Taj Mohammad, Saleha Anwar, Mohamed F Alajmi, Afzal Hussain, Md Imtaiyaz Hassan, Faizan Ahmad, Asimul Islam. Probing the interaction of Rivastigmine Tartrate, an important Alzheimer's drug, with serum albumin: Attempting treatment of Alzheimer's disease. International journal of biological macromolecules. 2020 Apr; 148(?):533-542. doi: 10.1016/j.ijbiomac.2020.01.134. [PMID: 31954794]
  • Zhipei Sang, Keren Wang, Jian Shi, Xinfeng Cheng, Gaofeng Zhu, Rongrui Wei, Qinge Ma, Lintao Yu, Yiyang Zhao, Zhenghuai Tan, Wenmin Liu. Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2020 Feb; 187(?):111958. doi: 10.1016/j.ejmech.2019.111958. [PMID: 31865014]
  • Roma Ghai, Kandasamy Nagarajan, Meenakshi Arora, Parul Grover, Nazakat Ali, Garima Kapoor. Current Strategies and Novel Drug Approaches for Alzheimer Disease. CNS & neurological disorders drug targets. 2020; 19(9):676-690. doi: 10.2174/1871527319666200717091513. [PMID: 32679025]
  • Marion Ortner, Marion Stange, Heike Schneider, Charlotte Schröder, Katharina Buerger, Claudia Müller, Felix Müller-Sarnowski, Janine Diehl-Schmid, Hans Förstl, Timo Grimmer, Werner Steimer. Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil. Drug design, development and therapy. 2020; 14(?):3251-3262. doi: 10.2147/dddt.s247259. [PMID: 32848364]
  • Meenakshi Kanwar Chauhan, Pankaj Kumar Sharma. Optimization and characterization of rivastigmine nanolipid carrier loaded transdermal patches for the treatment of dementia. Chemistry and physics of lipids. 2019 11; 224(?):104794. doi: 10.1016/j.chemphyslip.2019.104794. [PMID: 31361985]
  • Zhipei Sang, Keren Wang, Pengfei Zhang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2019 Oct; 180(?):238-252. doi: 10.1016/j.ejmech.2019.07.021. [PMID: 31310916]
  • Zhipei Sang, Keren Wang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2019 Sep; 178(?):726-739. doi: 10.1016/j.ejmech.2019.06.026. [PMID: 31229875]
  • Ping-Song Chou, Kai-Ming Jhang, Ling-Chun Huang, Wen-Fu Wang, Yuan-Han Yang. Skinfold thickness for rivastigmine patch application in Alzheimer's disease. Psychopharmacology. 2019 Apr; 236(4):1255-1260. doi: 10.1007/s00213-018-5135-x. [PMID: 30645680]
  • Qing Song, Yan Li, Zhongcheng Cao, Hongyan Liu, Chaoquan Tian, Ziyi Yang, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2018 12; 26(23-24):6115-6127. doi: 10.1016/j.bmc.2018.11.015. [PMID: 30470598]
  • D M Ali, W Y Abdelzaher, Smn Abdel-Hafez. Evaluation of the rivastigmine role against botulinum toxin-A-induced osteoporosis in albino rats: A biochemical, histological, and immunohistochemical study. Human & experimental toxicology. 2018 Dec; 37(12):1323-1335. doi: 10.1177/0960327118774941. [PMID: 29739252]
  • Xudong Cao, Yifang Zhang, Yin Chen, Yinli Qiu, Minquan Yu, Xiangqing Xu, Xin Liu, Bi-Feng Liu, Liangren Zhang, Guisen Zhang. Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics. Journal of medicinal chemistry. 2018 11; 61(22):10017-10039. doi: 10.1021/acs.jmedchem.8b01096. [PMID: 30383372]
  • Sara I Shafiey, Wafaa R Mohamed, Ali A Abo-Saif. Paroxetine and rivastigmine mitigates adjuvant-induced rheumatoid arthritis in rats: Impact on oxidative stress, apoptosis and RANKL/OPG signals. Life sciences. 2018 Nov; 212(?):109-118. doi: 10.1016/j.lfs.2018.09.046. [PMID: 30267788]
  • Eylem Ulaş Saz, Ali Yurtseven, Mehmet Arda Kilinç, Ferhat Sari, Hasan Ağin. The First Use of Pralidoxime in a Child With Rivastigmine Poisoning. Pediatric emergency care. 2018 Oct; 34(10):e184-e186. doi: 10.1097/pec.0000000000001086. [PMID: 28328690]
  • Agnaldo Bruno Chies, Paula Carolina Grande Nakazato, Maria Angélica Spadella, Patrícia Zorzi, Maria Cecília Jordani Gomes, Luiz Augusto Carneiro D'Albuquerque, Orlando Castro-E-Silva. Rivastigmine prevents injury induced by ischemia and reperfusion in rat liver. Acta cirurgica brasileira. 2018 Sep; 33(9):775-784. doi: 10.1590/s0102-865020180090000005. [PMID: 30328909]
  • Fariba Malekpour-Galogahi, Ashrafalsadat Hatamian-Zarmi, Fariba Ganji, Bahman Ebrahimi-Hosseinzadeh, Fahimeh Nojoki, Razi Sahraeian, Zahra Beagom Mokhtari-Hosseini. Preparation and optimization of rivastigmine-loaded tocopherol succinate-based solid lipid nanoparticles. Journal of liposome research. 2018 Sep; 28(3):226-235. doi: 10.1080/08982104.2017.1349143. [PMID: 28670949]
  • Atsushi Kuroda, Manabu Setoguchi, Yasushi Uchino, Kazuya Nagata, Daisuke Hokonohara. Effect of rivastigmine on plasma butyrylcholine esterase activity and plasma ghrelin levels in patients with dementia in Alzheimer's disease. Geriatrics & gerontology international. 2018 Jun; 18(6):886-891. doi: 10.1111/ggi.13275. [PMID: 29441654]
  • Ehsan Mirparizi, Maryam Rajabi, Alireza Asghari. Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid-liquid microextraction followed by high-performance liquid chromatography. Journal of separation science. 2018 May; 41(10):2214-2220. doi: 10.1002/jssc.201701135. [PMID: 29427354]
  • Brian H May, Mei Feng, Anna J Hyde, Helmut Hügel, Su-Yueh Chang, Lin Dong, Xinfeng Guo, Anthony L Zhang, Chuanjian Lu, Charlie C Xue. Comparisons between traditional medicines and pharmacotherapies for Alzheimer disease: A systematic review and meta-analysis of cognitive outcomes. International journal of geriatric psychiatry. 2018 03; 33(3):449-458. doi: 10.1002/gps.4830. [PMID: 29239495]
  • Preeti Wavikar, Rohan Pai, Pradeep Vavia. Nose to Brain Delivery of Rivastigmine by In Situ Gelling Cationic Nanostructured Lipid Carriers: Enhanced Brain Distribution and Pharmacodynamics. Journal of pharmaceutical sciences. 2017 12; 106(12):3613-3622. doi: 10.1016/j.xphs.2017.08.024. [PMID: 28923321]
  • Yoshiki Suzuki, Yoshito Kamijo, Tomohiro Yoshizawa, Yuji Fujita, Kiyotaka Usui, Tohru Kishino. Acute cholinergic syndrome in a patient with mild Alzheimer's type dementia who had applied a large number of rivastigmine transdermal patches on her body. Clinical toxicology (Philadelphia, Pa.). 2017 Nov; 55(9):1008-1010. doi: 10.1080/15563650.2017.1329536. [PMID: 28594244]
  • Sara Nageeb El-Helaly, Ahmed Abd Elbary, Mohamed A Kassem, Mohamed A El-Nabarawi. Electrosteric stealth Rivastigmine loaded liposomes for brain targeting: preparation, characterization, ex vivo, bio-distribution and in vivo pharmacokinetic studies. Drug delivery. 2017 Nov; 24(1):692-700. doi: 10.1080/10717544.2017.1309476. [PMID: 28415883]
  • C-Y Lai, M-Y Wu, J-H Chiang, M-F Sun, Y-H Chen, C-T Chang, J-G Lin, H-R Yen. Utilization of Western medicine and traditional Chinese medicine among patients with Alzheimer's disease in Taiwan: a nationwide population-based study. European journal of neurology. 2017 09; 24(9):1166-1172. doi: 10.1111/ene.13361. [PMID: 28744942]
  • Dhiraj Abhyankar, Ashish Shedage, Milind Gole, Preeti Raut. Bioequivalence Study of Rivastigmine 6 mg Capsules (Single Dose) in Healthy Volunteers. American journal of Alzheimer's disease and other dementias. 2017 Sep; 32(6):360-366. doi: 10.1177/1533317517712890. [PMID: 28670911]
  • M Rejwan Ali, Mostafa Sadoqi, Simon G Møller, Allal Boutajangout, Mihaly Mezei. Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies. Journal of molecular graphics & modelling. 2017 09; 76(?):36-42. doi: 10.1016/j.jmgm.2017.06.027. [PMID: 28711758]
  • Nobuyasu Bando, Yu Nakamura. Preliminary evidence that rivastigmine-induced inhibition of serum butyrylcholinesterase activity improves behavioral symptoms in Japanese patients with Alzheimer's disease. Geriatrics & gerontology international. 2017 Sep; 17(9):1306-1312. doi: 10.1111/ggi.12865. [PMID: 27546156]
  • Helena Shifrin, Odelia Mouhadeb, Nathan Gluck, Chen Varol, Marta Weinstock. Cholinergic Anti-Inflammatory Pathway Does Not Contribute to Prevention of Ulcerative Colitis by Novel Indoline Carbamates. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2017 09; 12(3):484-491. doi: 10.1007/s11481-017-9735-8. [PMID: 28271317]
  • Tzu-Hua Chen, Mei-Chuan Chou, Chiou-Lian Lai, Shyh-Jong Wu, Chia-Ling Hsu, Yuan-Han Yang. Factors affecting therapeutic response to Rivastigmine in Alzheimer's disease patients in Taiwan. The Kaohsiung journal of medical sciences. 2017 Jun; 33(6):277-283. doi: 10.1016/j.kjms.2017.04.006. [PMID: 28601231]
  • Emma L Wightman. Potential benefits of phytochemicals against Alzheimer's disease. The Proceedings of the Nutrition Society. 2017 05; 76(2):106-112. doi: 10.1017/s0029665116002962. [PMID: 28143625]
  • Timothy M Morgan, Bob Soh. Absolute bioavailability and safety of a novel rivastigmine nasal spray in healthy elderly individuals. British journal of clinical pharmacology. 2017 03; 83(3):510-516. doi: 10.1111/bcp.13133. [PMID: 27639640]
  • Akanksha Kulshreshtha, Poonam Piplani. Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction. European journal of medicinal chemistry. 2016 Oct; 122(?):557-573. doi: 10.1016/j.ejmech.2016.06.046. [PMID: 27448914]
  • Hui-min Wang, Guo-guang Wei, Ming-yue Gao, Xiang-qin Gu, Shi-rui Mao. [Intranasal absorption of rivastigmine hydrogen tartrate and brain targeting evaluation]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 10; 51(10):1616-21. doi: NULL. [PMID: 29932610]
  • Gilbert Lefèvre, Francesca Callegari, Sandro Gsteiger, Yuan Xiong. Effects of Renal Impairment on Steady-State Plasma Concentrations of Rivastigmine: A Population Pharmacokinetic Analysis of Capsule and Patch Formulations in Patients with Alzheimer's Disease. Drugs & aging. 2016 10; 33(10):725-736. doi: 10.1007/s40266-016-0405-y. [PMID: 27681702]
  • Sachiko Nozaki, Masayuki Yamaguchi, Gilbert Lefèvre. Pharmacokinetic Modeling to Simulate the Concentration-Time Profiles After Dermal Application of Rivastigmine Patch. Journal of pharmaceutical sciences. 2016 07; 105(7):2213-21. doi: 10.1016/j.xphs.2016.04.011. [PMID: 27212635]
  • Yuxing Li, Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Ganyuan Xiao, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters. 2016 Apr; 26(8):2035-9. doi: 10.1016/j.bmcl.2016.02.079. [PMID: 26947607]
  • Rachel A Nieto, William James Deardorff, George T Grossberg. Efficacy of rivastigmine tartrate, transdermal system, in Alzheimer's disease. Expert opinion on pharmacotherapy. 2016; 17(6):861-70. doi: 10.1517/14656566.2016.1159296. [PMID: 26918774]
  • Brijesh Shah, Dignesh Khunt, Himanshu Bhatt, Manju Misra, Harish Padh. Application of quality by design approach for intranasal delivery of rivastigmine loaded solid lipid nanoparticles: Effect on formulation and characterization parameters. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2015 Oct; 78(?):54-66. doi: 10.1016/j.ejps.2015.07.002. [PMID: 26143262]
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